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The map label for this gene is lysP

Identifier: 170757067

GI number: 170757067

Start: 313311

End: 314774

Strand: Direct

Name: lysP

Synonym: CLD_0514

Alternate gene names: 170757067

Gene position: 313311-314774 (Clockwise)

Preceding gene: 170755347

Following gene: 170755819

Centisome position: 7.92

GC content: 34.63

Gene sequence:

>1464_bases
ATGAGTACTACAAAAGAAAAAGATTCTAATTCACATAATCTTAAAAGAAGTTTACAAGCAAGACATCTTAATATGATTGC
CATGGGTGGAGCTATAGGAACAGGAATATTCCTAGCACTTGGTGCTACTATCAAGCAAGCAGGACCTGGTGGAGCACTTA
CTGCTTATGCTTGCATAGGAGTTATGGTTTACTTTCTAATGACAAGCTTAGGAGAAATGGCGACCTTTATGCCTGTATCA
GGTTCTTTCGAAACTTATGCTTCAAGATTCATCGATCCTGCATTTGGATTTGCGCTTGGTTGGAATTACTGGTATAACTG
GGCTATTACAGTTGCTGCTGAAATGGTGGCAGGTGCACTAATTATGAAATTTTGGTTTCCTAATGTTCCAGCTATTATTT
GGAGTGTTTTATTCCTTGTATTAATAGTTAGCCTTAACTTATTATCTACAAAAGCTTATGGTGAATCAGAATATTGGTTT
GCAGGTATTAAAGTATTTACTGTTATTGTATTTTTATTAATAGGTATTGCTACTATTTTAGGTATATTAGGTGGGCATAC
AGTAGGACTTCAGAACTTTACTATTAAGGATGCTCCATTTGTTGGAGGAGTTAAATCTATTTTTATGGTATTTTTAATTG
CAGGTTTTTCTTTCCAAGGTACAGAGCTTGTTGGTATAGCTGCTGGTGAAAGTGAAAACCCTAAGAAAACTATTCCCAAA
GCAATCAATACAATATTTTGGAGAATTATAGTTTTTTATTTAGGAACAATATTTGTTGTAAGTGCAATAATTCCTTATAC
AGATGCTGGAGTTAATACAAGTCCATTTACATTAGTATTTGAAAGAGCTGGTATTGCAGCTGCTGCATCGCTAATGAACG
CAGTTATTTTAACCTCAGTAATATCTTGTGGAAACTCAGGAATGTATGCTTCAAGTAGAATGCTGTATGCAATGGCTAAA
GAAGGGAAAGCACCTAGTTGGTTAGGAAAACTTAATTCAAGAGGAGTTCCAGTAAATGCATTAGCATTAACTACTCTAGT
AGCATCAGCTTGTTTCTTAACAGGGCTTTATGCTGAAACCACTGTTTATGTGTGGCTAGTTGCAGCTTCAGGACTTGCAG
GTTTTATTGCTTGGGTTGGTATAGCATTATGTCATTATCGTTTCCGTAAAGCTTATGTTGCTCAAGGACGTGATTTGAAT
AAGCTTGTTTATAAAGCAAAGCTATTCCCACTTGGTCCAATAATAGCGCTAGTATTATGCATAATAGTTATTCTAGGACA
AGGTATTAGCTATTTTGAAGCTACTAAAATTGACTGGAATGGAATAATAGCATCTTATATAGGATTACCAATATTCTTTG
GTTTATGGTTTAGTTATAAGAAGAAACATAAGACAAAAGTTGTTAACTTACAGGAGATAAGCTTTGATGTAGAAGATACT
CATTCAAAAACAGAAATTGTTTAA

Upstream 100 bases:

>100_bases
AAATACATTATTTAATATCCTGAGATAGCCTCAGGATATTTTTTTATGCTCGTCTTAGTTAATTCGCTTATCGGAAAATA
AAACCGATAAGGAGGAAAAA

Downstream 100 bases:

>100_bases
GATAAAATATAAAGACTGCTGATATTTAATCAGCAGTCTTTATATTTATTAGGTGATAGTATGAAACAATATATAAGGTA
ATTCATAAATGAAGCTATAT

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HSKTEIV

Sequences:

>Translated_487_residues
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HSKTEIV
>Mature_486_residues
STTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVSG
SFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFA
GIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPKA
INTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSVISCGNSGMYASSRMLYAMAKE
GKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNK
LVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDTH
SKTEIV

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=485, Percent_Identity=55.2577319587629, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=38.4778012684989, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.6206896551724, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1786789, Length=427, Percent_Identity=36.5339578454333, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1786302, Length=420, Percent_Identity=37.6190476190476, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1789017, Length=396, Percent_Identity=35.6060606060606, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1790653, Length=431, Percent_Identity=35.0348027842227, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87081915, Length=504, Percent_Identity=30.952380952381, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1786602, Length=385, Percent_Identity=37.1428571428571, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081869, Length=327, Percent_Identity=23.8532110091743, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=503, Percent_Identity=35.7852882703777, Blast_Score=316, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=35.7575757575758, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=504, Percent_Identity=34.7222222222222, Blast_Score=296, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=510, Percent_Identity=34.3137254901961, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6324924, Length=491, Percent_Identity=33.4012219959267, Blast_Score=275, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322892, Length=490, Percent_Identity=33.469387755102, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=31.5040650406504, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=496, Percent_Identity=33.2661290322581, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319824, Length=495, Percent_Identity=30.5050505050505, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=477, Percent_Identity=29.559748427673, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6321053, Length=472, Percent_Identity=32.4152542372881, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320251, Length=510, Percent_Identity=30, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6319542, Length=491, Percent_Identity=29.5315682281059, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319543, Length=472, Percent_Identity=29.6610169491525, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322967, Length=504, Percent_Identity=28.968253968254, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324981, Length=487, Percent_Identity=31.8275154004107, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319608, Length=509, Percent_Identity=28.6836935166994, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=563, Percent_Identity=26.6429840142096, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI221512776, Length=427, Percent_Identity=23.1850117096019, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24666159, Length=427, Percent_Identity=23.1850117096019, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52745; Mature: 52614

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCEECCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HSKTEIV
CCCCCCC
>Mature Secondary Structure 
STTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCEECCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAAAASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HSKTEIV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]