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The map label for this gene is dctA1 [H]

Identifier: 182679201

GI number: 182679201

Start: 2572911

End: 2574242

Strand: Reverse

Name: dctA1 [H]

Synonym: Bind_2241

Alternate gene names: 182679201

Gene position: 2574242-2572911 (Counterclockwise)

Preceding gene: 182679204

Following gene: 182679200

Centisome position: 61.73

GC content: 57.36

Gene sequence:

>1332_bases
ATGGTCGCGATAAATCCGGAAAATCTCGCCAAGCCTCTCGGCGCGCCCCGCGCCGTGCCATTCTACCGCATCCTCTATGT
CCAGGTGCTGATCGGCATTTTGCTTGGCGTCCTGTTTGGTTGGCTCTGGCCGGCGACGGCTTCCGCCGATTGGGTGAAGG
CGCTCGGCGATGGCTTCATCAAACTCATCAAGATGATGATCGCGCCGATTATCTTCTGCACCGTGGTCTCCGGCATCGCG
CATGTCTCGAGCGCGCAAAAGGTCGGGCGCATCGGTGTCAAGGCGCTCGTCTATTTCGAGGTGGTCTCGACCTTCGCTTT
GGTTCTCGGACTTGTGATCGGTAATCTCGTGCAGCCCGGCCGCGGCATTGCCGACAAGGTCGATGCAGGAGCCGTCGCCA
AATATGTGGGGCAGGAGCATTCGACAGTTCAGTTCCTGCTCGATCTCATTCCGGATAGCGTGGTCGGTGGTTTCGCGCGC
GGCGATGTGCTGCAAGTTCTTTTATTTTCCATTCTCTTCGGCTTTGCCCTTCTGGGGCTTGGATCTCGCGGCGAAAGCCT
GACGAAGCTGATCGACGATGTTGCACAGGCGGTTTTCGGCGTCATCGCTATCGTCATGCGGGCGGCGCCGATTGGCGCCT
TCGGTGCCATGGCCTATACGGTCGGCCGCTATGGTCCGCAAACGCTCGGCAATCTCCTTGGTCTTGTCGCCACCTTCTAT
CTCACGGCGATTTTGTTCATCGTGATCGTCCTCGGGACGATCGCCAGGCTCGCGGGTTTCAGCATTTTCAAATTCCTTGC
CTATATCAAAGATGAATTGCTGATCGTGCTTGGCACCAGTTCTTCGGAAAGCGCCTTGCCGGCCTTGATGGAGAAACTCG
AACGGCTCGGCTGTTCCAAACCCGTCGTCGGTCTCGTGGTGCCGACTGGCTATTCCTTCAATCTGGACGGCACCAATATC
TATATGACACTCGCGACCCTTTTTGTCGCGCAGGCGCTCGGCGTTCCCTTGAACCTTGAGGAACAGATTACGATTCTTTT
GGTCGCCATGGTTGCCTCAAAAGGGGCGAGCGGTATTTCTGGCGCAGGATTCATCACGCTCGCGGCGACGCTCGCCGCCG
TCAATCCTATTCTTGTGCCGGGCATGGCCATGTTGCTCGGAGTCGATAAATTCATGAGCGAATGCCGGGCCTTGACCAAT
ATTATCGGCAATGGGGTGGCAACGATCATCGTCTCCCGCTGGGAAAAGGAGATCGACCCCCGAGCGTTGCGCGCCGCATT
GGAAAAGACCGTGGATACAACCCATTTCACGGCGGAGGATCAGCCGCTTTAG

Upstream 100 bases:

>100_bases
GAAACCGGAATCCACTTCCTCCAAGATTCCCGGTAGGATGGGATTCGTCATCAAGACATGCCGCTATCTATCCTATCTCC
GCCGAGAGCCGAGCAAAACA

Downstream 100 bases:

>100_bases
AAGAAGCCATCTATGATCGCGACAATAGAGCATCGGACTTTTACTGTCCGATGCTCTATCTTTTTGTAAACGCATCAAAT
TGGTCTTTTGGGTCTGATGC

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVAINPENLAKPLGAPRAVPFYRILYVQVLIGILLGVLFGWLWPATASADWVKALGDGFIKLIKMMIAPIIFCTVVSGIA
HVSSAQKVGRIGVKALVYFEVVSTFALVLGLVIGNLVQPGRGIADKVDAGAVAKYVGQEHSTVQFLLDLIPDSVVGGFAR
GDVLQVLLFSILFGFALLGLGSRGESLTKLIDDVAQAVFGVIAIVMRAAPIGAFGAMAYTVGRYGPQTLGNLLGLVATFY
LTAILFIVIVLGTIARLAGFSIFKFLAYIKDELLIVLGTSSSESALPALMEKLERLGCSKPVVGLVVPTGYSFNLDGTNI
YMTLATLFVAQALGVPLNLEEQITILLVAMVASKGASGISGAGFITLAATLAAVNPILVPGMAMLLGVDKFMSECRALTN
IIGNGVATIIVSRWEKEIDPRALRAALEKTVDTTHFTAEDQPL

Sequences:

>Translated_443_residues
MVAINPENLAKPLGAPRAVPFYRILYVQVLIGILLGVLFGWLWPATASADWVKALGDGFIKLIKMMIAPIIFCTVVSGIA
HVSSAQKVGRIGVKALVYFEVVSTFALVLGLVIGNLVQPGRGIADKVDAGAVAKYVGQEHSTVQFLLDLIPDSVVGGFAR
GDVLQVLLFSILFGFALLGLGSRGESLTKLIDDVAQAVFGVIAIVMRAAPIGAFGAMAYTVGRYGPQTLGNLLGLVATFY
LTAILFIVIVLGTIARLAGFSIFKFLAYIKDELLIVLGTSSSESALPALMEKLERLGCSKPVVGLVVPTGYSFNLDGTNI
YMTLATLFVAQALGVPLNLEEQITILLVAMVASKGASGISGAGFITLAATLAAVNPILVPGMAMLLGVDKFMSECRALTN
IIGNGVATIIVSRWEKEIDPRALRAALEKTVDTTHFTAEDQPL
>Mature_443_residues
MVAINPENLAKPLGAPRAVPFYRILYVQVLIGILLGVLFGWLWPATASADWVKALGDGFIKLIKMMIAPIIFCTVVSGIA
HVSSAQKVGRIGVKALVYFEVVSTFALVLGLVIGNLVQPGRGIADKVDAGAVAKYVGQEHSTVQFLLDLIPDSVVGGFAR
GDVLQVLLFSILFGFALLGLGSRGESLTKLIDDVAQAVFGVIAIVMRAAPIGAFGAMAYTVGRYGPQTLGNLLGLVATFY
LTAILFIVIVLGTIARLAGFSIFKFLAYIKDELLIVLGTSSSESALPALMEKLERLGCSKPVVGLVVPTGYSFNLDGTNI
YMTLATLFVAQALGVPLNLEEQITILLVAMVASKGASGISGAGFITLAATLAAVNPILVPGMAMLLGVDKFMSECRALTN
IIGNGVATIIVSRWEKEIDPRALRAALEKTVDTTHFTAEDQPL

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=449, Percent_Identity=25.8351893095768, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4827012, Length=423, Percent_Identity=26.4775413711584, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI40254478, Length=456, Percent_Identity=24.780701754386, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194239697, Length=457, Percent_Identity=25.164113785558, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21314632, Length=427, Percent_Identity=24.3559718969555, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI66773030, Length=401, Percent_Identity=25.6857855361596, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5032093, Length=424, Percent_Identity=26.4150943396226, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI223468564, Length=299, Percent_Identity=28.7625418060201, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223468566, Length=299, Percent_Identity=28.7625418060201, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI262359914, Length=377, Percent_Identity=25.1989389920424, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789947, Length=413, Percent_Identity=56.4164648910412, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=36.768149882904, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1788024, Length=415, Percent_Identity=24.0963855421687, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789473, Length=328, Percent_Identity=24.6951219512195, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=438, Percent_Identity=25.1141552511416, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=25.4424778761062, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=462, Percent_Identity=24.025974025974, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71983106, Length=462, Percent_Identity=24.025974025974, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193206505, Length=462, Percent_Identity=22.9437229437229, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193206654, Length=436, Percent_Identity=22.7064220183486, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17541374, Length=449, Percent_Identity=21.380846325167, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583025, Length=447, Percent_Identity=21.923937360179, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17137668, Length=447, Percent_Identity=21.923937360179, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24583023, Length=447, Percent_Identity=21.923937360179, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281360483, Length=480, Percent_Identity=22.5, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137666, Length=480, Percent_Identity=22.5, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281360481, Length=480, Percent_Identity=22.5, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46725; Mature: 46725

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA