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The map label for this gene is gppA [H]

Identifier: 182678542

GI number: 182678542

Start: 1768327

End: 1769844

Strand: Reverse

Name: gppA [H]

Synonym: Bind_1567

Alternate gene names: 182678542

Gene position: 1769844-1768327 (Counterclockwise)

Preceding gene: 182678543

Following gene: 182678538

Centisome position: 42.44

GC content: 61.53

Gene sequence:

>1518_bases
ATGATGGTGCCACCACGCCCCGCCATCTTGTCCACGACGATCGATCGGCCCGTGGCGATCGTCGACATCGGCTCCAATTC
GGTCCGCCTCGTCGTCTATGAGCGTTTGACGCGCTCACCACGGACGATCTTCAACGAAAAGTCCCTCTGCGCGCTCGGCC
ACGGTGTCGTCACCACCGGGCGTTTGTCGAAAAGCGGCGTCGAAAAAGCGCTGATGGCCTTGCGCCGCTTTCGTGTCCTT
TGCGGCATTATGGAAGTCGGCGAGATCCATGTGCTGGCCACCGCCGCGGCGCGCGACGCGAGCAATGGCGCCGAATTTCT
GGCCGCCGCCACGGAAGCGATCGGCACGCCGATCTCACTGCTGTCAGGCAGCCGCGAGGCCGAGCTCTCGGCGCAGGGTG
TCCTTTCCGGCGTGGCGAAACCCGATGGCGTCGTCGGCGATCTCGGCGGAGGCTCGCTCGAATTGATCGACGTCAAAGGC
GATTCCATCGGCAAGGGGACCACTCTCCCGCTTGGTGGCCTCGCTTTGATGGATGCCTCCAACCAGAACCTGCGCGAGGC
CGTGAAAATCGCCCGAGCGCATCTCGCCAAATCCAAGCTGCCGGAGCGTATGCTGGGGCGTACTTTCTATGCCGTGGGCG
GCACGTGGCGCGCGCTCGCCAAGCTGCATATGAGCCAGCATAATTATCCGATGAACATCATGCACGGTTATACAATGGCC
GCGCGGGATGCTTCCGACCTGACGAGCCTCGTCGAAAAGGTCAATACCGATACTCTGGTCTCGATCGAATCGGTGAATGC
CGCGCGTCGCCCCTTGCTCGCTTACGGCGCCGTGGTGCTCGACGAAATCATTCGCAAGGGCAACCCCAAAAAGGTCATGA
TCTCGACGACCGGTGTGCGCGAGGGCCTGCTTTATGAAAAGCTCGACGCTGCAACGCGCCGACTTGACCCCTTGCTGGTC
GCAGCCGAGGAATTCAATGTCCTGTTCGCCCGCTCGCCCGCTCACGCGGAGGAATTATGCGGCTGGACCGATGTTTTCAT
GGCTTCGACGCCGCTCGAGGAAAGCGACACGGAAAAACGCCTGCGCCACGCCGCCTGCCTGTTGAGCGATGTGAACTGGC
GCGCCCATCCCGATTACCGCGGCGAGGAAAGCTTGAACCTTGTCGTTAACGGCTCCTTCATCGGCATTGATCATCCAGGC
CGCGCCTTCCTGATCCTGTCGGCTTCCTATCGCTATCTCGGCCTCGACGAAGATGTGAATCCGCAATTACGCGGTCTCGT
GTCCTCGCGTTTGCTCGACAAGGCGAGGACGCTCGCCGCCACTTTGCGCGTGGCGACGGTCATATCCGGGTCGATGGGCG
GAATCCTGCCACGCACCTCGCTGACCTGCGTGAAGAGCAAAGTGATCCTGAGCCTACCCGGCGATTTGGTCGATCTCGTC
AGCGAGCGTCTGCAGAACCGGCTGAAACAATTGTCACGGTTGATCGGGCGCGAACCCCAGGTCGAGATCAAGGGGTGA

Upstream 100 bases:

>100_bases
TCCTATTTCATGACCAATCCGAGTCTCTCAGGCCGTGGCAAATCGCTCAAGGAATCAAGCCCAAAGACGCTTTTCAAGCG
GTTGGAAAAACATTGACACC

Downstream 100 bases:

>100_bases
TTTGCCGAGCCTTATAAGCTCGCTGCTGTTTGTAGCGGAGGCCTCCATCGGGCATGAACTGACGGTGGATGCTCTTGAGA
TCGGTTTGGCGCTGCCATCG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MMVPPRPAILSTTIDRPVAIVDIGSNSVRLVVYERLTRSPRTIFNEKSLCALGHGVVTTGRLSKSGVEKALMALRRFRVL
CGIMEVGEIHVLATAAARDASNGAEFLAAATEAIGTPISLLSGSREAELSAQGVLSGVAKPDGVVGDLGGGSLELIDVKG
DSIGKGTTLPLGGLALMDASNQNLREAVKIARAHLAKSKLPERMLGRTFYAVGGTWRALAKLHMSQHNYPMNIMHGYTMA
ARDASDLTSLVEKVNTDTLVSIESVNAARRPLLAYGAVVLDEIIRKGNPKKVMISTTGVREGLLYEKLDAATRRLDPLLV
AAEEFNVLFARSPAHAEELCGWTDVFMASTPLEESDTEKRLRHAACLLSDVNWRAHPDYRGEESLNLVVNGSFIGIDHPG
RAFLILSASYRYLGLDEDVNPQLRGLVSSRLLDKARTLAATLRVATVISGSMGGILPRTSLTCVKSKVILSLPGDLVDLV
SERLQNRLKQLSRLIGREPQVEIKG

Sequences:

>Translated_505_residues
MMVPPRPAILSTTIDRPVAIVDIGSNSVRLVVYERLTRSPRTIFNEKSLCALGHGVVTTGRLSKSGVEKALMALRRFRVL
CGIMEVGEIHVLATAAARDASNGAEFLAAATEAIGTPISLLSGSREAELSAQGVLSGVAKPDGVVGDLGGGSLELIDVKG
DSIGKGTTLPLGGLALMDASNQNLREAVKIARAHLAKSKLPERMLGRTFYAVGGTWRALAKLHMSQHNYPMNIMHGYTMA
ARDASDLTSLVEKVNTDTLVSIESVNAARRPLLAYGAVVLDEIIRKGNPKKVMISTTGVREGLLYEKLDAATRRLDPLLV
AAEEFNVLFARSPAHAEELCGWTDVFMASTPLEESDTEKRLRHAACLLSDVNWRAHPDYRGEESLNLVVNGSFIGIDHPG
RAFLILSASYRYLGLDEDVNPQLRGLVSSRLLDKARTLAATLRVATVISGSMGGILPRTSLTCVKSKVILSLPGDLVDLV
SERLQNRLKQLSRLIGREPQVEIKG
>Mature_505_residues
MMVPPRPAILSTTIDRPVAIVDIGSNSVRLVVYERLTRSPRTIFNEKSLCALGHGVVTTGRLSKSGVEKALMALRRFRVL
CGIMEVGEIHVLATAAARDASNGAEFLAAATEAIGTPISLLSGSREAELSAQGVLSGVAKPDGVVGDLGGGSLELIDVKG
DSIGKGTTLPLGGLALMDASNQNLREAVKIARAHLAKSKLPERMLGRTFYAVGGTWRALAKLHMSQHNYPMNIMHGYTMA
ARDASDLTSLVEKVNTDTLVSIESVNAARRPLLAYGAVVLDEIIRKGNPKKVMISTTGVREGLLYEKLDAATRRLDPLLV
AAEEFNVLFARSPAHAEELCGWTDVFMASTPLEESDTEKRLRHAACLLSDVNWRAHPDYRGEESLNLVVNGSFIGIDHPG
RAFLILSASYRYLGLDEDVNPQLRGLVSSRLLDKARTLAATLRVATVISGSMGGILPRTSLTCVKSKVILSLPGDLVDLV
SERLQNRLKQLSRLIGREPQVEIKG

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=305, Percent_Identity=26.5573770491803, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321185, Length=438, Percent_Identity=24.4292237442922, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54380; Mature: 54380

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVPPRPAILSTTIDRPVAIVDIGSNSVRLVVYERLTRSPRTIFNEKSLCALGHGVVTTG
CCCCCCCCCEECCCCCCEEEEEECCCCEEEEEEHHHCCCCHHHHCCCCHHHHCCCEEEEC
RLSKSGVEKALMALRRFRVLCGIMEVGEIHVLATAAARDASNGAEFLAAATEAIGTPISL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCHHHHHHHHHHHCCCHHH
LSGSREAELSAQGVLSGVAKPDGVVGDLGGGSLELIDVKGDSIGKGTTLPLGGLALMDAS
HCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCEEEECCC
NQNLREAVKIARAHLAKSKLPERMLGRTFYAVGGTWRALAKLHMSQHNYPMNIMHGYTMA
CCHHHHHHHHHHHHHHHHHCHHHHHCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCEEH
ARDASDLTSLVEKVNTDTLVSIESVNAARRPLLAYGAVVLDEIIRKGNPKKVMISTTGVR
HCCHHHHHHHHHHCCCCCEEEEECCCHHHCHHHHHHHHHHHHHHHCCCCCEEEEEECCCH
EGLLYEKLDAATRRLDPLLVAAEEFNVLFARSPAHAEELCGWTDVFMASTPLEESDTEKR
HHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHCCHHHHHHCCCCCCCCHHHHH
LRHAACLLSDVNWRAHPDYRGEESLNLVVNGSFIGIDHPGRAFLILSASYRYLGLDEDVN
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEEECCCCCEEEEEECCCEEECCCCCCC
PQLRGLVSSRLLDKARTLAATLRVATVISGSMGGILPRTSLTCVKSKVILSLPGDLVDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCEEEEECCCHHHHHH
SERLQNRLKQLSRLIGREPQVEIKG
HHHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MMVPPRPAILSTTIDRPVAIVDIGSNSVRLVVYERLTRSPRTIFNEKSLCALGHGVVTTG
CCCCCCCCCEECCCCCCEEEEEECCCCEEEEEEHHHCCCCHHHHCCCCHHHHCCCEEEEC
RLSKSGVEKALMALRRFRVLCGIMEVGEIHVLATAAARDASNGAEFLAAATEAIGTPISL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCHHHHHHHHHHHCCCHHH
LSGSREAELSAQGVLSGVAKPDGVVGDLGGGSLELIDVKGDSIGKGTTLPLGGLALMDAS
HCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCEEEECCC
NQNLREAVKIARAHLAKSKLPERMLGRTFYAVGGTWRALAKLHMSQHNYPMNIMHGYTMA
CCHHHHHHHHHHHHHHHHHCHHHHHCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCEEH
ARDASDLTSLVEKVNTDTLVSIESVNAARRPLLAYGAVVLDEIIRKGNPKKVMISTTGVR
HCCHHHHHHHHHHCCCCCEEEEECCCHHHCHHHHHHHHHHHHHHHCCCCCEEEEEECCCH
EGLLYEKLDAATRRLDPLLVAAEEFNVLFARSPAHAEELCGWTDVFMASTPLEESDTEKR
HHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHCCHHHHHHCCCCCCCCHHHHH
LRHAACLLSDVNWRAHPDYRGEESLNLVVNGSFIGIDHPGRAFLILSASYRYLGLDEDVN
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEEECCCCCEEEEEECCCEEECCCCCCC
PQLRGLVSSRLLDKARTLAATLRVATVISGSMGGILPRTSLTCVKSKVILSLPGDLVDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCEEEEECCCHHHHHH
SERLQNRLKQLSRLIGREPQVEIKG
HHHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA