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The map label for this gene is alkA [C]

Identifier: 170757241

GI number: 170757241

Start: 759797

End: 760453

Strand: Reverse

Name: alkA [C]

Synonym: CLD_0120

Alternate gene names: 170757241

Gene position: 760453-759797 (Counterclockwise)

Preceding gene: 170756624

Following gene: 170754344

Centisome position: 19.21

GC content: 43.68

Gene sequence:

>657_bases
TTGTATTTTGAATATGGCCGCGAAGAAACTGAATTTTTAAAAAGCCGCGATGAATTGCTGGGGGCGGCAATTGACCGAAT
TGGGCATATATACCGGGCAGTCGATAGCGATCTTTTTTCTTCTGTCGTTCATCATATCATCGGACAACAAATCTCCACTC
GGGCGCAAGCGACAATCTGGAAAAGACTAGAGGATAGGTTGGAAATTGTCGATGCTGATGCTATCTGCTCTCTTGAATTA
GAAGAACTTCAAAGACTGGGTATGACATTTAAGAAGGCAGAATATATCAAGGGATTTGCACAGAAGGTCAAAAACAAGAA
ATTTGACGTCGAAGCACTGAACAATCTGCCTGATTCCGAGGTCATCAAAGAACTTTCGGCTCTGAAAGGAATTGGTATAT
GGACTGCCGGAATGATTATAATATTCTGTATGCAGCGCCCCGATATTATAAGTTTCGGGGACCTTGCTATTCAGCGCGGA
ATGCGGATGCTATATCATCACAGAAGTATCCACAGAAAAAAATTTACAAAATACGCAAGGCGCTACTCTCCCTATGGAAC
GGTAGCAGGCCTGTATCTTTGGGCGATTGCCGGGGGTGCGATTCCGGAAATGCGGGATTATGCGCCAAAAAAGAAAAAGG
AGGTGACAAAGAAATGA

Upstream 100 bases:

>100_bases
TTTAAAACAGAAGCTTGCTGTACCTCGAATTGAATATCCAAAATTGAGAAGAAAGTTACCAAATGCCTATGCTAAAATTG
TAATGGATGGAGGTGATGTT

Downstream 100 bases:

>100_bases
TTGAGGAAGAAATGTGGAAAGCAGTATCCGAAAATGATGTAGCCTATGACGGTATCTTTTTCTACGCAGTCAAGTCCACT
GGAATTTATTGCCGCCCCTC

Product: methylated-DNA--protein-cysteine methyltransferase

Products: DNA; protein S-methyl-L-cysteine

Alternate protein names: DNA-3-Methyladenine Glycosylase II; HhH-GPD; DNA-3-Methyladenine Glycosylase; DNA-3-Methyladenine Glycosidase; DNA-3-Methyladenine Glycosidase II; DNA-3-Methyladenine Glycosidase II Protein; Base Excision DNA Repair Protein HhH-GPD Family; Methylated-DNA-Protein-Cysteine Methyltransferase; DNA-3-Methyladenine Glycosylase I; Hhh-Gpd Family Protein; 3-Methyladenine DNA Glycosylase; Glycosidase; DNA Glycosylase; Base Excision DNA Repair Protein; 3-Methyladenine DNA Glycosylase II; DNA N-Glycosylase / DNA Lyase; 3-Methyl-Adenine DNA Glycosylase II; DNA-Modified Purine Glycosidase; DNA Repair Protein; Na-3-Methyladenine Glycosylase Protein; HhH-GPD Superfamily Base Excision DNA Repair Family Protein; DNA-3-Methyladenine Glycosidase I; DNA-Glycosylase Family Protein

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MYFEYGREETEFLKSRDELLGAAIDRIGHIYRAVDSDLFSSVVHHIIGQQISTRAQATIWKRLEDRLEIVDADAICSLEL
EELQRLGMTFKKAEYIKGFAQKVKNKKFDVEALNNLPDSEVIKELSALKGIGIWTAGMIIIFCMQRPDIISFGDLAIQRG
MRMLYHHRSIHRKKFTKYARRYSPYGTVAGLYLWAIAGGAIPEMRDYAPKKKKEVTKK

Sequences:

>Translated_218_residues
MYFEYGREETEFLKSRDELLGAAIDRIGHIYRAVDSDLFSSVVHHIIGQQISTRAQATIWKRLEDRLEIVDADAICSLEL
EELQRLGMTFKKAEYIKGFAQKVKNKKFDVEALNNLPDSEVIKELSALKGIGIWTAGMIIIFCMQRPDIISFGDLAIQRG
MRMLYHHRSIHRKKFTKYARRYSPYGTVAGLYLWAIAGGAIPEMRDYAPKKKKEVTKK
>Mature_218_residues
MYFEYGREETEFLKSRDELLGAAIDRIGHIYRAVDSDLFSSVVHHIIGQQISTRAQATIWKRLEDRLEIVDADAICSLEL
EELQRLGMTFKKAEYIKGFAQKVKNKKFDVEALNNLPDSEVIKELSALKGIGIWTAGMIIIFCMQRPDIISFGDLAIQRG
MRMLYHHRSIHRKKFTKYARRYSPYGTVAGLYLWAIAGGAIPEMRDYAPKKKKEVTKK

Specific function: Hydrolysis Of The Deoxyribose N-Glycosidic Bond To Excise 3- Methyladenine, 3- Methylguanine, 7- Methylguanine, O2- Methylthymine, And O2 -Methylcytosine From The Damaged DNA Polymer Formed By Alkylation Lesions. [C]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.63; 3.2.2.21

Molecular weight: Translated: 25107; Mature: 25107

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFEYGREETEFLKSRDELLGAAIDRIGHIYRAVDSDLFSSVVHHIIGQQISTRAQATIW
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLEDRLEIVDADAICSLELEELQRLGMTFKKAEYIKGFAQKVKNKKFDVEALNNLPDSE
HHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHH
VIKELSALKGIGIWTAGMIIIFCMQRPDIISFGDLAIQRGMRMLYHHRSIHRKKFTKYAR
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYSPYGTVAGLYLWAIAGGAIPEMRDYAPKKKKEVTKK
HHCCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MYFEYGREETEFLKSRDELLGAAIDRIGHIYRAVDSDLFSSVVHHIIGQQISTRAQATIW
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLEDRLEIVDADAICSLELEELQRLGMTFKKAEYIKGFAQKVKNKKFDVEALNNLPDSE
HHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHH
VIKELSALKGIGIWTAGMIIIFCMQRPDIISFGDLAIQRGMRMLYHHRSIHRKKFTKYAR
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYSPYGTVAGLYLWAIAGGAIPEMRDYAPKKKKEVTKK
HHCCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA containing 6-O-methylguanine; protein L-cysteine

Specific reaction: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA