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The map label for this gene is ilvC

Identifier: 182679370

GI number: 182679370

Start: 2759397

End: 2760416

Strand: Reverse

Name: ilvC

Synonym: Bind_2418

Alternate gene names: 182679370

Gene position: 2760416-2759397 (Counterclockwise)

Preceding gene: 182679371

Following gene: 182679369

Centisome position: 66.19

GC content: 57.55

Gene sequence:

>1020_bases
ATGCGTGTCTATTATGATCGGGATGCCGATATCAATCTCGTCAAGGGCAAGAAAGTGGCGATCATTGGCTATGGCAGTCA
AGGTCATGCGCATGCGTTGAACCTGCGCGATTCCGGCGTCAAGGAGATCGCCATCGCTTTGCGCGAGGGTTCATCCACGG
CCAAGAAGGCGGAGGCCGAAGGGCTTACTGTCAAGACTGTTGTCGATGCCGCGCAATGGGCCGACGTTGTCATGGTTTTG
ACGCCAGATGAATTGCAGGCCGATATTTATCACCAGCTTCTGGCCAAGAATCTCAAGCAGGGCGCGGCTCTCCTCTTCGC
GCATGGCTTGAGCGTGCATTTCAATCTGATCGAGCCGCGCGCCGATCTCGATGTCCTGATGGTCGCGCCCAAGGGACCTG
GTCATACCGTGCGCTCTGAATATAAGCGCGGTGGCGGTGTGCCGTGCCTGATCGCGGTGGCGCAGAACGCCTCCGGCAAT
GCGCATGATATCGCGCTCTCCTACGCTTCGGCGATTGGCGGCGGCCGCGCCGGTATCATCGAGACGACCTTCAAGGAAGA
ATGCGAGACCGATCTTTTCGGCGAGCAGGCGGTTCTCTGCGGCGGCCTCGTCGAATTGATCCGCGCCGGTTTCGAAACCC
TGGTCGAGGCCGGCTATGCGCCGGAAATGGCCTATTTCGAATGCTTGCACGAAGTGAAGCTGATCGTCGATCTCATTTAT
GAGGGCGGCATCGCCAATATGAATTATTCGATTTCGAATACGGCGGAATATGGCGAATATGTCACCGGCCCGCGCATCAT
CACGCCCGAAACCAAGGCTGAGATGAAGCGTGTGCTTGAAGACATTCAGGGTGGCAAGTTCACGCGTGACTGGATGCTGG
AAAACAAGGTCCACCAGACCTCGTTCAAGGCGACCCGTGCCAAGGTGGCCGCGCATCCGATCGAAAAGGTCGGCGCGGAA
TTGCGCGCGATGATGCCGTGGATCGGCGCCAGCAAGCTGGTCGATAAGTCGAAGAACTAA

Upstream 100 bases:

>100_bases
CCGCTGATCGGTGATTTCCCACCAAGGCCCGATGTTGTAGAAGGCCCTCATTCAAACAACCGCAAGGCTTGACCGCCTCA
GCACAAGGAAAGCTTCGTCT

Downstream 100 bases:

>100_bases
GGTTGGGCGGTGTAGGACCGCTTTCCCGCCTCTTGATGGAGACTCGGCTGCAACGTGATGCGTTTACGTTGCATCTCCTT
GAGTCCATCCCGAACTGATA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADINLVKGKKVAIIGYGSQGHAHALNLRDSGVKEIAIALREGSSTAKKAEAEGLTVKTVVDAAQWADVVMVL
TPDELQADIYHQLLAKNLKQGAALLFAHGLSVHFNLIEPRADLDVLMVAPKGPGHTVRSEYKRGGGVPCLIAVAQNASGN
AHDIALSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLEDIQGGKFTRDWMLENKVHQTSFKATRAKVAAHPIEKVGAE
LRAMMPWIGASKLVDKSKN

Sequences:

>Translated_339_residues
MRVYYDRDADINLVKGKKVAIIGYGSQGHAHALNLRDSGVKEIAIALREGSSTAKKAEAEGLTVKTVVDAAQWADVVMVL
TPDELQADIYHQLLAKNLKQGAALLFAHGLSVHFNLIEPRADLDVLMVAPKGPGHTVRSEYKRGGGVPCLIAVAQNASGN
AHDIALSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLEDIQGGKFTRDWMLENKVHQTSFKATRAKVAAHPIEKVGAE
LRAMMPWIGASKLVDKSKN
>Mature_339_residues
MRVYYDRDADINLVKGKKVAIIGYGSQGHAHALNLRDSGVKEIAIALREGSSTAKKAEAEGLTVKTVVDAAQWADVVMVL
TPDELQADIYHQLLAKNLKQGAALLFAHGLSVHFNLIEPRADLDVLMVAPKGPGHTVRSEYKRGGGVPCLIAVAQNASGN
AHDIALSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLEDIQGGKFTRDWMLENKVHQTSFKATRAKVAAHPIEKVGAE
LRAMMPWIGASKLVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=38.8704318936877, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=336, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BEII9 (B2IHY4)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833516.1
- ProteinModelPortal:   B2IHY4
- GeneID:   6199835
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_2418
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36728; Mature: 36728

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADINLVKGKKVAIIGYGSQGHAHALNLRDSGVKEIAIALREGSSTAKKAEAE
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHCC
GLTVKTVVDAAQWADVVMVLTPDELQADIYHQLLAKNLKQGAALLFAHGLSVHFNLIEPR
CCEEHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCHHEEEECCCEEEEEEECCC
ADLDVLMVAPKGPGHTVRSEYKRGGGVPCLIAVAQNASGNAHDIALSYASAIGGGRAGII
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLEDIQGGKFTRDWMLENKVHQT
CCCCCCCCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEHHHHHHCHHHHH
SFKATRAKVAAHPIEKVGAELRAMMPWIGASKLVDKSKN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure
MRVYYDRDADINLVKGKKVAIIGYGSQGHAHALNLRDSGVKEIAIALREGSSTAKKAEAE
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHCC
GLTVKTVVDAAQWADVVMVLTPDELQADIYHQLLAKNLKQGAALLFAHGLSVHFNLIEPR
CCEEHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCHHEEEECCCEEEEEEECCC
ADLDVLMVAPKGPGHTVRSEYKRGGGVPCLIAVAQNASGNAHDIALSYASAIGGGRAGII
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLEDIQGGKFTRDWMLENKVHQT
CCCCCCCCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEHHHHHHCHHHHH
SFKATRAKVAAHPIEKVGAELRAMMPWIGASKLVDKSKN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA