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The map label for this gene is slt [H]

Identifier: 182678838

GI number: 182678838

Start: 2131515

End: 2133686

Strand: Direct

Name: slt [H]

Synonym: Bind_1871

Alternate gene names: 182678838

Gene position: 2131515-2133686 (Clockwise)

Preceding gene: 182678834

Following gene: 182678839

Centisome position: 51.11

GC content: 60.87

Gene sequence:

>2172_bases
ATGGCCAGCAAGCGGGCTTCCAAATCACTGACGAAAGGGGCAATCGCCCTGACCATCGGCGCCATGGCGGCCCTCGGTTT
CCACGAGATGAACCTCGATGGAATAAGGCTCAAGGACAAGACGCCTGACGCCATTCCCCTCGACGGCCGCATGGAAACAG
CCACACGTCCGGAAAAACCGGATGCCGGTCTTGAGACTGGTCTTGCCCCTGCCCTTCCCGAACCGACCCAAGAAGCGACC
ACCAAACTCACCCTGGACACACTCGGCCTCGACACAACCGGTCTGAACGAGGCTCTGGATCTTTATCGCAAGGGTGATCT
CGCCGCGGCGGACAAAGCCACTGGCACACTCGTCAAGGACGATACAGTCCGCACCGCGATCGAATGGATCGTTCTCCAAC
GCTTCTCAAGCGGATTTACCCGCCTGCAAGCCTTCGCCAAGGCGCATCCACAATGGCCCGCGCAGGACTGGCTGCGCAAG
CGTTCCGAAGAAGCCCTTTATAACGAGCGCAAGGTTTCGCCGGAAGGCCGTGCTTTTCTCGAGGAGACGACCCCCAAGAC
GCCGGCGGGCAAGATCGCTCTCGCACGTCTCATGATCCTGGACGACAAGCCGCAAGTAGCGGCGAAGCTCGTGCGCCAGG
TCTGGCGGGAAAGCGATTTCAGCACCGCCATGGAAGCCAAGCTCAAAAGCGAATTCGGTTCCTTGCTCGAAAAGGCCGAT
TATAAGTACCGCGCCGAACGCTTTCTTTATAAAGAGCAAGGGGCCGAGGCCATGCGCCTTGCCTCGCTCGCCGGCCCGGA
CATGGTTCCCCTGGTGCGTCTGCGCATCGCTTCGTTCGAGGGAATCGCCAACGACAAGCTCTTTGCGGCCGTCCCCGCCA
GCCTGCAAAATGACCCGGCTTATCTTTTCGCTCGCATCCAAAAATTGCGGCGCAGCGAAAAAATTACCGAGGCCGCGACC
CTCATGCTCGGCGCGCCGCATGATCCCGCTCGTCTCGTCAATGGCGATGAATGGTGGGTGGAACGTCGGCTGATCGCCCG
CAAGCTGCTCGATCAGAATGATGCCGCCACGGCCTATAAAATCTGCGCCGAACATTCGGCTGTCTCGCGCGACCTGCGTA
TCGAAGCCGAATTTCACGCCGGTTGGATCGCCTTGCGATTCCTGCATGATCCGGAAAAGGCCATGACGCATTTCGCGCAA
GCCGCGCAATTTGCCGAGACGCCGATTTCCATCGCGCGCGCGGCCTATTGGCAAGGCCGCGCCGCCGAAGACGACATGAG
GGCCGAGGTGGCGGTCACCGCCAATGGATATTATGGAAAAGCCGCGCGGCAATCGGCGACCTATTACGGTCAGCTCGCGC
GCACCAAGCTGGGTCTGCCCCTCGTGACAGAGGCACCCGCCCGCCATGCGCTTTTGCCGGCGGAACAGGATCCCTCGATC
CGCATCATCGCCCTGCTGCAAGCCCTGGATCAAAAGGATCTGGCGCAATCCCTGTCCATCGCCGCCGCGCAGCATTTGGA
AGGCGACGGCCAGATGGCCGCCCTGGCTGATGTCGTCGACACCCAGCATGACGCGCATCTCGCTTTGATGATTGGCAAGC
TCGCAGGCTATCGCGGCTACGCCTTGCAGAATCTGGCCTTCCCGACCTATGGCATTCCGAGTTTCGAGCCCTTGCCGAAT
TCGGCGGCCCGCTCGCTGGTCTATGCGATCGCGCGTCAGGAAAGCGCCTTCGACACCAAGGCCGTTTCATCGGCTGGAGC
GCGTGGCGTCATGCAGATGATCGTCTCGACAGCACGCCGCACTGCCGAGCGCGCCGGCATTCCCTTCAATGAGACGCGCC
TGCTTTCCGATGCCGCTTTCAACGCGCAGCTCGCGGCCGCGCATCTCGGCGATCTCCTCGCGGAACAACGCGGCTCCTGG
ATCTTGACCTTCGCCGCCTATAATGCCGGCGGCAAGAAGGTCAAACAATGGATCGATGCTTATGGCGATCCACGCGATCC
GGCAGTAGATCCAATCGATTGGGTCGAGCGCATTCCCTTCACGGAAACCCGCAATTACGTCCAGAGAGTCGTCGAAAATC
TCGCCATGTATCAGCTTCGCTTCGGCGAGGATCATCGGGCTTTCGGCGAAGCCTTGCTGCGGCTCTCGCCGCCCAACCCC
GTCAGATTGTAA

Upstream 100 bases:

>100_bases
GGTTTGTTAAGGAAAACACGGTCAAATTTTCGAGAATTCAACAGGCAAGCGCCGACCACGGAAGGCTTGCAACGGGTCTA
GGCGCCAACAAGGGAACAGA

Downstream 100 bases:

>100_bases
TCGTCCTCATCACGAAAGATCCAGCGCATCGGAGCTTCACGTTGAAGGCCAACCGATAGGCTGGATCTTTGAAACGTATA
GATGGATCTCAACAGGAAAC

Product: lytic transglycosylase

Products: 1,6-Anhydrobond [C]

Alternate protein names: Peptidoglycan lytic exotransglycosylase [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MASKRASKSLTKGAIALTIGAMAALGFHEMNLDGIRLKDKTPDAIPLDGRMETATRPEKPDAGLETGLAPALPEPTQEAT
TKLTLDTLGLDTTGLNEALDLYRKGDLAAADKATGTLVKDDTVRTAIEWIVLQRFSSGFTRLQAFAKAHPQWPAQDWLRK
RSEEALYNERKVSPEGRAFLEETTPKTPAGKIALARLMILDDKPQVAAKLVRQVWRESDFSTAMEAKLKSEFGSLLEKAD
YKYRAERFLYKEQGAEAMRLASLAGPDMVPLVRLRIASFEGIANDKLFAAVPASLQNDPAYLFARIQKLRRSEKITEAAT
LMLGAPHDPARLVNGDEWWVERRLIARKLLDQNDAATAYKICAEHSAVSRDLRIEAEFHAGWIALRFLHDPEKAMTHFAQ
AAQFAETPISIARAAYWQGRAAEDDMRAEVAVTANGYYGKAARQSATYYGQLARTKLGLPLVTEAPARHALLPAEQDPSI
RIIALLQALDQKDLAQSLSIAAAQHLEGDGQMAALADVVDTQHDAHLALMIGKLAGYRGYALQNLAFPTYGIPSFEPLPN
SAARSLVYAIARQESAFDTKAVSSAGARGVMQMIVSTARRTAERAGIPFNETRLLSDAAFNAQLAAAHLGDLLAEQRGSW
ILTFAAYNAGGKKVKQWIDAYGDPRDPAVDPIDWVERIPFTETRNYVQRVVENLAMYQLRFGEDHRAFGEALLRLSPPNP
VRL

Sequences:

>Translated_723_residues
MASKRASKSLTKGAIALTIGAMAALGFHEMNLDGIRLKDKTPDAIPLDGRMETATRPEKPDAGLETGLAPALPEPTQEAT
TKLTLDTLGLDTTGLNEALDLYRKGDLAAADKATGTLVKDDTVRTAIEWIVLQRFSSGFTRLQAFAKAHPQWPAQDWLRK
RSEEALYNERKVSPEGRAFLEETTPKTPAGKIALARLMILDDKPQVAAKLVRQVWRESDFSTAMEAKLKSEFGSLLEKAD
YKYRAERFLYKEQGAEAMRLASLAGPDMVPLVRLRIASFEGIANDKLFAAVPASLQNDPAYLFARIQKLRRSEKITEAAT
LMLGAPHDPARLVNGDEWWVERRLIARKLLDQNDAATAYKICAEHSAVSRDLRIEAEFHAGWIALRFLHDPEKAMTHFAQ
AAQFAETPISIARAAYWQGRAAEDDMRAEVAVTANGYYGKAARQSATYYGQLARTKLGLPLVTEAPARHALLPAEQDPSI
RIIALLQALDQKDLAQSLSIAAAQHLEGDGQMAALADVVDTQHDAHLALMIGKLAGYRGYALQNLAFPTYGIPSFEPLPN
SAARSLVYAIARQESAFDTKAVSSAGARGVMQMIVSTARRTAERAGIPFNETRLLSDAAFNAQLAAAHLGDLLAEQRGSW
ILTFAAYNAGGKKVKQWIDAYGDPRDPAVDPIDWVERIPFTETRNYVQRVVENLAMYQLRFGEDHRAFGEALLRLSPPNP
VRL
>Mature_722_residues
ASKRASKSLTKGAIALTIGAMAALGFHEMNLDGIRLKDKTPDAIPLDGRMETATRPEKPDAGLETGLAPALPEPTQEATT
KLTLDTLGLDTTGLNEALDLYRKGDLAAADKATGTLVKDDTVRTAIEWIVLQRFSSGFTRLQAFAKAHPQWPAQDWLRKR
SEEALYNERKVSPEGRAFLEETTPKTPAGKIALARLMILDDKPQVAAKLVRQVWRESDFSTAMEAKLKSEFGSLLEKADY
KYRAERFLYKEQGAEAMRLASLAGPDMVPLVRLRIASFEGIANDKLFAAVPASLQNDPAYLFARIQKLRRSEKITEAATL
MLGAPHDPARLVNGDEWWVERRLIARKLLDQNDAATAYKICAEHSAVSRDLRIEAEFHAGWIALRFLHDPEKAMTHFAQA
AQFAETPISIARAAYWQGRAAEDDMRAEVAVTANGYYGKAARQSATYYGQLARTKLGLPLVTEAPARHALLPAEQDPSIR
IIALLQALDQKDLAQSLSIAAAQHLEGDGQMAALADVVDTQHDAHLALMIGKLAGYRGYALQNLAFPTYGIPSFEPLPNS
AARSLVYAIARQESAFDTKAVSSAGARGVMQMIVSTARRTAERAGIPFNETRLLSDAAFNAQLAAAHLGDLLAEQRGSWI
LTFAAYNAGGKKVKQWIDAYGDPRDPAVDPIDWVERIPFTETRNYVQRVVENLAMYQLRFGEDHRAFGEALLRLSPPNPV
RL

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082441, Length=141, Percent_Identity=34.7517730496454, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011989
- InterPro:   IPR016026
- InterPro:   IPR008258
- InterPro:   IPR012289
- InterPro:   IPR008939
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 79524; Mature: 79393

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKRASKSLTKGAIALTIGAMAALGFHEMNLDGIRLKDKTPDAIPLDGRMETATRPEKP
CCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
DAGLETGLAPALPEPTQEATTKLTLDTLGLDTTGLNEALDLYRKGDLAAADKATGTLVKD
CCCCCCCCCCCCCCCCHHHHHEEEEHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECC
DTVRTAIEWIVLQRFSSGFTRLQAFAKAHPQWPAQDWLRKRSEEALYNERKVSPEGRAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
EETTPKTPAGKIALARLMILDDKPQVAAKLVRQVWRESDFSTAMEAKLKSEFGSLLEKAD
HHCCCCCCCCHHHHHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
YKYRAERFLYKEQGAEAMRLASLAGPDMVPLVRLRIASFEGIANDKLFAAVPASLQNDPA
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
YLFARIQKLRRSEKITEAATLMLGAPHDPARLVNGDEWWVERRLIARKLLDQNDAATAYK
HHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
ICAEHSAVSRDLRIEAEFHAGWIALRFLHDPEKAMTHFAQAAQFAETPISIARAAYWQGR
HHHHHHHHCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
AAEDDMRAEVAVTANGYYGKAARQSATYYGQLARTKLGLPLVTEAPARHALLPAEQDPSI
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
RIIALLQALDQKDLAQSLSIAAAQHLEGDGQMAALADVVDTQHDAHLALMIGKLAGYRGY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
ALQNLAFPTYGIPSFEPLPNSAARSLVYAIARQESAFDTKAVSSAGARGVMQMIVSTARR
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAERAGIPFNETRLLSDAAFNAQLAAAHLGDLLAEQRGSWILTFAAYNAGGKKVKQWIDA
HHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHH
YGDPRDPAVDPIDWVERIPFTETRNYVQRVVENLAMYQLRFGEDHRAFGEALLRLSPPNP
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
VRL
CCC
>Mature Secondary Structure 
ASKRASKSLTKGAIALTIGAMAALGFHEMNLDGIRLKDKTPDAIPLDGRMETATRPEKP
CCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
DAGLETGLAPALPEPTQEATTKLTLDTLGLDTTGLNEALDLYRKGDLAAADKATGTLVKD
CCCCCCCCCCCCCCCCHHHHHEEEEHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECC
DTVRTAIEWIVLQRFSSGFTRLQAFAKAHPQWPAQDWLRKRSEEALYNERKVSPEGRAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
EETTPKTPAGKIALARLMILDDKPQVAAKLVRQVWRESDFSTAMEAKLKSEFGSLLEKAD
HHCCCCCCCCHHHHHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
YKYRAERFLYKEQGAEAMRLASLAGPDMVPLVRLRIASFEGIANDKLFAAVPASLQNDPA
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
YLFARIQKLRRSEKITEAATLMLGAPHDPARLVNGDEWWVERRLIARKLLDQNDAATAYK
HHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
ICAEHSAVSRDLRIEAEFHAGWIALRFLHDPEKAMTHFAQAAQFAETPISIARAAYWQGR
HHHHHHHHCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
AAEDDMRAEVAVTANGYYGKAARQSATYYGQLARTKLGLPLVTEAPARHALLPAEQDPSI
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
RIIALLQALDQKDLAQSLSIAAAQHLEGDGQMAALADVVDTQHDAHLALMIGKLAGYRGY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
ALQNLAFPTYGIPSFEPLPNSAARSLVYAIARQESAFDTKAVSSAGARGVMQMIVSTARR
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAERAGIPFNETRLLSDAAFNAQLAAAHLGDLLAEQRGSWILTFAAYNAGGKKVKQWIDA
HHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHH
YGDPRDPAVDPIDWVERIPFTETRNYVQRVVENLAMYQLRFGEDHRAFGEALLRLSPPNP
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
VRL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]