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The map label for this gene is fabF [H]

Identifier: 182679505

GI number: 182679505

Start: 2923125

End: 2924408

Strand: Reverse

Name: fabF [H]

Synonym: Bind_2560

Alternate gene names: 182679505

Gene position: 2924408-2923125 (Counterclockwise)

Preceding gene: 182679506

Following gene: 182679504

Centisome position: 70.13

GC content: 61.14

Gene sequence:

>1284_bases
ATGAGACGTATTGTTATCACAGGCATGGGCGCAGTCAGCCCCCTCGCTGCCGGTGTGGAGGCAAGCTGGTCACGGCTTCT
GGCAGGCCAGTCCGGTATTCGGTGCCTGCCGAAAGAAATCGTAGCGGACCTTCCGGTCAAGATCGGTGGGATGGTCCCGT
CGCATACAGACGACACGGCTGGTTTGGACCCTCATGCCGTCGTTCTGCCGAAGGAACAACGGAAGATGGACCGCTTCATC
CTTTTCGGCCTTGCGGCCGCGAAGGAAGCGCTGGCGCAAGCGGGCTGGGAGCCCCGCTCGGCCGAAGAGCAGCAGCGGAC
CGCGACCATCATTGCCTCCGGCATCGGTGGTTTTCCGGCGATCACCGAGGCCGTGCGAACAGTGGAGCGGCATGGTGTGA
GGCGGCTCTCCCCCTTCACGATCCCGTCGTTCCTCGTAAACCTCGCGGCCGGGCATATTTCGATCCGCTTCGGTTTCAAG
GGACCAATCGGGGCGCCAGTGACGGCTTGCGCGGCCGGTGTGCAGGCGATCGGCGACGCTGCGCGACTCATTCGCGGAGG
GGAAGCCGATGTTGCTGTCTGCGGTGGCACTGAAGCTTGCATCGATAGCGTCAGTCTCGGCGGCTTCGCCGCGGCGCGTG
CTCTGGCGACCCGTTTCAATGACATGCCCGCGCAGGCCTCTCGGCCGTTCGATATCTCGCGCGATGGCTTCGTCATGGGC
GAAGGCGCCGGCATTTTGGTGATTGAAGCGCTTGATCATGCCCTCGCGCGCAAGGCGCTGCCATTGGCCGAATTGGTCGG
TTACGGGACGACCGCTGATGCCTACCACATCACATCCGGACCAGAGGATGGAGAAGGGGCGCAACGGGCCATGCAACAGG
CGATCGCTCAGGCTGGGATCTCCCCATCGGACATTCAACATTTGAACGCCCATGCAACCTCGACGCAACTGGGCGACAAG
AGTGAGATGGCCGCGATCAAATCCGTTTTTGGAGCAGATGGTGGAATTGCGGTCAGCAGCACAAAATCAGCAACTGGACA
TCTGCTAGGAGCGGCTGGCGGACTGGAGGCCATCTTCACGATTCTGGCGCTCCGGAATCAAATCGCTCCACCCACACTCA
ATTTAGATGCACCAGATCCGGTGGGCGCGGGAATCGACTTCGTGGCGAATAAAGCCCGGCCGATGCGTATGGATTACGCT
ATCTCCAATGGCTTTGGCTTTGGAGGCGTCAACGCCAGCACCCTGTTCTGTCGATATGGACTTCACCCCTTGGGTCGACA
CTGA

Upstream 100 bases:

>100_bases
CCAAGCGCAGCGGCACAATTTCACGCGGGGCAAGCCGTCGCCGGAGTGCCCAGCCATCACGCGATGGCTGCTGAATAAAA
ACAAAAAATCGAGGCGACCA

Downstream 100 bases:

>100_bases
TCAGGCAGAAATGCAGTCGGTACTACGTGGCTCCGCCTTCTCATCGCGATGCATGCCCAGCAATGGCTTGATGTATTTGA
TCCCAATGATGTCCCGTAAC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRRIVITGMGAVSPLAAGVEASWSRLLAGQSGIRCLPKEIVADLPVKIGGMVPSHTDDTAGLDPHAVVLPKEQRKMDRFI
LFGLAAAKEALAQAGWEPRSAEEQQRTATIIASGIGGFPAITEAVRTVERHGVRRLSPFTIPSFLVNLAAGHISIRFGFK
GPIGAPVTACAAGVQAIGDAARLIRGGEADVAVCGGTEACIDSVSLGGFAAARALATRFNDMPAQASRPFDISRDGFVMG
EGAGILVIEALDHALARKALPLAELVGYGTTADAYHITSGPEDGEGAQRAMQQAIAQAGISPSDIQHLNAHATSTQLGDK
SEMAAIKSVFGADGGIAVSSTKSATGHLLGAAGGLEAIFTILALRNQIAPPTLNLDAPDPVGAGIDFVANKARPMRMDYA
ISNGFGFGGVNASTLFCRYGLHPLGRH

Sequences:

>Translated_427_residues
MRRIVITGMGAVSPLAAGVEASWSRLLAGQSGIRCLPKEIVADLPVKIGGMVPSHTDDTAGLDPHAVVLPKEQRKMDRFI
LFGLAAAKEALAQAGWEPRSAEEQQRTATIIASGIGGFPAITEAVRTVERHGVRRLSPFTIPSFLVNLAAGHISIRFGFK
GPIGAPVTACAAGVQAIGDAARLIRGGEADVAVCGGTEACIDSVSLGGFAAARALATRFNDMPAQASRPFDISRDGFVMG
EGAGILVIEALDHALARKALPLAELVGYGTTADAYHITSGPEDGEGAQRAMQQAIAQAGISPSDIQHLNAHATSTQLGDK
SEMAAIKSVFGADGGIAVSSTKSATGHLLGAAGGLEAIFTILALRNQIAPPTLNLDAPDPVGAGIDFVANKARPMRMDYA
ISNGFGFGGVNASTLFCRYGLHPLGRH
>Mature_427_residues
MRRIVITGMGAVSPLAAGVEASWSRLLAGQSGIRCLPKEIVADLPVKIGGMVPSHTDDTAGLDPHAVVLPKEQRKMDRFI
LFGLAAAKEALAQAGWEPRSAEEQQRTATIIASGIGGFPAITEAVRTVERHGVRRLSPFTIPSFLVNLAAGHISIRFGFK
GPIGAPVTACAAGVQAIGDAARLIRGGEADVAVCGGTEACIDSVSLGGFAAARALATRFNDMPAQASRPFDISRDGFVMG
EGAGILVIEALDHALARKALPLAELVGYGTTADAYHITSGPEDGEGAQRAMQQAIAQAGISPSDIQHLNAHATSTQLGDK
SEMAAIKSVFGADGGIAVSSTKSATGHLLGAAGGLEAIFTILALRNQIAPPTLNLDAPDPVGAGIDFVANKARPMRMDYA
ISNGFGFGGVNASTLFCRYGLHPLGRH

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=44.3396226415094, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI223972627, Length=188, Percent_Identity=35.6382978723404, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=24.3559718969555, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=48.4486873508353, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1788663, Length=422, Percent_Identity=35.781990521327, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=429, Percent_Identity=38.6946386946387, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=271, Percent_Identity=42.4354243542435, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=434, Percent_Identity=26.036866359447, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=285, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=38.3928571428571, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=45.6470588235294, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI221330659, Length=430, Percent_Identity=24.1860465116279, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19920632, Length=430, Percent_Identity=24.1860465116279, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24581345, Length=431, Percent_Identity=22.737819025522, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44039; Mature: 44039

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVITGMGAVSPLAAGVEASWSRLLAGQSGIRCLPKEIVADLPVKIGGMVPSHTDDTA
CCEEEEECCCCHHHHHHCHHHHHHHHHCCCCCCEECHHHHHHHCCHHCCCCCCCCCCCCC
GLDPHAVVLPKEQRKMDRFILFGLAAAKEALAQAGWEPRSAEEQQRTATIIASGIGGFPA
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHH
ITEAVRTVERHGVRRLSPFTIPSFLVNLAAGHISIRFGFKGPIGAPVTACAAGVQAIGDA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
ARLIRGGEADVAVCGGTEACIDSVSLGGFAAARALATRFNDMPAQASRPFDISRDGFVMG
HHHHCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
EGAGILVIEALDHALARKALPLAELVGYGTTADAYHITSGPEDGEGAQRAMQQAIAQAGI
CCCCEEEEHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCC
SPSDIQHLNAHATSTQLGDKSEMAAIKSVFGADGGIAVSSTKSATGHLLGAAGGLEAIFT
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHHHH
ILALRNQIAPPTLNLDAPDPVGAGIDFVANKARPMRMDYAISNGFGFGGVNASTLFCRYG
HHHHHHHCCCCEECCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHC
LHPLGRH
CCCCCCC
>Mature Secondary Structure
MRRIVITGMGAVSPLAAGVEASWSRLLAGQSGIRCLPKEIVADLPVKIGGMVPSHTDDTA
CCEEEEECCCCHHHHHHCHHHHHHHHHCCCCCCEECHHHHHHHCCHHCCCCCCCCCCCCC
GLDPHAVVLPKEQRKMDRFILFGLAAAKEALAQAGWEPRSAEEQQRTATIIASGIGGFPA
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHH
ITEAVRTVERHGVRRLSPFTIPSFLVNLAAGHISIRFGFKGPIGAPVTACAAGVQAIGDA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
ARLIRGGEADVAVCGGTEACIDSVSLGGFAAARALATRFNDMPAQASRPFDISRDGFVMG
HHHHCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
EGAGILVIEALDHALARKALPLAELVGYGTTADAYHITSGPEDGEGAQRAMQQAIAQAGI
CCCCEEEEHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCC
SPSDIQHLNAHATSTQLGDKSEMAAIKSVFGADGGIAVSSTKSATGHLLGAAGGLEAIFT
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCHHHHHH
ILALRNQIAPPTLNLDAPDPVGAGIDFVANKARPMRMDYAISNGFGFGGVNASTLFCRYG
HHHHHHHCCCCEECCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHC
LHPLGRH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]