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The map label for this gene is yhdN [H]

Identifier: 182677866

GI number: 182677866

Start: 996162

End: 997157

Strand: Direct

Name: yhdN [H]

Synonym: Bind_0873

Alternate gene names: 182677866

Gene position: 996162-997157 (Clockwise)

Preceding gene: 182677865

Following gene: 182677871

Centisome position: 23.89

GC content: 58.73

Gene sequence:

>996_bases
ATGGAAACCATCACAATTGGCACTTCCAGCATCGTTACGTCACGCATCGGGCTTGGCACCTGGGCGATCGGTGGCTGGAT
GTGGGGTGGGACCGACGACGCCGAGGCCATCGCGACGATCAGATCCGCGATCGAACGCGGTATCCGTTTGATCGATACGG
CACCCGTCTATGGGTTTGGTCATTCCGAGGAAGTGATCGGCAAAGCCCTGGCGGAAAGCGGCCTGCGCGACGAGGTCCAG
ATCGCGACCAAGCTCGGCCTCGCCTGGAAGGACGGCAAAGTCTATCGCGATTCAAGCCCGGCCCGTATCCGTCAGGAAAT
CGAGGATTCGCTCAAGCGCCTGCGCACGGATGTCATCGATCTCTATCAGGTTCATTGGCCCGATCCCGCTATTCCCTTCG
AGGAAACAGCGCGCACGCTCGAGGATTTGCGTGACGCGGGCAAGATCCGGGCGATCGGCGTCAGCAATTACAGCCCGGCG
CAAATGGATGAATTCAGCAGGGGTGGCAAGCTCGATGCGGTCCAACCGCCCTATAATCTCTTCGAGCGCGAGATCGAGGC
CGATGTCCTCCCCTATGCCGAAAAAAACGGCCTGACATCGCTCTGCTATGGGGCGCTCTGCCGGGGACTGCTTGCCGGCA
AGATGACCAAGGGCCATGAATTCCACGGCGATGATCTGCGCTTAAAGGACCCTAAATTTCAGGGTGAGCGCTTTATTCAT
TATCTTGCCGCCGTTGAGGAATTGCAGACACTGGCGCGGGAGCGCTTCAATAAATCCGTGCTCGCGCTTGCGGTGCGTTG
GGTCCTCGATCAGGGTCAGACCATTGCGCTCTGGGGTGCGCGGCGTCCTGATCAGCTTGATCCGATCGGTGAAATCGAAG
GCTGGCATCTGGATGAAGCCAGCAAGAAAGAGATCGACGCGATCCTTTCGCGCAATATCAAAAATCCGATCTCGCCGGAA
TTCATGGCTCCACCTCTGCACCGCGACGCCGCCTGA

Upstream 100 bases:

>100_bases
TAGAACGGTTTCACGAGATTTTTAGGGTACTTCCCGTGTTCTCGGGGATTATAGTCGCGTGATCCGCCCTTCACTTTCCT
CACAACGGGAGACGCGACTT

Downstream 100 bases:

>100_bases
TCCCAGAACGATGTCAAACCTTGTCGTCCACGGGCTGGGCAGATGCACGAGCCCGTGTTCCAGGATCGTGCTATTGCAGC
GGCGCGTATTTTACGCGTTG

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
METITIGTSSIVTSRIGLGTWAIGGWMWGGTDDAEAIATIRSAIERGIRLIDTAPVYGFGHSEEVIGKALAESGLRDEVQ
IATKLGLAWKDGKVYRDSSPARIRQEIEDSLKRLRTDVIDLYQVHWPDPAIPFEETARTLEDLRDAGKIRAIGVSNYSPA
QMDEFSRGGKLDAVQPPYNLFEREIEADVLPYAEKNGLTSLCYGALCRGLLAGKMTKGHEFHGDDLRLKDPKFQGERFIH
YLAAVEELQTLARERFNKSVLALAVRWVLDQGQTIALWGARRPDQLDPIGEIEGWHLDEASKKEIDAILSRNIKNPISPE
FMAPPLHRDAA

Sequences:

>Translated_331_residues
METITIGTSSIVTSRIGLGTWAIGGWMWGGTDDAEAIATIRSAIERGIRLIDTAPVYGFGHSEEVIGKALAESGLRDEVQ
IATKLGLAWKDGKVYRDSSPARIRQEIEDSLKRLRTDVIDLYQVHWPDPAIPFEETARTLEDLRDAGKIRAIGVSNYSPA
QMDEFSRGGKLDAVQPPYNLFEREIEADVLPYAEKNGLTSLCYGALCRGLLAGKMTKGHEFHGDDLRLKDPKFQGERFIH
YLAAVEELQTLARERFNKSVLALAVRWVLDQGQTIALWGARRPDQLDPIGEIEGWHLDEASKKEIDAILSRNIKNPISPE
FMAPPLHRDAA
>Mature_331_residues
METITIGTSSIVTSRIGLGTWAIGGWMWGGTDDAEAIATIRSAIERGIRLIDTAPVYGFGHSEEVIGKALAESGLRDEVQ
IATKLGLAWKDGKVYRDSSPARIRQEIEDSLKRLRTDVIDLYQVHWPDPAIPFEETARTLEDLRDAGKIRAIGVSNYSPA
QMDEFSRGGKLDAVQPPYNLFEREIEADVLPYAEKNGLTSLCYGALCRGLLAGKMTKGHEFHGDDLRLKDPKFQGERFIH
YLAAVEELQTLARERFNKSVLALAVRWVLDQGQTIALWGARRPDQLDPIGEIEGWHLDEASKKEIDAILSRNIKNPISPE
FMAPPLHRDAA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=321, Percent_Identity=30.8411214953271, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4504825, Length=321, Percent_Identity=30.8411214953271, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI223718702, Length=258, Percent_Identity=31.3953488372093, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27436964, Length=327, Percent_Identity=29.0519877675841, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436962, Length=326, Percent_Identity=29.4478527607362, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI27436966, Length=323, Percent_Identity=29.1021671826625, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI41327764, Length=272, Percent_Identity=32.3529411764706, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI41152114, Length=258, Percent_Identity=29.8449612403101, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI27436971, Length=330, Percent_Identity=25.7575757575758, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI223718708, Length=136, Percent_Identity=36.7647058823529, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788070, Length=302, Percent_Identity=38.0794701986755, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789199, Length=347, Percent_Identity=32.2766570605187, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1788081, Length=206, Percent_Identity=35.4368932038835, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081735, Length=307, Percent_Identity=29.9674267100977, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789375, Length=305, Percent_Identity=30.8196721311475, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082198, Length=173, Percent_Identity=36.4161849710983, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994888, Length=169, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786400, Length=203, Percent_Identity=30.0492610837438, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787674, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645785, Length=223, Percent_Identity=31.390134529148, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=209, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17564128, Length=219, Percent_Identity=29.6803652968037, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=169, Percent_Identity=31.9526627218935, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71998625, Length=220, Percent_Identity=28.6363636363636, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17552492, Length=210, Percent_Identity=27.1428571428571, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325169, Length=307, Percent_Identity=26.7100977198697, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323998, Length=300, Percent_Identity=28.6666666666667, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319958, Length=274, Percent_Identity=27.3722627737226, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324694, Length=222, Percent_Identity=27.4774774774775, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319951, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322615, Length=266, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646155, Length=221, Percent_Identity=35.7466063348416, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646159, Length=221, Percent_Identity=33.4841628959276, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640980, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549126, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24662789, Length=214, Percent_Identity=28.0373831775701, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36846; Mature: 36846

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METITIGTSSIVTSRIGLGTWAIGGWMWGGTDDAEAIATIRSAIERGIRLIDTAPVYGFG
CCEEECCHHHHHHHHHCCCHHHHCCEECCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCC
HSEEVIGKALAESGLRDEVQIATKLGLAWKDGKVYRDSSPARIRQEIEDSLKRLRTDVID
CCHHHHHHHHHHCCCHHHHHHHHHHCEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
LYQVHWPDPAIPFEETARTLEDLRDAGKIRAIGVSNYSPAQMDEFSRGGKLDAVQPPYNL
HHHEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHH
FEREIEADVLPYAEKNGLTSLCYGALCRGLLAGKMTKGHEFHGDDLRLKDPKFQGERFIH
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHH
YLAAVEELQTLARERFNKSVLALAVRWVLDQGQTIALWGARRPDQLDPIGEIEGWHLDEA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCH
SKKEIDAILSRNIKNPISPEFMAPPLHRDAA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
METITIGTSSIVTSRIGLGTWAIGGWMWGGTDDAEAIATIRSAIERGIRLIDTAPVYGFG
CCEEECCHHHHHHHHHCCCHHHHCCEECCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCC
HSEEVIGKALAESGLRDEVQIATKLGLAWKDGKVYRDSSPARIRQEIEDSLKRLRTDVID
CCHHHHHHHHHHCCCHHHHHHHHHHCEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
LYQVHWPDPAIPFEETARTLEDLRDAGKIRAIGVSNYSPAQMDEFSRGGKLDAVQPPYNL
HHHEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHH
FEREIEADVLPYAEKNGLTSLCYGALCRGLLAGKMTKGHEFHGDDLRLKDPKFQGERFIH
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHH
YLAAVEELQTLARERFNKSVLALAVRWVLDQGQTIALWGARRPDQLDPIGEIEGWHLDEA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCH
SKKEIDAILSRNIKNPISPEFMAPPLHRDAA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]