Click here to switch to the map view.

The map label for this gene is trpB

Identifier: 182678956

GI number: 182678956

Start: 2274131

End: 2275375

Strand: Reverse

Name: trpB

Synonym: Bind_1990

Alternate gene names: 182678956

Gene position: 2275375-2274131 (Counterclockwise)

Preceding gene: 182678957

Following gene: 182678955

Centisome position: 54.56

GC content: 59.44

Gene sequence:

>1245_bases
ATGCCCCACGAACCTCTCAATTCCTATCGCTCGGGCCCGGATGAGAGAGGGCATTTCGGCATTTTTGGTGGTCGATTCGT
CGCCGAAACCTTGATGCCGCTGATTCTCGATCTCGAAAAGCATTATGCGCTGGCACGCGTCGATCCCGCCTTCAAGGCGG
AGCTCGATGGTCTTCTGACGCATTATGTCGGCAGGCCGAGCCCTCTTTATTACGCTGAGCGTTTGACCGAACATGTGCGT
GCTATTGCGGCGCACGCCGGTGGCAGGGGAGGCGCCAAGGTCTATTTCAAGCGCGAGGAGCTGAACCATACGGGCGCGCA
TAAGATCAATAATGTGCTCGGCCAGATTCTCTTGGCGCGGCGGATGGGCAAGACGCGCATCATCGCCGAGACGGGGGCCG
GCCAGCATGGCGTAGCGACCGCCACGGCCTGCGCGCGCTTCGGCCTCGAATGCGTGATCTATATGGGCGCGGTCGACGTC
GAACGGCAAAAGCCCAATGTCTTTCGCATGAACCTTTTGGGTGCCAAGGTTGTGCCCGTGCAATCGGGAGCACGAACCCT
GAAGGATGCGATGAACGAGGCCTTGCGTGACTGGGTGACCAATGTCACCGATACATTCTATTGCATTGGCACGGCGGCGG
GTCCGCATCCTTATCCAGCCATGGTGCGTGATTTCCAATGCGTGATCGGCGAGGAAACTCGCACGCAAATGCTGGAACGC
GAGGGGCGGCTTCCCGACTCGCTTTTTGCCTGCATTGGCGGCGGTTCCAATGCAATCGGCCTGTTTCATCCCTTTCTCGA
CGAGCCGAATGTGGAGATTTACGGGGTCGAGGCGGCGGGTTTCGGCCTCGACAAGCAACATGCCGCCTCGCTAGCGGGTG
GACGGCCTGGCGTCTTGCACGGTAATCGGACTTATCTTCTCATGGACGCGGATGGTCAGATCGAAGAAGGCCACTCGATC
TCGGCGGGGCTGGATTATCCGGGGATCGGCCCGGAACACGCATGGTTGAAGGAGACCGGCCGCGTCACCTATCTCTCGGC
CCGAGACGATGAGGCCTTGGACGCCTTTCAGCTTTGCGCAAAGCTCGAGGGAATCATCCCGGCGCTGGAGCCGGCTCATG
CCTTGGCGAAGGTGGTCGAAGTCGCGCCCTCAAAGCCGCGTGATCATCTTTTGGTGGTCAATATTTCAGGCCGTGGTGAC
AAAGACATTTTCACGGTCGCCGATTATCTGGCGCCAGTTGGCTAG

Upstream 100 bases:

>100_bases
ATTTGACGAGAAGCTATTTTCTCGATCCAAGCCCATTGGCTAGGGTTGCAAACGCCCCGACTGAACAAAGGAGGGGCGAA
GAAGGAAACAGGATCAAACC

Downstream 100 bases:

>100_bases
TGCCATCAGCAGCGATCCAATCAGATGGACCTGCGGCCTTGTTCCATCTGATTGGGCATCACTTTTGGGATCAATCTGAT
GTACAATTGGACATCGAGAA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPHEPLNSYRSGPDERGHFGIFGGRFVAETLMPLILDLEKHYALARVDPAFKAELDGLLTHYVGRPSPLYYAERLTEHVR
AIAAHAGGRGGAKVYFKREELNHTGAHKINNVLGQILLARRMGKTRIIAETGAGQHGVATATACARFGLECVIYMGAVDV
ERQKPNVFRMNLLGAKVVPVQSGARTLKDAMNEALRDWVTNVTDTFYCIGTAAGPHPYPAMVRDFQCVIGEETRTQMLER
EGRLPDSLFACIGGGSNAIGLFHPFLDEPNVEIYGVEAAGFGLDKQHAASLAGGRPGVLHGNRTYLLMDADGQIEEGHSI
SAGLDYPGIGPEHAWLKETGRVTYLSARDDEALDAFQLCAKLEGIIPALEPAHALAKVVEVAPSKPRDHLLVVNISGRGD
KDIFTVADYLAPVG

Sequences:

>Translated_414_residues
MPHEPLNSYRSGPDERGHFGIFGGRFVAETLMPLILDLEKHYALARVDPAFKAELDGLLTHYVGRPSPLYYAERLTEHVR
AIAAHAGGRGGAKVYFKREELNHTGAHKINNVLGQILLARRMGKTRIIAETGAGQHGVATATACARFGLECVIYMGAVDV
ERQKPNVFRMNLLGAKVVPVQSGARTLKDAMNEALRDWVTNVTDTFYCIGTAAGPHPYPAMVRDFQCVIGEETRTQMLER
EGRLPDSLFACIGGGSNAIGLFHPFLDEPNVEIYGVEAAGFGLDKQHAASLAGGRPGVLHGNRTYLLMDADGQIEEGHSI
SAGLDYPGIGPEHAWLKETGRVTYLSARDDEALDAFQLCAKLEGIIPALEPAHALAKVVEVAPSKPRDHLLVVNISGRGD
KDIFTVADYLAPVG
>Mature_413_residues
PHEPLNSYRSGPDERGHFGIFGGRFVAETLMPLILDLEKHYALARVDPAFKAELDGLLTHYVGRPSPLYYAERLTEHVRA
IAAHAGGRGGAKVYFKREELNHTGAHKINNVLGQILLARRMGKTRIIAETGAGQHGVATATACARFGLECVIYMGAVDVE
RQKPNVFRMNLLGAKVVPVQSGARTLKDAMNEALRDWVTNVTDTFYCIGTAAGPHPYPAMVRDFQCVIGEETRTQMLERE
GRLPDSLFACIGGGSNAIGLFHPFLDEPNVEIYGVEAAGFGLDKQHAASLAGGRPGVLHGNRTYLLMDADGQIEEGHSIS
AGLDYPGIGPEHAWLKETGRVTYLSARDDEALDAFQLCAKLEGIIPALEPAHALAKVVEVAPSKPRDHLLVVNISGRGDK
DIFTVADYLAPVG

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=399, Percent_Identity=55.6390977443609, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321412, Length=398, Percent_Identity=54.7738693467337, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_BEII9 (B2IF48)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833102.1
- GeneID:   6200757
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1990
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 44837; Mature: 44706

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHEPLNSYRSGPDERGHFGIFGGRFVAETLMPLILDLEKHYALARVDPAFKAELDGLLT
CCCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
HYVGRPSPLYYAERLTEHVRAIAAHAGGRGGAKVYFKREELNHTGAHKINNVLGQILLAR
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHH
RMGKTRIIAETGAGQHGVATATACARFGLECVIYMGAVDVERQKPNVFRMNLLGAKVVPV
HCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCEECCCCCCCEEEEEECCCEEEEC
QSGARTLKDAMNEALRDWVTNVTDTFYCIGTAAGPHPYPAMVRDFQCVIGEETRTQMLER
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
EGRLPDSLFACIGGGSNAIGLFHPFLDEPNVEIYGVEAAGFGLDKQHAASLAGGRPGVLH
HCCCCHHHHHEECCCCCCEEEEHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEE
GNRTYLLMDADGQIEEGHSISAGLDYPGIGPEHAWLKETGRVTYLSARDDEALDAFQLCA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHH
KLEGIIPALEPAHALAKVVEVAPSKPRDHLLVVNISGRGDKDIFTVADYLAPVG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
PHEPLNSYRSGPDERGHFGIFGGRFVAETLMPLILDLEKHYALARVDPAFKAELDGLLT
CCCCCHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
HYVGRPSPLYYAERLTEHVRAIAAHAGGRGGAKVYFKREELNHTGAHKINNVLGQILLAR
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHH
RMGKTRIIAETGAGQHGVATATACARFGLECVIYMGAVDVERQKPNVFRMNLLGAKVVPV
HCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCEECCCCCCCEEEEEECCCEEEEC
QSGARTLKDAMNEALRDWVTNVTDTFYCIGTAAGPHPYPAMVRDFQCVIGEETRTQMLER
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
EGRLPDSLFACIGGGSNAIGLFHPFLDEPNVEIYGVEAAGFGLDKQHAASLAGGRPGVLH
HCCCCHHHHHEECCCCCCEEEEHHCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEE
GNRTYLLMDADGQIEEGHSISAGLDYPGIGPEHAWLKETGRVTYLSARDDEALDAFQLCA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHH
KLEGIIPALEPAHALAKVVEVAPSKPRDHLLVVNISGRGDKDIFTVADYLAPVG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA