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The map label for this gene is gdhA [H]

Identifier: 182678927

GI number: 182678927

Start: 2236417

End: 2238066

Strand: Reverse

Name: gdhA [H]

Synonym: Bind_1961

Alternate gene names: 182678927

Gene position: 2238066-2236417 (Counterclockwise)

Preceding gene: 182678928

Following gene: 182678925

Centisome position: 53.67

GC content: 60.91

Gene sequence:

>1650_bases
ATGGTGGATCATCCCGTTCGCCTGTTGCTGGTCGAGGACAATCCCCTTCACGTTAAGCTGGTCCTGCGATTTCTTGCGGG
GGACGTGCAACTGCGGTGTGCCGTGGAGGTGGTTGATTGTCTCAGCGATGGCTTGGCGCGGCTCGGCCGCGGCGCGCTCG
ATCTCGTTCTGCTCGACCTGATCCTGCCTGACAGCCAAGAACTGGAGACCCTGTTCAAGGTCCGAGCCGCTGCCCCAGAC
ACGCCGGTCATCGTGCTGACCAGCATGGATGATGTGAAGCTGGCCGCGCGGGCGGTGGATGTGGGCGCGTATGCCTATCT
GCTCAAAACCCAGATCAATGCGGTCTCGCTTGGCCGCGCGATCCGCTACACACTGGCGCGGGCGCGGACGCGCGGTAACG
AATGGGACTCGCCAATATTCCGGCTTGCCCAGCAGCAGTTCCTGAAAGCAGCCCAGATCATGAACCTGGACGACAATTTT
CGTCAGCGGCTGCTGTTCCCAGAGCGCACTCAGGTGGTATCGTTTCCCTTCATCCGCGACGATCAACAGCAGGTGGAAAC
GGTCTTCGGCTACCGCGTGCAGCATGTGCTGAGCATGGGGCCGACCAAGGGCGGTATCCGCTATCATCAGGACGTCGGGC
TTGGCGACGTGGCGGCGCTGTCGACTTGGATGACCTGGAAATGCGCACTCATGAAGCTGCCCTTTGGCGGCGCCAAGGGC
GGTGTGCGGATCGATCCGACTGGTCTGTCCAACAGAGAATTGCAGCGGCTGACCCGGCGCTATACTTCCGAGATTATCAA
CATCATTGGACCAGAGAAAGACATTCCTGCGCCCGATATGGGTACGAACGAGCAGGTGATGGCCTGGGTGATGGACACCT
ACAGCCAGCAGATGGGATATGCGGTGCCGGCGGTGGTCACGGGCAAGCCTGTCGTCCTCGGCGGTTCCCTAGGGCGGAAG
GAAGCGACCGGCCGGGGCTTAGTCTATCTTGTCCAGGCCGCGGCGCAGCACATCGGGCTCGACCTCAAAGAGGCGACGGC
CGTGGTCCAGGGATTCGGCAATGTCGGCAGCTTCACAGTGCAATTCCTTGCTGAAACAGGGGTAAAGATCATCGGTGTCA
GTGATGTCTCTACTGGCCTCTACAATCCCGCGGGCCTGTCGGTTGAGGCGCTCTTGAAATATGTCGCCACCAACCGAGAA
CTGAAGGGATTCCCTGACGCCGAGCCGATCTCCAATGCCGAACTTCTGGAGCTTGAATGCGACGTGCTGGCTGTGGCGGC
GCTGCAGAACCAGATCACAGCCGAGAATGCCGAACGGATCCATTGTCGTCTCCTGGCCGAAGGCGCCAATGGCCCGACCA
CCCTGGAGGCCGATGATGTGCTCAATGCGCGTGGCGTGTTCGTCCTGCCCGATATCCTCGCCAATGCCGGCGGTGTGACT
GTGTCCTATTTCGAATGGGTGCAGGGCACACAGAACTTGACCTGGACGCTGGAGGAGATCAACCAGCGATTGAAGGCGAT
CCTGCTTGATGCGTTCCAGCGCACGCTGCATCGTGCGGAGACCGACAAGCTCGATATGCGCACCGCGGCGCTGATCGAAG
GCGTCTCCCGCGTGACCGAGGCCAAACGGCTGCGCGGGGTGTTTCCGTAA

Upstream 100 bases:

>100_bases
GGGAAGCGATAAGATCAATTGTATATTGCTCCATAGCTCTGATGCTTGCACGGAAAGTGAAGAAGCCCAATATTTCTGAT
AGAATTCAGGAGTGTGGGTC

Downstream 100 bases:

>100_bases
GTGGCGGTTTCCTGTGACCGCCACTTCCACCCTTGAAGACCATGCCGGTTTTCAGCTTGTCATTTGAATGGTGTAACGCA
CTCTGGGATAAATTTCAGTG

Product: response regulator receiver protein

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MVDHPVRLLLVEDNPLHVKLVLRFLAGDVQLRCAVEVVDCLSDGLARLGRGALDLVLLDLILPDSQELETLFKVRAAAPD
TPVIVLTSMDDVKLAARAVDVGAYAYLLKTQINAVSLGRAIRYTLARARTRGNEWDSPIFRLAQQQFLKAAQIMNLDDNF
RQRLLFPERTQVVSFPFIRDDQQQVETVFGYRVQHVLSMGPTKGGIRYHQDVGLGDVAALSTWMTWKCALMKLPFGGAKG
GVRIDPTGLSNRELQRLTRRYTSEIINIIGPEKDIPAPDMGTNEQVMAWVMDTYSQQMGYAVPAVVTGKPVVLGGSLGRK
EATGRGLVYLVQAAAQHIGLDLKEATAVVQGFGNVGSFTVQFLAETGVKIIGVSDVSTGLYNPAGLSVEALLKYVATNRE
LKGFPDAEPISNAELLELECDVLAVAALQNQITAENAERIHCRLLAEGANGPTTLEADDVLNARGVFVLPDILANAGGVT
VSYFEWVQGTQNLTWTLEEINQRLKAILLDAFQRTLHRAETDKLDMRTAALIEGVSRVTEAKRLRGVFP

Sequences:

>Translated_549_residues
MVDHPVRLLLVEDNPLHVKLVLRFLAGDVQLRCAVEVVDCLSDGLARLGRGALDLVLLDLILPDSQELETLFKVRAAAPD
TPVIVLTSMDDVKLAARAVDVGAYAYLLKTQINAVSLGRAIRYTLARARTRGNEWDSPIFRLAQQQFLKAAQIMNLDDNF
RQRLLFPERTQVVSFPFIRDDQQQVETVFGYRVQHVLSMGPTKGGIRYHQDVGLGDVAALSTWMTWKCALMKLPFGGAKG
GVRIDPTGLSNRELQRLTRRYTSEIINIIGPEKDIPAPDMGTNEQVMAWVMDTYSQQMGYAVPAVVTGKPVVLGGSLGRK
EATGRGLVYLVQAAAQHIGLDLKEATAVVQGFGNVGSFTVQFLAETGVKIIGVSDVSTGLYNPAGLSVEALLKYVATNRE
LKGFPDAEPISNAELLELECDVLAVAALQNQITAENAERIHCRLLAEGANGPTTLEADDVLNARGVFVLPDILANAGGVT
VSYFEWVQGTQNLTWTLEEINQRLKAILLDAFQRTLHRAETDKLDMRTAALIEGVSRVTEAKRLRGVFP
>Mature_549_residues
MVDHPVRLLLVEDNPLHVKLVLRFLAGDVQLRCAVEVVDCLSDGLARLGRGALDLVLLDLILPDSQELETLFKVRAAAPD
TPVIVLTSMDDVKLAARAVDVGAYAYLLKTQINAVSLGRAIRYTLARARTRGNEWDSPIFRLAQQQFLKAAQIMNLDDNF
RQRLLFPERTQVVSFPFIRDDQQQVETVFGYRVQHVLSMGPTKGGIRYHQDVGLGDVAALSTWMTWKCALMKLPFGGAKG
GVRIDPTGLSNRELQRLTRRYTSEIINIIGPEKDIPAPDMGTNEQVMAWVMDTYSQQMGYAVPAVVTGKPVVLGGSLGRK
EATGRGLVYLVQAAAQHIGLDLKEATAVVQGFGNVGSFTVQFLAETGVKIIGVSDVSTGLYNPAGLSVEALLKYVATNRE
LKGFPDAEPISNAELLELECDVLAVAALQNQITAENAERIHCRLLAEGANGPTTLEADDVLNARGVFVLPDILANAGGVT
VSYFEWVQGTQNLTWTLEEINQRLKAILLDAFQRTLHRAETDKLDMRTAALIEGVSRVTEAKRLRGVFP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=336, Percent_Identity=42.5595238095238, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI4885281, Length=336, Percent_Identity=42.5595238095238, Blast_Score=283, Evalue=3e-76,
Organism=Escherichia coli, GI1788059, Length=402, Percent_Identity=32.8358208955224, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17544676, Length=364, Percent_Identity=42.032967032967, Blast_Score=282, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324951, Length=441, Percent_Identity=28.3446712018141, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319256, Length=433, Percent_Identity=29.3302540415704, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45553475, Length=458, Percent_Identity=36.6812227074236, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI45549226, Length=461, Percent_Identity=37.0932754880694, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24649283, Length=367, Percent_Identity=40.0544959128065, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24649460, Length=313, Percent_Identity=40.8945686900958, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 60112; Mature: 60112

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHPVRLLLVEDNPLHVKLVLRFLAGDVQLRCAVEVVDCLSDGLARLGRGALDLVLLDL
CCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ILPDSQELETLFKVRAAAPDTPVIVLTSMDDVKLAARAVDVGAYAYLLKTQINAVSLGRA
HCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IRYTLARARTRGNEWDSPIFRLAQQQFLKAAQIMNLDDNFRQRLLFPERTQVVSFPFIRD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCC
DQQQVETVFGYRVQHVLSMGPTKGGIRYHQDVGLGDVAALSTWMTWKCALMKLPFGGAKG
CHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCC
GVRIDPTGLSNRELQRLTRRYTSEIINIIGPEKDIPAPDMGTNEQVMAWVMDTYSQQMGY
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
AVPAVVTGKPVVLGGSLGRKEATGRGLVYLVQAAAQHIGLDLKEATAVVQGFGNVGSFTV
CCCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHH
QFLAETGVKIIGVSDVSTGLYNPAGLSVEALLKYVATNRELKGFPDAEPISNAELLELEC
HHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHH
DVLAVAALQNQITAENAERIHCRLLAEGANGPTTLEADDVLNARGVFVLPDILANAGGVT
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEECHHHCCCCCCCEEEHHHHCCCCCCE
VSYFEWVQGTQNLTWTLEEINQRLKAILLDAFQRTLHRAETDKLDMRTAALIEGVSRVTE
EHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AKRLRGVFP
HHHHCCCCC
>Mature Secondary Structure
MVDHPVRLLLVEDNPLHVKLVLRFLAGDVQLRCAVEVVDCLSDGLARLGRGALDLVLLDL
CCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ILPDSQELETLFKVRAAAPDTPVIVLTSMDDVKLAARAVDVGAYAYLLKTQINAVSLGRA
HCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IRYTLARARTRGNEWDSPIFRLAQQQFLKAAQIMNLDDNFRQRLLFPERTQVVSFPFIRD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCC
DQQQVETVFGYRVQHVLSMGPTKGGIRYHQDVGLGDVAALSTWMTWKCALMKLPFGGAKG
CHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCCC
GVRIDPTGLSNRELQRLTRRYTSEIINIIGPEKDIPAPDMGTNEQVMAWVMDTYSQQMGY
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
AVPAVVTGKPVVLGGSLGRKEATGRGLVYLVQAAAQHIGLDLKEATAVVQGFGNVGSFTV
CCCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHH
QFLAETGVKIIGVSDVSTGLYNPAGLSVEALLKYVATNRELKGFPDAEPISNAELLELEC
HHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHH
DVLAVAALQNQITAENAERIHCRLLAEGANGPTTLEADDVLNARGVFVLPDILANAGGVT
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEECHHHCCCCCCCEEEHHHHCCCCCCE
VSYFEWVQGTQNLTWTLEEINQRLKAILLDAFQRTLHRAETDKLDMRTAALIEGVSRVTE
EHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AKRLRGVFP
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]