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The map label for this gene is mdtA [H]

Identifier: 182679507

GI number: 182679507

Start: 2927547

End: 2928662

Strand: Reverse

Name: mdtA [H]

Synonym: Bind_2562

Alternate gene names: 182679507

Gene position: 2928662-2927547 (Counterclockwise)

Preceding gene: 182679513

Following gene: 182679506

Centisome position: 70.23

GC content: 62.28

Gene sequence:

>1116_bases
ATGAAACATACACGTCTCCTTTTAGGTCTTGGTTCCGGCGCCGTCATTCTGGCCGCGGCTGGCGCGGCGACCTTCTCCTT
TGCCTCAGGGTCAGCGCATCCGTCCGTTGACAACGATCCCCGAACGGCATCACCACTCGTCAAAGTCACCGAAACCGTGC
ATGCCGGCCTCTCCCAACGTGGCTTCACCGGGACGATTGCCGCGCGGGTGCAAAGCAATCTCGGTTTTCGCGTGCCCGGC
AAGATCATCGAGCGTCTCGTGGATACCGGCCAGCAGGTGAAAGCTGGACAACCCCTCATGCGGATCGACGAGAACGATCT
GCACCTCGCCATGGTGGCCAAGCAAAACGCTGTTGCCGCCGCGCGCGCTGCCTTGATTCAGGTGAGCGCCGACGAGAAGC
GATATGCCTCCCTGGTCGCGACCGGCTATACGCCAAGGCAGCGCTACGAAATTGCAAAGGCCGCCCTGGATACGACGACG
GCGCAACTTGCTGCGGCGGAGGCAGAAGCGCGGGTTGCGGAAAACGAGGCAACCTATTCGGTCCTGAAAGCAGATGCCGA
CGGGACAGTGATGGAGACATTGGGGGAACCGGGACAGGTCGTCGCCGCCGGGCAGACCGTGGTGCGGCTTGCTCATGCGG
GACCTCGCGAGGCCATTGTCGCTCTTCCCGAAACCATGCACCCGGCGATCGGCACGACGGCGGAAGCAAGTATCTATGGC
ACAGGGCAGCGGCGCTGGTCAGCGCGGCTACGGCAATTGTCCGACACGGCCGATCCACAGACGCGCACCTATGAAGCGCG
CTATGTGCTCGAGGGTGACGCTGCCCTGGCTCCGCTCGGAGCGACCGTCACGATCAGAGTAGCGAATGACGGAAATGCGC
CCGGAGTCGAAGTGCCCGTGGGGGCTGTCTTCGATGATGGCAACAAGATCGGAGTCTGGGTCGTGGATCAAGCTTCATCC
ACCGTCCGCTTCAAGCCGATCACCATTCACCGGCTGGGCGAGGAAACCGCCGTGGTCTCCGGGCTTCAGGCTGGGGAGTC
GATTGTGTCCCTTGGCGCTCATCTGCTGCATGACGGCGACAGCATCAGGACCTCTGTCGAGAAGGAGGGTTATTGA

Upstream 100 bases:

>100_bases
CATTTTTATCCTCGCTAATTAGATTGCACTCACAATCTATGCCTGATATAGATTGTGAGTGCAATCTATTTTTATGCCTC
AATGACCGAGGTACCCCGCC

Downstream 100 bases:

>100_bases
TGAGCTTCAATCTTTCCGCCGTCGCCGTACGTGAGCGAGCCGTCACCTTGTTCTTCATTATGCTTCTCGCGAGCGCCGGC
GCCTTGGCTTTTGTCCTGCT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKHTRLLLGLGSGAVILAAAGAATFSFASGSAHPSVDNDPRTASPLVKVTETVHAGLSQRGFTGTIAARVQSNLGFRVPG
KIIERLVDTGQQVKAGQPLMRIDENDLHLAMVAKQNAVAAARAALIQVSADEKRYASLVATGYTPRQRYEIAKAALDTTT
AQLAAAEAEARVAENEATYSVLKADADGTVMETLGEPGQVVAAGQTVVRLAHAGPREAIVALPETMHPAIGTTAEASIYG
TGQRRWSARLRQLSDTADPQTRTYEARYVLEGDAALAPLGATVTIRVANDGNAPGVEVPVGAVFDDGNKIGVWVVDQASS
TVRFKPITIHRLGEETAVVSGLQAGESIVSLGAHLLHDGDSIRTSVEKEGY

Sequences:

>Translated_371_residues
MKHTRLLLGLGSGAVILAAAGAATFSFASGSAHPSVDNDPRTASPLVKVTETVHAGLSQRGFTGTIAARVQSNLGFRVPG
KIIERLVDTGQQVKAGQPLMRIDENDLHLAMVAKQNAVAAARAALIQVSADEKRYASLVATGYTPRQRYEIAKAALDTTT
AQLAAAEAEARVAENEATYSVLKADADGTVMETLGEPGQVVAAGQTVVRLAHAGPREAIVALPETMHPAIGTTAEASIYG
TGQRRWSARLRQLSDTADPQTRTYEARYVLEGDAALAPLGATVTIRVANDGNAPGVEVPVGAVFDDGNKIGVWVVDQASS
TVRFKPITIHRLGEETAVVSGLQAGESIVSLGAHLLHDGDSIRTSVEKEGY
>Mature_371_residues
MKHTRLLLGLGSGAVILAAAGAATFSFASGSAHPSVDNDPRTASPLVKVTETVHAGLSQRGFTGTIAARVQSNLGFRVPG
KIIERLVDTGQQVKAGQPLMRIDENDLHLAMVAKQNAVAAARAALIQVSADEKRYASLVATGYTPRQRYEIAKAALDTTT
AQLAAAEAEARVAENEATYSVLKADADGTVMETLGEPGQVVAAGQTVVRLAHAGPREAIVALPETMHPAIGTTAEASIYG
TGQRRWSARLRQLSDTADPQTRTYEARYVLEGDAALAPLGATVTIRVANDGNAPGVEVPVGAVFDDGNKIGVWVVDQASS
TVRFKPITIHRLGEETAVVSGLQAGESIVSLGAHLLHDGDSIRTSVEKEGY

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=310, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38800; Mature: 38800

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTRLLLGLGSGAVILAAAGAATFSFASGSAHPSVDNDPRTASPLVKVTETVHAGLSQR
CCCEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
GFTGTIAARVQSNLGFRVPGKIIERLVDTGQQVKAGQPLMRIDENDLHLAMVAKQNAVAA
CCCEEEEEEHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHH
ARAALIQVSADEKRYASLVATGYTPRQRYEIAKAALDTTTAQLAAAEAEARVAENEATYS
HHEEEEEECCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VLKADADGTVMETLGEPGQVVAAGQTVVRLAHAGPREAIVALPETMHPAIGTTAEASIYG
EEEECCCCHHHHHCCCCCCEEECCHHEEEECCCCCCCEEEECCCHHCCCCCCCCCEEEEE
TGQRRWSARLRQLSDTADPQTRTYEARYVLEGDAALAPLGATVTIRVANDGNAPGVEVPV
CCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEECCCCEEEEEEECCCCCCCEEEEE
GAVFDDGNKIGVWVVDQASSTVRFKPITIHRLGEETAVVSGLQAGESIVSLGAHLLHDGD
EEEEECCCEEEEEEEECCCCEEEEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCC
SIRTSVEKEGY
HHHHCHHCCCC
>Mature Secondary Structure
MKHTRLLLGLGSGAVILAAAGAATFSFASGSAHPSVDNDPRTASPLVKVTETVHAGLSQR
CCCEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
GFTGTIAARVQSNLGFRVPGKIIERLVDTGQQVKAGQPLMRIDENDLHLAMVAKQNAVAA
CCCEEEEEEHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEEEECCCHHHH
ARAALIQVSADEKRYASLVATGYTPRQRYEIAKAALDTTTAQLAAAEAEARVAENEATYS
HHEEEEEECCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VLKADADGTVMETLGEPGQVVAAGQTVVRLAHAGPREAIVALPETMHPAIGTTAEASIYG
EEEECCCCHHHHHCCCCCCEEECCHHEEEECCCCCCCEEEECCCHHCCCCCCCCCEEEEE
TGQRRWSARLRQLSDTADPQTRTYEARYVLEGDAALAPLGATVTIRVANDGNAPGVEVPV
CCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCEEECCCCEEEEEEECCCCCCCEEEEE
GAVFDDGNKIGVWVVDQASSTVRFKPITIHRLGEETAVVSGLQAGESIVSLGAHLLHDGD
EEEEECCCEEEEEEEECCCCEEEEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCC
SIRTSVEKEGY
HHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA