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The map label for this gene is aslA [H]

Identifier: 182678912

GI number: 182678912

Start: 2217698

End: 2219338

Strand: Reverse

Name: aslA [H]

Synonym: Bind_1946

Alternate gene names: 182678912

Gene position: 2219338-2217698 (Counterclockwise)

Preceding gene: 182678914

Following gene: 182678911

Centisome position: 53.22

GC content: 55.03

Gene sequence:

>1641_bases
ATGGAGATGATTCGAACTTTATGGCTTAGCCTCGTTGCGCTGGTTTCCGTCACTATGGCGGTGACTACCCCGGCGTCCGC
GCAGCCGCAGAAACCTAACATTCTCTTTATCATGGGCGATGACATCGGCTGGTTCAACATCGGCGCCTACCATCAGGGCC
TCATGTATTCGACGACGCCAAATCTCGACAAGCTTGCCACCGAAGGCATGCGTTTCACCGATTATTACGCGGAACCGAGT
TGTACTGCGGGCCGCGCCAATTTCATCACCGGGGAACTGCCGATCCGCACGGGGCTGACCACGGTTGGTCAGGCGGGCGC
CACGGTCGGTATTCCAGACGAGGCCCCCACGATCGCCACAGCGCTCAAGGCGATGGGCTATGTCACGGGCCAATTCGGCA
AGAACCATTTGGGCGATTTGAATCGCTACCTGCCGACCGTCCATGGGTTCGACGAATATTTCGGCTACCTCTATCACCTC
GACGCAATGGAGGACCCGTTTTGGCATTCCTATCCTCCTGCGTTGAAGGATCAGGTCGGACCGCGCAACTTGATTCACAG
CTTTGCCACGACGACCGATGACCCGACCGAACAGCCTCGTTGGGGCAAGATCGGCAAGCAGAGGATCGAGGATGCGGGGC
CGCTACCGCCGCATCCTATACAGGGCATCAAATACAATATGGAAACGGTCGACGAAGACATTCTCGACTATTCGGTGAAG
TTCATCGACAAGGCCAAGCAGGACGGCAAGCCGTTTTTCATGTGGGTCAATCCCACCCGTGCGCATGTTCTCTCGCACCT
GTCGCCGAAATATGCCGCGAAGCTGACCGGTGATAATGAATGGTATCTGGAAGAAGGCGTGATGGCCCAGCTTGATGACG
TCGTCGGGGGCTTGTTGGCTAAGCTTAAAGCCGAAGGGCTGGAAGATAATACGATCGTTGTGTTCACGACTGACAATGGG
GCCGAGAATTTTACTTGGCCAGACGGTGGGAACACGCCATTTGCTGCGGGCAAGGGAACGATCATGGAAGGTGGCATGCG
TGTGCCAATGATCATTCGCTGGCCGGGTCATATTCCAGCAGGAAAGGTCGAGAATGGTCTCATGTCGGGTCTGGACTTCT
TCCCGACATTCGCCGCCATAGCCGGCAATCCGAACATCAAGGAAGAGCTGCAGAAGGGCAAGCAACTCGGAGACACGACA
TACAAGGTTCATCTCGACGGTTACAATCAGTTGGATTTTCTGACCGGCAAGGGCCCATCCAATCGGAAAGAGATCTTCTA
CTTTGCCGAGGGTACTCTTGGGGCGGTTCGCCTCGGGGACTGGAAATATAGAATGATCGACCAACCCGACGGTTGGATTG
GGGGAACGGTCCACCTCGATATGCCGGTCCTCAGTAATCTTCGGCTGGATCCGTTCGAGCGCATGCAATATCCGAAGGGC
AACATGGGCTCTTACTTCTTTTTCCCGGATTTCTATGTCCATGAGTTCTGGCGCTTCGTCTTCCTTCAGCAAAAGGTTGG
CGAATATGCTCAGACATTCATCGATTTTCCGCCGATGCAACGGGGTGCGAGCTTCAATCTCGAAGCAGTCAAGGCCGAAA
TCGCTGAACGTGTCAGGGCGATGAAAGGCAAGCTGGAATAG

Upstream 100 bases:

>100_bases
GCGTCGCTAATCACACCCAACGACAAATGCGCAAACAGGCGCATCTCTAAACCCGCAATGAAGACGGGAGGAATAGCCAT
GTCTCATAGGAGGAATAACC

Downstream 100 bases:

>100_bases
CCGGAAAGAAGGAACCACCACAAAGCCCGCTCAGCCAATGCTTGAGCGGGCTTTGGCATAATGAGGGCAAGGCTGCTTAG
GAGGCCGTGATCTTGGGGCG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MEMIRTLWLSLVALVSVTMAVTTPASAQPQKPNILFIMGDDIGWFNIGAYHQGLMYSTTPNLDKLATEGMRFTDYYAEPS
CTAGRANFITGELPIRTGLTTVGQAGATVGIPDEAPTIATALKAMGYVTGQFGKNHLGDLNRYLPTVHGFDEYFGYLYHL
DAMEDPFWHSYPPALKDQVGPRNLIHSFATTTDDPTEQPRWGKIGKQRIEDAGPLPPHPIQGIKYNMETVDEDILDYSVK
FIDKAKQDGKPFFMWVNPTRAHVLSHLSPKYAAKLTGDNEWYLEEGVMAQLDDVVGGLLAKLKAEGLEDNTIVVFTTDNG
AENFTWPDGGNTPFAAGKGTIMEGGMRVPMIIRWPGHIPAGKVENGLMSGLDFFPTFAAIAGNPNIKEELQKGKQLGDTT
YKVHLDGYNQLDFLTGKGPSNRKEIFYFAEGTLGAVRLGDWKYRMIDQPDGWIGGTVHLDMPVLSNLRLDPFERMQYPKG
NMGSYFFFPDFYVHEFWRFVFLQQKVGEYAQTFIDFPPMQRGASFNLEAVKAEIAERVRAMKGKLE

Sequences:

>Translated_546_residues
MEMIRTLWLSLVALVSVTMAVTTPASAQPQKPNILFIMGDDIGWFNIGAYHQGLMYSTTPNLDKLATEGMRFTDYYAEPS
CTAGRANFITGELPIRTGLTTVGQAGATVGIPDEAPTIATALKAMGYVTGQFGKNHLGDLNRYLPTVHGFDEYFGYLYHL
DAMEDPFWHSYPPALKDQVGPRNLIHSFATTTDDPTEQPRWGKIGKQRIEDAGPLPPHPIQGIKYNMETVDEDILDYSVK
FIDKAKQDGKPFFMWVNPTRAHVLSHLSPKYAAKLTGDNEWYLEEGVMAQLDDVVGGLLAKLKAEGLEDNTIVVFTTDNG
AENFTWPDGGNTPFAAGKGTIMEGGMRVPMIIRWPGHIPAGKVENGLMSGLDFFPTFAAIAGNPNIKEELQKGKQLGDTT
YKVHLDGYNQLDFLTGKGPSNRKEIFYFAEGTLGAVRLGDWKYRMIDQPDGWIGGTVHLDMPVLSNLRLDPFERMQYPKG
NMGSYFFFPDFYVHEFWRFVFLQQKVGEYAQTFIDFPPMQRGASFNLEAVKAEIAERVRAMKGKLE
>Mature_546_residues
MEMIRTLWLSLVALVSVTMAVTTPASAQPQKPNILFIMGDDIGWFNIGAYHQGLMYSTTPNLDKLATEGMRFTDYYAEPS
CTAGRANFITGELPIRTGLTTVGQAGATVGIPDEAPTIATALKAMGYVTGQFGKNHLGDLNRYLPTVHGFDEYFGYLYHL
DAMEDPFWHSYPPALKDQVGPRNLIHSFATTTDDPTEQPRWGKIGKQRIEDAGPLPPHPIQGIKYNMETVDEDILDYSVK
FIDKAKQDGKPFFMWVNPTRAHVLSHLSPKYAAKLTGDNEWYLEEGVMAQLDDVVGGLLAKLKAEGLEDNTIVVFTTDNG
AENFTWPDGGNTPFAAGKGTIMEGGMRVPMIIRWPGHIPAGKVENGLMSGLDFFPTFAAIAGNPNIKEELQKGKQLGDTT
YKVHLDGYNQLDFLTGKGPSNRKEIFYFAEGTLGAVRLGDWKYRMIDQPDGWIGGTVHLDMPVLSNLRLDPFERMQYPKG
NMGSYFFFPDFYVHEFWRFVFLQQKVGEYAQTFIDFPPMQRGASFNLEAVKAEIAERVRAMKGKLE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=501, Percent_Identity=30.938123752495, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI146229331, Length=444, Percent_Identity=32.2072072072072, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI146229329, Length=444, Percent_Identity=32.2072072072072, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI6005990, Length=444, Percent_Identity=32.2072072072072, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI146229324, Length=444, Percent_Identity=32.2072072072072, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI45430057, Length=481, Percent_Identity=29.9376299376299, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI58743319, Length=466, Percent_Identity=27.4678111587983, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI109389362, Length=424, Percent_Identity=25.4716981132075, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI38569407, Length=402, Percent_Identity=26.865671641791, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI71852584, Length=466, Percent_Identity=26.8240343347639, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI146229327, Length=362, Percent_Identity=29.2817679558011, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI38569405, Length=423, Percent_Identity=26.241134751773, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI157266309, Length=167, Percent_Identity=36.5269461077844, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI31742482, Length=166, Percent_Identity=34.9397590361446, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI71852586, Length=156, Percent_Identity=37.1794871794872, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI53831991, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI59797060, Length=127, Percent_Identity=37.007874015748, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790233, Length=461, Percent_Identity=32.1041214750542, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI115533416, Length=428, Percent_Identity=27.1028037383178, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=420, Percent_Identity=25.952380952381, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17559078, Length=141, Percent_Identity=41.1347517730496, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363223, Length=471, Percent_Identity=27.3885350318471, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366397, Length=468, Percent_Identity=27.1367521367521, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281366395, Length=468, Percent_Identity=27.1367521367521, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24666163, Length=468, Percent_Identity=27.1367521367521, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24666175, Length=383, Percent_Identity=28.4595300261097, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24666109, Length=444, Percent_Identity=26.5765765765766, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 60937; Mature: 60937

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIRTLWLSLVALVSVTMAVTTPASAQPQKPNILFIMGDDIGWFNIGAYHQGLMYSTTP
CHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEECHHHCCEEEECCC
NLDKLATEGMRFTDYYAEPSCTAGRANFITGELPIRTGLTTVGQAGATVGIPDEAPTIAT
CHHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCHHCCCHHHCCCCCEECCCCCCHHHHH
ALKAMGYVTGQFGKNHLGDLNRYLPTVHGFDEYFGYLYHLDAMEDPFWHSYPPALKDQVG
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCCCCCCHHHHCCC
PRNLIHSFATTTDDPTEQPRWGKIGKQRIEDAGPLPPHPIQGIKYNMETVDEDILDYSVK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHH
FIDKAKQDGKPFFMWVNPTRAHVLSHLSPKYAAKLTGDNEWYLEEGVMAQLDDVVGGLLA
HHHHHHCCCCCEEEEECCHHHHHHHHCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHH
KLKAEGLEDNTIVVFTTDNGAENFTWPDGGNTPFAAGKGTIMEGGMRVPMIIRWPGHIPA
HHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCC
GKVENGLMSGLDFFPTFAAIAGNPNIKEELQKGKQLGDTTYKVHLDGYNQLDFLTGKGPS
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCC
NRKEIFYFAEGTLGAVRLGDWKYRMIDQPDGWIGGTVHLDMPVLSNLRLDPFERMQYPKG
CCCEEEEEECCCCCEEEECCEEEEEECCCCCCCCCEEEECCHHHCCCCCCHHHHHCCCCC
NMGSYFFFPDFYVHEFWRFVFLQQKVGEYAQTFIDFPPMQRGASFNLEAVKAEIAERVRA
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
MKGKLE
HHCCCC
>Mature Secondary Structure
MEMIRTLWLSLVALVSVTMAVTTPASAQPQKPNILFIMGDDIGWFNIGAYHQGLMYSTTP
CHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEECHHHCCEEEECCC
NLDKLATEGMRFTDYYAEPSCTAGRANFITGELPIRTGLTTVGQAGATVGIPDEAPTIAT
CHHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCHHCCCHHHCCCCCEECCCCCCHHHHH
ALKAMGYVTGQFGKNHLGDLNRYLPTVHGFDEYFGYLYHLDAMEDPFWHSYPPALKDQVG
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCCCCCCHHHHCCC
PRNLIHSFATTTDDPTEQPRWGKIGKQRIEDAGPLPPHPIQGIKYNMETVDEDILDYSVK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHH
FIDKAKQDGKPFFMWVNPTRAHVLSHLSPKYAAKLTGDNEWYLEEGVMAQLDDVVGGLLA
HHHHHHCCCCCEEEEECCHHHHHHHHCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHH
KLKAEGLEDNTIVVFTTDNGAENFTWPDGGNTPFAAGKGTIMEGGMRVPMIIRWPGHIPA
HHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCC
GKVENGLMSGLDFFPTFAAIAGNPNIKEELQKGKQLGDTTYKVHLDGYNQLDFLTGKGPS
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCC
NRKEIFYFAEGTLGAVRLGDWKYRMIDQPDGWIGGTVHLDMPVLSNLRLDPFERMQYPKG
CCCEEEEEECCCCCEEEECCEEEEEECCCCCCCCCEEEECCHHHCCCCCCHHHHHCCCCC
NMGSYFFFPDFYVHEFWRFVFLQQKVGEYAQTFIDFPPMQRGASFNLEAVKAEIAERVRA
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
MKGKLE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]