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The map label for this gene is fsr [H]

Identifier: 182678973

GI number: 182678973

Start: 2292555

End: 2293826

Strand: Reverse

Name: fsr [H]

Synonym: Bind_2007

Alternate gene names: 182678973

Gene position: 2293826-2292555 (Counterclockwise)

Preceding gene: 182678975

Following gene: 182678969

Centisome position: 55.01

GC content: 58.18

Gene sequence:

>1272_bases
ATGGTCAATCCTCAAAGCCCGAATGATCAAGAGCCAATGGGCCGTTCAGCGCCGCAAGGACCGCAATTCGCGGTTCTTGG
CGCGATCAGCCTTTGCCATATGCTGAATGACACGATTCAATCCTTGATTGTTGCCATTTATCCCCTCTTGAAAAGCTCCC
TGGCCTTGAGTTTCGCGCAGATCGGGCTGATCACGTTCGTCTATCAATTGAGCGCGTCTCTGTTTCAGCCGGTCATCGGA
TATTACACGGATCTCAAGCCGAAACCGTTCTCGCTCGTCATTGGCATGAGTTGCAGTCTTATGGGCCTGCTGCTCCTTTC
GGTAGCGCCGGCCTATGGCATCGTCCTGGCGGCGGTCGGGCTGATTGGACTCGGCTCCTCCGTGTTTCACCCGGAATCCT
CGCGCATCGCTCGATTGGCGTCGGGCGGTCAGCCGGGCCTTGCTCAATCGGTTTTTCAGGTCGGCGGCAATTTCGGCACC
GCGATCGGTCCTTTGCTCGCGGCCTTTATCGTTTTGCCGCAGGGCAGGGGGAGCCTCGCCTGGTTTTCCGTGCTGGCCTT
GATTGCCATGGCGTTTCTGTTTCGCATCGGCCTCTGGTATGGCCGTGAACTCGTGCGCAGAAAAGCCAAGGCGCGACAGG
CCAATGTCCGAGCGCTGCCCTTGCCGAAAAAGCAGGTGGCGGTCTCAGTCGCGATTCTGCTCGTCCTGATCTTTTCTAAA
TATTTCTATCTGGCGAGTATCTCCAGTTATTACCTTTTCTATCTCATCCACAAATTCGGGATCAGTCCTGAAGAGGCGCA
ACTCCGCCTGTTCATCTTTCTTGGCTCGGTCGCAGCCGGCACCTTGATCGGCGGGCCGATAGGAGACCGGATCGGCCGCA
AATATGTCATCTGGGGCTCGATCCTCGGCGTTCTGCCTTTCTCGCTGGCGCTCCCCCATGCGGACCTGTTCTGGACGGCC
GTGCTCACGGTGCCGATCGGCATCATTCTGTCCTCGGCCTTTGCGGCGATCCTTGTCTATGCCCAGGACTTGATCCCGGG
GCGAACCGGCACGGTGGCCGGCTTGTTCTTCGGCTTTGCTTTTGGAATGGGCGGCATTGGCGCGGCGGTGCTGGGTGGTC
TTGCTGATAGCCATGGCATTGAGTTCGTCTATCAGCTTTGCGCCTGGCTTCCCGCCATCGGCCTGCTCGCCATGTTCTTG
CCGGATCTGCGCGAGAAGGAGCCGAAGGTGAAGGTCGTGACCAATGTAACCGAACAGGCCTCGCAAGCCTGA

Upstream 100 bases:

>100_bases
GAGACCAGGGTTCGGGGGACGGGGCAAGACATGAATCAAAACAGAAGCCGATAAGTGTCATCATCCCTCGACCTCCATTC
TGTTCCGCTAGGCCGCGACC

Downstream 100 bases:

>100_bases
AGGTTACAGAGCCGGAATCTGATCGAGTCCGTAGAGATCCTCGATAGCCTCGGCGGTCAACACGCTGTCCGCCGGACCAT
CGGCTTTGATACGGCCTTTC

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MVNPQSPNDQEPMGRSAPQGPQFAVLGAISLCHMLNDTIQSLIVAIYPLLKSSLALSFAQIGLITFVYQLSASLFQPVIG
YYTDLKPKPFSLVIGMSCSLMGLLLLSVAPAYGIVLAAVGLIGLGSSVFHPESSRIARLASGGQPGLAQSVFQVGGNFGT
AIGPLLAAFIVLPQGRGSLAWFSVLALIAMAFLFRIGLWYGRELVRRKAKARQANVRALPLPKKQVAVSVAILLVLIFSK
YFYLASISSYYLFYLIHKFGISPEEAQLRLFIFLGSVAAGTLIGGPIGDRIGRKYVIWGSILGVLPFSLALPHADLFWTA
VLTVPIGIILSSAFAAILVYAQDLIPGRTGTVAGLFFGFAFGMGGIGAAVLGGLADSHGIEFVYQLCAWLPAIGLLAMFL
PDLREKEPKVKVVTNVTEQASQA

Sequences:

>Translated_423_residues
MVNPQSPNDQEPMGRSAPQGPQFAVLGAISLCHMLNDTIQSLIVAIYPLLKSSLALSFAQIGLITFVYQLSASLFQPVIG
YYTDLKPKPFSLVIGMSCSLMGLLLLSVAPAYGIVLAAVGLIGLGSSVFHPESSRIARLASGGQPGLAQSVFQVGGNFGT
AIGPLLAAFIVLPQGRGSLAWFSVLALIAMAFLFRIGLWYGRELVRRKAKARQANVRALPLPKKQVAVSVAILLVLIFSK
YFYLASISSYYLFYLIHKFGISPEEAQLRLFIFLGSVAAGTLIGGPIGDRIGRKYVIWGSILGVLPFSLALPHADLFWTA
VLTVPIGIILSSAFAAILVYAQDLIPGRTGTVAGLFFGFAFGMGGIGAAVLGGLADSHGIEFVYQLCAWLPAIGLLAMFL
PDLREKEPKVKVVTNVTEQASQA
>Mature_423_residues
MVNPQSPNDQEPMGRSAPQGPQFAVLGAISLCHMLNDTIQSLIVAIYPLLKSSLALSFAQIGLITFVYQLSASLFQPVIG
YYTDLKPKPFSLVIGMSCSLMGLLLLSVAPAYGIVLAAVGLIGLGSSVFHPESSRIARLASGGQPGLAQSVFQVGGNFGT
AIGPLLAAFIVLPQGRGSLAWFSVLALIAMAFLFRIGLWYGRELVRRKAKARQANVRALPLPKKQVAVSVAILLVLIFSK
YFYLASISSYYLFYLIHKFGISPEEAQLRLFIFLGSVAAGTLIGGPIGDRIGRKYVIWGSILGVLPFSLALPHADLFWTA
VLTVPIGIILSSAFAAILVYAQDLIPGRTGTVAGLFFGFAFGMGGIGAAVLGGLADSHGIEFVYQLCAWLPAIGLLAMFL
PDLREKEPKVKVVTNVTEQASQA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=386, Percent_Identity=62.9533678756477, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45021; Mature: 45021

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]