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The map label for this gene is trxA [H]

Identifier: 197294802

GI number: 197294802

Start: 805864

End: 806187

Strand: Reverse

Name: trxA [H]

Synonym: PAa_0784

Alternate gene names: 197294802

Gene position: 806187-805864 (Counterclockwise)

Preceding gene: 197294803

Following gene: 197294801

Centisome position: 91.62

GC content: 31.17

Gene sequence:

>324_bases
ATGTTAACAAAAAAAGTTATCAGTTATCAAGGGCAAAATTTTTCTGATTTTATTAACCGTGAAGGTTTGGTTCTTGTTGA
TTTTTTTGCTGTATGGTGCCCTCCATGTCGCAAATTAGAACCTATTTTAGAAGAGGTCGCGCGAGTTCAAAGAGAAGTAT
TTTTTGCTAAAGTTGATATTGATTTATTTCGAGAAGTAACCTTGGAGCAAAAAGTTGCAAGCTTTCCAACTCTTATTTTG
TATAAAAACCAGAAAGAAGTAGCTAGAAATAACGGTTTCTTAGATAAAGAAGAATTATTATCTTTTCTCCAAAAACATAA
ATAA

Upstream 100 bases:

>100_bases
AACAGAGAAAGAATAAAATAAAAGAAGTTTATTTAATCCAATTATAACTTTTTTAAGTTATAATTAATTGTAGTCTTAAT
AAAAAAAAGGAGTTATTAAA

Downstream 100 bases:

>100_bases
TGTTATCATGTTCCAATAAAAATAAAATGAATGGTTTCTTTTTAGTTCACAAACCTTCCCAACTCACTTCTCATGATGTA
GTTTATCAAATTAAAAAAAA

Product: Thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MLTKKVISYQGQNFSDFINREGLVLVDFFAVWCPPCRKLEPILEEVARVQREVFFAKVDIDLFREVTLEQKVASFPTLIL
YKNQKEVARNNGFLDKEELLSFLQKHK

Sequences:

>Translated_107_residues
MLTKKVISYQGQNFSDFINREGLVLVDFFAVWCPPCRKLEPILEEVARVQREVFFAKVDIDLFREVTLEQKVASFPTLIL
YKNQKEVARNNGFLDKEELLSFLQKHK
>Mature_107_residues
MLTKKVISYQGQNFSDFINREGLVLVDFFAVWCPPCRKLEPILEEVARVQREVFFAKVDIDLFREVTLEQKVASFPTLIL
YKNQKEVARNNGFLDKEELLSFLQKHK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=41.2371134020619, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=34.5794392523364, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=32.0754716981132, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=37.8048780487805, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=96, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=42.3076923076923, Blast_Score=73, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=39.2405063291139, Blast_Score=72, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573567, Length=89, Percent_Identity=42.6966292134831, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24658597, Length=84, Percent_Identity=36.9047619047619, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12596; Mature: 12596

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKKVISYQGQNFSDFINREGLVLVDFFAVWCPPCRKLEPILEEVARVQREVFFAKVDI
CCCHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLFREVTLEQKVASFPTLILYKNQKEVARNNGFLDKEELLSFLQKHK
HHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLTKKVISYQGQNFSDFINREGLVLVDFFAVWCPPCRKLEPILEEVARVQREVFFAKVDI
CCCHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLFREVTLEQKVASFPTLILYKNQKEVARNNGFLDKEELLSFLQKHK
HHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]