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The map label for this gene is penA [H]

Identifier: 182677679

GI number: 182677679

Start: 765790

End: 767634

Strand: Direct

Name: penA [H]

Synonym: Bind_0686

Alternate gene names: 182677679

Gene position: 765790-767634 (Clockwise)

Preceding gene: 182677678

Following gene: 182677680

Centisome position: 18.36

GC content: 59.73

Gene sequence:

>1845_bases
ATGGAGATGGACCCGCGGATGACGCCGATCCCTGACCCGCATGCTCCCGTCATGCCTTCTCCCGTCATGCCCCCGCCGAC
CGCCGATGGAGCGGCAAGGCCGGCCGTGGAAAGGCGTGGGTGGAAACAGCGTATCGCGCCCTTCTTCGGGACGAGGCTGA
GCAAAAGTTCCGGGCGCGCCAAGCTCATCGCGCTTGGCTTTCTGGGTCTTTACGGCATCATTGGGGGCAAGCTCGTCTAT
TTCGGCCTGCATCCAGAGGCCCCGCAAGAGGCCAAGCGGAGCGGTGATCAGGTTGCGGCGGCGCGGCCCGATCTTCTCGA
CCGTAATGGCGAAGTGCTCGCCACCGATGTGAAGGTCATGTCGGTCTTCGCCGAGCCGCGCCGCATCATCGACAAGGACG
AGGCCGTCGAACTTTTGACGGCGGTCTTGCCCGATATTGACGCGCGCGATCTCCGGCAGCGTCTTGGCTCGCGCAAGGGG
TTCATCTGGGTCAAACGTGCGATCACGCCTAAACAGCGTGAGGAAGTGCATCGGCTGGGCCTGCCGGGCGTCGGCTTTCT
GGCCGAGAACAAACGCGTCTATCCCAATGGGCCGATCGCCGCGCATGTGCTGGGTTTCGCCAATCTCGATGGCGTCGGCA
TTTCCGGCCTGGAGAAATATATCGACGGACAGGGGCTCGCCGATCTACATGGCGCCGGCTTTAGCCTGACGCAGCAGGAT
CTGAAGCCGATCGTGACGTCCCTTGATCTCAAGGCGACTTACGCCGTGCGCGACGAATTGGCCAAGGGCATTGCGCATTT
CAAGGCGAAGGCTGGGGCTGCCTGTATTCTCGACGTGAATACGGGCGAGGTCATCGCCATGGCCTCACTACCAGATTATG
ATCCGAACACGCCGGCCGATGCGCTTGATCCCAATCATATCAACCGGCTGTCCGTCGGTGTTTATGAAATGGGCTCGACT
TTCAAGGCGATTTCCATCGCCATGGCGCTCGAGGGCAATAGGGTCAATCTCAATTCCCGGATCGACGCGCGCGATTCCCT
GCGCTACGGCCGTTTTACCATTCATGATTTCCACGCCCAGCACCGCATGCTGAGTGTGCCGGAAGTCTTTACTTATTCCT
CGAATATTGGCACCGCGCGCATGGCTTTGATGGTCGGCGTCGAGGGGCACAAAGCCTTTTTGCGCAAAATGGGCCAATTG
AACCGGCTGACCACTGAATTGCCGGAATCTGCTGAGCCTCTGGTGCCGAGGAATTGGGGTGAACTCAATACGATGACCAT
CGCCTTCGGCCAAGGCCTCAATGTCGCCCCCTTGCAAGCGACCATGGCGGTGGGAGCCTTGGTCAATGGCGGGCTGTTGA
TCAAGCCGACTTTCTTGAAACGCAGTGAGGAAGAGGCAAAACGCAATGTGCCGCGCGTCGTGCGTCCGGAAACGTCTGAA
TCGATGCGCTATCTGATGCGTCTGAATGCGGAAATTGGATCGGCGCGTCTGGTTGATATCAAGGGCTATTTCATCGGCGG
CAAGACCGGCACGGCCGACAAGATCGTGCATGGCCATTACGCCAAGGATAAAGTGTTCACGACGTTCATGGCGATCATGC
CGGCCGACAAGCCGAAATATCTTTTCCTGACGCTGATGGATGAGCCGCAGGGCCTGCCGGAAACGGGCGGTTATCGGACG
GCTGCCTGGAACTCTGGCTCGGTGACGGCACGGATCATCGAACGGACCGGGCCTTTGCTTGGCATTCCGCCGCGTCTCGA
ATTGCCGACACAGCCTTTCCCGCTGCTCGCCAAGCTCGGCTATGGCATCGCCAATGTTCCCCAGACGAGTCGGGGAGAGC
ATTGA

Upstream 100 bases:

>100_bases
GCTCGAAGCTTTGGGACTCGACCAGCCGACGACCACGCCGCGCGAGGGAGGCTCGGGCGATGCCGCGACGCCGACCTCGG
CGCAACGATAGGAGCGCTGG

Downstream 100 bases:

>100_bases
TGCGGCTTGATGCACTCTTCCCCGATGCATTAATCGAACCGCCGGCTTTTGGTGCGCGTGAGATCGCTGGCCTTGCCTGT
GACAGCCGATTGGTTGCCAA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MEMDPRMTPIPDPHAPVMPSPVMPPPTADGAARPAVERRGWKQRIAPFFGTRLSKSSGRAKLIALGFLGLYGIIGGKLVY
FGLHPEAPQEAKRSGDQVAAARPDLLDRNGEVLATDVKVMSVFAEPRRIIDKDEAVELLTAVLPDIDARDLRQRLGSRKG
FIWVKRAITPKQREEVHRLGLPGVGFLAENKRVYPNGPIAAHVLGFANLDGVGISGLEKYIDGQGLADLHGAGFSLTQQD
LKPIVTSLDLKATYAVRDELAKGIAHFKAKAGAACILDVNTGEVIAMASLPDYDPNTPADALDPNHINRLSVGVYEMGST
FKAISIAMALEGNRVNLNSRIDARDSLRYGRFTIHDFHAQHRMLSVPEVFTYSSNIGTARMALMVGVEGHKAFLRKMGQL
NRLTTELPESAEPLVPRNWGELNTMTIAFGQGLNVAPLQATMAVGALVNGGLLIKPTFLKRSEEEAKRNVPRVVRPETSE
SMRYLMRLNAEIGSARLVDIKGYFIGGKTGTADKIVHGHYAKDKVFTTFMAIMPADKPKYLFLTLMDEPQGLPETGGYRT
AAWNSGSVTARIIERTGPLLGIPPRLELPTQPFPLLAKLGYGIANVPQTSRGEH

Sequences:

>Translated_614_residues
MEMDPRMTPIPDPHAPVMPSPVMPPPTADGAARPAVERRGWKQRIAPFFGTRLSKSSGRAKLIALGFLGLYGIIGGKLVY
FGLHPEAPQEAKRSGDQVAAARPDLLDRNGEVLATDVKVMSVFAEPRRIIDKDEAVELLTAVLPDIDARDLRQRLGSRKG
FIWVKRAITPKQREEVHRLGLPGVGFLAENKRVYPNGPIAAHVLGFANLDGVGISGLEKYIDGQGLADLHGAGFSLTQQD
LKPIVTSLDLKATYAVRDELAKGIAHFKAKAGAACILDVNTGEVIAMASLPDYDPNTPADALDPNHINRLSVGVYEMGST
FKAISIAMALEGNRVNLNSRIDARDSLRYGRFTIHDFHAQHRMLSVPEVFTYSSNIGTARMALMVGVEGHKAFLRKMGQL
NRLTTELPESAEPLVPRNWGELNTMTIAFGQGLNVAPLQATMAVGALVNGGLLIKPTFLKRSEEEAKRNVPRVVRPETSE
SMRYLMRLNAEIGSARLVDIKGYFIGGKTGTADKIVHGHYAKDKVFTTFMAIMPADKPKYLFLTLMDEPQGLPETGGYRT
AAWNSGSVTARIIERTGPLLGIPPRLELPTQPFPLLAKLGYGIANVPQTSRGEH
>Mature_614_residues
MEMDPRMTPIPDPHAPVMPSPVMPPPTADGAARPAVERRGWKQRIAPFFGTRLSKSSGRAKLIALGFLGLYGIIGGKLVY
FGLHPEAPQEAKRSGDQVAAARPDLLDRNGEVLATDVKVMSVFAEPRRIIDKDEAVELLTAVLPDIDARDLRQRLGSRKG
FIWVKRAITPKQREEVHRLGLPGVGFLAENKRVYPNGPIAAHVLGFANLDGVGISGLEKYIDGQGLADLHGAGFSLTQQD
LKPIVTSLDLKATYAVRDELAKGIAHFKAKAGAACILDVNTGEVIAMASLPDYDPNTPADALDPNHINRLSVGVYEMGST
FKAISIAMALEGNRVNLNSRIDARDSLRYGRFTIHDFHAQHRMLSVPEVFTYSSNIGTARMALMVGVEGHKAFLRKMGQL
NRLTTELPESAEPLVPRNWGELNTMTIAFGQGLNVAPLQATMAVGALVNGGLLIKPTFLKRSEEEAKRNVPRVVRPETSE
SMRYLMRLNAEIGSARLVDIKGYFIGGKTGTADKIVHGHYAKDKVFTTFMAIMPADKPKYLFLTLMDEPQGLPETGGYRT
AAWNSGSVTARIIERTGPLLGIPPRLELPTQPFPLLAKLGYGIANVPQTSRGEH

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=557, Percent_Identity=28.0071813285458, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1786854, Length=496, Percent_Identity=24.7983870967742, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66875; Mature: 66875

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMDPRMTPIPDPHAPVMPSPVMPPPTADGAARPAVERRGWKQRIAPFFGTRLSKSSGRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCE
KLIALGFLGLYGIIGGKLVYFGLHPEAPQEAKRSGDQVAAARPDLLDRNGEVLATDVKVM
EEEEHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCEECCCCHHHCCCCCEEEEHHHHH
SVFAEPRRIIDKDEAVELLTAVLPDIDARDLRQRLGSRKGFIWVKRAITPKQREEVHRLG
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCC
LPGVGFLAENKRVYPNGPIAAHVLGFANLDGVGISGLEKYIDGQGLADLHGAGFSLTQQD
CCCCCEEECCCEECCCCCHHEEEEECCCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCHHH
LKPIVTSLDLKATYAVRDELAKGIAHFKAKAGAACILDVNTGEVIAMASLPDYDPNTPAD
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCC
ALDPNHINRLSVGVYEMGSTFKAISIAMALEGNRVNLNSRIDARDSLRYGRFTIHDFHAQ
CCCCCCCCEEEEEHHHCCCCEEEEEEEEEECCCEEECCCCCCHHHCCCCCCEEEEEHHHH
HRMLSVPEVFTYSSNIGTARMALMVGVEGHKAFLRKMGQLNRLTTELPESAEPLVPRNWG
HHHCCCCHHEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ELNTMTIAFGQGLNVAPLQATMAVGALVNGGLLIKPTFLKRSEEEAKRNVPRVVRPETSE
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHCCCCEECCCCHH
SMRYLMRLNAEIGSARLVDIKGYFIGGKTGTADKIVHGHYAKDKVFTTFMAIMPADKPKY
HHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCE
LFLTLMDEPQGLPETGGYRTAAWNSGSVTARIIERTGPLLGIPPRLELPTQPFPLLAKLG
EEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHCCCEECCCCCCCCCCCCCHHHHHHC
YGIANVPQTSRGEH
CCCCCCCCCCCCCC
>Mature Secondary Structure
MEMDPRMTPIPDPHAPVMPSPVMPPPTADGAARPAVERRGWKQRIAPFFGTRLSKSSGRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCE
KLIALGFLGLYGIIGGKLVYFGLHPEAPQEAKRSGDQVAAARPDLLDRNGEVLATDVKVM
EEEEHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCEECCCCHHHCCCCCEEEEHHHHH
SVFAEPRRIIDKDEAVELLTAVLPDIDARDLRQRLGSRKGFIWVKRAITPKQREEVHRLG
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCC
LPGVGFLAENKRVYPNGPIAAHVLGFANLDGVGISGLEKYIDGQGLADLHGAGFSLTQQD
CCCCCEEECCCEECCCCCHHEEEEECCCCCCCCHHHHHHHHCCCCCCHHCCCCCCCCHHH
LKPIVTSLDLKATYAVRDELAKGIAHFKAKAGAACILDVNTGEVIAMASLPDYDPNTPAD
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCCC
ALDPNHINRLSVGVYEMGSTFKAISIAMALEGNRVNLNSRIDARDSLRYGRFTIHDFHAQ
CCCCCCCCEEEEEHHHCCCCEEEEEEEEEECCCEEECCCCCCHHHCCCCCCEEEEEHHHH
HRMLSVPEVFTYSSNIGTARMALMVGVEGHKAFLRKMGQLNRLTTELPESAEPLVPRNWG
HHHCCCCHHEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ELNTMTIAFGQGLNVAPLQATMAVGALVNGGLLIKPTFLKRSEEEAKRNVPRVVRPETSE
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHCCCCEECCCCHH
SMRYLMRLNAEIGSARLVDIKGYFIGGKTGTADKIVHGHYAKDKVFTTFMAIMPADKPKY
HHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCE
LFLTLMDEPQGLPETGGYRTAAWNSGSVTARIIERTGPLLGIPPRLELPTQPFPLLAKLG
EEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHCCCEECCCCCCCCCCCCCHHHHHHC
YGIANVPQTSRGEH
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]