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The map label for this gene is tmk [H]

Identifier: 197294444

GI number: 197294444

Start: 376715

End: 377344

Strand: Reverse

Name: tmk [H]

Synonym: PAa_0365

Alternate gene names: 197294444

Gene position: 377344-376715 (Counterclockwise)

Preceding gene: 197294445

Following gene: 197294443

Centisome position: 42.88

GC content: 33.02

Gene sequence:

>630_bases
ATGAAAATAATAATTTTTGAAGGCTTAGACGGAAGCGGAAAAACTACTTTTATCCAAAACATCAAAGAAGAATTACAAGC
CCAAAACCAAGAAGTCATCACGCTACAAGGATTAGGCAGTTCATCAATTGGCCCACAAATCCGCAAAATGTTTTTAACTC
ACGAAAACTTAGACAACCAAACACGCCTTTTATTGAGTTTTTCAAACATGATTCAAACCCAAGAAGAACAAATAACTCCA
CACATTTTCTCAAACAAAATCATTTTAATTGACCGTTGGTTAGGCTCAAATTTCGCTTATCGCATTTATCCCTCCCAAAA
CAAAAGAGATTACCAAATTTTTTATAACTTATTCAATCGCTTCATCAAACCCGACATGACTGTATACTTAAAAACAAACC
CTGAAATTGGCATCAACCGCAAACGCACTCAATCAAACCACAAATTAGACGTCATCGAATCAAGTCCAATATCATATTTC
AAAAAAGTTGAACAAGGTTATGATGAGTTTTTGAAACTACCAAACCTCGGAACAAAAATAATTTTAGATACAACCGATTT
CACAAACATCTCGCAACACCAAAAAAATATAATAAAAAAGATAGGAAACATAAAACAATGGCAATTATAA

Upstream 100 bases:

>100_bases
CCCCACCACCAAAAACCACTGAACTAATGACAGAATAACGCTAAAGACCTTCTCGCGAAGGTCTTTTTTCATTTAAAAAT
TAAATTAAGGAGAAAAAAAT

Downstream 100 bases:

>100_bases
TTCAAAAACAATGCAAAAATGGCAACACATATATCTACTACTCCAACGGAAAAATCAAAACCATCCACAAAGACGGCAAG
ATTACTTGGCGTACCAAAAG

Product: Thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKIIIFEGLDGSGKTTFIQNIKEELQAQNQEVITLQGLGSSSIGPQIRKMFLTHENLDNQTRLLLSFSNMIQTQEEQITP
HIFSNKIILIDRWLGSNFAYRIYPSQNKRDYQIFYNLFNRFIKPDMTVYLKTNPEIGINRKRTQSNHKLDVIESSPISYF
KKVEQGYDEFLKLPNLGTKIILDTTDFTNISQHQKNIIKKIGNIKQWQL

Sequences:

>Translated_209_residues
MKIIIFEGLDGSGKTTFIQNIKEELQAQNQEVITLQGLGSSSIGPQIRKMFLTHENLDNQTRLLLSFSNMIQTQEEQITP
HIFSNKIILIDRWLGSNFAYRIYPSQNKRDYQIFYNLFNRFIKPDMTVYLKTNPEIGINRKRTQSNHKLDVIESSPISYF
KKVEQGYDEFLKLPNLGTKIILDTTDFTNISQHQKNIIKKIGNIKQWQL
>Mature_209_residues
MKIIIFEGLDGSGKTTFIQNIKEELQAQNQEVITLQGLGSSSIGPQIRKMFLTHENLDNQTRLLLSFSNMIQTQEEQITP
HIFSNKIILIDRWLGSNFAYRIYPSQNKRDYQIFYNLFNRFIKPDMTVYLKTNPEIGINRKRTQSNHKLDVIESSPISYF
KKVEQGYDEFLKLPNLGTKIILDTTDFTNISQHQKNIIKKIGNIKQWQL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24430; Mature: 24430

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIIFEGLDGSGKTTFIQNIKEELQAQNQEVITLQGLGSSSIGPQIRKMFLTHENLDNQ
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCH
TRLLLSFSNMIQTQEEQITPHIFSNKIILIDRWLGSNFAYRIYPSQNKRDYQIFYNLFNR
HHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHH
FIKPDMTVYLKTNPEIGINRKRTQSNHKLDVIESSPISYFKKVEQGYDEFLKLPNLGTKI
HCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEE
ILDTTDFTNISQHQKNIIKKIGNIKQWQL
EEECCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIIIFEGLDGSGKTTFIQNIKEELQAQNQEVITLQGLGSSSIGPQIRKMFLTHENLDNQ
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCH
TRLLLSFSNMIQTQEEQITPHIFSNKIILIDRWLGSNFAYRIYPSQNKRDYQIFYNLFNR
HHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHH
FIKPDMTVYLKTNPEIGINRKRTQSNHKLDVIESSPISYFKKVEQGYDEFLKLPNLGTKI
HCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEE
ILDTTDFTNISQHQKNIIKKIGNIKQWQL
EEECCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA