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The map label for this gene is dxr

Identifier: 170757564

GI number: 170757564

Start: 2548412

End: 2549569

Strand: Reverse

Name: dxr

Synonym: CLD_2214

Alternate gene names: 170757564

Gene position: 2549569-2548412 (Counterclockwise)

Preceding gene: 170754604

Following gene: 170756743

Centisome position: 64.41

GC content: 30.66

Gene sequence:

>1158_bases
TTGAAGAACATTACCATATTAGGCGCAACAGGTTCTATTGGAACCCAAACTTTAGATGTAATAAGAAAAGAAAAGGAAGA
ATTAAAATTAGTAGCCATATCCGCGAATAAAAGCTATAAAAAAGTTATAGAAATTATAAAGGAATTTAAACCTAAATATG
CAGTTTTAATGGAAGAGAATGCTTTTAAAATAGTAGAAGATTTTTGTATAGATAATAAAATAGATACAAAAGTTTTAAAA
GGTATGGAAGGGATGATATATATAAGCACCTTAGAGGAGGTAAATACAGTAGTTACCTCTGTGGTAGGAATGATAGGATT
AGTTCCAACCATAAAAGCTATAGAAAGTGGAAAAGATATAGCTTTAGCTAACAAAGAAACCTTAGTAGTAGCTGGAGAAC
TAGTTATTAGTAAAGCTAAAGAGCATAATGTAAATATATTACCTGTAGATTCAGAGCACGGAGCTATTTTTCAATGTTTA
AGAGGAAATAAAAAGGAAGAAGTTAAAAATATAATAGTAACAGCTTCAGGAGGACCTTTTAGAGGTAAAAAGAAGGAAGA
ACTCATAGAGGTAAAGCCAGAGCATGCTCTTAAACATCCTAAATGGAATATGGGAAGAAAAATATCTATAGATTCTGCCA
CATTAATGAATAAAGGGTTAGAGGTTATAGAAGCTCACTTTTTATTTGGTGTGGATTATGAAAATATAAAGGTGGTGGTA
CATCCACAAAGTATAGTCCATTCTATGGTAGAATATAAAGATGGAAGTGTAATAGCGCAAATGGCAACTCCAGATATGAA
ATTACCTATACAATATGCTTTGAATTATCCTAATAGGAAAGAAAGCCAAATAGAACCTTTAGATTTTTATAAAATATCTA
ATTTAACCTTTGAAAAACCGGATATGGATACATTCTTACCACTAAAGTTGGCTTATGAAGCAGGAGAAAAAGGTGGAGTA
ATGCCAGCCATATTAAATGGGGCCAATGAGGTTGCAGTAGATTTATTTTTAAAGGGCAAAATAGAATTTTTACAGATAGG
TGACCTATTACAAGAATGTATGAATAAATTTTATAAATCTATGGAAGCTACATTAGAGAATGTAATAAGTGTAGATAAGG
AAGTTAGAGAGTATTTAGGTAAAAAATATGATATATAA

Upstream 100 bases:

>100_bases
TTTTAGGTTTTTTAGGGTTACTTCTAGGACCATTATATATAATAACCCTTAAAGAATTTGTAAAAACTTAAATGAAAGTT
ATTAGAGGAGAGATGACATT

Downstream 100 bases:

>100_bases
TAATAAAATTAATTTATAGGTACAATTTTAAGGGAGGTTAGTTAATGTATATAGTAGCGGCTATTTTAGCCTTTGGCATA
TTAGTTTTAGTCCATGAATT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKNITILGATGSIGTQTLDVIRKEKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIEVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGEKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI

Sequences:

>Translated_385_residues
MKNITILGATGSIGTQTLDVIRKEKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIEVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGEKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI
>Mature_385_residues
MKNITILGATGSIGTQTLDVIRKEKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIEVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGEKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=44.1326530612245, Blast_Score=338, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43026; Mature: 43026

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNITILGATGSIGTQTLDVIRKEKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEEN
CCCEEEEECCCCCCHHHHHHHHHCHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC
RGKKKEELIEVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
CCCCHHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCEEEECCCEECCC
DMDTFLPLKLAYEAGEKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS
CCCCCCEEEEEEECCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
MEATLENVISVDKEVREYLGKKYDI
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNITILGATGSIGTQTLDVIRKEKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEEN
CCCEEEEECCCCCCHHHHHHHHHCHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC
RGKKKEELIEVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
CCCCHHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCEEEECCCEECCC
DMDTFLPLKLAYEAGEKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS
CCCCCCEEEEEEECCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
MEATLENVISVDKEVREYLGKKYDI
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA