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The map label for this gene is guaA [H]

Identifier: 182679806

GI number: 182679806

Start: 3301041

End: 3302642

Strand: Reverse

Name: guaA [H]

Synonym: Bind_2895

Alternate gene names: 182679806

Gene position: 3302642-3301041 (Counterclockwise)

Preceding gene: 182679807

Following gene: 182679804

Centisome position: 79.2

GC content: 57.55

Gene sequence:

>1602_bases
ATGATGAGCCAATCCGATCCGCGCCAGGAGAATGTGAATCGCCATGACAAGGTGCTGATTGTCGATTTCGGCTCGCAGGT
CACGCAATTGATCGCGCGGCGGGTCCGGGAGGCAGGGGTCTATTGCGAAATCGCGCCATTCCAATCGGCTGAGCGTGCCT
TCGAGACCCTGGCGCCTAAGGCCGTGATCCTCTCCGGCGGTCCAGCTTCCGTGCTCGATCAAGGCTCCCCCCGTGTGCCG
GATGTGATTTTCAGCTCGAAAGTGCCGGTGCTTGGCATTTGCTATGGCGAGCAGGTGATGGCACTGCAACTGGGCGGCAA
GGTAGCCGCGGGCAAGACGCGTGAATTCGGCCGGGCGGATGTCGAAATTCTGGCCGAGAGTGCCTTGTTCGACAATGTCT
GGGAAAAAGGCCAGAGCTATCCCGTCTGGATGAGCCATGGCGATGCTGTCATTGATCTGCCGCCAGGCTTTGTGCGGGCC
GCAACCTCACGCCAGGAAGCCGTAGCCGTAATGGCCGACGAGGCGCGCCATTATTATGGCGTGCAGTTCCATCTTGAAGT
CGTGCATACGCCGCAAGGTGCGCGGTTGATCGAGAATTTCGTGCATAAAGTGGCGGGTCTCAGCCGAGACTGGACCATGC
GCGCCTTCCGGCAGGAGGCCATCGCTGCTATCCAGGCCAAAGTGGGCACGGGCCGTGTCCTCTGCGGTCTCTCCGGAGGA
GTCGATTCCGCCGTCGCGGCTTTGCTGATCCATGAGGCAATAGGCGATCGCCTGACTTGTGTGTTCGTCGATCATGGTTT
GTTACGCCATGGCGAGGCGGAGGAAATTGTCAGCCTGTTCCGTGGCCATTACAATATCCCTCTGATTCATGCGCAGGCGC
AGGATCTGTTTCTCGATGCGCTTGCGGGGGTCAGTGATCCCGAAGAAAAGCGGCGCATCATCGGGCGTCTGTTCATCGAA
ACATTCGAGGCCGAAGCGAAGACCATTGCCTCCGATGGCAAGGGAGTTCCGGAATTTCTCGGCCAGGGAACATTGTATCC
GGATGTGATCGAAAGTGTATCCTTCACGGGTGGTCCTTCCGTCACCATTAAATCCCATCATAATGTCGGCGGCCTCCCCG
AGCGGATGAATATGAAGCTCGTCGAGCCCTTGCGGGAATTGTTCAAGGACGAAGTCCGCGAATTAGGCCGCGAACTCGGT
CTGCCGGAAGCCTTCGTTAGCCGACATCCTTTCCCTGGTCCCGGCCTCGCGATCCGTTGTCCGGGAGGCGTCACAAGGGA
GAAACTCGCCATCTTGCGGCAGGCCGATGCGATCTATCTCGATGAGATCAGAAAAGCGGGTCTCTATGACAAGATCTGGC
AAGCTTTCGCTGTCTTGTTGCCGGTGCAGACGGTTGGTGTGATGGGGGATGGCCGCACTTACGAGTTTGTATGCGCCCTG
CGTGCGGTGACATCGGTCGATGGCATGACTGCGGATTTCTATAGCTTTGAAATGGATTTTCTCGGTCGAGCGGCGACCAG
GATTATCAATGAAGTGCAAGGAATTAATCGCGTTGTCTATGATGTAACGTCGAAACCGCCAGGCACGATCGAGTGGGAAT
GA

Upstream 100 bases:

>100_bases
ATCGGCCCGCGCCTTTGTTTTGGTCTATCGCCCTTCATTTTAGAACGAGCCAAGATCGGGACCGGGGTCGCCGCCTAGCC
TGATCTCCTATCAGGGAATG

Downstream 100 bases:

>100_bases
TTTTGGCCTATCCGGGCGTATCCAAAACTACGCTACGGCGCGATATTCGGCATCTGTTGATACCTATCGGTGGGCAAAGA
TCGCGGCCGTCGGCCCCGTT

Product: GMP synthase, large subunit

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MMSQSDPRQENVNRHDKVLIVDFGSQVTQLIARRVREAGVYCEIAPFQSAERAFETLAPKAVILSGGPASVLDQGSPRVP
DVIFSSKVPVLGICYGEQVMALQLGGKVAAGKTREFGRADVEILAESALFDNVWEKGQSYPVWMSHGDAVIDLPPGFVRA
ATSRQEAVAVMADEARHYYGVQFHLEVVHTPQGARLIENFVHKVAGLSRDWTMRAFRQEAIAAIQAKVGTGRVLCGLSGG
VDSAVAALLIHEAIGDRLTCVFVDHGLLRHGEAEEIVSLFRGHYNIPLIHAQAQDLFLDALAGVSDPEEKRRIIGRLFIE
TFEAEAKTIASDGKGVPEFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRELGRELG
LPEAFVSRHPFPGPGLAIRCPGGVTREKLAILRQADAIYLDEIRKAGLYDKIWQAFAVLLPVQTVGVMGDGRTYEFVCAL
RAVTSVDGMTADFYSFEMDFLGRAATRIINEVQGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_533_residues
MMSQSDPRQENVNRHDKVLIVDFGSQVTQLIARRVREAGVYCEIAPFQSAERAFETLAPKAVILSGGPASVLDQGSPRVP
DVIFSSKVPVLGICYGEQVMALQLGGKVAAGKTREFGRADVEILAESALFDNVWEKGQSYPVWMSHGDAVIDLPPGFVRA
ATSRQEAVAVMADEARHYYGVQFHLEVVHTPQGARLIENFVHKVAGLSRDWTMRAFRQEAIAAIQAKVGTGRVLCGLSGG
VDSAVAALLIHEAIGDRLTCVFVDHGLLRHGEAEEIVSLFRGHYNIPLIHAQAQDLFLDALAGVSDPEEKRRIIGRLFIE
TFEAEAKTIASDGKGVPEFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRELGRELG
LPEAFVSRHPFPGPGLAIRCPGGVTREKLAILRQADAIYLDEIRKAGLYDKIWQAFAVLLPVQTVGVMGDGRTYEFVCAL
RAVTSVDGMTADFYSFEMDFLGRAATRIINEVQGINRVVYDVTSKPPGTIEWE
>Mature_533_residues
MMSQSDPRQENVNRHDKVLIVDFGSQVTQLIARRVREAGVYCEIAPFQSAERAFETLAPKAVILSGGPASVLDQGSPRVP
DVIFSSKVPVLGICYGEQVMALQLGGKVAAGKTREFGRADVEILAESALFDNVWEKGQSYPVWMSHGDAVIDLPPGFVRA
ATSRQEAVAVMADEARHYYGVQFHLEVVHTPQGARLIENFVHKVAGLSRDWTMRAFRQEAIAAIQAKVGTGRVLCGLSGG
VDSAVAALLIHEAIGDRLTCVFVDHGLLRHGEAEEIVSLFRGHYNIPLIHAQAQDLFLDALAGVSDPEEKRRIIGRLFIE
TFEAEAKTIASDGKGVPEFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRELGRELG
LPEAFVSRHPFPGPGLAIRCPGGVTREKLAILRQADAIYLDEIRKAGLYDKIWQAFAVLLPVQTVGVMGDGRTYEFVCAL
RAVTSVDGMTADFYSFEMDFLGRAATRIINEVQGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=34.7197106690778, Blast_Score=276, Evalue=5e-74,
Organism=Escherichia coli, GI1788854, Length=529, Percent_Identity=53.1190926275992, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=35.6401384083045, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=35.6401384083045, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=35.6401384083045, Blast_Score=289, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=524, Percent_Identity=50.763358778626, Blast_Score=508, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=33.9892665474061, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- InterPro:   IPR004506 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF03054 tRNA_Me_trans [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58333; Mature: 58333

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQSDPRQENVNRHDKVLIVDFGSQVTQLIARRVREAGVYCEIAPFQSAERAFETLAPK
CCCCCCCCHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCC
AVILSGGPASVLDQGSPRVPDVIFSSKVPVLGICYGEQVMALQLGGKVAAGKTREFGRAD
EEEECCCCHHHHCCCCCCCCCHHHCCCCCEEEEECCCEEEEEEECCEEECCCCCCCCCHH
VEILAESALFDNVWEKGQSYPVWMSHGDAVIDLPPGFVRAATSRQEAVAVMADEARHYYG
HHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCHHHHHCCHHHHHHHHHHCCCCEEE
VQFHLEVVHTPQGARLIENFVHKVAGLSRDWTMRAFRQEAIAAIQAKVGTGRVLCGLSGG
EEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
VDSAVAALLIHEAIGDRLTCVFVDHGLLRHGEAEEIVSLFRGHYNIPLIHAQAQDLFLDA
HHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHH
LAGVSDPEEKRRIIGRLFIETFEAEAKTIASDGKGVPEFLGQGTLYPDVIESVSFTGGPS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCCCCCCE
VTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRELGRELGLPEAFVSRHPFPGPGLAIRC
EEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEC
PGGVTREKLAILRQADAIYLDEIRKAGLYDKIWQAFAVLLPVQTVGVMGDGRTYEFVCAL
CCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHH
RAVTSVDGMTADFYSFEMDFLGRAATRIINEVQGINRVVYDVTSKPPGTIEWE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MMSQSDPRQENVNRHDKVLIVDFGSQVTQLIARRVREAGVYCEIAPFQSAERAFETLAPK
CCCCCCCCHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCC
AVILSGGPASVLDQGSPRVPDVIFSSKVPVLGICYGEQVMALQLGGKVAAGKTREFGRAD
EEEECCCCHHHHCCCCCCCCCHHHCCCCCEEEEECCCEEEEEEECCEEECCCCCCCCCHH
VEILAESALFDNVWEKGQSYPVWMSHGDAVIDLPPGFVRAATSRQEAVAVMADEARHYYG
HHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCHHHHHCCHHHHHHHHHHCCCCEEE
VQFHLEVVHTPQGARLIENFVHKVAGLSRDWTMRAFRQEAIAAIQAKVGTGRVLCGLSGG
EEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
VDSAVAALLIHEAIGDRLTCVFVDHGLLRHGEAEEIVSLFRGHYNIPLIHAQAQDLFLDA
HHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHH
LAGVSDPEEKRRIIGRLFIETFEAEAKTIASDGKGVPEFLGQGTLYPDVIESVSFTGGPS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCCCCCCE
VTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRELGRELGLPEAFVSRHPFPGPGLAIRC
EEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEC
PGGVTREKLAILRQADAIYLDEIRKAGLYDKIWQAFAVLLPVQTVGVMGDGRTYEFVCAL
CCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHH
RAVTSVDGMTADFYSFEMDFLGRAATRIINEVQGINRVVYDVTSKPPGTIEWE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]