Click here to switch to the map view.

The map label for this gene is fhs

Identifier: 182678628

GI number: 182678628

Start: 1870025

End: 1871692

Strand: Reverse

Name: fhs

Synonym: Bind_1654

Alternate gene names: 182678628

Gene position: 1871692-1870025 (Counterclockwise)

Preceding gene: 182678629

Following gene: 182678623

Centisome position: 44.88

GC content: 59.53

Gene sequence:

>1668_bases
ATGTCCAGTGATCTGGAAATTGCCCGCGCCGCGAAACTTCGGCCGATTGCCACCGTCGCCGACGAGGCCAAGATTCCAGC
CGAGGCGTTGCATTCCTATGGCCTGCATGTGGCCAAGATCGACACGAGCCTGTTGCCGAAAAAGGACCGCCCGGCCAAGC
TAGTCCTTGTGACCGCCATCAATCCGACCCCGGCGGGCGAGGGCAAGACAACCACCACAATCGGACTCGGTGATGCCTTG
CGCCGTCTCGGCAAGGCTTGTGTCATCGCTTTGCGTGAACCTTCGCTTGGTCCCTGTTTTGGGACCAAAGGGGGGGCCAC
GGGCGGCGGTTACGCGCAGATCGTGCCGATGGAACGCATCAATCTGCATCTCACCGGCGATTTCCACGCGATCACCAGCG
CGCATAATCTCCTCGCCGCCTTGATCGACAATCATCTTTACTGGGGCGCCGAGCCCAAAATCGATTCCCGCAAAGTCGCG
TGGCGTCGCGTGCTCGACATGAACGACCGTGCCTTGCGTCAAATCGTGGTCGGTCTGGGGGGAGGGGGCAATGGCTACCC
CCGTGAAACAGGTTTCGACATTACCGCCGCTTCCGAGATTATGGCGATCTTCTGCCTTTCGAAAGATCTCGCGGATCTGC
AACAAAGGCTCGCACAAATCATCGTCGCGCAGGATGTCAACAAACAGCCCGTGCGTGCTGATGCGTTGCAGGCCGTCGGC
GCCATGACAGTCCTGCTCAAGGACGCGCTCATGCCCAATCTGGTGCAAACGCTCGAAGGCACGCCCACTTTCGTTCATGG
CGGTCCCTTTGCCAATATTGCCCATGGCTGCAATTCAGTGGCGGCGACGCTGGCCGCCATGCAACTTGGCGATTACGTCG
TGACGGAAGCAGGCTTCGGCGCCGATTTGGGGGCCGAGAAATTTCTGGACATCAAATGCCGCCAGGCGGGGATCGCGCCC
TCCGCGGCGGTGATCGTTGCGACGGCCCGTGCCTTGAAATCGCATGGCGGTGTCGCTCCGGCCGATCTCAATAAGGAAAA
TCTCGACGCCCTCAAGGCGGGCCTCGCCAATCTCGGGCGCCATATCGCCAATGTCAAAAAGTTCGGGCTGCCGGTTGTCG
TGGCGATCAATCATTTCCTTTCGGATACAGAGGCGGAACAGGAACTGATTGCGCATACATGCCGCGATGAATACGGGGTC
GAGGCGATTGATTGCCGGCATTGGGCGGCCGGTGGCAAGGGCGCCCTGGCGCTGGCTGAAAAGGTGATCGCCTTGGTCGA
GGGTGGCACGGCCCAATTCAAGATGCTGTATGAAGATACTTTGCCACTCATTGAGAAAATGCGCCGCATCGCGCAGGAAA
TCTATGGCGCAGCGGATATTTCCCTGGACGCAAAGGCCAAGAAACAGCTTGCCGATATTGAGGCGCAGGGGTTCGGTCAT
TTCCCGGTCTGTGTCGCGAAAACCCAATATTCCTTCGCTGCCGATCCGAAACTACTCGGCGCGCCAACGGGCCATATCGT
ACCCATTCGCGAAGTCCGGCTCTCCGCCGGGGCCGGCTTCGTCGTGATGATCTGCGGTGACATCATGACCATGCCGGGGC
TCTCCCGCCAGCCAGCGGCCTGGAAGATCGGCCTCGATGCGCAAGGTAATATTGAAGGGCTGTTTTAA

Upstream 100 bases:

>100_bases
CCGTAACGGTGCCAACCGGCCGGCCATGGCGTCGAAACCTGTGCCGGACCGTCGTTTGACGCCCGTTTTCAATCGTTTGC
TGTTTCGAGGACTTGTTCGA

Downstream 100 bases:

>100_bases
AGGCTATCCGGATTCAGTTGTATTTGCCTCGTTGGATCGTCCTCATTACCAGAAGCTCAGTTTGTGTGTTTAGGATGGTC
CACATGGCCCCTCCGCAACC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MSSDLEIARAAKLRPIATVADEAKIPAEALHSYGLHVAKIDTSLLPKKDRPAKLVLVTAINPTPAGEGKTTTTIGLGDAL
RRLGKACVIALREPSLGPCFGTKGGATGGGYAQIVPMERINLHLTGDFHAITSAHNLLAALIDNHLYWGAEPKIDSRKVA
WRRVLDMNDRALRQIVVGLGGGGNGYPRETGFDITAASEIMAIFCLSKDLADLQQRLAQIIVAQDVNKQPVRADALQAVG
AMTVLLKDALMPNLVQTLEGTPTFVHGGPFANIAHGCNSVAATLAAMQLGDYVVTEAGFGADLGAEKFLDIKCRQAGIAP
SAAVIVATARALKSHGGVAPADLNKENLDALKAGLANLGRHIANVKKFGLPVVVAINHFLSDTEAEQELIAHTCRDEYGV
EAIDCRHWAAGGKGALALAEKVIALVEGGTAQFKMLYEDTLPLIEKMRRIAQEIYGAADISLDAKAKKQLADIEAQGFGH
FPVCVAKTQYSFAADPKLLGAPTGHIVPIREVRLSAGAGFVVMICGDIMTMPGLSRQPAAWKIGLDAQGNIEGLF

Sequences:

>Translated_555_residues
MSSDLEIARAAKLRPIATVADEAKIPAEALHSYGLHVAKIDTSLLPKKDRPAKLVLVTAINPTPAGEGKTTTTIGLGDAL
RRLGKACVIALREPSLGPCFGTKGGATGGGYAQIVPMERINLHLTGDFHAITSAHNLLAALIDNHLYWGAEPKIDSRKVA
WRRVLDMNDRALRQIVVGLGGGGNGYPRETGFDITAASEIMAIFCLSKDLADLQQRLAQIIVAQDVNKQPVRADALQAVG
AMTVLLKDALMPNLVQTLEGTPTFVHGGPFANIAHGCNSVAATLAAMQLGDYVVTEAGFGADLGAEKFLDIKCRQAGIAP
SAAVIVATARALKSHGGVAPADLNKENLDALKAGLANLGRHIANVKKFGLPVVVAINHFLSDTEAEQELIAHTCRDEYGV
EAIDCRHWAAGGKGALALAEKVIALVEGGTAQFKMLYEDTLPLIEKMRRIAQEIYGAADISLDAKAKKQLADIEAQGFGH
FPVCVAKTQYSFAADPKLLGAPTGHIVPIREVRLSAGAGFVVMICGDIMTMPGLSRQPAAWKIGLDAQGNIEGLF
>Mature_554_residues
SSDLEIARAAKLRPIATVADEAKIPAEALHSYGLHVAKIDTSLLPKKDRPAKLVLVTAINPTPAGEGKTTTTIGLGDALR
RLGKACVIALREPSLGPCFGTKGGATGGGYAQIVPMERINLHLTGDFHAITSAHNLLAALIDNHLYWGAEPKIDSRKVAW
RRVLDMNDRALRQIVVGLGGGGNGYPRETGFDITAASEIMAIFCLSKDLADLQQRLAQIIVAQDVNKQPVRADALQAVGA
MTVLLKDALMPNLVQTLEGTPTFVHGGPFANIAHGCNSVAATLAAMQLGDYVVTEAGFGADLGAEKFLDIKCRQAGIAPS
AAVIVATARALKSHGGVAPADLNKENLDALKAGLANLGRHIANVKKFGLPVVVAINHFLSDTEAEQELIAHTCRDEYGVE
AIDCRHWAAGGKGALALAEKVIALVEGGTAQFKMLYEDTLPLIEKMRRIAQEIYGAADISLDAKAKKQLADIEAQGFGHF
PVCVAKTQYSFAADPKLLGAPTGHIVPIREVRLSAGAGFVVMICGDIMTMPGLSRQPAAWKIGLDAQGNIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=44.2834138486312, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI36796743, Length=620, Percent_Identity=43.5483870967742, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=44.1860465116279, Blast_Score=83, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=44.6945337620579, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=44.6945337620579, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.1553090332805, Blast_Score=458, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.0127795527157, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=45.4838709677419, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=45.4838709677419, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=45.8064516129032, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=45.8064516129032, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_BEII9 (B2IC30)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832774.1
- GeneID:   6200473
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1654
- HOGENOM:   HBG677721
- OMA:   VVASEVM
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58603; Mature: 58471

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDLEIARAAKLRPIATVADEAKIPAEALHSYGLHVAKIDTSLLPKKDRPAKLVLVTAI
CCCCCCHHHHHCCCCHHHHHCCCCCCHHHHHHCCCEEEEECHHHCCCCCCCCEEEEEEEE
NPTPAGEGKTTTTIGLGDALRRLGKACVIALREPSLGPCFGTKGGATGGGYAQIVPMERI
CCCCCCCCCCEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEHE
NLHLTGDFHAITSAHNLLAALIDNHLYWGAEPKIDSRKVAWRRVLDMNDRALRQIVVGLG
EEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHEEC
GGGNGYPRETGFDITAASEIMAIFCLSKDLADLQQRLAQIIVAQDVNKQPVRADALQAVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AMTVLLKDALMPNLVQTLEGTPTFVHGGPFANIAHGCNSVAATLAAMQLGDYVVTEAGFG
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
ADLGAEKFLDIKCRQAGIAPSAAVIVATARALKSHGGVAPADLNKENLDALKAGLANLGR
CCCCCCHHEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HIANVKKFGLPVVVAINHFLSDTEAEQELIAHTCRDEYGVEAIDCRHWAAGGKGALALAE
HHHHHHHHCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECHHHCCCCCHHHHHHH
KVIALVEGGTAQFKMLYEDTLPLIEKMRRIAQEIYGAADISLDAKAKKQLADIEAQGFGH
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
FPVCVAKTQYSFAADPKLLGAPTGHIVPIREVRLSAGAGFVVMICGDIMTMPGLSRQPAA
CCEEEEECCCCCCCCCCEECCCCCCEEEHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCCE
WKIGLDAQGNIEGLF
EEEECCCCCCCCCCC
>Mature Secondary Structure 
SSDLEIARAAKLRPIATVADEAKIPAEALHSYGLHVAKIDTSLLPKKDRPAKLVLVTAI
CCCCCHHHHHCCCCHHHHHCCCCCCHHHHHHCCCEEEEECHHHCCCCCCCCEEEEEEEE
NPTPAGEGKTTTTIGLGDALRRLGKACVIALREPSLGPCFGTKGGATGGGYAQIVPMERI
CCCCCCCCCCEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEHE
NLHLTGDFHAITSAHNLLAALIDNHLYWGAEPKIDSRKVAWRRVLDMNDRALRQIVVGLG
EEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHEEC
GGGNGYPRETGFDITAASEIMAIFCLSKDLADLQQRLAQIIVAQDVNKQPVRADALQAVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AMTVLLKDALMPNLVQTLEGTPTFVHGGPFANIAHGCNSVAATLAAMQLGDYVVTEAGFG
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
ADLGAEKFLDIKCRQAGIAPSAAVIVATARALKSHGGVAPADLNKENLDALKAGLANLGR
CCCCCCHHEEEEHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HIANVKKFGLPVVVAINHFLSDTEAEQELIAHTCRDEYGVEAIDCRHWAAGGKGALALAE
HHHHHHHHCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECHHHCCCCCHHHHHHH
KVIALVEGGTAQFKMLYEDTLPLIEKMRRIAQEIYGAADISLDAKAKKQLADIEAQGFGH
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
FPVCVAKTQYSFAADPKLLGAPTGHIVPIREVRLSAGAGFVVMICGDIMTMPGLSRQPAA
CCEEEEECCCCCCCCCCEECCCCCCEEEHHHHHCCCCCCEEEEEEHHHHHCCCCCCCCCE
WKIGLDAQGNIEGLF
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA