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The map label for this gene is clpP [H]

Identifier: 182679147

GI number: 182679147

Start: 2496448

End: 2497101

Strand: Reverse

Name: clpP [H]

Synonym: Bind_2184

Alternate gene names: 182679147

Gene position: 2497101-2496448 (Counterclockwise)

Preceding gene: 182679148

Following gene: 182679146

Centisome position: 59.88

GC content: 55.81

Gene sequence:

>654_bases
ATGGCCATGCGTGACCGCGATCCGATCGAGATTTATGACAATTATCTGATTCCTCAGGTGATCGAGAACACCAGCCGTGG
CGAACGGGGTTTCGACATCTATTCGCGCCTGTTGCGTGAGCGGATCATTTTCCTCACCGGTCAGGTCGAGGACAATATGG
CGTCTGTCATCATCGCCCAATTGCTCTTCCTGGAGGCGGAAAACCCCAAGAAGGAAATTTCCATGTACATCAACTCGCCG
GGCGGCGTGGTGACGGCTGGCCTTGCGATCTATGACACGATGCAGTTCATCAGGCCCAAAGTCTCGACGCTGTGTGTTGG
CCAGGCGGCCTCCATGGGTTCGCTTCTGCTGTGCGCTGGTGAAGCGGGCATGCGCTACGCGACCCCCAATTCCCGTATCA
TGGTGCATCAGCCGTCTGGCGGCTTCTCCGGCCAGGCTTCCGATATCCTCCGCCATGCTGAGGACATTATGAAGGTCAAA
CGTCGGCTCAACGAGATCTATGTGAAACATACCGGCCGGGACTATGACACGATCGAGACGACGCTCGACCGCGATCATTT
CATGTCTGCTCAGGAAACGAAGGAATTCGGGATCATCGATAATGTGATCGACAAACGTCCCGACGAACTCGCCCTGACCA
CCGAGGCGAAATAG

Upstream 100 bases:

>100_bases
TTCGGGCGACCAGAGCGGTTGCCCTCCCACCGTAACATCGCTCGTTCCAGGGCATTTTCGTTCATGACGATCATGCCCTC
AGCTCAGGAAAGACAAGACC

Downstream 100 bases:

>100_bases
GAAGATTCGTCTTTTGGTCGGCAAACCGGAGCTTGGAATAGAACGAAAGTGGTTCTAAGCTTCGGATTCGTCGGCGAACC
CGAGCGAAAACGCGGCGTTT

Product: endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAMRDRDPIEIYDNYLIPQVIENTSRGERGFDIYSRLLRERIIFLTGQVEDNMASVIIAQLLFLEAENPKKEISMYINSP
GGVVTAGLAIYDTMQFIRPKVSTLCVGQAASMGSLLLCAGEAGMRYATPNSRIMVHQPSGGFSGQASDILRHAEDIMKVK
RRLNEIYVKHTGRDYDTIETTLDRDHFMSAQETKEFGIIDNVIDKRPDELALTTEAK

Sequences:

>Translated_217_residues
MAMRDRDPIEIYDNYLIPQVIENTSRGERGFDIYSRLLRERIIFLTGQVEDNMASVIIAQLLFLEAENPKKEISMYINSP
GGVVTAGLAIYDTMQFIRPKVSTLCVGQAASMGSLLLCAGEAGMRYATPNSRIMVHQPSGGFSGQASDILRHAEDIMKVK
RRLNEIYVKHTGRDYDTIETTLDRDHFMSAQETKEFGIIDNVIDKRPDELALTTEAK
>Mature_216_residues
AMRDRDPIEIYDNYLIPQVIENTSRGERGFDIYSRLLRERIIFLTGQVEDNMASVIIAQLLFLEAENPKKEISMYINSPG
GVVTAGLAIYDTMQFIRPKVSTLCVGQAASMGSLLLCAGEAGMRYATPNSRIMVHQPSGGFSGQASDILRHAEDIMKVKR
RLNEIYVKHTGRDYDTIETTLDRDHFMSAQETKEFGIIDNVIDKRPDELALTTEAK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=194, Percent_Identity=61.8556701030928, Blast_Score=256, Evalue=8e-69,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=63.3507853403141, Blast_Score=270, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=66.6666666666667, Blast_Score=255, Evalue=1e-68,
Organism=Drosophila melanogaster, GI20129427, Length=201, Percent_Identity=59.7014925373134, Blast_Score=267, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24410; Mature: 24279

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMRDRDPIEIYDNYLIPQVIENTSRGERGFDIYSRLLRERIIFLTGQVEDNMASVIIAQ
CCCCCCCCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHH
LLFLEAENPKKEISMYINSPGGVVTAGLAIYDTMQFIRPKVSTLCVGQAASMGSLLLCAG
HHHHCCCCCHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
EAGMRYATPNSRIMVHQPSGGFSGQASDILRHAEDIMKVKRRLNEIYVKHTGRDYDTIET
CCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TLDRDHFMSAQETKEFGIIDNVIDKRPDELALTTEAK
HHCHHHHCCHHHHHHHCHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
AMRDRDPIEIYDNYLIPQVIENTSRGERGFDIYSRLLRERIIFLTGQVEDNMASVIIAQ
CCCCCCCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHH
LLFLEAENPKKEISMYINSPGGVVTAGLAIYDTMQFIRPKVSTLCVGQAASMGSLLLCAG
HHHHCCCCCHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
EAGMRYATPNSRIMVHQPSGGFSGQASDILRHAEDIMKVKRRLNEIYVKHTGRDYDTIET
CCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TLDRDHFMSAQETKEFGIIDNVIDKRPDELALTTEAK
HHCHHHHCCHHHHHHHCHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA