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The map label for this gene is metC [H]

Identifier: 182678579

GI number: 182678579

Start: 1810876

End: 1812063

Strand: Direct

Name: metC [H]

Synonym: Bind_1604

Alternate gene names: 182678579

Gene position: 1810876-1812063 (Clockwise)

Preceding gene: 182678578

Following gene: 182678580

Centisome position: 43.42

GC content: 61.36

Gene sequence:

>1188_bases
ATGACCGACACGAAGCGAGACGGGCACAAGGGTTTTAAAAGCCGGACCAGGCTGGTGCATGCCGGGCGCGATCCGTCCGA
GCAATTCGGCTATGTTAACACGCCGATTTATCGCGGCTCGACCGTGCTCTATCCGACGCTCGATGATCTTTATGCAAGGC
GTGGACGTTTCTCCTATGGCACGCAGGGCACGCCCACGACGCAGGCCCTGGAAACGGCCTGGACCGAGCTCGCCGGTGCG
GCAGGGACCGTTCTAGTTCCGACCGGACTGGCCGCGATCACACTCGCGCTCCTGACCGCGGTCAAGGCAGGCGACCATAT
TCTCGTGACCGATTCGGCTTATCGGCCGTGCCGCAATTTTTGCGACACGGTTTTGCGCCGCATGGGCGTCGAAACGACTT
ATTACGATCCTTTGATCGGTGGCGGGCTCGAATCGCTCGTGCGCCAGAATACACGCGTCGTTTTCCTCGAAACACCCGGA
TCGCAGAGTTTCGAGCTTCAAGATGTCGTGGCCATCAAGGCGGTGGCCGAGGCGCATGATCTGTGCACCATCATCGACAA
TACCTGGGGCACCCCCCTCTTCTTCCCGCCGCATGAGCGCGGCATGGATATGGCGATCGAAGCCGGCACGAAATATCTCT
CCGGCCATTCTGATCTTCTGCTCGGCCTCGTCTCGGCTAATGCCCGCTGGTATCCGCGCCTGCGCGCGACCTATGACGCC
TTTGCCATGTGCCCCGGCCCGGAGGATGTGTTTCTCGCTTTGCGCGGACTGCGTACCATGGAATTGCGTCTGCGCGAGGC
CGAACGCCAGGGCCTCGCTATGGCGCGCTGGCTGGCCGCGCGGCCGGAAGTCGTGCAGGTCCTGCATCCAGCTTTGCCGC
AATGCCCTGGTCATGCCTTGTGGAAACGCGATTTCCTGGGCTCGACCGGCTTATTTTCAGTACTGCTCGCCCCTTTCTCG
CGCGAGGCGCTCGCCGCCATGCTCGATGGTCTCGAATTATTCGGCATGGGCTATTCCTGGGGCGGTTTCGAAAGCCTCGT
CATTCCCTTCGATTGCCGGACCTATCGCACGGCGACGCAATGGAATCCGCCGGGGCCTGCCTTGCGTTTCTCGATTGGCC
TCGAAGATATCGAGGATCTGCAAGCCGATCTCGCCGCCGGTTTCGAGCGTCTCAACGCGCATGCCTGA

Upstream 100 bases:

>100_bases
GGTTCGCCGCCGGGAATCATATTGCTCTCAGCCGCACCTTGACGAGTCTCGCCTCCACGAGGAAAACGTGAGGGGCGAGA
ACGGCAGGCAGGCGGAACGA

Downstream 100 bases:

>100_bases
AGTGGCTCCATCAGTCCAAAGAGGCCATTGCGCAAAGCGGACTTGACGGCATTGCCTGAGGACAGCTTTATGGGGGCGCC
CGAGCCTTCGGGAATGACTG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTDTKRDGHKGFKSRTRLVHAGRDPSEQFGYVNTPIYRGSTVLYPTLDDLYARRGRFSYGTQGTPTTQALETAWTELAGA
AGTVLVPTGLAAITLALLTAVKAGDHILVTDSAYRPCRNFCDTVLRRMGVETTYYDPLIGGGLESLVRQNTRVVFLETPG
SQSFELQDVVAIKAVAEAHDLCTIIDNTWGTPLFFPPHERGMDMAIEAGTKYLSGHSDLLLGLVSANARWYPRLRATYDA
FAMCPGPEDVFLALRGLRTMELRLREAERQGLAMARWLAARPEVVQVLHPALPQCPGHALWKRDFLGSTGLFSVLLAPFS
REALAAMLDGLELFGMGYSWGGFESLVIPFDCRTYRTATQWNPPGPALRFSIGLEDIEDLQADLAAGFERLNAHA

Sequences:

>Translated_395_residues
MTDTKRDGHKGFKSRTRLVHAGRDPSEQFGYVNTPIYRGSTVLYPTLDDLYARRGRFSYGTQGTPTTQALETAWTELAGA
AGTVLVPTGLAAITLALLTAVKAGDHILVTDSAYRPCRNFCDTVLRRMGVETTYYDPLIGGGLESLVRQNTRVVFLETPG
SQSFELQDVVAIKAVAEAHDLCTIIDNTWGTPLFFPPHERGMDMAIEAGTKYLSGHSDLLLGLVSANARWYPRLRATYDA
FAMCPGPEDVFLALRGLRTMELRLREAERQGLAMARWLAARPEVVQVLHPALPQCPGHALWKRDFLGSTGLFSVLLAPFS
REALAAMLDGLELFGMGYSWGGFESLVIPFDCRTYRTATQWNPPGPALRFSIGLEDIEDLQADLAAGFERLNAHA
>Mature_394_residues
TDTKRDGHKGFKSRTRLVHAGRDPSEQFGYVNTPIYRGSTVLYPTLDDLYARRGRFSYGTQGTPTTQALETAWTELAGAA
GTVLVPTGLAAITLALLTAVKAGDHILVTDSAYRPCRNFCDTVLRRMGVETTYYDPLIGGGLESLVRQNTRVVFLETPGS
QSFELQDVVAIKAVAEAHDLCTIIDNTWGTPLFFPPHERGMDMAIEAGTKYLSGHSDLLLGLVSANARWYPRLRATYDAF
AMCPGPEDVFLALRGLRTMELRLREAERQGLAMARWLAARPEVVQVLHPALPQCPGHALWKRDFLGSTGLFSVLLAPFSR
EALAAMLDGLELFGMGYSWGGFESLVIPFDCRTYRTATQWNPPGPALRFSIGLEDIEDLQADLAAGFERLNAHA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=333, Percent_Identity=31.8318318318318, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI299473759, Length=334, Percent_Identity=28.7425149700599, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI25453487, Length=332, Percent_Identity=29.2168674698795, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1789383, Length=402, Percent_Identity=41.5422885572139, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1790375, Length=395, Percent_Identity=30.8860759493671, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71980708, Length=392, Percent_Identity=28.8265306122449, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=336, Percent_Identity=30.6547619047619, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=336, Percent_Identity=30.3571428571429, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=332, Percent_Identity=56.3253012048193, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319307, Length=402, Percent_Identity=29.3532338308458, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323333, Length=391, Percent_Identity=24.2966751918159, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=25.6997455470738, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=22.3880597014925, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922554, Length=388, Percent_Identity=30.1546391752577, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43460; Mature: 43329

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTKRDGHKGFKSRTRLVHAGRDPSEQFGYVNTPIYRGSTVLYPTLDDLYARRGRFSYG
CCCCCCCCHHHHHHHHHEEECCCCCHHHCCCCCCCEECCCEEEECCHHHHHHHCCCCCCC
TQGTPTTQALETAWTELAGAAGTVLVPTGLAAITLALLTAVKAGDHILVTDSAYRPCRNF
CCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
CDTVLRRMGVETTYYDPLIGGGLESLVRQNTRVVFLETPGSQSFELQDVVAIKAVAEAHD
HHHHHHHHCCCCEECCCHHCCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
LCTIIDNTWGTPLFFPPHERGMDMAIEAGTKYLSGHSDLLLGLVSANARWYPRLRATYDA
HHHHHCCCCCCCEECCCCCCCCCEEEHHCCHHHCCCHHHHHHHHHCCCCCCCHHHHCCHH
FAMCPGPEDVFLALRGLRTMELRLREAERQGLAMARWLAARPEVVQVLHPALPQCPGHAL
EEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
WKRDFLGSTGLFSVLLAPFSREALAAMLDGLELFGMGYSWGGFESLVIPFDCRTYRTATQ
HHHHHCCCCHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCC
WNPPGPALRFSIGLEDIEDLQADLAAGFERLNAHA
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDTKRDGHKGFKSRTRLVHAGRDPSEQFGYVNTPIYRGSTVLYPTLDDLYARRGRFSYG
CCCCCCCHHHHHHHHHEEECCCCCHHHCCCCCCCEECCCEEEECCHHHHHHHCCCCCCC
TQGTPTTQALETAWTELAGAAGTVLVPTGLAAITLALLTAVKAGDHILVTDSAYRPCRNF
CCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
CDTVLRRMGVETTYYDPLIGGGLESLVRQNTRVVFLETPGSQSFELQDVVAIKAVAEAHD
HHHHHHHHCCCCEECCCHHCCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
LCTIIDNTWGTPLFFPPHERGMDMAIEAGTKYLSGHSDLLLGLVSANARWYPRLRATYDA
HHHHHCCCCCCCEECCCCCCCCCEEEHHCCHHHCCCHHHHHHHHHCCCCCCCHHHHCCHH
FAMCPGPEDVFLALRGLRTMELRLREAERQGLAMARWLAARPEVVQVLHPALPQCPGHAL
EEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
WKRDFLGSTGLFSVLLAPFSREALAAMLDGLELFGMGYSWGGFESLVIPFDCRTYRTATQ
HHHHHCCCCHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCC
WNPPGPALRFSIGLEDIEDLQADLAAGFERLNAHA
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]