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The map label for this gene is pleC [H]

Identifier: 182678896

GI number: 182678896

Start: 2199043

End: 2200827

Strand: Direct

Name: pleC [H]

Synonym: Bind_1929

Alternate gene names: 182678896

Gene position: 2199043-2200827 (Clockwise)

Preceding gene: 182678892

Following gene: 182678897

Centisome position: 52.73

GC content: 59.1

Gene sequence:

>1785_bases
ATGAGTGCAATTGTCGCAAACTCTCTCCGGGAAAGGCCTTTCGCGGCAAATCATTTTGCCGCGCCGCAGGATGAAGGAAA
GCCACGACAAGAGGGGAGCGAGCCAAAGCAGGCGGATGAGCCCTACGCTTCCAAGCCCGATGCCCCTTCGATCGCCGATC
CCGGCATCAGGTCCGGTTCTCCAACTGGCCTTGGAAGTGGATCTGGAGAACAGACATTCGCCCTGGAGCTGGCTCAGACC
TATGCGCGCAAACGCTTGGCGTCGCTCCCACTGCTCGCTGGTTTGGATTGTCTCCTGGCGGCTGTCGGCCTTGCCTGGCT
CGATGGCGCGCTTGTGGCCGGCTGGCTCGGCTTCAATCTCCTGGGCCTCACGCTCGTTTACCACCTGCTCACTCGTTTTC
TGACACCGTCAGACGTTCATTGCCCAACGCCAAGCGAGCTCAAGACTTGGCAAACCGGCTTCGTGCTCGGTGAAGGGCTC
CACGGCCTCGTCTGGGGTCTGTTCATCGGCCTGATCGTCGAGGCCGGTGGCGAACCGGCTTTGACCATCGGCCTCGTCTT
CGCTTTGGCGATTGGCGCCACAAACCTGCGGCTCACCGCCCCCATCCCCGCCTGCGTCTTCGGCCCCCTGCTGCCGATGG
CCACAGCTATCGCGATCATTTCGCGTCTCACGATCGTGAGCCAGCAAGCGATGCCTCTCGCGGGTCTCGCAAGTGCGGTG
CTGCTCTATTTTTTAGTAACCGCGCAAAAGATCCGCGCTGGCGTCCTCGAAAAGCTCACAATCCAAAACGAAAAAGACGA
ATTGATCACCGAGCTCGAACAGGCACGAGTCAACAGTGATCTCGCTCGCCGCCGTGCCGAGGAAGCCAATCTCGCCAAAT
CCCGCTTTCTGGCGACGATGAGCCATGAATTACGAACGCCGCTCAATGCCATTCTCGGATTTTCGGAAGTCATGAAGGGC
GAATTGTTCGGCGCCCATGTCATTTCCTCCTACAAGGATTACTCGAACGACATTCATGCGAGTGGCCAGCATCTTTTGAC
CTTGATCAATGAAATCCTCGACCTCTCCCGCATCGAGGCGGGCCATCTGGAACTCCGGGATGATTGCGTGGCCCTCGCAC
ATGTCGTCGATGACTGCCGGCATCTTCTTGCACTGAAAGCCAAGAAACGCGGTCTCACGATCGAGGAGCATGTGGAACCC
GATCTGCCCCGGTTGCGCGCCGATGAACGCGCGCTGCGGCAGGTCGCGCTCAATCTTCTCACCAATGCGGTCAAATTCAC
GCCCCCCGGCGGCTGGATCAAGATCAAGATCGGCTGGACGGCGAACGGAGGCCAATATGTCTCCATCCACGATTCAGGAC
CCGGTATTCCTGAAGAGGAAATGCCGATCGTGATGTCTTCCTTTGGACGCGGCACCCTCGCTCAAAAAAACGCCCTGGAA
GGCTCGGGTCTCGGCCTGCCAATTGTCAAAGGCCTCGTCGACTTGCACAATGGAACATTCAGCCTGAAATCCCGTCTCCA
CGAGGGCACGGAGGCCATTGTCGTCCTGCCGGCCGAACGTGTGCTAGCGGCCAATGCCGCTCCTTCTGTCGTCCCTTTGA
CCGTTTCCACCCCCACGCGGTTGGCAACCGAGTCGATAGGCGACGCATCTACGCCCAATCCCTCGCTCGATGGACTAACC
CTCAACGATTTCGCCTTGGACAAACAAGCCTTGAACGACCTCGTCCTCGATCATTTCAACCGGGACCATCTCGACCGCGC
TTGTCCGCCACGTTCCGCGGCCTGA

Upstream 100 bases:

>100_bases
TTTTAATTAAATCAAAGTATTATATCGAGTTTCTTGTTCATTTTTTTCATCCATCGTCACAACAGCTCGTGGGCAATGGT
ATCAGCCGGTTTTTTCAAGA

Downstream 100 bases:

>100_bases
TCTCTCAAGCCTTTTTCTTGCCCTTCTTCCCGGAAAGGGCTCCAAAGGCTGATCGCCCGCCGCCTGAATTGATGCTACCA
AAGGTCGCTCTTCCTGATCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSAIVANSLRERPFAANHFAAPQDEGKPRQEGSEPKQADEPYASKPDAPSIADPGIRSGSPTGLGSGSGEQTFALELAQT
YARKRLASLPLLAGLDCLLAAVGLAWLDGALVAGWLGFNLLGLTLVYHLLTRFLTPSDVHCPTPSELKTWQTGFVLGEGL
HGLVWGLFIGLIVEAGGEPALTIGLVFALAIGATNLRLTAPIPACVFGPLLPMATAIAIISRLTIVSQQAMPLAGLASAV
LLYFLVTAQKIRAGVLEKLTIQNEKDELITELEQARVNSDLARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKG
ELFGAHVISSYKDYSNDIHASGQHLLTLINEILDLSRIEAGHLELRDDCVALAHVVDDCRHLLALKAKKRGLTIEEHVEP
DLPRLRADERALRQVALNLLTNAVKFTPPGGWIKIKIGWTANGGQYVSIHDSGPGIPEEEMPIVMSSFGRGTLAQKNALE
GSGLGLPIVKGLVDLHNGTFSLKSRLHEGTEAIVVLPAERVLAANAAPSVVPLTVSTPTRLATESIGDASTPNPSLDGLT
LNDFALDKQALNDLVLDHFNRDHLDRACPPRSAA

Sequences:

>Translated_594_residues
MSAIVANSLRERPFAANHFAAPQDEGKPRQEGSEPKQADEPYASKPDAPSIADPGIRSGSPTGLGSGSGEQTFALELAQT
YARKRLASLPLLAGLDCLLAAVGLAWLDGALVAGWLGFNLLGLTLVYHLLTRFLTPSDVHCPTPSELKTWQTGFVLGEGL
HGLVWGLFIGLIVEAGGEPALTIGLVFALAIGATNLRLTAPIPACVFGPLLPMATAIAIISRLTIVSQQAMPLAGLASAV
LLYFLVTAQKIRAGVLEKLTIQNEKDELITELEQARVNSDLARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKG
ELFGAHVISSYKDYSNDIHASGQHLLTLINEILDLSRIEAGHLELRDDCVALAHVVDDCRHLLALKAKKRGLTIEEHVEP
DLPRLRADERALRQVALNLLTNAVKFTPPGGWIKIKIGWTANGGQYVSIHDSGPGIPEEEMPIVMSSFGRGTLAQKNALE
GSGLGLPIVKGLVDLHNGTFSLKSRLHEGTEAIVVLPAERVLAANAAPSVVPLTVSTPTRLATESIGDASTPNPSLDGLT
LNDFALDKQALNDLVLDHFNRDHLDRACPPRSAA
>Mature_593_residues
SAIVANSLRERPFAANHFAAPQDEGKPRQEGSEPKQADEPYASKPDAPSIADPGIRSGSPTGLGSGSGEQTFALELAQTY
ARKRLASLPLLAGLDCLLAAVGLAWLDGALVAGWLGFNLLGLTLVYHLLTRFLTPSDVHCPTPSELKTWQTGFVLGEGLH
GLVWGLFIGLIVEAGGEPALTIGLVFALAIGATNLRLTAPIPACVFGPLLPMATAIAIISRLTIVSQQAMPLAGLASAVL
LYFLVTAQKIRAGVLEKLTIQNEKDELITELEQARVNSDLARRRAEEANLAKSRFLATMSHELRTPLNAILGFSEVMKGE
LFGAHVISSYKDYSNDIHASGQHLLTLINEILDLSRIEAGHLELRDDCVALAHVVDDCRHLLALKAKKRGLTIEEHVEPD
LPRLRADERALRQVALNLLTNAVKFTPPGGWIKIKIGWTANGGQYVSIHDSGPGIPEEEMPIVMSSFGRGTLAQKNALEG
SGLGLPIVKGLVDLHNGTFSLKSRLHEGTEAIVVLPAERVLAANAAPSVVPLTVSTPTRLATESIGDASTPNPSLDGLTL
NDFALDKQALNDLVLDHFNRDHLDRACPPRSAA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=250, Percent_Identity=36, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788713, Length=285, Percent_Identity=31.9298245614035, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI48994928, Length=290, Percent_Identity=28.6206896551724, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI87081816, Length=280, Percent_Identity=34.2857142857143, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=33.955223880597, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=32.7731092436975, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=31.1355311355311, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786783, Length=328, Percent_Identity=24.390243902439, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=28.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=26.25, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788549, Length=264, Percent_Identity=24.2424242424242, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082128, Length=214, Percent_Identity=28.5046728971963, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788279, Length=206, Percent_Identity=27.1844660194175, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=24.4635193133047, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790551, Length=244, Percent_Identity=26.6393442622951, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63478; Mature: 63347

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIVANSLRERPFAANHFAAPQDEGKPRQEGSEPKQADEPYASKPDAPSIADPGIRSGS
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTGLGSGSGEQTFALELAQTYARKRLASLPLLAGLDCLLAAVGLAWLDGALVAGWLGFNL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLTLVYHLLTRFLTPSDVHCPTPSELKTWQTGFVLGEGLHGLVWGLFIGLIVEAGGEPA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCH
LTIGLVFALAIGATNLRLTAPIPACVFGPLLPMATAIAIISRLTIVSQQAMPLAGLASAV
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LLYFLVTAQKIRAGVLEKLTIQNEKDELITELEQARVNSDLARRRAEEANLAKSRFLATM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLNAILGFSEVMKGELFGAHVISSYKDYSNDIHASGQHLLTLINEILDLSRIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCC
GHLELRDDCVALAHVVDDCRHLLALKAKKRGLTIEEHVEPDLPRLRADERALRQVALNLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHCHHHHHHHHHHHHHH
TNAVKFTPPGGWIKIKIGWTANGGQYVSIHDSGPGIPEEEMPIVMSSFGRGTLAQKNALE
HHHHEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
GSGLGLPIVKGLVDLHNGTFSLKSRLHEGTEAIVVLPAERVLAANAAPSVVPLTVSTPTR
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECHHHHHHCCCCCCEEEEEECCCHH
LATESIGDASTPNPSLDGLTLNDFALDKQALNDLVLDHFNRDHLDRACPPRSAA
HHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
SAIVANSLRERPFAANHFAAPQDEGKPRQEGSEPKQADEPYASKPDAPSIADPGIRSGS
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTGLGSGSGEQTFALELAQTYARKRLASLPLLAGLDCLLAAVGLAWLDGALVAGWLGFNL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLTLVYHLLTRFLTPSDVHCPTPSELKTWQTGFVLGEGLHGLVWGLFIGLIVEAGGEPA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCH
LTIGLVFALAIGATNLRLTAPIPACVFGPLLPMATAIAIISRLTIVSQQAMPLAGLASAV
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LLYFLVTAQKIRAGVLEKLTIQNEKDELITELEQARVNSDLARRRAEEANLAKSRFLATM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLNAILGFSEVMKGELFGAHVISSYKDYSNDIHASGQHLLTLINEILDLSRIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCC
GHLELRDDCVALAHVVDDCRHLLALKAKKRGLTIEEHVEPDLPRLRADERALRQVALNLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHCHHHHHHHHHHHHHH
TNAVKFTPPGGWIKIKIGWTANGGQYVSIHDSGPGIPEEEMPIVMSSFGRGTLAQKNALE
HHHHEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
GSGLGLPIVKGLVDLHNGTFSLKSRLHEGTEAIVVLPAERVLAANAAPSVVPLTVSTPTR
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECHHHHHHCCCCCCEEEEEECCCHH
LATESIGDASTPNPSLDGLTLNDFALDKQALNDLVLDHFNRDHLDRACPPRSAA
HHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]