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The map label for this gene is arsB [H]

Identifier: 182679100

GI number: 182679100

Start: 2440469

End: 2441551

Strand: Reverse

Name: arsB [H]

Synonym: Bind_2137

Alternate gene names: 182679100

Gene position: 2441551-2440469 (Counterclockwise)

Preceding gene: 182679101

Following gene: 182679099

Centisome position: 58.55

GC content: 55.86

Gene sequence:

>1083_bases
ATGTCCTCTGTTCAACCCGAGTCTCGCCTCTCTTTCCTGGACCGTTATCTCACGGTCTGGATTTTTGCTGCCATGGCTGG
CGGTGTCCTTCTCGGCACGGCCTTCAAAGGCTTGCCGGAAGCCTTGAACGCACTGTCGGTCGGCACGACCAATATTCCGA
TCGCCATCGGGCTCATCCTCATGATGTATCCGCCGCTGGCAAAGGTGCGTTACGAGGAGCTTCATGAGGTCTTTCGGGAC
AAGCGGATTCTGGCTCTCTCCCTTGTGCAGAACTGGCTGATCGGGCCTGTCCTCATGTTCGCACTGGCCGTTCTCTTCCT
GCGTGATTCACCCGAATATATGACCGGGCTCATCCTGATTGGCCTCGCGCGGTGTATCGCCATGGTCCTTGTCTGGAACC
AGCTCGCGCGTGGTGACAATCAATATGTCGCGGGTCTGGTTGCCTTCAATTCGATCTTCCAGATCCTGTTCTTCAGCATC
TATGCCTGGATCTTCCTGACGCTTCTTCCACCTCTGTTCGGTCTGCAAGGCAGCATTGTCAATGTGAGTTTTTGGACCAT
TGCCGAGGCGGTGTTGATCTATCTCGGCATTCCTTTCCTGGCTGGTTTCCTCACGCGCCGCATCCTCATCGCTCTCAAGG
GCCGAGCCTGGTACGAGCACGAATTTCTTCCCCGTATCAGCCCGATGACCTTGGCCGCGCTCCTGTTCACTATTGTCGCC
ATGTTCAGTTTGAAGGGCGGTGATGTCCTGCGCCTGCCTGTCGATGCGGTGCGGATCGCGATCCCTTTGTCGCTTTATTT
CATCATTCAATTCTCAATCAGTTTCGTCATGGGCAAGCTGATCGAGGCCGCTTATCCTCGTACAACGGCGATCGCTTTTA
CCGCTGCCGGCAATAATTTCGAATTGGCGATCGCCGTCGCCATCGCGGCTTTCGGTCTTGCCTCGCCGGTTGCCTTTGCT
GCTGTCATTGGTCCTCTCGTGGAAGTGCCGGTGTTACTGCTTCTCGTCCATGTAGCCTTGAGGCTCGGACACCGCTGGTT
TCCGCAATCCTGCGGCACTGTTCCGACACCATCCAAAGCTTGA

Upstream 100 bases:

>100_bases
GGCGGTTGTCGATGATGACGGCCAGCGCGTGATCTAAGCTTTTCTTCTTCACTGTCTCAAGGCTCTTGGCGCAGGCATGG
TCACGCCTGGGAGATTATCT

Downstream 100 bases:

>100_bases
GGGATAAATGAGACTGCGCGAACTCCCCGATGCAACCCATCTCCCAGCGCTTGATCCTCGCTATGTTATCAAAAGGCCGG
GGCAGGGGCTTGGACCCGAT

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSSVQPESRLSFLDRYLTVWIFAAMAGGVLLGTAFKGLPEALNALSVGTTNIPIAIGLILMMYPPLAKVRYEELHEVFRD
KRILALSLVQNWLIGPVLMFALAVLFLRDSPEYMTGLILIGLARCIAMVLVWNQLARGDNQYVAGLVAFNSIFQILFFSI
YAWIFLTLLPPLFGLQGSIVNVSFWTIAEAVLIYLGIPFLAGFLTRRILIALKGRAWYEHEFLPRISPMTLAALLFTIVA
MFSLKGGDVLRLPVDAVRIAIPLSLYFIIQFSISFVMGKLIEAAYPRTTAIAFTAAGNNFELAIAVAIAAFGLASPVAFA
AVIGPLVEVPVLLLLVHVALRLGHRWFPQSCGTVPTPSKA

Sequences:

>Translated_360_residues
MSSVQPESRLSFLDRYLTVWIFAAMAGGVLLGTAFKGLPEALNALSVGTTNIPIAIGLILMMYPPLAKVRYEELHEVFRD
KRILALSLVQNWLIGPVLMFALAVLFLRDSPEYMTGLILIGLARCIAMVLVWNQLARGDNQYVAGLVAFNSIFQILFFSI
YAWIFLTLLPPLFGLQGSIVNVSFWTIAEAVLIYLGIPFLAGFLTRRILIALKGRAWYEHEFLPRISPMTLAALLFTIVA
MFSLKGGDVLRLPVDAVRIAIPLSLYFIIQFSISFVMGKLIEAAYPRTTAIAFTAAGNNFELAIAVAIAAFGLASPVAFA
AVIGPLVEVPVLLLLVHVALRLGHRWFPQSCGTVPTPSKA
>Mature_359_residues
SSVQPESRLSFLDRYLTVWIFAAMAGGVLLGTAFKGLPEALNALSVGTTNIPIAIGLILMMYPPLAKVRYEELHEVFRDK
RILALSLVQNWLIGPVLMFALAVLFLRDSPEYMTGLILIGLARCIAMVLVWNQLARGDNQYVAGLVAFNSIFQILFFSIY
AWIFLTLLPPLFGLQGSIVNVSFWTIAEAVLIYLGIPFLAGFLTRRILIALKGRAWYEHEFLPRISPMTLAALLFTIVAM
FSLKGGDVLRLPVDAVRIAIPLSLYFIIQFSISFVMGKLIEAAYPRTTAIAFTAAGNNFELAIAVAIAAFGLASPVAFAA
VIGPLVEVPVLLLLVHVALRLGHRWFPQSCGTVPTPSKA

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=320, Percent_Identity=37.1875, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 39444; Mature: 39313

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVQPESRLSFLDRYLTVWIFAAMAGGVLLGTAFKGLPEALNALSVGTTNIPIAIGLIL
CCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MMYPPLAKVRYEELHEVFRDKRILALSLVQNWLIGPVLMFALAVLFLRDSPEYMTGLILI
HHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GLARCIAMVLVWNQLARGDNQYVAGLVAFNSIFQILFFSIYAWIFLTLLPPLFGLQGSIV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NVSFWTIAEAVLIYLGIPFLAGFLTRRILIALKGRAWYEHEFLPRISPMTLAALLFTIVA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHH
MFSLKGGDVLRLPVDAVRIAIPLSLYFIIQFSISFVMGKLIEAAYPRTTAIAFTAAGNNF
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
ELAIAVAIAAFGLASPVAFAAVIGPLVEVPVLLLLVHVALRLGHRWFPQSCGTVPTPSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSVQPESRLSFLDRYLTVWIFAAMAGGVLLGTAFKGLPEALNALSVGTTNIPIAIGLIL
CCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MMYPPLAKVRYEELHEVFRDKRILALSLVQNWLIGPVLMFALAVLFLRDSPEYMTGLILI
HHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GLARCIAMVLVWNQLARGDNQYVAGLVAFNSIFQILFFSIYAWIFLTLLPPLFGLQGSIV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
NVSFWTIAEAVLIYLGIPFLAGFLTRRILIALKGRAWYEHEFLPRISPMTLAALLFTIVA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHH
MFSLKGGDVLRLPVDAVRIAIPLSLYFIIQFSISFVMGKLIEAAYPRTTAIAFTAAGNNF
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
ELAIAVAIAAFGLASPVAFAAVIGPLVEVPVLLLLVHVALRLGHRWFPQSCGTVPTPSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]