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The map label for this gene is glcD [H]

Identifier: 182678866

GI number: 182678866

Start: 2166075

End: 2167565

Strand: Direct

Name: glcD [H]

Synonym: Bind_1899

Alternate gene names: 182678866

Gene position: 2166075-2167565 (Clockwise)

Preceding gene: 182678865

Following gene: 182678867

Centisome position: 51.94

GC content: 59.76

Gene sequence:

>1491_bases
ATGACCTTGCAAATGCCACATCCCGAGGCGGCCATCCTGACACATCGCGGGGAAATCGTCGCGCGGCTTGAACAGATTGT
TCCAGGCGGTGTCATTCATACCGAACGGGAAATGCGCGTCTATGAATGCGACGCCCTGACCCTCTACAGGCAATTGCCGC
TCGTCGTCGTCTTGCCCGAGACGGTGGAACAGGTGTCGCAGATTCTGCGGCTGGCGCAGGACATGAACATCAAGGTCGTG
CCGCGCGGCAGCGGGACATCCCTTTCCGGCGGCTCGCTACCGCTCGCCGATGCGATCCTGCTCGGCATGAGCAAGTTCAA
TCGCATTCTCGAAACCGATTTCGAAAATCGCTGCGCTCGTGTGCAACCCGGCGTGACCAATAGCGCGATCAGCCGGGCCG
TCGAGGACCATGGCTTCTATTATGCGCCGGACCCGTCCTCACAGATCGCCTGTTCGATCGGCGGTAATGTCGCTGAAAAC
TCCGGCGGCGTGCATTGCCTGAAATATGGCTTGACCACCAATAATATTCTCGGCCTCGAAGTCGTGCTGATGGGCGGCGA
GGTGTTGCGGCTCGGCGGCAAGCATCTCGATTCCGATCTCTATGATCTCATCGGCGTGCTGACCGGTTCGGAAGGTTTGC
TCGGCGTCATCACCGAGGTCACCGTGCGCATCCTGCAAAAGCCGGAGACGGCGCGCGGCGTTCTGCTCGGCTTTCCGACG
GTCCAGGCGGGCGGAGATTGCGTCGCCGAAATCATCGCCCGCGGCATCATCCCGGGTGGCCTCGAAATGATGGACAAAGC
CTCGATCGACGCGGCCGAGGCCTTTCAGCCCTGCGGCTATCCCCGCGATGCCGGCAGCCTCGTGATCGTCGAACTCGACG
GGACGCAGGCCGAGGTCGATGTGCTGATTGAAAGGGTCGCGGCCATTGCCCTGGAACAGGGGGCGACCTCGATCAAGGTC
TCTCAAAATGAGGCGGAGCGGCTGCGTTTCTGGTCAGGCCGGAAAAATGCGTTTCCGGCGGTCGGCGCCATCGGCCCCGA
TTATCTGTGCATGGATGGCACGATCCCACGCTTTCAGCTCTCGAATGTTTTGGCGCGGATGGATCAACTCGCCGCCCAAT
ATGGATTGCGCGTCGCCAATGTTTTTCATGCTGGCGATGGCAATCTGCATCCCTTGATCCTCTATGATTCATCAAAGCCC
GGCGACAGCGAAAAGGCCGAGGCTTTCGGCGCCGATATTCTTTGCCTTTGCGTCGAGGTCGGCGGTGTGTTGACCGGCGA
ACACGGGGTCGGCGTCGAAAAACGCGATTTAATGGATCGCATGTTCAATGAGATCGACCTGCAGCAGCAGGAGCGTTTGA
AATGCGCTTTCGATCCGGCCCACCGGCTCAATCCGGGTAAAGTCTTTCCCACTCTGCACCGCTGCGCGGAACTCAGCCGC
ATGCATGTGCACAATGGTCAATTGCCCTTCCCCGATCTGCCACGGTTTTGA

Upstream 100 bases:

>100_bases
CTTTTGTAAAAGCCTATGATCTATGGTAGCGGCAAAATCGAAGCGGCCCATTCATGCCGTTTCCAGAAGGAAAACATCCG
CCGCTCGGGAGACGCGACCT

Downstream 100 bases:

>100_bases
ACGATCGGGAAATCGGCCCGCCAAGCCGAAAGTCATAAACCTGCATCATCCGCGACCATGATACTGTCACAAGGTCGCGG
ATCGGCAGGGTGAGGTCGGC

Product: D-lactate dehydrogenase (cytochrome)

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTLQMPHPEAAILTHRGEIVARLEQIVPGGVIHTEREMRVYECDALTLYRQLPLVVVLPETVEQVSQILRLAQDMNIKVV
PRGSGTSLSGGSLPLADAILLGMSKFNRILETDFENRCARVQPGVTNSAISRAVEDHGFYYAPDPSSQIACSIGGNVAEN
SGGVHCLKYGLTTNNILGLEVVLMGGEVLRLGGKHLDSDLYDLIGVLTGSEGLLGVITEVTVRILQKPETARGVLLGFPT
VQAGGDCVAEIIARGIIPGGLEMMDKASIDAAEAFQPCGYPRDAGSLVIVELDGTQAEVDVLIERVAAIALEQGATSIKV
SQNEAERLRFWSGRKNAFPAVGAIGPDYLCMDGTIPRFQLSNVLARMDQLAAQYGLRVANVFHAGDGNLHPLILYDSSKP
GDSEKAEAFGADILCLCVEVGGVLTGEHGVGVEKRDLMDRMFNEIDLQQQERLKCAFDPAHRLNPGKVFPTLHRCAELSR
MHVHNGQLPFPDLPRF

Sequences:

>Translated_496_residues
MTLQMPHPEAAILTHRGEIVARLEQIVPGGVIHTEREMRVYECDALTLYRQLPLVVVLPETVEQVSQILRLAQDMNIKVV
PRGSGTSLSGGSLPLADAILLGMSKFNRILETDFENRCARVQPGVTNSAISRAVEDHGFYYAPDPSSQIACSIGGNVAEN
SGGVHCLKYGLTTNNILGLEVVLMGGEVLRLGGKHLDSDLYDLIGVLTGSEGLLGVITEVTVRILQKPETARGVLLGFPT
VQAGGDCVAEIIARGIIPGGLEMMDKASIDAAEAFQPCGYPRDAGSLVIVELDGTQAEVDVLIERVAAIALEQGATSIKV
SQNEAERLRFWSGRKNAFPAVGAIGPDYLCMDGTIPRFQLSNVLARMDQLAAQYGLRVANVFHAGDGNLHPLILYDSSKP
GDSEKAEAFGADILCLCVEVGGVLTGEHGVGVEKRDLMDRMFNEIDLQQQERLKCAFDPAHRLNPGKVFPTLHRCAELSR
MHVHNGQLPFPDLPRF
>Mature_495_residues
TLQMPHPEAAILTHRGEIVARLEQIVPGGVIHTEREMRVYECDALTLYRQLPLVVVLPETVEQVSQILRLAQDMNIKVVP
RGSGTSLSGGSLPLADAILLGMSKFNRILETDFENRCARVQPGVTNSAISRAVEDHGFYYAPDPSSQIACSIGGNVAENS
GGVHCLKYGLTTNNILGLEVVLMGGEVLRLGGKHLDSDLYDLIGVLTGSEGLLGVITEVTVRILQKPETARGVLLGFPTV
QAGGDCVAEIIARGIIPGGLEMMDKASIDAAEAFQPCGYPRDAGSLVIVELDGTQAEVDVLIERVAAIALEQGATSIKVS
QNEAERLRFWSGRKNAFPAVGAIGPDYLCMDGTIPRFQLSNVLARMDQLAAQYGLRVANVFHAGDGNLHPLILYDSSKPG
DSEKAEAFGADILCLCVEVGGVLTGEHGVGVEKRDLMDRMFNEIDLQQQERLKCAFDPAHRLNPGKVFPTLHRCAELSRM
HVHNGQLPFPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=28.9760348583878, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=27.8008298755187, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI119964728, Length=462, Percent_Identity=30.3030303030303, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4501993, Length=331, Percent_Identity=26.2839879154079, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1789351, Length=482, Percent_Identity=57.2614107883817, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1787977, Length=505, Percent_Identity=26.3366336633663, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI48994907, Length=489, Percent_Identity=23.5173824130879, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71992373, Length=472, Percent_Identity=28.8135593220339, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71992381, Length=469, Percent_Identity=28.1449893390192, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71992392, Length=368, Percent_Identity=27.445652173913, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17534361, Length=437, Percent_Identity=27.9176201372998, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17556096, Length=230, Percent_Identity=27.8260869565217, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320027, Length=435, Percent_Identity=29.1954022988506, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320764, Length=455, Percent_Identity=26.5934065934066, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320023, Length=458, Percent_Identity=26.8558951965066, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI18921117, Length=460, Percent_Identity=25.6521739130435, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639277, Length=460, Percent_Identity=25.6521739130435, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639275, Length=460, Percent_Identity=25.6521739130435, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653753, Length=233, Percent_Identity=29.6137339055794, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53559; Mature: 53428

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQMPHPEAAILTHRGEIVARLEQIVPGGVIHTEREMRVYECDALTLYRQLPLVVVLPE
CCCCCCCCCCEEEECCHHHHHHHHHHCCCCEEECCCCCEEEECHHHHHHHHCCEEEECCH
TVEQVSQILRLAQDMNIKVVPRGSGTSLSGGSLPLADAILLGMSKFNRILETDFENRCAR
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCC
VQPGVTNSAISRAVEDHGFYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTTNNILGLE
CCCCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEE
VVLMGGEVLRLGGKHLDSDLYDLIGVLTGSEGLLGVITEVTVRILQKPETARGVLLGFPT
EEEECCHHEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC
VQAGGDCVAEIIARGIIPGGLEMMDKASIDAAEAFQPCGYPRDAGSLVIVELDGTQAEVD
CCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCCHHHHH
VLIERVAAIALEQGATSIKVSQNEAERLRFWSGRKNAFPAVGAIGPDYLCMDGTIPRFQL
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHH
SNVLARMDQLAAQYGLRVANVFHAGDGNLHPLILYDSSKPGDSEKAEAFGADILCLCVEV
HHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHHHH
GGVLTGEHGVGVEKRDLMDRMFNEIDLQQQERLKCAFDPAHRLNPGKVFPTLHRCAELSR
CCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHEECCHHHCCCCCCCCHHHHHHHHHHH
MHVHNGQLPFPDLPRF
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TLQMPHPEAAILTHRGEIVARLEQIVPGGVIHTEREMRVYECDALTLYRQLPLVVVLPE
CCCCCCCCCEEEECCHHHHHHHHHHCCCCEEECCCCCEEEECHHHHHHHHCCEEEECCH
TVEQVSQILRLAQDMNIKVVPRGSGTSLSGGSLPLADAILLGMSKFNRILETDFENRCAR
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCC
VQPGVTNSAISRAVEDHGFYYAPDPSSQIACSIGGNVAENSGGVHCLKYGLTTNNILGLE
CCCCCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEE
VVLMGGEVLRLGGKHLDSDLYDLIGVLTGSEGLLGVITEVTVRILQKPETARGVLLGFPT
EEEECCHHEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC
VQAGGDCVAEIIARGIIPGGLEMMDKASIDAAEAFQPCGYPRDAGSLVIVELDGTQAEVD
CCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCCHHHHH
VLIERVAAIALEQGATSIKVSQNEAERLRFWSGRKNAFPAVGAIGPDYLCMDGTIPRFQL
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHH
SNVLARMDQLAAQYGLRVANVFHAGDGNLHPLILYDSSKPGDSEKAEAFGADILCLCVEV
HHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHHHH
GGVLTGEHGVGVEKRDLMDRMFNEIDLQQQERLKCAFDPAHRLNPGKVFPTLHRCAELSR
CCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHEECCHHHCCCCCCCCHHHHHHHHHHH
MHVHNGQLPFPDLPRF
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]