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The map label for this gene is trxA [H]

Identifier: 182679073

GI number: 182679073

Start: 2410513

End: 2410836

Strand: Direct

Name: trxA [H]

Synonym: Bind_2110

Alternate gene names: 182679073

Gene position: 2410513-2410836 (Clockwise)

Preceding gene: 182679072

Following gene: 182679078

Centisome position: 57.8

GC content: 57.41

Gene sequence:

>324_bases
ATGCCAAGCCTGAAAGTGACTGACGCTACCTTCGCCCGCGCTGTCATCGACGCGGGCCTTCCCGTTTTTGTGGATTTCTG
GGCGGATTGGTGTGGCCCCTGCCACGCTGTCGCCCCTCTTCTCGAAGACCTCGCCGATGAATTGCAAGGCCGGGTTATCG
TCGCCAAGCTGAATATCGACGAGAATCCGGATACGACGGCGCTCCAAGACATCCATTCCGTCCCGACTTTCAAAATCTTC
AAAAATGGCGAGCTCGCCGCGCAGGATATTGGCGCCTATACCAAGGACGCCCTGCGTGCCTGGATTCTTGAAACGATCGC
CTGA

Upstream 100 bases:

>100_bases
TTTGCTTATATTTTAAAATTCAAAGCAGCATTGGTTTTGCGTCGAAGGCGAAATCAATCGTGGCTTTAGCCATGCAAGGC
CGCTGAGGTTAGAGGCAGAG

Downstream 100 bases:

>100_bases
TGAAAGTTCACATTGAGAGCATCGGATGTTTGAGTCCGATGCTCTGTATCCCATTTAGGCCTGATGCGCTGCCCGGATTT
CGATCAATTCACGACCGATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MPSLKVTDATFARAVIDAGLPVFVDFWADWCGPCHAVAPLLEDLADELQGRVIVAKLNIDENPDTTALQDIHSVPTFKIF
KNGELAAQDIGAYTKDALRAWILETIA

Sequences:

>Translated_107_residues
MPSLKVTDATFARAVIDAGLPVFVDFWADWCGPCHAVAPLLEDLADELQGRVIVAKLNIDENPDTTALQDIHSVPTFKIF
KNGELAAQDIGAYTKDALRAWILETIA
>Mature_106_residues
PSLKVTDATFARAVIDAGLPVFVDFWADWCGPCHAVAPLLEDLADELQGRVIVAKLNIDENPDTTALQDIHSVPTFKIFK
NGELAAQDIGAYTKDALRAWILETIA

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=35.0515463917526, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI21361657, Length=97, Percent_Identity=36.0824742268041, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=46.1538461538462, Blast_Score=107, Evalue=1e-25,
Organism=Escherichia coli, GI1788936, Length=87, Percent_Identity=41.3793103448276, Blast_Score=81, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=104, Percent_Identity=39.4230769230769, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=38.0281690140845, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=43.8356164383562, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664269, Length=88, Percent_Identity=39.7727272727273, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=37.5, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=37.5, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=33.695652173913, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11665; Mature: 11534

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLKVTDATFARAVIDAGLPVFVDFWADWCGPCHAVAPLLEDLADELQGRVIVAKLNID
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
ENPDTTALQDIHSVPTFKIFKNGELAAQDIGAYTKDALRAWILETIA
CCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSLKVTDATFARAVIDAGLPVFVDFWADWCGPCHAVAPLLEDLADELQGRVIVAKLNID
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
ENPDTTALQDIHSVPTFKIFKNGELAAQDIGAYTKDALRAWILETIA
CCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]