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The map label for this gene is bioA [H]

Identifier: 182677808

GI number: 182677808

Start: 908995

End: 910278

Strand: Direct

Name: bioA [H]

Synonym: Bind_0815

Alternate gene names: 182677808

Gene position: 908995-910278 (Clockwise)

Preceding gene: 182677804

Following gene: 182677813

Centisome position: 21.8

GC content: 56.31

Gene sequence:

>1284_bases
ATGACACAGGCGCCGGATTGGTACCAGGCTGGCATGCCGCATATCTGGCTGCCCTATGCGCAAATGCAGACCACCTTACC
GCCCTTGCCGGTGAAGGCGACGCAAGGCACGCGCATTCAATTGGCCGATGGCCGCATCCTGATTGACGGCATTGCGAGCT
GGTGGACCGCCTGCCATGGTTACAATCACCCCGTTCTTCTGCAAGCGTTGACAGAACAGGCGAAATTGATGCCGCATGTC
ATGTTCGGCGGGCTCGTGCATGAGCCTGCCTTGCGGCTGGCGCGCCGTCTTGCCGATCTTTTACCGGGTGATCTCTCGCA
TGTCTTTTTTAGCGACAGCGGCTCGGTCGCGGTCGAAGTCGCGATGAAAATGGCGGTGCAATATTGGCTGAATCGAGGTG
AGCGAGGGCGCAATCATTTTCTCAGTTTCAGATTTGGTTATCATGGAGATACATTCGCGACCATGGCCGTGTGCGATCCT
GATGAAGGCATGCATAAACATTTCAGCGATGTGTTGATGCCTCAGACGATCGCCGATCTGCCACGCGGAGAGGAAGGTGA
AGCTGTCTTTGCTAAGCTCTTGGAAATCGAGGCCGGCAAACTCGCCGGCATTATCGTCGAGCCTTTGGTTCAGGGCGCCG
GTGGTATGGTCTTTCATGACCCCAGCACGCTGCAAATCTTGCGCAGACTCGCCGATCAGCATGGCCTCTTGCTGATTTTC
GATGAGATTTTTACGGGGTTCGGCCGCACGGGCTCGATGTTCGCTTGTGAAGCAGCCGCGGTCGTGCCCGATATCATCAC
TTTATCCAAAGCGCTTACCGGCGGTACCTTGCCGCTCGCCGCGACCGTGGCCAGCACACGTATTTTTGAGGCTTTTCTGT
CCGAGAAGGATATACATGCCTTGATGCATGGGCCAACCTTCATGGCCAATGCGCTCGCTTGTGCTGTTGCCAATGCCTCG
CTTGATCTTTTTGCCAGCGAGCTGCGTCTCGAACAGGTGGCGCGGATCGCGCTATGGCTGGAACAGGGTCTCGCGCCGTG
CCGGAATCTTCCCGGTGTGTGTGATGTGCGTGTGAAGGGGGCAATCGGTGTTGTCGAACTTGATTGGATCGCTGATCTCA
AGGGACTGAAACAGGCCTTGCTCGCGCAGCACGTTTGGATTCGTCCGTTCGGTCGTATCGTCTATCTGACCCCGGCTCTG
ACAATTGAGGAGGAGGATCTTGCGGGCCTGTGCCGAGCCATTGCAACAGTGTTGAAACAGCGCGATTGGTCGCAAGAATT
TTAA

Upstream 100 bases:

>100_bases
TGCGTGATCTAGCGACTTGCCGCGCGACATGGCAAATGAAGAGAGCCCTGGCTTTCGGCAGGGTTGCGGCGTTCATGAAA
AGAGTTTCGGAAAGGCGAGG

Downstream 100 bases:

>100_bases
TGTTTTGGGGTCGGCGGAATCGGCAGCCAATGCGTGGCCCCGTGATAAGGCTCGGCATTGCGATCGAGCCAGGCCTGCAA
TATCGGGTTCCAGGAGATGA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTQAPDWYQAGMPHIWLPYAQMQTTLPPLPVKATQGTRIQLADGRILIDGIASWWTACHGYNHPVLLQALTEQAKLMPHV
MFGGLVHEPALRLARRLADLLPGDLSHVFFSDSGSVAVEVAMKMAVQYWLNRGERGRNHFLSFRFGYHGDTFATMAVCDP
DEGMHKHFSDVLMPQTIADLPRGEEGEAVFAKLLEIEAGKLAGIIVEPLVQGAGGMVFHDPSTLQILRRLADQHGLLLIF
DEIFTGFGRTGSMFACEAAAVVPDIITLSKALTGGTLPLAATVASTRIFEAFLSEKDIHALMHGPTFMANALACAVANAS
LDLFASELRLEQVARIALWLEQGLAPCRNLPGVCDVRVKGAIGVVELDWIADLKGLKQALLAQHVWIRPFGRIVYLTPAL
TIEEEDLAGLCRAIATVLKQRDWSQEF

Sequences:

>Translated_427_residues
MTQAPDWYQAGMPHIWLPYAQMQTTLPPLPVKATQGTRIQLADGRILIDGIASWWTACHGYNHPVLLQALTEQAKLMPHV
MFGGLVHEPALRLARRLADLLPGDLSHVFFSDSGSVAVEVAMKMAVQYWLNRGERGRNHFLSFRFGYHGDTFATMAVCDP
DEGMHKHFSDVLMPQTIADLPRGEEGEAVFAKLLEIEAGKLAGIIVEPLVQGAGGMVFHDPSTLQILRRLADQHGLLLIF
DEIFTGFGRTGSMFACEAAAVVPDIITLSKALTGGTLPLAATVASTRIFEAFLSEKDIHALMHGPTFMANALACAVANAS
LDLFASELRLEQVARIALWLEQGLAPCRNLPGVCDVRVKGAIGVVELDWIADLKGLKQALLAQHVWIRPFGRIVYLTPAL
TIEEEDLAGLCRAIATVLKQRDWSQEF
>Mature_426_residues
TQAPDWYQAGMPHIWLPYAQMQTTLPPLPVKATQGTRIQLADGRILIDGIASWWTACHGYNHPVLLQALTEQAKLMPHVM
FGGLVHEPALRLARRLADLLPGDLSHVFFSDSGSVAVEVAMKMAVQYWLNRGERGRNHFLSFRFGYHGDTFATMAVCDPD
EGMHKHFSDVLMPQTIADLPRGEEGEAVFAKLLEIEAGKLAGIIVEPLVQGAGGMVFHDPSTLQILRRLADQHGLLLIFD
EIFTGFGRTGSMFACEAAAVVPDIITLSKALTGGTLPLAATVASTRIFEAFLSEKDIHALMHGPTFMANALACAVANASL
DLFASELRLEQVARIALWLEQGLAPCRNLPGVCDVRVKGAIGVVELDWIADLKGLKQALLAQHVWIRPFGRIVYLTPALT
IEEEDLAGLCRAIATVLKQRDWSQEF

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=28, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI13994255, Length=358, Percent_Identity=27.9329608938547, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI37574042, Length=411, Percent_Identity=25.3041362530414, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442709, Length=379, Percent_Identity=25.3298153034301, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI226442705, Length=407, Percent_Identity=24.8157248157248, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI284507298, Length=217, Percent_Identity=33.1797235023041, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI24119277, Length=363, Percent_Identity=25.6198347107438, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=48.4261501210654, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1789759, Length=310, Percent_Identity=34.8387096774194, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=32.9923273657289, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI145693181, Length=287, Percent_Identity=34.1463414634146, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789016, Length=354, Percent_Identity=31.3559322033898, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787560, Length=372, Percent_Identity=29.5698924731183, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786349, Length=326, Percent_Identity=28.2208588957055, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=396, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=429, Percent_Identity=27.039627039627, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=219, Percent_Identity=31.5068493150685, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=453, Percent_Identity=35.7615894039735, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323470, Length=413, Percent_Identity=27.8450363196126, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=27.1604938271605, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574759, Length=373, Percent_Identity=30.5630026809651, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161085790, Length=373, Percent_Identity=30.5630026809651, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357415, Length=396, Percent_Identity=25.5050505050505, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356575, Length=438, Percent_Identity=24.6575342465753, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46790; Mature: 46659

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAPDWYQAGMPHIWLPYAQMQTTLPPLPVKATQGTRIQLADGRILIDGIASWWTACHG
CCCCCCHHHCCCCEEEECHHHHHHCCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHCC
YNHPVLLQALTEQAKLMPHVMFGGLVHEPALRLARRLADLLPGDLSHVFFSDSGSVAVEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
AMKMAVQYWLNRGERGRNHFLSFRFGYHGDTFATMAVCDPDEGMHKHFSDVLMPQTIADL
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHC
PRGEEGEAVFAKLLEIEAGKLAGIIVEPLVQGAGGMVFHDPSTLQILRRLADQHGLLLIF
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCEEEEE
DEIFTGFGRTGSMFACEAAAVVPDIITLSKALTGGTLPLAATVASTRIFEAFLSEKDIHA
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHH
LMHGPTFMANALACAVANASLDLFASELRLEQVARIALWLEQGLAPCRNLPGVCDVRVKG
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECC
AIGVVELDWIADLKGLKQALLAQHVWIRPFGRIVYLTPALTIEEEDLAGLCRAIATVLKQ
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHH
RDWSQEF
CCCCCCC
>Mature Secondary Structure 
TQAPDWYQAGMPHIWLPYAQMQTTLPPLPVKATQGTRIQLADGRILIDGIASWWTACHG
CCCCCHHHCCCCEEEECHHHHHHCCCCCCCCCCCCCEEEEECCEEEEHHHHHHHHHHCC
YNHPVLLQALTEQAKLMPHVMFGGLVHEPALRLARRLADLLPGDLSHVFFSDSGSVAVEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
AMKMAVQYWLNRGERGRNHFLSFRFGYHGDTFATMAVCDPDEGMHKHFSDVLMPQTIADL
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHC
PRGEEGEAVFAKLLEIEAGKLAGIIVEPLVQGAGGMVFHDPSTLQILRRLADQHGLLLIF
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCEEEEE
DEIFTGFGRTGSMFACEAAAVVPDIITLSKALTGGTLPLAATVASTRIFEAFLSEKDIHA
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHH
LMHGPTFMANALACAVANASLDLFASELRLEQVARIALWLEQGLAPCRNLPGVCDVRVKG
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECC
AIGVVELDWIADLKGLKQALLAQHVWIRPFGRIVYLTPALTIEEEDLAGLCRAIATVLKQ
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHH
RDWSQEF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]