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The map label for this gene is moeB

Identifier: 170757662

GI number: 170757662

Start: 2067968

End: 2068651

Strand: Reverse

Name: moeB

Synonym: CLD_2690

Alternate gene names: 170757662

Gene position: 2068651-2067968 (Counterclockwise)

Preceding gene: 170757369

Following gene: 170757851

Centisome position: 52.26

GC content: 27.05

Gene sequence:

>684_bases
ATGTCTAGATATGATAGAAATATAAAAACTCTTTCTTTAGAAGAAAATGAAAAACTTAAAGACTTTAAAGTCTGCGTAAT
TGGATGTGGAGGATTAGGTGGATATATAATCGAAATGCTAGGAAGAATTGGGATAGGCTATATAACAGTAGTAGATGGTG
ATAATTTTAGCGAATCTAATTTGAATAGACAAATTATTAGTAGTAATTTAAATTTAGGAAAAAATAAGGCTATAGAAGCT
AAAAAAAGAATGAAAATAGTTAATGATTTAATATATGTAAATCCTATTACAACATTTATAAATAAGGATAATGTATTAGA
TATTTTAAAAGAACATGATGTAGTTATTGATGCGATTGATAATATAGAAACTAGATTTTTATTACAAGAAAGTTGTGAGA
AACTTAAAATACCATTTATTCATGGTGCTATTGCAGGTTGGTATGGACAAGTAACAACTATATTTCCGGGGGATAGAACA
CTGGATATTATTTATAAGAATAAAAGTAAAAAGGGCATAGAAGATGTCCTTGGGAATCCTTCTTTTACACCAGCTTTAGT
GGCTTCTATACAAGTAAGTGAAGCACTAAAAGTGTTAATTAATAGAGGAGAAATTCTAAGAAATAAAATATTCATGATAG
ATCTACTGTATCAAGATTTCTATATATTGAATTTAAAAGAATAG

Upstream 100 bases:

>100_bases
GTGGCTATATTACTTATTAATGGGAGAGATGGAAAGGTAGATACTTTATTGAAGGATGGGGATGTATTGTCTTTATTCCC
ACCAGTAGGAGGAGGATAGA

Downstream 100 bases:

>100_bases
TTTAAAGTTGTATATAGGGGTTTTTACGTAACTTCATAAGTTGGTTTTAAACTAAAATGATATTTTTCATAAGTGAATTC
AATTTGAAATTAAAAATTAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGIGYITVVDGDNFSESNLNRQIISSNLNLGKNKAIEA
KKRMKIVNDLIYVNPITTFINKDNVLDILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRT
LDIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE

Sequences:

>Translated_227_residues
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGIGYITVVDGDNFSESNLNRQIISSNLNLGKNKAIEA
KKRMKIVNDLIYVNPITTFINKDNVLDILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRT
LDIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
>Mature_226_residues
SRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGIGYITVVDGDNFSESNLNRQIISSNLNLGKNKAIEAK
KRMKIVNDLIYVNPITTFINKDNVLDILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTL
DIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=152, Percent_Identity=30.9210526315789, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=30.718954248366, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=232, Percent_Identity=29.7413793103448, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082356, Length=156, Percent_Identity=30.1282051282051, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789177, Length=134, Percent_Identity=35.8208955223881, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17540406, Length=157, Percent_Identity=32.484076433121, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193203301, Length=146, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=156, Percent_Identity=31.4102564102564, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322639, Length=169, Percent_Identity=31.3609467455621, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325323, Length=178, Percent_Identity=28.6516853932584, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320598, Length=148, Percent_Identity=27.7027027027027, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24582879, Length=227, Percent_Identity=28.1938325991189, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573937, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24660640, Length=145, Percent_Identity=31.7241379310345, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25644; Mature: 25513

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGIGYITVVDGDNFSESN
CCCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
LNRQIISSNLNLGKNKAIEAKKRMKIVNDLIYVNPITTFINKDNVLDILKEHDVVIDAID
CCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHHHHCCEEEEECC
NIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTLDIIYKNKSKKGIEDVLGNP
CHHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCHHHHHCCC
SFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCEEEEEECC
>Mature Secondary Structure 
SRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGIGYITVVDGDNFSESN
CCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
LNRQIISSNLNLGKNKAIEAKKRMKIVNDLIYVNPITTFINKDNVLDILKEHDVVIDAID
CCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHHHHCCEEEEECC
NIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTLDIIYKNKSKKGIEDVLGNP
CHHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCHHHHHCCC
SFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]