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The map label for this gene is argG [H]

Identifier: 182678257

GI number: 182678257

Start: 1480481

End: 1481761

Strand: Direct

Name: argG [H]

Synonym: Bind_1273

Alternate gene names: 182678257

Gene position: 1480481-1481761 (Clockwise)

Preceding gene: 182678256

Following gene: 182678258

Centisome position: 35.5

GC content: 58.0

Gene sequence:

>1281_bases
ATGCGCTATAAAGCCCGCGCTTTGATTCTCCTGCCCGGGTTCTTCATGTCCACAGACCAAAAATCCATCAAGAAAGTCGT
GCTGGCCTATTCTGGGGGCCTCGATACGTCGATCATCCTCAAATGGCTGCAAACCACTTATGGCTGCGAGGTCGTGACCT
TTACCGCCGATCTCGGCCAGGGCGAGGAATTGGGGCCGGCCCGCGACAAGGCGCTCCTGCTTGGCATCAAGCCGGAAAAT
ATTTTCATCGAGGATCTGCGCGAGGAATTCGTGCGCGATTACGTCTTTCCGATGTTTCGCGCCAATACCCAATATGAAGG
GCTCTATCTGCTCGGGACCTCAATCGCACGGCCCTTGATCGCCAAGAAGCAGATCGAGATCGCGCGGGCGACCGGCGCCG
ACGCCGTGGCGCATGGCGCGACCGGTAAGGGCAATGATCAGGTGCGCTTTGAGCTGTCCTATTATGCGCTCGAACCCGAC
ATCAAGGTGATCGCCCCCTGGCGTGAATGGGATTTGACTTCCCGCACCGCGCTCCTCGAATTCGCCGAGAAGAATCAGAT
CCCGATTGCCAAGGACAAGCGCGGCGAGGCGCCGTTCTCGGTCGATGCCAATCTCCTGCATGCTTCTTCCGAGGGCAAGG
TTCTAGAAGATCCGGCGCAGGATGTGCCCGATTATGTCTATTCCCGAACCCTGAGCCCAGAAGACGCGCCGAACCAGCCG
ACCTTCATCGAAGTTGATTTCGTCAAGGGCGATGCGGTGGCGATCGACGGCGAGGCACTGTCACCGGCAAGCCTGCTCAC
GCGGCTCAATAAGCTCGGCCATGATAATGGCATCGGCCGCCTCGACCTCGTCGAGAACAGATTCGTTGGCATGAAATCGC
GCGGCATGTATGAGACGCCCGGCGGCACCATTCTCTATTTCGCGCATCGCGGCATTGAGCAGATCACTCTCGATCGCGGC
GCCGCCCATCTCAAGGATGAGCTCATGCCGAAATATGCCGAGCTCATCTATAATGGGTTCTGGTTCTCGCCAGAGAGGGA
AATGCTGCAGGCTTTGATCGACAAGAGCCAGGAATTCGTGACGGGCCGGGTTCGCCTGAAACTCTATAAGGGCGGCGTCT
ATGTGGTTGGCCGCTCCAGCCCCCATTCGCTCTATGATCAGGATCTCGTTACCTTCGAGGAAGGGGCTGTCGCTTATGAT
CACCACGACGCGGCGGGTTTCATCAAGCTTAATGCGTTGCGGCTTCGTACCCTGGCGAAACGGGCACGTAAGCTGGCCTG
A

Upstream 100 bases:

>100_bases
TCATGACGGTCATGATCGGGAAGACCCAAGATAAGTCCTCCCGGTGTCGAGCACTCGGAGGGGGCCTGCATAAAATTGGA
CTACCCAATTTTTGAATTTG

Downstream 100 bases:

>100_bases
TGCGAAGTTTTTCGAATCGAAGTGATTCGAAAAGGATATGGAATCAGGGACCGGGAGGGCGATGACTGGCCCTTCCCTCA
GCGGACGGAAGCCATTTGCG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRYKARALILLPGFFMSTDQKSIKKVVLAYSGGLDTSIILKWLQTTYGCEVVTFTADLGQGEELGPARDKALLLGIKPEN
IFIEDLREEFVRDYVFPMFRANTQYEGLYLLGTSIARPLIAKKQIEIARATGADAVAHGATGKGNDQVRFELSYYALEPD
IKVIAPWREWDLTSRTALLEFAEKNQIPIAKDKRGEAPFSVDANLLHASSEGKVLEDPAQDVPDYVYSRTLSPEDAPNQP
TFIEVDFVKGDAVAIDGEALSPASLLTRLNKLGHDNGIGRLDLVENRFVGMKSRGMYETPGGTILYFAHRGIEQITLDRG
AAHLKDELMPKYAELIYNGFWFSPEREMLQALIDKSQEFVTGRVRLKLYKGGVYVVGRSSPHSLYDQDLVTFEEGAVAYD
HHDAAGFIKLNALRLRTLAKRARKLA

Sequences:

>Translated_426_residues
MRYKARALILLPGFFMSTDQKSIKKVVLAYSGGLDTSIILKWLQTTYGCEVVTFTADLGQGEELGPARDKALLLGIKPEN
IFIEDLREEFVRDYVFPMFRANTQYEGLYLLGTSIARPLIAKKQIEIARATGADAVAHGATGKGNDQVRFELSYYALEPD
IKVIAPWREWDLTSRTALLEFAEKNQIPIAKDKRGEAPFSVDANLLHASSEGKVLEDPAQDVPDYVYSRTLSPEDAPNQP
TFIEVDFVKGDAVAIDGEALSPASLLTRLNKLGHDNGIGRLDLVENRFVGMKSRGMYETPGGTILYFAHRGIEQITLDRG
AAHLKDELMPKYAELIYNGFWFSPEREMLQALIDKSQEFVTGRVRLKLYKGGVYVVGRSSPHSLYDQDLVTFEEGAVAYD
HHDAAGFIKLNALRLRTLAKRARKLA
>Mature_426_residues
MRYKARALILLPGFFMSTDQKSIKKVVLAYSGGLDTSIILKWLQTTYGCEVVTFTADLGQGEELGPARDKALLLGIKPEN
IFIEDLREEFVRDYVFPMFRANTQYEGLYLLGTSIARPLIAKKQIEIARATGADAVAHGATGKGNDQVRFELSYYALEPD
IKVIAPWREWDLTSRTALLEFAEKNQIPIAKDKRGEAPFSVDANLLHASSEGKVLEDPAQDVPDYVYSRTLSPEDAPNQP
TFIEVDFVKGDAVAIDGEALSPASLLTRLNKLGHDNGIGRLDLVENRFVGMKSRGMYETPGGTILYFAHRGIEQITLDRG
AAHLKDELMPKYAELIYNGFWFSPEREMLQALIDKSQEFVTGRVRLKLYKGGVYVVGRSSPHSLYDQDLVTFEEGAVAYD
HHDAAGFIKLNALRLRTLAKRARKLA

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=410, Percent_Identity=48.5365853658537, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI16950633, Length=410, Percent_Identity=48.5365853658537, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1789563, Length=412, Percent_Identity=26.9417475728155, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324514, Length=407, Percent_Identity=43.2432432432432, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI21358151, Length=405, Percent_Identity=43.7037037037037, Blast_Score=321, Evalue=5e-88,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 47556; Mature: 47556

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYKARALILLPGFFMSTDQKSIKKVVLAYSGGLDTSIILKWLQTTYGCEVVTFTADLGQ
CCCCCEEEEEECCCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GEELGPARDKALLLGIKPENIFIEDLREEFVRDYVFPMFRANTQYEGLYLLGTSIARPLI
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHH
AKKQIEIARATGADAVAHGATGKGNDQVRFELSYYALEPDIKVIAPWREWDLTSRTALLE
HHHHHEEEECCCCCHHHCCCCCCCCCEEEEEEEEEEECCCCEEEECCHHCCCCHHHHHHH
FAEKNQIPIAKDKRGEAPFSVDANLLHASSEGKVLEDPAQDVPDYVYSRTLSPEDAPNQP
HHHCCCCCCCCCCCCCCCCEECCEEEEECCCCCEECCCHHHCHHHHHHCCCCCCCCCCCC
TFIEVDFVKGDAVAIDGEALSPASLLTRLNKLGHDNGIGRLDLVENRFVGMKSRGMYETP
CEEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECC
GGTILYFAHRGIEQITLDRGAAHLKDELMPKYAELIYNGFWFSPEREMLQALIDKSQEFV
CCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEE
TGRVRLKLYKGGVYVVGRSSPHSLYDQDLVTFEEGAVAYDHHDAAGFIKLNALRLRTLAK
EEEEEEEEEECCEEEEECCCCCCHHHCCCEEECCCCEEEECCCCCCEEEEHHHHHHHHHH
RARKLA
HHHHCC
>Mature Secondary Structure
MRYKARALILLPGFFMSTDQKSIKKVVLAYSGGLDTSIILKWLQTTYGCEVVTFTADLGQ
CCCCCEEEEEECCCCCCCCHHHHHHEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GEELGPARDKALLLGIKPENIFIEDLREEFVRDYVFPMFRANTQYEGLYLLGTSIARPLI
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHH
AKKQIEIARATGADAVAHGATGKGNDQVRFELSYYALEPDIKVIAPWREWDLTSRTALLE
HHHHHEEEECCCCCHHHCCCCCCCCCEEEEEEEEEEECCCCEEEECCHHCCCCHHHHHHH
FAEKNQIPIAKDKRGEAPFSVDANLLHASSEGKVLEDPAQDVPDYVYSRTLSPEDAPNQP
HHHCCCCCCCCCCCCCCCCEECCEEEEECCCCCEECCCHHHCHHHHHHCCCCCCCCCCCC
TFIEVDFVKGDAVAIDGEALSPASLLTRLNKLGHDNGIGRLDLVENRFVGMKSRGMYETP
CEEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECC
GGTILYFAHRGIEQITLDRGAAHLKDELMPKYAELIYNGFWFSPEREMLQALIDKSQEFV
CCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEE
TGRVRLKLYKGGVYVVGRSSPHSLYDQDLVTFEEGAVAYDHHDAAGFIKLNALRLRTLAK
EEEEEEEEEECCEEEEECCCCCCHHHCCCEEECCCCEEEECCCCCCEEEEHHHHHHHHHH
RARKLA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA