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The map label for this gene is plcH [H]

Identifier: 182677016

GI number: 182677016

Start: 14538

End: 16481

Strand: Direct

Name: plcH [H]

Synonym: Bind_0014

Alternate gene names: 182677016

Gene position: 14538-16481 (Clockwise)

Preceding gene: 182677015

Following gene: 182677017

Centisome position: 0.35

GC content: 56.58

Gene sequence:

>1944_bases
ATGTCTTTCATGACACGCATACTTGCAGCAAGCAAACGCATCACCGCCAGCACGACCGCCTTGGCGATTGCGTTGATGTC
GGCCGGCTTTTCATCTCCGAGCTTGAGCGCCGAGGGGCCTACGCCTTCCGGCACGGTGACACCGATCAAGCACGTTATCA
TCATCGTCGGCGAAAACCGGTCTTTTGACCATGTTTTCGGCGCCTACCAGCCGCCAAAAGGCGAGACGGTCTATAACCTG
CTTTCGCAGGGCATTATCAAGGCCGATGGAACGCCAGGCCCCAATTTCGCTCTCGCCAAGCAATATCAGGGTAGCCTGCA
GGCGCCCGCGAAATATTCCCTGGTTCCGACGTCCAAGACCCCTTATCAGGTCCTGCCGGCGCCCAATACGGGGGGAACGC
ATACGGCGCCCAGCGATGCCAACCCGCCGCCCTTCGCCTCCCTGGCGCTCGCAACCCAAGCCGAATCCGCTGCGCTGCTT
CCGGAAGATCTCCAGCTTCTGACCACGGGCGCGAGCGGCTTGCCGAAAGGCGTCGTCGATACACGCATTGCCAATGCGAC
TAATTTGCCGAGCGGGCCGTTCCAACTGACCCCGAGCCTGCCCTATGACGCTTACGCCGCGGGCGCGGTGCATCGTTTCT
ATCAGAATTGGCAGCAGCTCGATTGCAGCATTGCCCATGCGACGAAAAAGAATCCGAGCGGCTGTCTCGGCGATCTCTTC
GCCTGGGTGGAAGTCACGATTGGCGCCGGCAGCAATGGCAAATCGCAGCCGACTGGTTTCAATGACGAGACGACCCATGA
AGGCGCTAGCGCCTTGGGATTCTACAATACGAATAATGGCGATATGCCCTATTTCACCGCGCTCGCGCAGACCTATGCGC
TCAGCGACAATTATCACCAGCCGGTCTCGGGTGGTACCGGTGCCAATAGCATCATGCTCGGCACCGCCGATGCCATCTAT
TATACGGATGGCCAAGGCCATGTCGCGACGCCGCCTGCCAATCAGATCGAAAATCCAGATCCCGCGCCAAGCACCAATAA
TTGGTACACGCAGGATGGCTACAGCGGCGGCTCCTACAGCAATTGTTCCGACCCGACTCAGCCAGGTGTCGGCGCCATCA
TCAGCTATCTCCGGTCGTTGCCCCATAAGCCAAGGGCGAATTGCGCGCCGGGCGCCTATTATCTGCTGAATAATTATGAT
CCCGGTTATAATGGTGACGGCTCTCTCCATACGAGCAATCCCTTCACCATTCCGCCGTCGCCGGTGCATACCATCGCCAA
CAGGCTTAACGAGAAAGATATCTCGTGGAAATATTATGGCGAGGGTTGGAATTCATTCGTCGCCAATAGCCCCTTGAGTG
TTTATTGCAACATCTGCAATCCGTTCCTTTATCAAACCGCGGTCATGACCAACCCGTCTGCTCGCGCAAAGAATCTGAAG
GACACGACGGATCTTTATAGCGATATTGCGAGCGGCGAACTGCCGGCCGTTTCCTATGTCAAACCCGGTGGGCTGCTCGA
TGGTCACCCCACTTCGTCCAAGTTCGATCTGTTCGAGGCCTTCACCAAGAAGATCATTCTTGCGGTTCAAAACAATCCGA
AGCTGTGGGCGGATACGGCCATCTTCGTCACGGTCGATGAAGGCGGCGGTTACTATGATTCAGGCTATGTCCAGCCGCTC
GATTTCTTCGGCGATGGTCCCCGCATTCCCTTGATCGTGGTTTCGCCCTATTCCACCGGCGGTCATGTGGTGCATACCTA
TTATGACCATGCCTCGCTGCTGAAATTCATCGAACGCAATTGGAGCCTTCAGCCGATCACCCATCGCAGCCGCGATAATC
TGCCCAATCCGGTGGCTGAAGACGAAAACCCCTATGTTCCGGTCAATAGCCCGGCGATCGGCGATCTGTTCGAAATGTTC
GATTTCGGTAAAAAGGGTCACTAA

Upstream 100 bases:

>100_bases
CAGATTATTTCAAATCCAAAGGTATTTGCTAAGCTAACCTACGCATTTCTGTAATAGTGCCTGACTATGGTCCGCCCGTC
CAAACTGAGTGACGGGGGAC

Downstream 100 bases:

>100_bases
CATGAAAAGCCATCACGCGTGATTGCGACGCGTGAGTTTGAGGCGTCAAACTGATACCAGCTCTTGATGAGCATGACTCA
TCAAGAGCTGCCCCCGCGAC

Product: phosphoesterase

Products: NA

Alternate protein names: Heat-labile hemolysin; PLC-H; Phosphatidylcholine cholinephosphohydrolase [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MSFMTRILAASKRITASTTALAIALMSAGFSSPSLSAEGPTPSGTVTPIKHVIIIVGENRSFDHVFGAYQPPKGETVYNL
LSQGIIKADGTPGPNFALAKQYQGSLQAPAKYSLVPTSKTPYQVLPAPNTGGTHTAPSDANPPPFASLALATQAESAALL
PEDLQLLTTGASGLPKGVVDTRIANATNLPSGPFQLTPSLPYDAYAAGAVHRFYQNWQQLDCSIAHATKKNPSGCLGDLF
AWVEVTIGAGSNGKSQPTGFNDETTHEGASALGFYNTNNGDMPYFTALAQTYALSDNYHQPVSGGTGANSIMLGTADAIY
YTDGQGHVATPPANQIENPDPAPSTNNWYTQDGYSGGSYSNCSDPTQPGVGAIISYLRSLPHKPRANCAPGAYYLLNNYD
PGYNGDGSLHTSNPFTIPPSPVHTIANRLNEKDISWKYYGEGWNSFVANSPLSVYCNICNPFLYQTAVMTNPSARAKNLK
DTTDLYSDIASGELPAVSYVKPGGLLDGHPTSSKFDLFEAFTKKIILAVQNNPKLWADTAIFVTVDEGGGYYDSGYVQPL
DFFGDGPRIPLIVVSPYSTGGHVVHTYYDHASLLKFIERNWSLQPITHRSRDNLPNPVAEDENPYVPVNSPAIGDLFEMF
DFGKKGH

Sequences:

>Translated_647_residues
MSFMTRILAASKRITASTTALAIALMSAGFSSPSLSAEGPTPSGTVTPIKHVIIIVGENRSFDHVFGAYQPPKGETVYNL
LSQGIIKADGTPGPNFALAKQYQGSLQAPAKYSLVPTSKTPYQVLPAPNTGGTHTAPSDANPPPFASLALATQAESAALL
PEDLQLLTTGASGLPKGVVDTRIANATNLPSGPFQLTPSLPYDAYAAGAVHRFYQNWQQLDCSIAHATKKNPSGCLGDLF
AWVEVTIGAGSNGKSQPTGFNDETTHEGASALGFYNTNNGDMPYFTALAQTYALSDNYHQPVSGGTGANSIMLGTADAIY
YTDGQGHVATPPANQIENPDPAPSTNNWYTQDGYSGGSYSNCSDPTQPGVGAIISYLRSLPHKPRANCAPGAYYLLNNYD
PGYNGDGSLHTSNPFTIPPSPVHTIANRLNEKDISWKYYGEGWNSFVANSPLSVYCNICNPFLYQTAVMTNPSARAKNLK
DTTDLYSDIASGELPAVSYVKPGGLLDGHPTSSKFDLFEAFTKKIILAVQNNPKLWADTAIFVTVDEGGGYYDSGYVQPL
DFFGDGPRIPLIVVSPYSTGGHVVHTYYDHASLLKFIERNWSLQPITHRSRDNLPNPVAEDENPYVPVNSPAIGDLFEMF
DFGKKGH
>Mature_646_residues
SFMTRILAASKRITASTTALAIALMSAGFSSPSLSAEGPTPSGTVTPIKHVIIIVGENRSFDHVFGAYQPPKGETVYNLL
SQGIIKADGTPGPNFALAKQYQGSLQAPAKYSLVPTSKTPYQVLPAPNTGGTHTAPSDANPPPFASLALATQAESAALLP
EDLQLLTTGASGLPKGVVDTRIANATNLPSGPFQLTPSLPYDAYAAGAVHRFYQNWQQLDCSIAHATKKNPSGCLGDLFA
WVEVTIGAGSNGKSQPTGFNDETTHEGASALGFYNTNNGDMPYFTALAQTYALSDNYHQPVSGGTGANSIMLGTADAIYY
TDGQGHVATPPANQIENPDPAPSTNNWYTQDGYSGGSYSNCSDPTQPGVGAIISYLRSLPHKPRANCAPGAYYLLNNYDP
GYNGDGSLHTSNPFTIPPSPVHTIANRLNEKDISWKYYGEGWNSFVANSPLSVYCNICNPFLYQTAVMTNPSARAKNLKD
TTDLYSDIASGELPAVSYVKPGGLLDGHPTSSKFDLFEAFTKKIILAVQNNPKLWADTAIFVTVDEGGGYYDSGYVQPLD
FFGDGPRIPLIVVSPYSTGGHVVHTYYDHASLLKFIERNWSLQPITHRSRDNLPNPVAEDENPYVPVNSPAIGDLFEMFD
FGKKGH

Specific function: Hydrolyzes sphingomyelin in addition to phosphatidylcholine [H]

COG id: COG3511

COG function: function code M; Phospholipase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial phospholipase C family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007312
- InterPro:   IPR008475
- InterPro:   IPR017767
- InterPro:   IPR006311 [H]

Pfam domain/function: PF05506 DUF756; PF04185 Phosphoesterase [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 69148; Mature: 69017

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFMTRILAASKRITASTTALAIALMSAGFSSPSLSAEGPTPSGTVTPIKHVIIIVGENR
CHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
SFDHVFGAYQPPKGETVYNLLSQGIIKADGTPGPNFALAKQYQGSLQAPAKYSLVPTSKT
CCHHHHCCCCCCCCHHHHHHHHCCEEECCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCC
PYQVLPAPNTGGTHTAPSDANPPPFASLALATQAESAALLPEDLQLLTTGASGLPKGVVD
CEEEEECCCCCCCCCCCCCCCCCCCHHEEEHHCCCCCCCCHHHHHEEECCCCCCCCCHHH
TRIANATNLPSGPFQLTPSLPYDAYAAGAVHRFYQNWQQLDCSIAHATKKNPSGCLGDLF
HHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHE
AWVEVTIGAGSNGKSQPTGFNDETTHEGASALGFYNTNNGDMPYFTALAQTYALSDNYHQ
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
PVSGGTGANSIMLGTADAIYYTDGQGHVATPPANQIENPDPAPSTNNWYTQDGYSGGSYS
CCCCCCCCCEEEEECCCEEEEECCCCEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
NCSDPTQPGVGAIISYLRSLPHKPRANCAPGAYYLLNNYDPGYNGDGSLHTSNPFTIPPS
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCCCCCCC
PVHTIANRLNEKDISWKYYGEGWNSFVANSPLSVYCNICNPFLYQTAVMTNPSARAKNLK
HHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCEEEEEHHCHHHHHHHHCCCCCHHHCCCC
DTTDLYSDIASGELPAVSYVKPGGLLDGHPTSSKFDLFEAFTKKIILAVQNNPKLWADTA
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCEEECEE
IFVTVDEGGGYYDSGYVQPLDFFGDGPRIPLIVVSPYSTGGHVVHTYYDHASLLKFIERN
EEEEECCCCCEECCCCCCCHHHCCCCCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHC
WSLQPITHRSRDNLPNPVAEDENPYVPVNSPAIGDLFEMFDFGKKGH
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFMTRILAASKRITASTTALAIALMSAGFSSPSLSAEGPTPSGTVTPIKHVIIIVGENR
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
SFDHVFGAYQPPKGETVYNLLSQGIIKADGTPGPNFALAKQYQGSLQAPAKYSLVPTSKT
CCHHHHCCCCCCCCHHHHHHHHCCEEECCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCC
PYQVLPAPNTGGTHTAPSDANPPPFASLALATQAESAALLPEDLQLLTTGASGLPKGVVD
CEEEEECCCCCCCCCCCCCCCCCCCHHEEEHHCCCCCCCCHHHHHEEECCCCCCCCCHHH
TRIANATNLPSGPFQLTPSLPYDAYAAGAVHRFYQNWQQLDCSIAHATKKNPSGCLGDLF
HHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHE
AWVEVTIGAGSNGKSQPTGFNDETTHEGASALGFYNTNNGDMPYFTALAQTYALSDNYHQ
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
PVSGGTGANSIMLGTADAIYYTDGQGHVATPPANQIENPDPAPSTNNWYTQDGYSGGSYS
CCCCCCCCCEEEEECCCEEEEECCCCEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
NCSDPTQPGVGAIISYLRSLPHKPRANCAPGAYYLLNNYDPGYNGDGSLHTSNPFTIPPS
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCCCCCCC
PVHTIANRLNEKDISWKYYGEGWNSFVANSPLSVYCNICNPFLYQTAVMTNPSARAKNLK
HHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCEEEEEHHCHHHHHHHHCCCCCHHHCCCC
DTTDLYSDIASGELPAVSYVKPGGLLDGHPTSSKFDLFEAFTKKIILAVQNNPKLWADTA
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCEEECEE
IFVTVDEGGGYYDSGYVQPLDFFGDGPRIPLIVVSPYSTGGHVVHTYYDHASLLKFIERN
EEEEECCCCCEECCCCCCCHHHCCCCCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHC
WSLQPITHRSRDNLPNPVAEDENPYVPVNSPAIGDLFEMFDFGKKGH
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3087958; 10984043 [H]