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The map label for this gene is pyrC [H]

Identifier: 182677706

GI number: 182677706

Start: 800960

End: 802282

Strand: Direct

Name: pyrC [H]

Synonym: Bind_0713

Alternate gene names: 182677706

Gene position: 800960-802282 (Clockwise)

Preceding gene: 182677701

Following gene: 182677707

Centisome position: 19.21

GC content: 60.7

Gene sequence:

>1323_bases
ATGCCGCACAATTTCGATCTTCTCCTGAAAGGGGGGATTGTCGTCGATCATAATGGAATCGCCGCCCGCGATATTGGTAT
CAGGGATGGCAAGATTGCCGCGATCGGCCACCTGCGGCAGGCGAGTGCCGGTGAAACCATTGCCGCCGAGGGGCTGCACA
TTTTGCCTGGCGTCATTGATACGCAGGTGCACTTCCGTGAGCCCGGTCTGACCCATAAGGAAGATCTCGAAACCGGCTCG
CGCGGGGCCGTGCTTGGCGGCGTCACGGCAGTGTTTGAAATGCCCAACACCAATCCGCTGACGACGGGGGCGGTGGAACT
GGCCGATAAAGTGGCCCGCGCGACGCATCGCATGCATTGCGATTTCGCGTTCTGGGTCGGCGGCACTTATGACAATCCCA
AGGACATTCCGGAATTGGAGCGCCTGCCGGGCTCGGCCGGCATCAAGGTCTTCATGGGCTCCTCGACCGGCAGCCTGCTC
GTCGAGGATGATGAGGGCATTGCCCGCATTCTTGCCCAAACCCGTCGCCGCGCGGCTTTTCATTCCGAGGATGAAGCGCG
TTTGAATGAACGCAAGCCTGTGCGGGTGGCGGGTGACCCTTCCTCGCATCCCTTGTGGCGTGATGAGGAAGCGGCTCTTC
TCTCGACGCGGCGCCTCGTGCGGATCGCCCATGAACAGAACGCGCTCGTGCATGTGCTGCATGTGTCGACCGCTGAGGAA
ATCGATTTCCTAGCCGCGCACAAGGAACGCGTCAGCATCGAGATCACGCCGCATCATTTGACGCTGTCTTCCGAGGATTA
TGCGCGGCTTGGCACTTTGATGCAGATGAACCCGCCTGTGCGCGACGCGCGCCACCGGGAAAGACTCTGGTATGGGCTCG
ATCAGAGCATCGTTGATATTCTTGGCTCCGATCACGCGCCGCATACATTGGAGGAAAAGGCTAAACCCTATCCGCAGAGC
CCCTCGGGGATGACCGGCGTGCAGACATTGGTGCCCTTGATGCTCGATCATGTCCAGGCGGGACGCCTGACGCTTCAGCG
TTTCGTCGATCTGACGAGTGCCGGCCCGGCGCGTCTCTTCGGAATAGCAGGCAAAGGCCGGATCGCGGTCGGTTATGACG
CGGATTTGACTGTCGTCGATCTGAAACGGCGGGAGACGATCACCAATGAATGGATTGCCTCGCGCGCCGGCTGGACGCCT
TATCATGGCAAGACCGTCACCGGCTGGCCTATTGGCACCCTGGTTCGGGGCCGCAAGGTGATGTGGGAGGGTGAAATCGT
GACAGCGGGGCAGGGAGAGCCTGTGCGGTTTCTGACACGGTAG

Upstream 100 bases:

>100_bases
AAAAATCTGTTCCGCCCTTGCGGTCCATTGGTCTACTGAACGCATCATCTCGCAAGCCGTCACGCGCAAGCTTGTCGGTG
GAACAAGCAATGGATGGGCC

Downstream 100 bases:

>100_bases
AGCGTCTTCTCACAACAAGAGTAAAGCCGCCGAAGGAGCGTGCCGTCTTATTGCAGACCCGAAGAACAGGGCCATGTCCG
TTGCAAGGTTGCGCGCACCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MPHNFDLLLKGGIVVDHNGIAARDIGIRDGKIAAIGHLRQASAGETIAAEGLHILPGVIDTQVHFREPGLTHKEDLETGS
RGAVLGGVTAVFEMPNTNPLTTGAVELADKVARATHRMHCDFAFWVGGTYDNPKDIPELERLPGSAGIKVFMGSSTGSLL
VEDDEGIARILAQTRRRAAFHSEDEARLNERKPVRVAGDPSSHPLWRDEEAALLSTRRLVRIAHEQNALVHVLHVSTAEE
IDFLAAHKERVSIEITPHHLTLSSEDYARLGTLMQMNPPVRDARHRERLWYGLDQSIVDILGSDHAPHTLEEKAKPYPQS
PSGMTGVQTLVPLMLDHVQAGRLTLQRFVDLTSAGPARLFGIAGKGRIAVGYDADLTVVDLKRRETITNEWIASRAGWTP
YHGKTVTGWPIGTLVRGRKVMWEGEIVTAGQGEPVRFLTR

Sequences:

>Translated_440_residues
MPHNFDLLLKGGIVVDHNGIAARDIGIRDGKIAAIGHLRQASAGETIAAEGLHILPGVIDTQVHFREPGLTHKEDLETGS
RGAVLGGVTAVFEMPNTNPLTTGAVELADKVARATHRMHCDFAFWVGGTYDNPKDIPELERLPGSAGIKVFMGSSTGSLL
VEDDEGIARILAQTRRRAAFHSEDEARLNERKPVRVAGDPSSHPLWRDEEAALLSTRRLVRIAHEQNALVHVLHVSTAEE
IDFLAAHKERVSIEITPHHLTLSSEDYARLGTLMQMNPPVRDARHRERLWYGLDQSIVDILGSDHAPHTLEEKAKPYPQS
PSGMTGVQTLVPLMLDHVQAGRLTLQRFVDLTSAGPARLFGIAGKGRIAVGYDADLTVVDLKRRETITNEWIASRAGWTP
YHGKTVTGWPIGTLVRGRKVMWEGEIVTAGQGEPVRFLTR
>Mature_439_residues
PHNFDLLLKGGIVVDHNGIAARDIGIRDGKIAAIGHLRQASAGETIAAEGLHILPGVIDTQVHFREPGLTHKEDLETGSR
GAVLGGVTAVFEMPNTNPLTTGAVELADKVARATHRMHCDFAFWVGGTYDNPKDIPELERLPGSAGIKVFMGSSTGSLLV
EDDEGIARILAQTRRRAAFHSEDEARLNERKPVRVAGDPSSHPLWRDEEAALLSTRRLVRIAHEQNALVHVLHVSTAEEI
DFLAAHKERVSIEITPHHLTLSSEDYARLGTLMQMNPPVRDARHRERLWYGLDQSIVDILGSDHAPHTLEEKAKPYPQSP
SGMTGVQTLVPLMLDHVQAGRLTLQRFVDLTSAGPARLFGIAGKGRIAVGYDADLTVVDLKRRETITNEWIASRAGWTPY
HGKTVTGWPIGTLVRGRKVMWEGEIVTAGQGEPVRFLTR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=32.75, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI19923821, Length=460, Percent_Identity=28.0434782608696, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4503051, Length=468, Percent_Identity=26.4957264957265, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI62422571, Length=468, Percent_Identity=26.4957264957265, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI190194363, Length=469, Percent_Identity=26.226012793177, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=25.8695652173913, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4503377, Length=466, Percent_Identity=25.3218884120172, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4503375, Length=465, Percent_Identity=25.8064516129032, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1786722, Length=452, Percent_Identity=30.5309734513274, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082175, Length=458, Percent_Identity=28.1659388646288, Blast_Score=168, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI193204318, Length=397, Percent_Identity=30.7304785894207, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17539558, Length=454, Percent_Identity=26.431718061674, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71989490, Length=462, Percent_Identity=26.1904761904762, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=25.5079006772009, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=386, Percent_Identity=29.5336787564767, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642586, Length=393, Percent_Identity=33.8422391857506, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI18859883, Length=463, Percent_Identity=25.9179265658747, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137462, Length=450, Percent_Identity=27.1111111111111, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644287, Length=248, Percent_Identity=27.4193548387097, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48261; Mature: 48129

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHNFDLLLKGGIVVDHNGIAARDIGIRDGKIAAIGHLRQASAGETIAAEGLHILPGVID
CCCCEEEEEECCEEEECCCEEEEECCCCCCCEEEEECHHHCCCCCEEHHCCCEECCCEEC
TQVHFREPGLTHKEDLETGSRGAVLGGVTAVFEMPNTNPLTTGAVELADKVARATHRMHC
CEEEECCCCCCCHHHCCCCCCCCEEECEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEC
DFAFWVGGTYDNPKDIPELERLPGSAGIKVFMGSSTGSLLVEDDEGIARILAQTRRRAAF
EEEEEECCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHC
HSEDEARLNERKPVRVAGDPSSHPLWRDEEAALLSTRRLVRIAHEQNALVHVLHVSTAEE
CCCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
IDFLAAHKERVSIEITPHHLTLSSEDYARLGTLMQMNPPVRDARHRERLWYGLDQSIVDI
HHHHHCCCCEEEEEEECCEEEECCCHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHH
LGSDHAPHTLEEKAKPYPQSPSGMTGVQTLVPLMLDHVQAGRLTLQRFVDLTSAGPARLF
HCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GIAGKGRIAVGYDADLTVVDLKRRETITNEWIASRAGWTPYHGKTVTGWPIGTLVRGRKV
EECCCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHCCCEE
MWEGEIVTAGQGEPVRFLTR
EEECEEEECCCCCCEECCCC
>Mature Secondary Structure 
PHNFDLLLKGGIVVDHNGIAARDIGIRDGKIAAIGHLRQASAGETIAAEGLHILPGVID
CCCEEEEEECCEEEECCCEEEEECCCCCCCEEEEECHHHCCCCCEEHHCCCEECCCEEC
TQVHFREPGLTHKEDLETGSRGAVLGGVTAVFEMPNTNPLTTGAVELADKVARATHRMHC
CEEEECCCCCCCHHHCCCCCCCCEEECEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEC
DFAFWVGGTYDNPKDIPELERLPGSAGIKVFMGSSTGSLLVEDDEGIARILAQTRRRAAF
EEEEEECCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHC
HSEDEARLNERKPVRVAGDPSSHPLWRDEEAALLSTRRLVRIAHEQNALVHVLHVSTAEE
CCCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
IDFLAAHKERVSIEITPHHLTLSSEDYARLGTLMQMNPPVRDARHRERLWYGLDQSIVDI
HHHHHCCCCEEEEEEECCEEEECCCHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHH
LGSDHAPHTLEEKAKPYPQSPSGMTGVQTLVPLMLDHVQAGRLTLQRFVDLTSAGPARLF
HCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GIAGKGRIAVGYDADLTVVDLKRRETITNEWIASRAGWTPYHGKTVTGWPIGTLVRGRKV
EECCCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHCCCEE
MWEGEIVTAGQGEPVRFLTR
EEECEEEECCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 7929010 [H]