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The map label for this gene is degP [H]

Identifier: 182679006

GI number: 182679006

Start: 2332174

End: 2333616

Strand: Direct

Name: degP [H]

Synonym: Bind_2041

Alternate gene names: 182679006

Gene position: 2332174-2333616 (Clockwise)

Preceding gene: 182679005

Following gene: 182679007

Centisome position: 55.93

GC content: 59.74

Gene sequence:

>1443_bases
ATGACCTCTTGCGGCCGTTCCCCTTTTTCTCCCCTTCGCCTCCTCGTTGCCCTCGGTCTGGCCACCGGTCTGCTCTGTGA
CTTTGGTCCTTCCGCCTCGGCCGAGACGCGAGAAATCCCGGTTTCTCATGATGACGTTCTGCTCTCCTTCGCCGGACCGG
TGAAAAAGGCGCAGCCTGCCGTTGTCAACGTCTATGCCTCGCGAACAGAGCGGCAGCCGCGCAACGTTCTCCTCGACGAT
CCGGTTTTCCGGCGTTTCTTTGGCGACGGCAATGGCCGCCGGCCTGGCGGTCCCACGGCGCAATCCCTCGGATCCGGCGT
GCTCGTTGATCCGTCAGGCCTTGTCGTCACCAATTTTCACGTCATCGAAGGCATGACCGACGTCAAGGTTGCCTTGACCG
ACAAGCGGGAATTCGAGGCAACGATCGTTTTACGGGATCAGCGCACTGATCTGGCCGTCTTGCGTCTGAAGGGGGGCGAT
GGGGCCTTCCCATCCATGGAAGTGGGTGATTCGGACACGCTCCAGGTCGGCGATCTCGTGCTCGCCATCGGCAATCCCTT
CGGCGTCGGCCAGACCGTTACCCAAGGCATTGTGTCGGCGCTTGCGCGGACACAGGTGGGCATTTCCGATTATGGTTTCT
TCATTCAGACGGATGCGGCGATCAATCCCGGTAATTCCGGCGGCGCCTTGATCGACATGAAGGCCCGCCTCGTCGGCATC
AATTCCGCCATCTTCTCCCAGACCGGCAGTTCGATTGGGATCGGTTTCGCCATTCCGGTCAATATGGTGAAAGTGGTCGT
CGCCGCCGCCAAAAGTGGCGGCCATCAGGTGCATCGGCCCTGGCTCGGCGCAAGCCTCCAGGGTGTTTCCCGCGAAATCG
CTGATTCCCTTGGCCTTGATCGCCCTTCGGGTGCCCTCATCGTCGAGGTGGCGAGCCAGAGCCCTGCTGCGGAAGCGGGC
CTCAAACGGGGTGATCTCATCACACGCATCGACGGGCAGACGCTGGAGGACCCGGAATCTTTCGGCTATCGTCTCGCGAC
GCGCCCACTTGGCGGCAAGGCCCAATTGACGGTCTTACGCAACGGCAAGCCGATCGACGCGACATTGAATCTTTCCGCCG
CTCCGGAACAACCCCCGCGCGATCCGGTCAAACTCAACGGCCATTCGCCCCTCACCGGCTTGAGTGTCGTCAATCTTTCT
CCCGCCGTCACTGAGGAATTCTCAATTCAGGGCGCATTCGAAGGCGTGGTGATCAATGACATTGACGAAAACTCTCCCGC
GGCCAATGTCAATTTTCAACGTGGCGATGTGATCATCGCCGTCAACGGTGCCAAGATCACCTCGACTCATCAGCTTGAAA
AAGCGATGAGCGAACAGCATTATTATTGGAAGGTAACGGTCGGTCGTGGCCATGATATTTTGACGACGGTGCTCGGCGGC
TGA

Upstream 100 bases:

>100_bases
TCAGATGGCCTTGATCCTCTTTCCAGATCATTCGACAAGGCAGTGGAACATTCCAAGCGGATGATCCAGTTGCTTCATGC
CCAGAAAGGGTGCCGACGCC

Downstream 100 bases:

>100_bases
AAGCTCGAAAGCGCCGGCGAATTCATTGCTGTTCCATGAGGCGGATCGGCCGCGATGAGCGATCTTTTCAGTGCCGCCGG
TCTTGAAAAGGATGTGCCGG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTSCGRSPFSPLRLLVALGLATGLLCDFGPSASAETREIPVSHDDVLLSFAGPVKKAQPAVVNVYASRTERQPRNVLLDD
PVFRRFFGDGNGRRPGGPTAQSLGSGVLVDPSGLVVTNFHVIEGMTDVKVALTDKREFEATIVLRDQRTDLAVLRLKGGD
GAFPSMEVGDSDTLQVGDLVLAIGNPFGVGQTVTQGIVSALARTQVGISDYGFFIQTDAAINPGNSGGALIDMKARLVGI
NSAIFSQTGSSIGIGFAIPVNMVKVVVAAAKSGGHQVHRPWLGASLQGVSREIADSLGLDRPSGALIVEVASQSPAAEAG
LKRGDLITRIDGQTLEDPESFGYRLATRPLGGKAQLTVLRNGKPIDATLNLSAAPEQPPRDPVKLNGHSPLTGLSVVNLS
PAVTEEFSIQGAFEGVVINDIDENSPAANVNFQRGDVIIAVNGAKITSTHQLEKAMSEQHYYWKVTVGRGHDILTTVLGG

Sequences:

>Translated_480_residues
MTSCGRSPFSPLRLLVALGLATGLLCDFGPSASAETREIPVSHDDVLLSFAGPVKKAQPAVVNVYASRTERQPRNVLLDD
PVFRRFFGDGNGRRPGGPTAQSLGSGVLVDPSGLVVTNFHVIEGMTDVKVALTDKREFEATIVLRDQRTDLAVLRLKGGD
GAFPSMEVGDSDTLQVGDLVLAIGNPFGVGQTVTQGIVSALARTQVGISDYGFFIQTDAAINPGNSGGALIDMKARLVGI
NSAIFSQTGSSIGIGFAIPVNMVKVVVAAAKSGGHQVHRPWLGASLQGVSREIADSLGLDRPSGALIVEVASQSPAAEAG
LKRGDLITRIDGQTLEDPESFGYRLATRPLGGKAQLTVLRNGKPIDATLNLSAAPEQPPRDPVKLNGHSPLTGLSVVNLS
PAVTEEFSIQGAFEGVVINDIDENSPAANVNFQRGDVIIAVNGAKITSTHQLEKAMSEQHYYWKVTVGRGHDILTTVLGG
>Mature_479_residues
TSCGRSPFSPLRLLVALGLATGLLCDFGPSASAETREIPVSHDDVLLSFAGPVKKAQPAVVNVYASRTERQPRNVLLDDP
VFRRFFGDGNGRRPGGPTAQSLGSGVLVDPSGLVVTNFHVIEGMTDVKVALTDKREFEATIVLRDQRTDLAVLRLKGGDG
AFPSMEVGDSDTLQVGDLVLAIGNPFGVGQTVTQGIVSALARTQVGISDYGFFIQTDAAINPGNSGGALIDMKARLVGIN
SAIFSQTGSSIGIGFAIPVNMVKVVVAAAKSGGHQVHRPWLGASLQGVSREIADSLGLDRPSGALIVEVASQSPAAEAGL
KRGDLITRIDGQTLEDPESFGYRLATRPLGGKAQLTVLRNGKPIDATLNLSAAPEQPPRDPVKLNGHSPLTGLSVVNLSP
AVTEEFSIQGAFEGVVINDIDENSPAANVNFQRGDVIIAVNGAKITSTHQLEKAMSEQHYYWKVTVGRGHDILTTVLGG

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=245, Percent_Identity=35.5102040816327, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI22129776, Length=300, Percent_Identity=30.6666666666667, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI24308541, Length=247, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI7019477, Length=290, Percent_Identity=33.448275862069, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786356, Length=457, Percent_Identity=36.1050328227571, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789629, Length=463, Percent_Identity=35.85313174946, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789630, Length=375, Percent_Identity=33.8666666666667, Blast_Score=166, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646839, Length=304, Percent_Identity=32.8947368421053, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50350; Mature: 50219

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSCGRSPFSPLRLLVALGLATGLLCDFGPSASAETREIPVSHDDVLLSFAGPVKKAQPA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCE
VVNVYASRTERQPRNVLLDDPVFRRFFGDGNGRRPGGPTAQSLGSGVLVDPSGLVVTNFH
EEEEEECCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCHHHHCCCEEECCCCEEEEEEE
VIEGMTDVKVALTDKREFEATIVLRDQRTDLAVLRLKGGDGAFPSMEVGDSDTLQVGDLV
EECCCCEEEEEEECCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCEEECEEE
LAIGNPFGVGQTVTQGIVSALARTQVGISDYGFFIQTDAAINPGNSGGALIDMKARLVGI
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCCCEEEEEEEEEEEC
NSAIFSQTGSSIGIGFAIPVNMVKVVVAAAKSGGHQVHRPWLGASLQGVSREIADSLGLD
CHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCC
RPSGALIVEVASQSPAAEAGLKRGDLITRIDGQTLEDPESFGYRLATRPLGGKAQLTVLR
CCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCHHHCCEEEEECCCCCCEEEEEEE
NGKPIDATLNLSAAPEQPPRDPVKLNGHSPLTGLSVVNLSPAVTEEFSIQGAFEGVVIND
CCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCEEECEEECCEEEEC
IDENSPAANVNFQRGDVIIAVNGAKITSTHQLEKAMSEQHYYWKVTVGRGHDILTTVLGG
CCCCCCCCCEEEECCCEEEEECCCEECCHHHHHHHHCCCCEEEEEEECCCCEEEHEECCC
>Mature Secondary Structure 
TSCGRSPFSPLRLLVALGLATGLLCDFGPSASAETREIPVSHDDVLLSFAGPVKKAQPA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCE
VVNVYASRTERQPRNVLLDDPVFRRFFGDGNGRRPGGPTAQSLGSGVLVDPSGLVVTNFH
EEEEEECCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCHHHHCCCEEECCCCEEEEEEE
VIEGMTDVKVALTDKREFEATIVLRDQRTDLAVLRLKGGDGAFPSMEVGDSDTLQVGDLV
EECCCCEEEEEEECCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCEEECEEE
LAIGNPFGVGQTVTQGIVSALARTQVGISDYGFFIQTDAAINPGNSGGALIDMKARLVGI
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCCCEEEEEEEEEEEC
NSAIFSQTGSSIGIGFAIPVNMVKVVVAAAKSGGHQVHRPWLGASLQGVSREIADSLGLD
CHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCC
RPSGALIVEVASQSPAAEAGLKRGDLITRIDGQTLEDPESFGYRLATRPLGGKAQLTVLR
CCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCHHHCCEEEEECCCCCCEEEEEEE
NGKPIDATLNLSAAPEQPPRDPVKLNGHSPLTGLSVVNLSPAVTEEFSIQGAFEGVVIND
CCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCEEECEEECCEEEEC
IDENSPAANVNFQRGDVIIAVNGAKITSTHQLEKAMSEQHYYWKVTVGRGHDILTTVLGG
CCCCCCCCCEEEECCCEEEEECCCEECCHHHHHHHHCCCCEEEEEEECCCCEEEHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]