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The map label for this gene is fkpA [H]

Identifier: 182681784

GI number: 182681784

Start: 1380401

End: 1381357

Strand: Reverse

Name: fkpA [H]

Synonym: XfasM23_1245

Alternate gene names: 182681784

Gene position: 1381357-1380401 (Counterclockwise)

Preceding gene: 182681785

Following gene: 182681783

Centisome position: 54.48

GC content: 51.83

Gene sequence:

>957_bases
ATGAAGATACAAATGCGCCATGCTGTCGTGTCGCTACTGGTCGCAGCAATGTCTGCCTCCTTACCCGCTATGTCCAAACA
ATCGGTTTCCGTTGTGAATAATCAAGAGAAAACGGTGTTGAGCACCGAAAAAGAGAAAGTCAGTTATGCCATTGGTTTGG
ACATTGCGCGATCGCATGTGTTCGAGCTGATTGCTCAAGACATTGATGTTGCTGCACTACAGCGTGCGATCGAAAATGTC
TTCAAGGGTGGGCCGCCTTTGATCTCTGAGGAAGTTGCTCAGACAACCGATACTGCGCTGCGTGCCATGTTGGCAGCTCG
TTCCGGGCAACAGGAAGCTTCGGGGACTGCGCCGCCTGCTGTATCCAAAGAGAACATTGGTCTCATGCTTGGGAGCTATA
TGGTCGGCCCGTCGCTGCTGGCGATCAAGGATGATATTGATCTTCCTGTGCTTCTACAGGCACTGCGTACCAGATTCGCA
AAGCGCACACCGTTGATGGATGAACAAGAAATGACCACAAGGATGCAAGCATTTGTGGCCTCTAAAAATGCTGTGGTTGC
AGGAAAAAATCGTGATGAGGGCAGTGCTTTTCTCTCTAAGAACAAGAACGAGAAGGGCGTGGTCACCACCGCTTCAGGTC
TTCAGTACATGGTGTTGCGGCAGGGAAGCGGCTCACGTCCGACCCCAAGTAATAATGTGCGTGTCAACTACGAGGGCAAG
CTGCTCAGCGGTCAAGTGTTTGATAGCTCTTATCAGCGTGGTCAGCCGGCCGAGTTTGGTCTTGGTCAGGTGATTAAAGG
GTGGTCTGAGGGGCTGTCGTTGATGCCTGTCGGTTCTAAGTACCGTTTTTGGATTCCTGCTGATCTTGCTTACGGGCAGC
AGGGGACTCCGGGTGGTCCGATTGGTCCTGATGCAACGTTGACCTTTGACGTGGAGCTGCTCAGTATCCTCCCTTAA

Upstream 100 bases:

>100_bases
ATGTCCAACAAAGTTATGTCCAATAAAGTTCATGAGACAATGTCAGGAATGCCGCAGTGGCAGCTGACCCATGATTTTAT
TTTTCCAGGAATCGCACTGA

Downstream 100 bases:

>100_bases
TCCCCCCCCCGTTTTAAGGAGTCATCATGCGTGTTGCGATTTTCGGTACTGGTTATGTCGGTCTCGTTACAGGAACTTGC
CTGGCTGAAGTCGGACATGA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKIQMRHAVVSLLVAAMSASLPAMSKQSVSVVNNQEKTVLSTEKEKVSYAIGLDIARSHVFELIAQDIDVAALQRAIENV
FKGGPPLISEEVAQTTDTALRAMLAARSGQQEASGTAPPAVSKENIGLMLGSYMVGPSLLAIKDDIDLPVLLQALRTRFA
KRTPLMDEQEMTTRMQAFVASKNAVVAGKNRDEGSAFLSKNKNEKGVVTTASGLQYMVLRQGSGSRPTPSNNVRVNYEGK
LLSGQVFDSSYQRGQPAEFGLGQVIKGWSEGLSLMPVGSKYRFWIPADLAYGQQGTPGGPIGPDATLTFDVELLSILP

Sequences:

>Translated_318_residues
MKIQMRHAVVSLLVAAMSASLPAMSKQSVSVVNNQEKTVLSTEKEKVSYAIGLDIARSHVFELIAQDIDVAALQRAIENV
FKGGPPLISEEVAQTTDTALRAMLAARSGQQEASGTAPPAVSKENIGLMLGSYMVGPSLLAIKDDIDLPVLLQALRTRFA
KRTPLMDEQEMTTRMQAFVASKNAVVAGKNRDEGSAFLSKNKNEKGVVTTASGLQYMVLRQGSGSRPTPSNNVRVNYEGK
LLSGQVFDSSYQRGQPAEFGLGQVIKGWSEGLSLMPVGSKYRFWIPADLAYGQQGTPGGPIGPDATLTFDVELLSILP
>Mature_318_residues
MKIQMRHAVVSLLVAAMSASLPAMSKQSVSVVNNQEKTVLSTEKEKVSYAIGLDIARSHVFELIAQDIDVAALQRAIENV
FKGGPPLISEEVAQTTDTALRAMLAARSGQQEASGTAPPAVSKENIGLMLGSYMVGPSLLAIKDDIDLPVLLQALRTRFA
KRTPLMDEQEMTTRMQAFVASKNAVVAGKNRDEGSAFLSKNKNEKGVVTTASGLQYMVLRQGSGSRPTPSNNVRVNYEGK
LLSGQVFDSSYQRGQPAEFGLGQVIKGWSEGLSLMPVGSKYRFWIPADLAYGQQGTPGGPIGPDATLTFDVELLSILP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=39.4495412844037, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=49.4252873563218, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=49.4252873563218, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=49.4252873563218, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224809329, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI224809327, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4758384, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI224809331, Length=132, Percent_Identity=35.6060606060606, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=125, Percent_Identity=53.6, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789745, Length=204, Percent_Identity=41.1764705882353, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71993519, Length=108, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=106, Percent_Identity=41.5094339622642, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17540882, Length=89, Percent_Identity=44.9438202247191, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=52.1276595744681, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=48.9130434782609, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323482, Length=97, Percent_Identity=45.360824742268, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323566, Length=97, Percent_Identity=44.3298969072165, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=43.9252336448598, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363946, Length=89, Percent_Identity=50.561797752809, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17352457, Length=89, Percent_Identity=50.561797752809, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=38.0952380952381, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=50, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647110, Length=97, Percent_Identity=40.2061855670103, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 34100; Mature: 34100

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQMRHAVVSLLVAAMSASLPAMSKQSVSVVNNQEKTVLSTEKEKVSYAIGLDIARSHV
CEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHH
FELIAQDIDVAALQRAIENVFKGGPPLISEEVAQTTDTALRAMLAARSGQQEASGTAPPA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VSKENIGLMLGSYMVGPSLLAIKDDIDLPVLLQALRTRFAKRTPLMDEQEMTTRMQAFVA
CCCCCCCEEEHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SKNAVVAGKNRDEGSAFLSKNKNEKGVVTTASGLQYMVLRQGSGSRPTPSNNVRVNYEGK
CCCEEEECCCCCCCHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCEEEEECCE
LLSGQVFDSSYQRGQPAEFGLGQVIKGWSEGLSLMPVGSKYRFWIPADLAYGQQGTPGGP
EEECCHHCCHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECHHCCCCCCCCCCC
IGPDATLTFDVELLSILP
CCCCCEEEEEEEEHHHCC
>Mature Secondary Structure
MKIQMRHAVVSLLVAAMSASLPAMSKQSVSVVNNQEKTVLSTEKEKVSYAIGLDIARSHV
CEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHH
FELIAQDIDVAALQRAIENVFKGGPPLISEEVAQTTDTALRAMLAARSGQQEASGTAPPA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VSKENIGLMLGSYMVGPSLLAIKDDIDLPVLLQALRTRFAKRTPLMDEQEMTTRMQAFVA
CCCCCCCEEEHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SKNAVVAGKNRDEGSAFLSKNKNEKGVVTTASGLQYMVLRQGSGSRPTPSNNVRVNYEGK
CCCEEEECCCCCCCHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCEEEEECCE
LLSGQVFDSSYQRGQPAEFGLGQVIKGWSEGLSLMPVGSKYRFWIPADLAYGQQGTPGGP
EEECCHHCCHHCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECHHCCCCCCCCCCC
IGPDATLTFDVELLSILP
CCCCCEEEEEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]