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The map label for this gene is uvrC [H]

Identifier: 182678685

GI number: 182678685

Start: 1932431

End: 1934509

Strand: Direct

Name: uvrC [H]

Synonym: Bind_1712

Alternate gene names: 182678685

Gene position: 1932431-1934509 (Clockwise)

Preceding gene: 182678674

Following gene: 182678686

Centisome position: 46.34

GC content: 59.31

Gene sequence:

>2079_bases
ATGGCCCGTATTCGCAAAATCATAGTCGGTGAAGCTGGTGTTGAGCCGACCGATGCTCCCCCTCCTTTCGACGCCGAGGA
TTTGGAAGCGCCGGACGAGCTCTTGTCTGTGCTTCCTTTGGCGGATATGGGCTCTGATCTCATCCTGGGAGAAGAAGAAA
AGGCAGCCGCTGACACCGAGGTCCGGCGCGGCGTCGCGGTCATCCGCCATTATTGGCAACATGCGCCGCATGGCCCAGGC
GTCTATCGGATGATCGGCGAGAGCGGCGAGGTTTTATACGTCGGCAAGGCGAAAAGCGTCCGCAAGAGAATTGCGAATTA
TCTGCGCGAGGGCGGTCATACCAACCGCATTGCCAGAATGATCAGCCTGACAGCCTCCATGGTCTTCGTCTCGACCGCGA
CAGAGACAGAAGCCTTGCTGCTCGAAACAAATTATATCAAGCAGATGAAGCCGCGCTTCAACGTCTTGATGCGCGATGAC
AAATCCTTTCCCTATATTCTGCTCAGCCGCGATCATGAGGCGCCGCAACTCACCAAGCATCGCGGCGCGCGCAGCCGCAA
GGGCGATTATTTCGGTCCCTTCGCGAGCGTCTGGGCCGTCAACCGAACCTTGAACGCTTTGCAGAGGGCCTTTCTTCTGC
GCTCCTGCACGGATAGCTATTACGAGAACCGGACACGGCCTTGCTTGCTCTATCAAATCAAGCGCTGTTCTGCGCCCTGC
ACTGGCGAGATCAGCCTCCACGATTATGATCATCTGGCCTCTGAGGCGCGTGACTTCCTCTCCGGTAAGAGCCGCGCGGT
GCGCGAACTTCTCGCCCGGGAAATGGAACAGGCCGCTGAAAATCTTGCCTTCGAACAGGCCGCCCGCCTGCGCGATCGAA
TCAGCGCACTTTCCACCATCCAGGGCGCGCAAGGCATTAATCCGAAAACCGTCGAGGAGGCCGATGTCTTCGCCATCGTC
GAAGAGGCCGGGCATTTCTGCGTCGAAGTCTTCTTCTTCCGCGCGTCGCAGAATTGGGGCAATCGCGCCTATTTTCCGCG
TGCGGACAAAAGCCTTTCCTTGAGTGAGGTTCTCGACGCCTTTCTCGCGCAATTTTATTCGGACAAACCCGCTGCCCGGC
TCCTTCTTCTCTCGGAAGAGATTGAAAATGCCGATGTGCTGGCGCAGGCACTCAGCGAGCGCAGCGGACACAAGGTCGAG
ATTGCCGTGCCGCAACGCGGCGAAAAGAAAGATCTCGTCGAGGCAGCCCGCCAAAACGGGCGTGAGACGCTCAGCCGCCA
ATTGTCGGAACAGGCCTCGCAGGAAAAACTCCTTGCCGAACTGGCAAAGGCCTTTGGCCTTGAGCGTGTTTTGCGGCGTG
TCGAAGTGTACGATAATTCCCACATTATGGGGACCAATGCGGTCGGCGCGATGATCGTCGCTGGTCCCTCGGGCTTCATG
AAGACCCATTACCGGACGTTCAACATCAAGGGCGAGGAGCTGACGCCCGGCGATGATTACGGCATGATGCGTGAAGTCCT
GCGCCGCCGTTTCAGCCGTCTGCTGCGCGAGGATCCCATCGCGCCCTCACCCGAGGCCGAGAGCGAGGAGGCTCCCCCTT
CGGAAAAGAACGAGGCTTTTCCGCAATGGCCGGATCTCATCCTGATCGACGGCGGCCAGGGTCAGTTCGATGCGGCGCGC
GCGATCCTCGACGAGCTCGGCATCGATAATGTCGCGCTGGCGTCCATCGCCAAGGGTGTTGATCGCGACGCCGGACGCGA
AACCTTCTTTGTGACCGGCCGCCCGCCCTTTCGACTGCCGCCGCGCGATCCAGCGCTCTATTTCGTGCAACGCCTGCGTG
ACGAGGCCCACCGTTTCGCCATTGGCACACATCGGGCGAAACGGCGCAAGGAATTTACCAAAAGCCCGCTGGACGAGATT
GCCGGCATTGGACCCGCCCGCAAGCGTGCCTTGCTGAATGCCTTCGGCACGGCTAAGGCGATTTCCCGCGCGGCTTTGCC
CGATCTCGAAAAAGTCCCGGGGATCAACGCCGCAAGCGCAAAGCTCATCTATGATTTTTTCCACGAGCGTGGCAAATAG

Upstream 100 bases:

>100_bases
CAGCGGTACTACATTCACAGAAGGCTGCAGTCTGAACCACGACCCTCGTAAGCCTGGGAAAGCTCTTTTCACTCTTCATC
CGCTCCCTTAAATCTACGCC

Downstream 100 bases:

>100_bases
AGGCATGGCGATTACCACGATCTCGCGAGGCTATGGGGGGACCTGGAGCCTGCCCAATATTTTGACTTATGGACGGCTGG
TTGCTGTGCCACTGGTCGTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MARIRKIIVGEAGVEPTDAPPPFDAEDLEAPDELLSVLPLADMGSDLILGEEEKAAADTEVRRGVAVIRHYWQHAPHGPG
VYRMIGESGEVLYVGKAKSVRKRIANYLREGGHTNRIARMISLTASMVFVSTATETEALLLETNYIKQMKPRFNVLMRDD
KSFPYILLSRDHEAPQLTKHRGARSRKGDYFGPFASVWAVNRTLNALQRAFLLRSCTDSYYENRTRPCLLYQIKRCSAPC
TGEISLHDYDHLASEARDFLSGKSRAVRELLAREMEQAAENLAFEQAARLRDRISALSTIQGAQGINPKTVEEADVFAIV
EEAGHFCVEVFFFRASQNWGNRAYFPRADKSLSLSEVLDAFLAQFYSDKPAARLLLLSEEIENADVLAQALSERSGHKVE
IAVPQRGEKKDLVEAARQNGRETLSRQLSEQASQEKLLAELAKAFGLERVLRRVEVYDNSHIMGTNAVGAMIVAGPSGFM
KTHYRTFNIKGEELTPGDDYGMMREVLRRRFSRLLREDPIAPSPEAESEEAPPSEKNEAFPQWPDLILIDGGQGQFDAAR
AILDELGIDNVALASIAKGVDRDAGRETFFVTGRPPFRLPPRDPALYFVQRLRDEAHRFAIGTHRAKRRKEFTKSPLDEI
AGIGPARKRALLNAFGTAKAISRAALPDLEKVPGINAASAKLIYDFFHERGK

Sequences:

>Translated_692_residues
MARIRKIIVGEAGVEPTDAPPPFDAEDLEAPDELLSVLPLADMGSDLILGEEEKAAADTEVRRGVAVIRHYWQHAPHGPG
VYRMIGESGEVLYVGKAKSVRKRIANYLREGGHTNRIARMISLTASMVFVSTATETEALLLETNYIKQMKPRFNVLMRDD
KSFPYILLSRDHEAPQLTKHRGARSRKGDYFGPFASVWAVNRTLNALQRAFLLRSCTDSYYENRTRPCLLYQIKRCSAPC
TGEISLHDYDHLASEARDFLSGKSRAVRELLAREMEQAAENLAFEQAARLRDRISALSTIQGAQGINPKTVEEADVFAIV
EEAGHFCVEVFFFRASQNWGNRAYFPRADKSLSLSEVLDAFLAQFYSDKPAARLLLLSEEIENADVLAQALSERSGHKVE
IAVPQRGEKKDLVEAARQNGRETLSRQLSEQASQEKLLAELAKAFGLERVLRRVEVYDNSHIMGTNAVGAMIVAGPSGFM
KTHYRTFNIKGEELTPGDDYGMMREVLRRRFSRLLREDPIAPSPEAESEEAPPSEKNEAFPQWPDLILIDGGQGQFDAAR
AILDELGIDNVALASIAKGVDRDAGRETFFVTGRPPFRLPPRDPALYFVQRLRDEAHRFAIGTHRAKRRKEFTKSPLDEI
AGIGPARKRALLNAFGTAKAISRAALPDLEKVPGINAASAKLIYDFFHERGK
>Mature_691_residues
ARIRKIIVGEAGVEPTDAPPPFDAEDLEAPDELLSVLPLADMGSDLILGEEEKAAADTEVRRGVAVIRHYWQHAPHGPGV
YRMIGESGEVLYVGKAKSVRKRIANYLREGGHTNRIARMISLTASMVFVSTATETEALLLETNYIKQMKPRFNVLMRDDK
SFPYILLSRDHEAPQLTKHRGARSRKGDYFGPFASVWAVNRTLNALQRAFLLRSCTDSYYENRTRPCLLYQIKRCSAPCT
GEISLHDYDHLASEARDFLSGKSRAVRELLAREMEQAAENLAFEQAARLRDRISALSTIQGAQGINPKTVEEADVFAIVE
EAGHFCVEVFFFRASQNWGNRAYFPRADKSLSLSEVLDAFLAQFYSDKPAARLLLLSEEIENADVLAQALSERSGHKVEI
AVPQRGEKKDLVEAARQNGRETLSRQLSEQASQEKLLAELAKAFGLERVLRRVEVYDNSHIMGTNAVGAMIVAGPSGFMK
THYRTFNIKGEELTPGDDYGMMREVLRRRFSRLLREDPIAPSPEAESEEAPPSEKNEAFPQWPDLILIDGGQGQFDAARA
ILDELGIDNVALASIAKGVDRDAGRETFFVTGRPPFRLPPRDPALYFVQRLRDEAHRFAIGTHRAKRRKEFTKSPLDEIA
GIGPARKRALLNAFGTAKAISRAALPDLEKVPGINAASAKLIYDFFHERGK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=40.4220779220779, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788037, Length=180, Percent_Identity=30, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 77265; Mature: 77134

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIRKIIVGEAGVEPTDAPPPFDAEDLEAPDELLSVLPLADMGSDLILGEEEKAAADTE
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHHH
VRRGVAVIRHYWQHAPHGPGVYRMIGESGEVLYVGKAKSVRKRIANYLREGGHTNRIARM
HHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHH
ISLTASMVFVSTATETEALLLETNYIKQMKPRFNVLMRDDKSFPYILLSRDHEAPQLTKH
HHHHHHHHHEECCCCCCEEEEEHHHHHHHCCHHCEEEECCCCCCEEEEECCCCCCHHHHH
RGARSRKGDYFGPFASVWAVNRTLNALQRAFLLRSCTDSYYENRTRPCLLYQIKRCSAPC
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
TGEISLHDYDHLASEARDFLSGKSRAVRELLAREMEQAAENLAFEQAARLRDRISALSTI
CCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGAQGINPKTVEEADVFAIVEEAGHFCVEVFFFRASQNWGNRAYFPRADKSLSLSEVLDA
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLAQFYSDKPAARLLLLSEEIENADVLAQALSERSGHKVEIAVPQRGEKKDLVEAARQNG
HHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC
RETLSRQLSEQASQEKLLAELAKAFGLERVLRRVEVYDNSHIMGTNAVGAMIVAGPSGFM
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHH
KTHYRTFNIKGEELTPGDDYGMMREVLRRRFSRLLREDPIAPSPEAESEEAPPSEKNEAF
HHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PQWPDLILIDGGQGQFDAARAILDELGIDNVALASIAKGVDRDAGRETFFVTGRPPFRLP
CCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
PRDPALYFVQRLRDEAHRFAIGTHRAKRRKEFTKSPLDEIAGIGPARKRALLNAFGTAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHH
ISRAALPDLEKVPGINAASAKLIYDFFHERGK
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARIRKIIVGEAGVEPTDAPPPFDAEDLEAPDELLSVLPLADMGSDLILGEEEKAAADTE
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHHH
VRRGVAVIRHYWQHAPHGPGVYRMIGESGEVLYVGKAKSVRKRIANYLREGGHTNRIARM
HHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHH
ISLTASMVFVSTATETEALLLETNYIKQMKPRFNVLMRDDKSFPYILLSRDHEAPQLTKH
HHHHHHHHHEECCCCCCEEEEEHHHHHHHCCHHCEEEECCCCCCEEEEECCCCCCHHHHH
RGARSRKGDYFGPFASVWAVNRTLNALQRAFLLRSCTDSYYENRTRPCLLYQIKRCSAPC
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
TGEISLHDYDHLASEARDFLSGKSRAVRELLAREMEQAAENLAFEQAARLRDRISALSTI
CCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGAQGINPKTVEEADVFAIVEEAGHFCVEVFFFRASQNWGNRAYFPRADKSLSLSEVLDA
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLAQFYSDKPAARLLLLSEEIENADVLAQALSERSGHKVEIAVPQRGEKKDLVEAARQNG
HHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC
RETLSRQLSEQASQEKLLAELAKAFGLERVLRRVEVYDNSHIMGTNAVGAMIVAGPSGFM
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHH
KTHYRTFNIKGEELTPGDDYGMMREVLRRRFSRLLREDPIAPSPEAESEEAPPSEKNEAF
HHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PQWPDLILIDGGQGQFDAARAILDELGIDNVALASIAKGVDRDAGRETFFVTGRPPFRLP
CCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
PRDPALYFVQRLRDEAHRFAIGTHRAKRRKEFTKSPLDEIAGIGPARKRALLNAFGTAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHH
ISRAALPDLEKVPGINAASAKLIYDFFHERGK
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA