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The map label for this gene is adhc1 [H]

Identifier: 182678741

GI number: 182678741

Start: 2003853

End: 2004911

Strand: Reverse

Name: adhc1 [H]

Synonym: Bind_1770

Alternate gene names: 182678741

Gene position: 2004911-2003853 (Counterclockwise)

Preceding gene: 182678744

Following gene: 182678740

Centisome position: 48.08

GC content: 62.32

Gene sequence:

>1059_bases
ATGAAGACTATCGGCTTTGCATGCACATCGGCAGACACCCCTCTGGCCCCATTCAGGTTCGAACGGCGGGCTCCGCGTGC
GAACGATATTGTGATGGAAGTGCTCTATTGCGGCATCTGCCACTCAGACCTTCACCAGGCCCGCAACGACTGGGGTTGGA
GCCAATATCCGCTTGTTCCCGGTCACGAAATCGTCGGCCGTGTGATCGCGGTCGGCAACGCGGTCAAGCGCTATAAAATC
GGCGACCATGTAGCGGTCGGCTGCATGGTCGATAGCTGCCAGCATTGCGATCAGTGCCGGAAGGGCGAGGAGCAGCTCTG
CCGCGAGGGCAATACCCAGACCTATAACGACAAGGATCGCATCACCGGTGAGAGGACCTATGGTGGCTATTCCAAGCACC
TCGTGGTGCGCGAGGAGTTCGCCCTGCGTGTCCCGGATGGGCTCGATCTGTCCAAGGCTGCGCCGCTGCTCTGCGCCGGC
ATCACCACTTACTCGCCTCTGCGCACCTGGAATGTTGGCCCCGGCAGCCGGGTCGGCGTAATTGGTCTCGGTGGTCTCGG
CCATATGGCGGTGAAGCTCGCTGCCGCGATGGGCGCCGATGTGACTGTGTTGAGCCGCACGAAGGAGAAGGAGACGGACG
CGCTGGCGCTCGGTGCCGATCGGCTGCTCGTCTCCACGGACGAGGCGGCGATGATAAAGGCCGCGAACAGCTTTGACCTG
ATCATCGACACCGTGCCTGTGAAGCACGACATCAACCCTTACTTGCCGCTGCTGGACGTGGACGGTACGTTGGTGCTGGT
CGGACAGATTGGCCCGCTCGCCGAACCGAGCACGGTGCCTCTGCTGCTCGGCCGCCGTCGGGTCGCCGGCTCGCCCATCG
GCGGCATTGCCGAGACGCAGGAGATGCTCAACTTCTGCGCCAAGAAGAATGTCCTGCCCGATGTCGAGATGATCCGCATG
GACCAGATCAACGAGGCGTTCGTCCGACTCGAGCGCGCCGATGTACGCTACCGCTTCGTGATCGACATGGCCTCGATGCC
AGCGCCAGAGGCGGTATAA

Upstream 100 bases:

>100_bases
TCGCCTTCTACGCCGGCTGGCCCGTCGCGAACATGGCGGTGCCGATCCTCCGCAAGGCGTTCAAGGGCGCCGATACTAAT
CACCCCATCGAGGTTACCAG

Downstream 100 bases:

>100_bases
TCTTGATCGCAGCCATGATCATTCATGGCTGCGCGGCCTGATAGCGTATACATTGATGATTCAGGATCTCGACATTGCCA
TCATCGGTGCCGGCGCGGCC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKTIGFACTSADTPLAPFRFERRAPRANDIVMEVLYCGICHSDLHQARNDWGWSQYPLVPGHEIVGRVIAVGNAVKRYKI
GDHVAVGCMVDSCQHCDQCRKGEEQLCREGNTQTYNDKDRITGERTYGGYSKHLVVREEFALRVPDGLDLSKAAPLLCAG
ITTYSPLRTWNVGPGSRVGVIGLGGLGHMAVKLAAAMGADVTVLSRTKEKETDALALGADRLLVSTDEAAMIKAANSFDL
IIDTVPVKHDINPYLPLLDVDGTLVLVGQIGPLAEPSTVPLLLGRRRVAGSPIGGIAETQEMLNFCAKKNVLPDVEMIRM
DQINEAFVRLERADVRYRFVIDMASMPAPEAV

Sequences:

>Translated_352_residues
MKTIGFACTSADTPLAPFRFERRAPRANDIVMEVLYCGICHSDLHQARNDWGWSQYPLVPGHEIVGRVIAVGNAVKRYKI
GDHVAVGCMVDSCQHCDQCRKGEEQLCREGNTQTYNDKDRITGERTYGGYSKHLVVREEFALRVPDGLDLSKAAPLLCAG
ITTYSPLRTWNVGPGSRVGVIGLGGLGHMAVKLAAAMGADVTVLSRTKEKETDALALGADRLLVSTDEAAMIKAANSFDL
IIDTVPVKHDINPYLPLLDVDGTLVLVGQIGPLAEPSTVPLLLGRRRVAGSPIGGIAETQEMLNFCAKKNVLPDVEMIRM
DQINEAFVRLERADVRYRFVIDMASMPAPEAV
>Mature_352_residues
MKTIGFACTSADTPLAPFRFERRAPRANDIVMEVLYCGICHSDLHQARNDWGWSQYPLVPGHEIVGRVIAVGNAVKRYKI
GDHVAVGCMVDSCQHCDQCRKGEEQLCREGNTQTYNDKDRITGERTYGGYSKHLVVREEFALRVPDGLDLSKAAPLLCAG
ITTYSPLRTWNVGPGSRVGVIGLGGLGHMAVKLAAAMGADVTVLSRTKEKETDALALGADRLLVSTDEAAMIKAANSFDL
IIDTVPVKHDINPYLPLLDVDGTLVLVGQIGPLAEPSTVPLLLGRRRVAGSPIGGIAETQEMLNFCAKKNVLPDVEMIRM
DQINEAFVRLERADVRYRFVIDMASMPAPEAV

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=344, Percent_Identity=25, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI262073058, Length=344, Percent_Identity=25, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI4501933, Length=347, Percent_Identity=27.3775216138329, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=351, Percent_Identity=27.6353276353276, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4501939, Length=349, Percent_Identity=26.3610315186246, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=26.3610315186246, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501929, Length=347, Percent_Identity=27.0893371757925, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=231, Percent_Identity=28.1385281385281, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI71565154, Length=236, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=51.1627906976744, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI87082401, Length=339, Percent_Identity=39.2330383480826, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=30.9815950920245, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788073, Length=267, Percent_Identity=26.2172284644195, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790045, Length=186, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI226510992, Length=250, Percent_Identity=27.6, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082125, Length=330, Percent_Identity=25.7575757575758, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787863, Length=211, Percent_Identity=30.3317535545024, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788075, Length=259, Percent_Identity=26.6409266409266, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788407, Length=253, Percent_Identity=26.4822134387352, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=27.1232876712329, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=28.1524926686217, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=27.9883381924198, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=333, Percent_Identity=27.9279279279279, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=358, Percent_Identity=26.8156424581006, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=360, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=25.1428571428571, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=200, Percent_Identity=28, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=333, Percent_Identity=25.5255255255255, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=332, Percent_Identity=35.2409638554217, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=34.3373493975904, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323961, Length=328, Percent_Identity=30.7926829268293, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6319621, Length=328, Percent_Identity=30.7926829268293, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=30.4878048780488, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=27.4390243902439, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=322, Percent_Identity=25.1552795031056, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=267, Percent_Identity=27.7153558052434, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=267, Percent_Identity=27.7153558052434, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=306, Percent_Identity=25.4901960784314, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=355, Percent_Identity=25.6338028169014, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737897, Length=222, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=209, Percent_Identity=28.7081339712919, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38343; Mature: 38343

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGFACTSADTPLAPFRFERRAPRANDIVMEVLYCGICHSDLHQARNDWGWSQYPLVP
CCCEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GHEIVGRVIAVGNAVKRYKIGDHVAVGCMVDSCQHCDQCRKGEEQLCREGNTQTYNDKDR
CHHHHHHHHHHCCHHHEEECCCCEEEHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHH
ITGERTYGGYSKHLVVREEFALRVPDGLDLSKAAPLLCAGITTYSPLRTWNVGPGSRVGV
CCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHCCCEEEECCCCCCCCEEECCCCCCEEEE
IGLGGLGHMAVKLAAAMGADVTVLSRTKEKETDALALGADRLLVSTDEAAMIKAANSFDL
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCEEEEECCCHHEEEECCCCEE
IIDTVPVKHDINPYLPLLDVDGTLVLVGQIGPLAEPSTVPLLLGRRRVAGSPIGGIAETQ
EEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHCCHHHCCCCCCCHHHHH
EMLNFCAKKNVLPDVEMIRMDQINEAFVRLERADVRYRFVIDMASMPAPEAV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKTIGFACTSADTPLAPFRFERRAPRANDIVMEVLYCGICHSDLHQARNDWGWSQYPLVP
CCCEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GHEIVGRVIAVGNAVKRYKIGDHVAVGCMVDSCQHCDQCRKGEEQLCREGNTQTYNDKDR
CHHHHHHHHHHCCHHHEEECCCCEEEHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHH
ITGERTYGGYSKHLVVREEFALRVPDGLDLSKAAPLLCAGITTYSPLRTWNVGPGSRVGV
CCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHCCCEEEECCCCCCCCEEECCCCCCEEEE
IGLGGLGHMAVKLAAAMGADVTVLSRTKEKETDALALGADRLLVSTDEAAMIKAANSFDL
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCEEEEECCCHHEEEECCCCEE
IIDTVPVKHDINPYLPLLDVDGTLVLVGQIGPLAEPSTVPLLLGRRRVAGSPIGGIAETQ
EEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHCCHHHCCCCCCCHHHHH
EMLNFCAKKNVLPDVEMIRMDQINEAFVRLERADVRYRFVIDMASMPAPEAV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]