Click here to switch to the map view.

The map label for this gene is kdc [H]

Identifier: 182678765

GI number: 182678765

Start: 2032037

End: 2033680

Strand: Direct

Name: kdc [H]

Synonym: Bind_1794

Alternate gene names: 182678765

Gene position: 2032037-2033680 (Clockwise)

Preceding gene: 182678764

Following gene: 182678769

Centisome position: 48.73

GC content: 57.36

Gene sequence:

>1644_bases
ATGACAATGACCGTAATCCAATTCGTTCTCGAACGGCTGAAAGCCATCGGGATTTCGGACATATTCGGTGTACCGGGCGA
CTATTCCTTTCCCGTGAACGATGCCATCTGCAATGATCCCCACATTCGCTGGATCGGCTGTTCAAATGAACTGAACGCCG
CCTATGCCGCCGACGGTTATGCTCGCGTCAAAGGGGTCGCGGCTTTGTGCACCACTTATGGCGTCGGTGAATTGAGTGCG
TTGAACGGCGTGGCCGGGGCCTATGCTGAACATCTGCCCATTTTTCATCTCGTCGGCACACCCTCCATGGCGATTCAATC
GGCCCGCGCGCCGATGCATCATACTTTGGGCAATGGCGAATATGATCTGTTTCGACGTATGACGGAATTAGTCGTCTGCG
CTTATGCTGTCATGACGCCGCAGAATGTTGCTTTCGAGACGGAGCGGCTGATCGCCGAGGCCCTGTTTCATCGGCGTCCG
GTCTATATGGCCTTTCCTGCCGATCTCGCCGAGCAGCCCGTGCTCGGCACAGCCGAACCCCTCGCCGCACCACGCAGCAA
TCCCGATCATCTCGCGCAAGCCACAACGGCCATTCTGAGCGCTCTCGAGAAAGCGGAAACGGCCTGTGTTCTGCCGGGCA
ATTTAATCCATCGCTGCGGATTGCAACGGACGATGCAGAACATCATCGACCGTTCCGGCCTGCCCTTCGCGACAATGTTC
ATGGATAAATCCGTCCTCGACGAGCATCAGCCAGCCTTCGTCGGCATGTATGATGGTGCGTTGATGAACGATGACGTCCG
CCAATTCGTTGAAGATGCCGATTGTGTGCTCACAATCGGCACACTCATGTCCGATCTCAATAGCGGTGCCTTTACTGCCC
GTCTCGATCCGGCGCGGACGATCACGATTGCCCATCACAATGTGCTGTGCGATGGCAAGACCTATATCGATGTCGAAATG
GGTGACATTCTGCGCGCTCTGGCGGAGAATGTGCCACACCGCGGCTGGAAGCGCATGAGCGCCCCCTCGCTTGGCGCGGC
AAAAGGCTCGGGTGACGACCCTATTGGTGTTGATGCGCTTTATCCGCGCTGGGCGGATTTTCTCTCTCCCGGCGACATAT
TGGTCGCCGAAACCGGTACGGCATCCATGGGGCTCGGCTTCGCCCGCATGCCGAAGGGGGCCACCTTTTACAACCAGACG
CTTTGGGGCTCGATCGGCTGGGCCACACCCGCAGCGGTCGGCGCCGCTATTGCCGCGCCCGGCCGCCGGGTCGTCCTGGT
GACAGGCGATGGCTCACATCAGATGACCGCGACGGAAATTGGTCTCTTTGGTCATCTCGGTCTCAAACCCATTGTTTTCG
TGCTCAACAATAACGGTTATCTGATCGAGCGGCTGCTCTGCAAAAATCCGGAAATTGCCTATAATGACATTGCGCCATGG
CGCTATAGCGAACTCCCGCACGCACTTGGCTGCGATGGCTGGTTGACGGCGCGGGTGACCACATGCGCCGAACTGGATGC
CGTGCTTGCGAAAGCCAAACATGCAGAGACTGGTGTGTATATTGAGATCGTGACGGATACCTACGCAGCCTCGCCCTTGG
CGATGAAGCTGCATGAAAACCTGAAGTCGCTCTACAAATCCTGA

Upstream 100 bases:

>100_bases
TTGGAGTCTATTGTCAAAAGCCTGCAGATCCTCCTGCAGGGCTTTCCGCTTACCCCTTTGATGTTTGAGCGGAGCGTCTC
GAATCTGTCGAGAGGTTGCA

Downstream 100 bases:

>100_bases
AGTGAACCTCGAAGTTCATATCGTCCTGAGCATGGTCTACTAGTCGGACCCTTAAGCCAATTCCACGATCAGCCCGCCGC
GCAGAGTTACACGCCGGTCC

Product: thiamine pyrophosphate binding domain-containing protein

Products: aldehyde; CO2

Alternate protein names: KDC [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTMTVIQFVLERLKAIGISDIFGVPGDYSFPVNDAICNDPHIRWIGCSNELNAAYAADGYARVKGVAALCTTYGVGELSA
LNGVAGAYAEHLPIFHLVGTPSMAIQSARAPMHHTLGNGEYDLFRRMTELVVCAYAVMTPQNVAFETERLIAEALFHRRP
VYMAFPADLAEQPVLGTAEPLAAPRSNPDHLAQATTAILSALEKAETACVLPGNLIHRCGLQRTMQNIIDRSGLPFATMF
MDKSVLDEHQPAFVGMYDGALMNDDVRQFVEDADCVLTIGTLMSDLNSGAFTARLDPARTITIAHHNVLCDGKTYIDVEM
GDILRALAENVPHRGWKRMSAPSLGAAKGSGDDPIGVDALYPRWADFLSPGDILVAETGTASMGLGFARMPKGATFYNQT
LWGSIGWATPAAVGAAIAAPGRRVVLVTGDGSHQMTATEIGLFGHLGLKPIVFVLNNNGYLIERLLCKNPEIAYNDIAPW
RYSELPHALGCDGWLTARVTTCAELDAVLAKAKHAETGVYIEIVTDTYAASPLAMKLHENLKSLYKS

Sequences:

>Translated_547_residues
MTMTVIQFVLERLKAIGISDIFGVPGDYSFPVNDAICNDPHIRWIGCSNELNAAYAADGYARVKGVAALCTTYGVGELSA
LNGVAGAYAEHLPIFHLVGTPSMAIQSARAPMHHTLGNGEYDLFRRMTELVVCAYAVMTPQNVAFETERLIAEALFHRRP
VYMAFPADLAEQPVLGTAEPLAAPRSNPDHLAQATTAILSALEKAETACVLPGNLIHRCGLQRTMQNIIDRSGLPFATMF
MDKSVLDEHQPAFVGMYDGALMNDDVRQFVEDADCVLTIGTLMSDLNSGAFTARLDPARTITIAHHNVLCDGKTYIDVEM
GDILRALAENVPHRGWKRMSAPSLGAAKGSGDDPIGVDALYPRWADFLSPGDILVAETGTASMGLGFARMPKGATFYNQT
LWGSIGWATPAAVGAAIAAPGRRVVLVTGDGSHQMTATEIGLFGHLGLKPIVFVLNNNGYLIERLLCKNPEIAYNDIAPW
RYSELPHALGCDGWLTARVTTCAELDAVLAKAKHAETGVYIEIVTDTYAASPLAMKLHENLKSLYKS
>Mature_546_residues
TMTVIQFVLERLKAIGISDIFGVPGDYSFPVNDAICNDPHIRWIGCSNELNAAYAADGYARVKGVAALCTTYGVGELSAL
NGVAGAYAEHLPIFHLVGTPSMAIQSARAPMHHTLGNGEYDLFRRMTELVVCAYAVMTPQNVAFETERLIAEALFHRRPV
YMAFPADLAEQPVLGTAEPLAAPRSNPDHLAQATTAILSALEKAETACVLPGNLIHRCGLQRTMQNIIDRSGLPFATMFM
DKSVLDEHQPAFVGMYDGALMNDDVRQFVEDADCVLTIGTLMSDLNSGAFTARLDPARTITIAHHNVLCDGKTYIDVEMG
DILRALAENVPHRGWKRMSAPSLGAAKGSGDDPIGVDALYPRWADFLSPGDILVAETGTASMGLGFARMPKGATFYNQTL
WGSIGWATPAAVGAAIAAPGRRVVLVTGDGSHQMTATEIGLFGHLGLKPIVFVLNNNGYLIERLLCKNPEIAYNDIAPWR
YSELPHALGCDGWLTARVTTCAELDAVLAKAKHAETGVYIEIVTDTYAASPLAMKLHENLKSLYKS

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes [H]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1787096, Length=569, Percent_Identity=22.4956063268893, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321524, Length=530, Percent_Identity=36.6037735849057, Blast_Score=346, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6323073, Length=519, Percent_Identity=35.645472061657, Blast_Score=326, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6320123, Length=532, Percent_Identity=31.9548872180451, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323163, Length=519, Percent_Identity=35.0674373795761, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6320588, Length=591, Percent_Identity=27.4111675126904, Blast_Score=215, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: 4.1.1.1

Molecular weight: Translated: 58965; Mature: 58834

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTVIQFVLERLKAIGISDIFGVPGDYSFPVNDAICNDPHIRWIGCSNELNAAYAADGY
CHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCH
ARVKGVAALCTTYGVGELSALNGVAGAYAEHLPIFHLVGTPSMAIQSARAPMHHTLGNGE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCHHHHCCCCH
YDLFRRMTELVVCAYAVMTPQNVAFETERLIAEALFHRRPVYMAFPADLAEQPVLGTAEP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
LAAPRSNPDHLAQATTAILSALEKAETACVLPGNLIHRCGLQRTMQNIIDRSGLPFATMF
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
MDKSVLDEHQPAFVGMYDGALMNDDVRQFVEDADCVLTIGTLMSDLNSGAFTARLDPART
HCHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHCCCCCEEEECCCCEE
ITIAHHNVLCDGKTYIDVEMGDILRALAENVPHRGWKRMSAPSLGAAKGSGDDPIGVDAL
EEEEECEEEECCCEEEEEEHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
YPRWADFLSPGDILVAETGTASMGLGFARMPKGATFYNQTLWGSIGWATPAAVGAAIAAP
CHHHHHHCCCCCEEEEECCCCHHCCCHHHCCCCCCEECHHHCCCCCCCCHHHHHHHHCCC
GRRVVLVTGDGSHQMTATEIGLFGHLGLKPIVFVLNNNGYLIERLLCKNPEIAYNDIAPW
CCEEEEEECCCCCCEEHHHHHHHCCCCCCEEEEEECCCCEEEHHHHHCCCCCCCCCCCCC
RYSELPHALGCDGWLTARVTTCAELDAVLAKAKHAETGVYIEIVTDTYAASPLAMKLHEN
CHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
LKSLYKS
HHHHHCC
>Mature Secondary Structure 
TMTVIQFVLERLKAIGISDIFGVPGDYSFPVNDAICNDPHIRWIGCSNELNAAYAADGY
HHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCH
ARVKGVAALCTTYGVGELSALNGVAGAYAEHLPIFHLVGTPSMAIQSARAPMHHTLGNGE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCHHHHCCCCH
YDLFRRMTELVVCAYAVMTPQNVAFETERLIAEALFHRRPVYMAFPADLAEQPVLGTAEP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
LAAPRSNPDHLAQATTAILSALEKAETACVLPGNLIHRCGLQRTMQNIIDRSGLPFATMF
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
MDKSVLDEHQPAFVGMYDGALMNDDVRQFVEDADCVLTIGTLMSDLNSGAFTARLDPART
HCHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHCCCCCEEEECCCCEE
ITIAHHNVLCDGKTYIDVEMGDILRALAENVPHRGWKRMSAPSLGAAKGSGDDPIGVDAL
EEEEECEEEECCCEEEEEEHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
YPRWADFLSPGDILVAETGTASMGLGFARMPKGATFYNQTLWGSIGWATPAAVGAAIAAP
CHHHHHHCCCCCEEEEECCCCHHCCCHHHCCCCCCEECHHHCCCCCCCCHHHHHHHHCCC
GRRVVLVTGDGSHQMTATEIGLFGHLGLKPIVFVLNNNGYLIERLLCKNPEIAYNDIAPW
CCEEEEEECCCCCCEEHHHHHHHCCCCCCEEEEEECCCCEEEHHHHHCCCCCCCCCCCCC
RYSELPHALGCDGWLTARVTTCAELDAVLAKAKHAETGVYIEIVTDTYAASPLAMKLHEN
CHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
LKSLYKS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-oxo acid

Specific reaction: A 2-oxo acid = an aldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA