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The map label for this gene is lon [H]

Identifier: 182678922

GI number: 182678922

Start: 2229728

End: 2230513

Strand: Reverse

Name: lon [H]

Synonym: Bind_1956

Alternate gene names: 182678922

Gene position: 2230513-2229728 (Counterclockwise)

Preceding gene: 182678923

Following gene: 182678918

Centisome position: 53.49

GC content: 56.11

Gene sequence:

>786_bases
ATGCGCGACTTTCGCGATGCTAAGGCCATGGCACAGACCCTGCGCGAAAACTTGACCGCCAAGGCCATCACAATCAGCTA
CAGCGAGAGCTTGGAACTGGTTTCGAAGATACTGGGCATTTCTGACTGGAACACCTTGTCGGCCTTACTCCAAGCGCGGC
TGCGGGAGACCGCAAGTCCTCCCACAAGGCACCCAGGTGGAACGGTAAACTATCCGGCCCTTCCGATTCGGGATTTCGTG
GTTTTCCCGACGATGAACGTCCCGCTTTTAGTCGGCCGTGACAAGACAAAGCACGCCCTCGACCATGCGTTTGAGCGTCA
CCGGGAGGTCGTGCTAGCCGTCCAAAAGGACCCCGCTATTGAAGAGCCTGGCTTTGGCGATGTTTACGAAGTTGGAGTGC
TTGCCAGGTTACTTGAGCTTGAGCGGTTTCCCGATAGCACAATGAAAATCCTGGTGCATGCGCACCGGCGTGTCGCGATC
TGCGGATTCATTGGGGAAGCAGGCGCGTTCCAGGCCGAAATCGCCGACATCAGCGAAGGGCCGATCCCTGATGCGCCTGA
ACTTATCCGAAAAGTTGTTGAACGGTTTGAACGCTACGTGGCTGTCCACGAAATCGATATACCGCAGACGTGGCCAGCCC
TTGGTCAAATCCGCGATCCTGGACGCGTCGCCGATGTTATCTCTCAGCACATGGCCATGCCGATCAGTAAGAAGCAGAGT
TTGCTGGCGACTCTTGATCCGGTGATCCGGCTCGAAAAAGTCGTTGCCCTGTTAGATGGTGAGTAG

Upstream 100 bases:

>100_bases
GGTGAACGTATCGAGCCTTCAGGCTTCCCTTTGCCCGAGCGACTGGGTCAGCAACGCAACCACCTGACACGCCTGGTTCG
CTCATGCAAAGGACCAAGAC

Downstream 100 bases:

>100_bases
GTGATTGCCAACCTGCCTATGCAGACGATGAACATATGAAAATGTCACCAGAAATCAGGTGACATTTTTGTGGTAGAGCC
AGATTGGAGATAGTGACAGT

Product: endopeptidase La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MRDFRDAKAMAQTLRENLTAKAITISYSESLELVSKILGISDWNTLSALLQARLRETASPPTRHPGGTVNYPALPIRDFV
VFPTMNVPLLVGRDKTKHALDHAFERHREVVLAVQKDPAIEEPGFGDVYEVGVLARLLELERFPDSTMKILVHAHRRVAI
CGFIGEAGAFQAEIADISEGPIPDAPELIRKVVERFERYVAVHEIDIPQTWPALGQIRDPGRVADVISQHMAMPISKKQS
LLATLDPVIRLEKVVALLDGE

Sequences:

>Translated_261_residues
MRDFRDAKAMAQTLRENLTAKAITISYSESLELVSKILGISDWNTLSALLQARLRETASPPTRHPGGTVNYPALPIRDFV
VFPTMNVPLLVGRDKTKHALDHAFERHREVVLAVQKDPAIEEPGFGDVYEVGVLARLLELERFPDSTMKILVHAHRRVAI
CGFIGEAGAFQAEIADISEGPIPDAPELIRKVVERFERYVAVHEIDIPQTWPALGQIRDPGRVADVISQHMAMPISKKQS
LLATLDPVIRLEKVVALLDGE
>Mature_261_residues
MRDFRDAKAMAQTLRENLTAKAITISYSESLELVSKILGISDWNTLSALLQARLRETASPPTRHPGGTVNYPALPIRDFV
VFPTMNVPLLVGRDKTKHALDHAFERHREVVLAVQKDPAIEEPGFGDVYEVGVLARLLELERFPDSTMKILVHAHRRVAI
CGFIGEAGAFQAEIADISEGPIPDAPELIRKVVERFERYVAVHEIDIPQTWPALGQIRDPGRVADVISQHMAMPISKKQS
LLATLDPVIRLEKVVALLDGE

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Escherichia coli, GI1786643, Length=196, Percent_Identity=35.2040816326531, Blast_Score=133, Evalue=1e-32,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 29004; Mature: 29004

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFRDAKAMAQTLRENLTAKAITISYSESLELVSKILGISDWNTLSALLQARLRETASP
CCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PTRHPGGTVNYPALPIRDFVVFPTMNVPLLVGRDKTKHALDHAFERHREVVLAVQKDPAI
CCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEECCCCC
EEPGFGDVYEVGVLARLLELERFPDSTMKILVHAHRRVAICGFIGEAGAFQAEIADISEG
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCC
PIPDAPELIRKVVERFERYVAVHEIDIPQTWPALGQIRDPGRVADVISQHMAMPISKKQS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCHHHHH
LLATLDPVIRLEKVVALLDGE
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDFRDAKAMAQTLRENLTAKAITISYSESLELVSKILGISDWNTLSALLQARLRETASP
CCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PTRHPGGTVNYPALPIRDFVVFPTMNVPLLVGRDKTKHALDHAFERHREVVLAVQKDPAI
CCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEECCCCC
EEPGFGDVYEVGVLARLLELERFPDSTMKILVHAHRRVAICGFIGEAGAFQAEIADISEG
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCC
PIPDAPELIRKVVERFERYVAVHEIDIPQTWPALGQIRDPGRVADVISQHMAMPISKKQS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCHHHHH
LLATLDPVIRLEKVVALLDGE
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8666236 [H]