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The map label for this gene is pdhA [H]

Identifier: 197294720

GI number: 197294720

Start: 695168

End: 696259

Strand: Direct

Name: pdhA [H]

Synonym: PAa_0686

Alternate gene names: 197294720

Gene position: 695168-696259 (Clockwise)

Preceding gene: 197294693

Following gene: 197294721

Centisome position: 79.0

GC content: 35.16

Gene sequence:

>1092_bases
ATGTTAACTAATGTTTATGATCCCCTCAAAGGAAAAAAATTAGAAATTCTTGACGCTCAAGGAAATCTCGTAAACCCCGA
ATTAGAACCACAAATTGAAAAAAACATTTTATTAAAAATGTACAAAACTATGGTTTTAAGCAGACAAGCGGATTTGGCGG
CTTTAAAATATCAACGTCAAGGAAGAATGGGTAATTACTTGCTTAATTCAGGTCAAGAAGCTTCTCAAGTTGGAGCTGCT
GCTGCTTTGGCACCACAAGATTGGGTTTCACCTTACTATCGCGATGCTGGTATTTTTCTTTATCGCGGAGTTTCTTTAGA
ACAATTTTATCTTTATTGGTATGGCAATGAAAAAGGTTCTCAATTAGATCCTAAATTACGTATTTTGCCGGCTAATATTA
TTATTGGATCAAGTGTTAACTTAGGTGCTGGTTTAGCTTTTGCAAGTAAGTACCAAAATAAAAAAGAAGCAACAATTGCA
ACTATTGGTGATGGAGGAACTGCTCACGAAGAGTTTAACGCTGGCCTAAATTATGCAGCTGTTTTTCGAGTTCCTTTAGT
AGTGTTGATTCAAAACAACCAATACTCTATTTCTAACCCTCGTAAAAACATTTCTAAAGCAGCAACTTTAGCTCAAAAAT
GTTATGCTTTTGGTATTCCAGGAATGCAAGTTGATGGCAACGATGTTTTAGCAGTTTATGTAGCAGTCAAAGAAGCCTTA
CAGCGCGCAAGAGATGGAGAAGGTCCGATTTTAATTGAAAACGTTGCTTACCGTCTAGAAGCTCACTCTACTAACGATAA
CGCCTCTGTTTATCGTAGCAAAGAAGAAGAAAACGAGTGGAGAAAAAAAGACCCTATTTTACGTTTCCAACTTTATTTAA
TTAAAAAAGGGTACCTCACTCAAGAACAAGTGAAACAAACAGAAGCAGAAGCTCAACAAGAAATAGTTTTAGCACATCAA
AAAGTTGAAAAAGATGGCGGACAAATCAAATTAAGAGAAATTTTTGAATACACTTATGAAAAAATGACTCCTCAATTAGA
AGAACAATACCAAGAATGCCAAGATTTTTTCAATCAGAAAGAAGGTAAATAA

Upstream 100 bases:

>100_bases
TAATTTACCACTATGTTTAAAAATTACTCAATATCAATTCAAAAATTGATTAATTAATCTCGATAAATTTTCTTTAATTA
AAAAAATAAGGAGCATGAAA

Downstream 100 bases:

>100_bases
TCATGGCTTTGATGACTTTATTACAAGCAATTAACCAAACTTTAGATAGTCAATTAAAAAAAGACCCCAATATGGTTGTT
TTTGGTCAAGATGTAGGTAA

Product: Pyruvate dehydrogenase E1 component,alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MLTNVYDPLKGKKLEILDAQGNLVNPELEPQIEKNILLKMYKTMVLSRQADLAALKYQRQGRMGNYLLNSGQEASQVGAA
AALAPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGNEKGSQLDPKLRILPANIIIGSSVNLGAGLAFASKYQNKKEATIA
TIGDGGTAHEEFNAGLNYAAVFRVPLVVLIQNNQYSISNPRKNISKAATLAQKCYAFGIPGMQVDGNDVLAVYVAVKEAL
QRARDGEGPILIENVAYRLEAHSTNDNASVYRSKEEENEWRKKDPILRFQLYLIKKGYLTQEQVKQTEAEAQQEIVLAHQ
KVEKDGGQIKLREIFEYTYEKMTPQLEEQYQECQDFFNQKEGK

Sequences:

>Translated_363_residues
MLTNVYDPLKGKKLEILDAQGNLVNPELEPQIEKNILLKMYKTMVLSRQADLAALKYQRQGRMGNYLLNSGQEASQVGAA
AALAPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGNEKGSQLDPKLRILPANIIIGSSVNLGAGLAFASKYQNKKEATIA
TIGDGGTAHEEFNAGLNYAAVFRVPLVVLIQNNQYSISNPRKNISKAATLAQKCYAFGIPGMQVDGNDVLAVYVAVKEAL
QRARDGEGPILIENVAYRLEAHSTNDNASVYRSKEEENEWRKKDPILRFQLYLIKKGYLTQEQVKQTEAEAQQEIVLAHQ
KVEKDGGQIKLREIFEYTYEKMTPQLEEQYQECQDFFNQKEGK
>Mature_363_residues
MLTNVYDPLKGKKLEILDAQGNLVNPELEPQIEKNILLKMYKTMVLSRQADLAALKYQRQGRMGNYLLNSGQEASQVGAA
AALAPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGNEKGSQLDPKLRILPANIIIGSSVNLGAGLAFASKYQNKKEATIA
TIGDGGTAHEEFNAGLNYAAVFRVPLVVLIQNNQYSISNPRKNISKAATLAQKCYAFGIPGMQVDGNDVLAVYVAVKEAL
QRARDGEGPILIENVAYRLEAHSTNDNASVYRSKEEENEWRKKDPILRFQLYLIKKGYLTQEQVKQTEAEAQQEIVLAHQ
KVEKDGGQIKLREIFEYTYEKMTPQLEEQYQECQDFFNQKEGK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=344, Percent_Identity=35.4651162790698, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI258645172, Length=344, Percent_Identity=35.4651162790698, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4885543, Length=299, Percent_Identity=33.4448160535117, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4505685, Length=311, Percent_Identity=30.5466237942122, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI291084742, Length=311, Percent_Identity=30.5466237942122, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI291084744, Length=306, Percent_Identity=31.0457516339869, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI291084757, Length=294, Percent_Identity=27.891156462585, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=349, Percent_Identity=33.5243553008596, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI86563355, Length=349, Percent_Identity=33.5243553008596, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17536047, Length=312, Percent_Identity=28.8461538461538, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=312, Percent_Identity=29.8076923076923, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=350, Percent_Identity=32, Blast_Score=141, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355903, Length=355, Percent_Identity=30.1408450704225, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24639740, Length=301, Percent_Identity=31.2292358803987, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639744, Length=301, Percent_Identity=31.2292358803987, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571106, Length=301, Percent_Identity=31.2292358803987, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=28.1345565749235, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24639746, Length=258, Percent_Identity=31.7829457364341, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40983; Mature: 40983

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNVYDPLKGKKLEILDAQGNLVNPELEPQIEKNILLKMYKTMVLSRQADLAALKYQRQ
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
GRMGNYLLNSGQEASQVGAAAALAPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGNEKGS
CCCCHHHHCCCCHHHHHHHHHHCCCHHHCCHHHCCCCEEEEECCCEEEEEEEEEECCCCC
QLDPKLRILPANIIIGSSVNLGAGLAFASKYQNKKEATIATIGDGGTAHEEFNAGLNYAA
CCCCCEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCCCEEE
VFRVPLVVLIQNNQYSISNPRKNISKAATLAQKCYAFGIPGMQVDGNDVLAVYVAVKEAL
EEECCEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEHHHHHHHHH
QRARDGEGPILIENVAYRLEAHSTNDNASVYRSKEEENEWRKKDPILRFQLYLIKKGYLT
HHHHCCCCCEEEECEEEEEEECCCCCCCCEEECCHHHHHHHHHCCEEEEEEEEECCCCCC
QEQVKQTEAEAQQEIVLAHQKVEKDGGQIKLREIFEYTYEKMTPQLEEQYQECQDFFNQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
EGK
CCC
>Mature Secondary Structure
MLTNVYDPLKGKKLEILDAQGNLVNPELEPQIEKNILLKMYKTMVLSRQADLAALKYQRQ
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
GRMGNYLLNSGQEASQVGAAAALAPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGNEKGS
CCCCHHHHCCCCHHHHHHHHHHCCCHHHCCHHHCCCCEEEEECCCEEEEEEEEEECCCCC
QLDPKLRILPANIIIGSSVNLGAGLAFASKYQNKKEATIATIGDGGTAHEEFNAGLNYAA
CCCCCEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCCCEEE
VFRVPLVVLIQNNQYSISNPRKNISKAATLAQKCYAFGIPGMQVDGNDVLAVYVAVKEAL
EEECCEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEHHHHHHHHH
QRARDGEGPILIENVAYRLEAHSTNDNASVYRSKEEENEWRKKDPILRFQLYLIKKGYLT
HHHHCCCCCEEEECEEEEEEECCCCCCCCEEECCHHHHHHHHHCCEEEEEEEEECCCCCC
QEQVKQTEAEAQQEIVLAHQKVEKDGGQIKLREIFEYTYEKMTPQLEEQYQECQDFFNQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
EGK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]