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The map label for this gene is pgsA [H]

Identifier: 182678280

GI number: 182678280

Start: 1503802

End: 1504350

Strand: Direct

Name: pgsA [H]

Synonym: Bind_1296

Alternate gene names: 182678280

Gene position: 1503802-1504350 (Clockwise)

Preceding gene: 182678279

Following gene: 182678281

Centisome position: 36.06

GC content: 57.74

Gene sequence:

>549_bases
ATGCAAGCGTCGAATTTCGGCAGTCTTCCAAATCTCATTACCTTGCTGCGCCTGGTGCTCGTCCCGGCCATTGTGGCGAT
GATTGCCTCTCAGCGCTGGGTGGCAGCCTGTCTCATCTTCCTTGTCGCCGGTCTGTCCGATGCCGCCGATGGGTGGATCG
CCAAGCAATTCAATCTCCGTACGGAGCTCGGTGCTTATCTTGACCCGCTCGCCGACAAGGCCTTGCTCGTTTCGATCTAT
GTGGCGCTGGCCATCACCAGAACCGTCCCGGTCACGCTGACAATCATCATCGTCGCGCGAGATCTCATGATCATTGGCGC
TTTCATGGTCGCCTGGCTCCTGCAAAAACCCATGCGGGTCGAGCCTTTGCTGATTTCCAAGTTGAATACGGCGGCGCAGA
TCGCCTTTGCCGCTCTGGTCCTCGGCATCAAGGCCTTTGCGCTTTCGCCCGAGCCTTGGTTCGGCTGGGGCGTCTATGGC
GTGGCGCTTCTGACTCTCGTGTCCATGGCCGCTTATTTCTGGCGATGGATCCATCATATGGAAGTATGA

Upstream 100 bases:

>100_bases
GAAATTGCCATGCCCCAGGCAAGGCAAAAAATGATGTCCACTTTCCGGCCCGATGCTGTAGCCTCTTTCCCTAGTGGCGT
CGCTTTTCCTGTCTCGGCTT

Downstream 100 bases:

>100_bases
AGGCGGCCGTAAGAGTCGCACTCGATCGTGGCGGCCTTGGAAAGACGTGATTTTCGGCCAGCGATGATCTATGAGGAGAG
GGATAAATCGGCGGGCGCGG

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MQASNFGSLPNLITLLRLVLVPAIVAMIASQRWVAACLIFLVAGLSDAADGWIAKQFNLRTELGAYLDPLADKALLVSIY
VALAITRTVPVTLTIIIVARDLMIIGAFMVAWLLQKPMRVEPLLISKLNTAAQIAFAALVLGIKAFALSPEPWFGWGVYG
VALLTLVSMAAYFWRWIHHMEV

Sequences:

>Translated_182_residues
MQASNFGSLPNLITLLRLVLVPAIVAMIASQRWVAACLIFLVAGLSDAADGWIAKQFNLRTELGAYLDPLADKALLVSIY
VALAITRTVPVTLTIIIVARDLMIIGAFMVAWLLQKPMRVEPLLISKLNTAAQIAFAALVLGIKAFALSPEPWFGWGVYG
VALLTLVSMAAYFWRWIHHMEV
>Mature_182_residues
MQASNFGSLPNLITLLRLVLVPAIVAMIASQRWVAACLIFLVAGLSDAADGWIAKQFNLRTELGAYLDPLADKALLVSIY
VALAITRTVPVTLTIIIVARDLMIIGAFMVAWLLQKPMRVEPLLISKLNTAAQIAFAALVLGIKAFALSPEPWFGWGVYG
VALLTLVSMAAYFWRWIHHMEV

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=161, Percent_Identity=36.6459627329193, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI10092647, Length=155, Percent_Identity=36.7741935483871, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71984838, Length=158, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71984834, Length=158, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320059, Length=120, Percent_Identity=34.1666666666667, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650130, Length=157, Percent_Identity=31.8471337579618, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650126, Length=157, Percent_Identity=31.8471337579618, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650128, Length=157, Percent_Identity=31.8471337579618, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 19934; Mature: 19934

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASNFGSLPNLITLLRLVLVPAIVAMIASQRWVAACLIFLVAGLSDAADGWIAKQFNLR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TELGAYLDPLADKALLVSIYVALAITRTVPVTLTIIIVARDLMIIGAFMVAWLLQKPMRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EPLLISKLNTAAQIAFAALVLGIKAFALSPEPWFGWGVYGVALLTLVSMAAYFWRWIHHM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EV
CC
>Mature Secondary Structure
MQASNFGSLPNLITLLRLVLVPAIVAMIASQRWVAACLIFLVAGLSDAADGWIAKQFNLR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TELGAYLDPLADKALLVSIYVALAITRTVPVTLTIIIVARDLMIIGAFMVAWLLQKPMRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EPLLISKLNTAAQIAFAALVLGIKAFALSPEPWFGWGVYGVALLTLVSMAAYFWRWIHHM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]