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The map label for this gene is adh [H]

Identifier: 182677767

GI number: 182677767

Start: 866745

End: 867773

Strand: Direct

Name: adh [H]

Synonym: Bind_0774

Alternate gene names: 182677767

Gene position: 866745-867773 (Clockwise)

Preceding gene: 182677766

Following gene: 182677768

Centisome position: 20.78

GC content: 55.59

Gene sequence:

>1029_bases
TTGGCGACTAAGATGAAGGCGGCGCTTGTCCATGCATTCGGGAAGCCGCTGAGCATTGAGGAGATCGATATTCCCTCGAT
TGGTCCAGACCAGATTCTCGTAAAATTGACGGCCTGTGGTGTCTGCCATACGGATCTGCATGCGGCGAGTGGTGATTGGC
CGGTCAAACCGAAACTGCCTTTCATTCCTGGGCATGAAGGCGTGGGGCAAATTGCAGCGGTCGGACAATCGGTCACATGG
GTCAAGGAAGGTGATATCGTCGGGGTGCCCTGGCTTTATTCCGCCTGCGGCCATTGTGATCATTGCCTGGCCGGCTGGGA
AACACTTTGCGAGCATCAGCAGGAAACCGGCTATTCGGTCAATGGCTGTTTCGCTGAATATGTCGTCGCGGATCCCAATT
ATGTCGCGCATCTGCCGCAAGGTCTCGACCCGATCAAGGTCGCGCCGGTCCTTTGCGCCGGGTTGACGGTCTACAAGGGC
CTCAAGATGACGGATACAAAGCCCGGAAATTGGGTGGCGATTTCCGGTGTTGGCGGATTGGGGCAAATGGCAGTGCAATA
TGGTATTGCCATGGGATTGAATGTCATCGCCATCGACATCGACGAAGAAAAGCTTGCGACCGCGAAAAAGCTCGGGGCAG
CCTTGACCATCAATGCCCTGCATCAAGATCCGGGCGAAGAGATACACAAAGCGGTTGGGGGTGTGCATGGCGCCTTGATT
ACCGCTGTCTCTCCCAAGGCTTTCTCGCAGGCGATGAAGGTCACGCGCCGTGGCGGAACCATTGTCCTGAATGGTCTGCC
GCCGGGCGAATTTCCCATCTCCATCTTCGACATGGTCATGGATGGCACGACCGTGCGCGGATCGATTGTCGGGACGCGTC
TCGATATGGTGGAAGCGCTTGACTTCTTTAAGCAGGGCAAGATTTCGACCGTTGTCGCGACCGACAGGCTGGACAATATC
AATGCGATTTTTGATCGCCTGCAACACGGCAAGGTCAATGGCCGTATCGTGATCGATTACAGATCCTGA

Upstream 100 bases:

>100_bases
ATCAATCGGAATCAACGATCATGTTCGAGCGCTTTCCCGCAATCACATGACCATGACGCTGTTCAATCGATTGAATGATC
GATCACCAGGAGACTAAACA

Downstream 100 bases:

>100_bases
TTCTGCCGATGGGCGATATTGCAAACGAGCAAAGGAGGACAAGGTGGCTTACCAAACTGTCAATCCTTATACCAATGAAG
TCGTGGCGACTTTTCCCGAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MATKMKAALVHAFGKPLSIEEIDIPSIGPDQILVKLTACGVCHTDLHAASGDWPVKPKLPFIPGHEGVGQIAAVGQSVTW
VKEGDIVGVPWLYSACGHCDHCLAGWETLCEHQQETGYSVNGCFAEYVVADPNYVAHLPQGLDPIKVAPVLCAGLTVYKG
LKMTDTKPGNWVAISGVGGLGQMAVQYGIAMGLNVIAIDIDEEKLATAKKLGAALTINALHQDPGEEIHKAVGGVHGALI
TAVSPKAFSQAMKVTRRGGTIVLNGLPPGEFPISIFDMVMDGTTVRGSIVGTRLDMVEALDFFKQGKISTVVATDRLDNI
NAIFDRLQHGKVNGRIVIDYRS

Sequences:

>Translated_342_residues
MATKMKAALVHAFGKPLSIEEIDIPSIGPDQILVKLTACGVCHTDLHAASGDWPVKPKLPFIPGHEGVGQIAAVGQSVTW
VKEGDIVGVPWLYSACGHCDHCLAGWETLCEHQQETGYSVNGCFAEYVVADPNYVAHLPQGLDPIKVAPVLCAGLTVYKG
LKMTDTKPGNWVAISGVGGLGQMAVQYGIAMGLNVIAIDIDEEKLATAKKLGAALTINALHQDPGEEIHKAVGGVHGALI
TAVSPKAFSQAMKVTRRGGTIVLNGLPPGEFPISIFDMVMDGTTVRGSIVGTRLDMVEALDFFKQGKISTVVATDRLDNI
NAIFDRLQHGKVNGRIVIDYRS
>Mature_341_residues
ATKMKAALVHAFGKPLSIEEIDIPSIGPDQILVKLTACGVCHTDLHAASGDWPVKPKLPFIPGHEGVGQIAAVGQSVTWV
KEGDIVGVPWLYSACGHCDHCLAGWETLCEHQQETGYSVNGCFAEYVVADPNYVAHLPQGLDPIKVAPVLCAGLTVYKGL
KMTDTKPGNWVAISGVGGLGQMAVQYGIAMGLNVIAIDIDEEKLATAKKLGAALTINALHQDPGEEIHKAVGGVHGALIT
AVSPKAFSQAMKVTRRGGTIVLNGLPPGEFPISIFDMVMDGTTVRGSIVGTRLDMVEALDFFKQGKISTVVATDRLDNIN
AIFDRLQHGKVNGRIVIDYRS

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=31.2154696132597, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=30.3867403314917, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=31.2154696132597, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=30.1630434782609, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=29.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI262073058, Length=320, Percent_Identity=28.4375, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71743840, Length=237, Percent_Identity=30.379746835443, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI156523966, Length=364, Percent_Identity=24.7252747252747, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=24.7252747252747, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI194239674, Length=268, Percent_Identity=27.6119402985075, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI13236495, Length=268, Percent_Identity=27.6119402985075, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI194239676, Length=204, Percent_Identity=29.9019607843137, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=338, Percent_Identity=42.3076923076923, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=32.4786324786325, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082401, Length=339, Percent_Identity=27.7286135693215, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=26.5060240963855, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788073, Length=274, Percent_Identity=29.9270072992701, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082125, Length=343, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=31.1827956989247, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=320, Percent_Identity=29.375, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=210, Percent_Identity=34.7619047619048, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=318, Percent_Identity=25.4716981132075, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=325, Percent_Identity=26.4615384615385, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790718, Length=269, Percent_Identity=23.7918215613383, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=34.5132743362832, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17562582, Length=344, Percent_Identity=35.1744186046512, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=32.6409495548961, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=28.8184438040346, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=235, Percent_Identity=32.3404255319149, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=367, Percent_Identity=26.9754768392371, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=369, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=225, Percent_Identity=28.4444444444444, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=42.2018348623853, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6323961, Length=339, Percent_Identity=39.8230088495575, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=38.8235294117647, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=39.7553516819572, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=30.3125, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=27.4924471299094, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=30.0813008130081, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=277, Percent_Identity=29.9638989169675, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=277, Percent_Identity=29.9638989169675, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=291, Percent_Identity=26.4604810996564, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=27.3458445040214, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737897, Length=250, Percent_Identity=30.8, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=27.1084337349398, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36294; Mature: 36163

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKMKAALVHAFGKPLSIEEIDIPSIGPDQILVKLTACGVCHTDLHAASGDWPVKPKLP
CCCHHHHHHHHHCCCCCCEEECCCCCCCHHHEEEEEECCCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGQIAAVGQSVTWVKEGDIVGVPWLYSACGHCDHCLAGWETLCEHQQETGYSV
CCCCCCCCCHHHHCCCCEEEEECCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
NGCFAEYVVADPNYVAHLPQGLDPIKVAPVLCAGLTVYKGLKMTDTKPGNWVAISGVGGL
CCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCH
GQMAVQYGIAMGLNVIAIDIDEEKLATAKKLGAALTINALHQDPGEEIHKAVGGVHGALI
HHHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHCCCCHHHE
TAVSPKAFSQAMKVTRRGGTIVLNGLPPGEFPISIFDMVMDGTTVRGSIVGTRLDMVEAL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCEEECEEEHHHHHHHHHH
DFFKQGKISTVVATDRLDNINAIFDRLQHGKVNGRIVIDYRS
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
ATKMKAALVHAFGKPLSIEEIDIPSIGPDQILVKLTACGVCHTDLHAASGDWPVKPKLP
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHEEEEEECCCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGQIAAVGQSVTWVKEGDIVGVPWLYSACGHCDHCLAGWETLCEHQQETGYSV
CCCCCCCCCHHHHCCCCEEEEECCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
NGCFAEYVVADPNYVAHLPQGLDPIKVAPVLCAGLTVYKGLKMTDTKPGNWVAISGVGGL
CCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCH
GQMAVQYGIAMGLNVIAIDIDEEKLATAKKLGAALTINALHQDPGEEIHKAVGGVHGALI
HHHHHHHHHHCCCEEEEEEECHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHCCCCHHHE
TAVSPKAFSQAMKVTRRGGTIVLNGLPPGEFPISIFDMVMDGTTVRGSIVGTRLDMVEAL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCEEECEEEHHHHHHHHHH
DFFKQGKISTVVATDRLDNINAIFDRLQHGKVNGRIVIDYRS
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]