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The map label for this gene is panF [H]

Identifier: 170757017

GI number: 170757017

Start: 453267

End: 454682

Strand: Direct

Name: panF [H]

Synonym: CLD_0384

Alternate gene names: 170757017

Gene position: 453267-454682 (Clockwise)

Preceding gene: 170757087

Following gene: 170755456

Centisome position: 11.45

GC content: 30.44

Gene sequence:

>1416_bases
GTGAAGGGATATTTAATATTTATAATAATATATGCCATAATACTTATATTAGCAGGATTTTTTGTAAAAAAATATGTAAA
AGGTGCTGCAGATTTTTTTGTGGCAGGAAGAAAACTTAACTCTAAATTATTATGTACTACTTTAATAGCAGCAAATATAG
GGGCAGGGTCCACTGTAGGCATAACGGGGATTGCATATAAGTATGGAGTATCTTCTTATTGGTGGATATTTATGTCTGCT
ATAGGAACAGCTGTACTAGCTTTTTGGGTAGGACCTAAAATATGGGAAAAATCTATGAAATACAATCTGTATACCTTAGG
AGATTATTTGGATATAAGATATTCTAAATATTTCAAAGGAGCTATATCTATAATGATGACCATAGGTACATTAGCATTAT
TTGCAGGTCAACTTATGGGAATTGCATGGATATTAGATGTAACTTCAGGTATTAATAAAAATATAGGAATTTTAATTGGG
GCAGTAGTTGTGGTTCTTTATTTTTCATCCGGTGGGCTTTTGTCTTCAGCTATAGTAAACGTATTGGAATTAGTAATAAT
AATACTAGGCTTCATAATTGCAGTACCATTTTGTATAAAAAGCGTAAATGGATTTAGCGGATTACATACAGCCATATTAA
ATAATTTACCGGCAAATGAAGGTGTAAATTATTTTAGTTTAAAAGGTATAGGTATAAGTACTATAGTAGGATGGTTTTTA
ATGCTTACACCATCATTTTTTATATCACCAGGATTAATAGGGAAAGTTTACGGAGCAAAAGATATGAAAACTATAAAAAA
GGGAGCAGGAATATGTGCAGTAGTTCAAGGATTATTTGCATTTTTGCCTACTATATTAGGAATGTGTGCCTTTGCAGTGT
TCCCTAATCTTAATCAACAGGAATTAGCATTACCTATGGTTATGAAAAACCTAATGCCTTTTTCAGTATCGGCTTTAGCA
TTAGCGGCTATATTTGCAGCGGAGGTTAGTACAGCAGATGCAGTTTTGTATATGCTAACAACCACCTTTACAGAAGATAT
ATATAAAACTTTTATAAATCCTAAAATAGAAGATAAAAAGTTATTAAAAGCAGGGAGAATAGTTACAATTGTAGGAGGAA
TATTAGGAGTAGCTATGGCTTTTATATTACCTAATATAATAACAGCATTGTCTATATTTTATACACTAATGTCAGTTTCT
TTAACAGTACCACTATTATTTGGACTATTTTCAGAAAAACCAAATACGAAAATTGCTTTTACATCATCCATAATAGGAAT
AATAATAACATTATATTTACAATTTCAAAACAATGACAAAGGTATATGGATATTAAATGCACAATCTACAGGCATATTAT
GTTCTTTGATTGTAATGATAATTTTTCTAGCCCTAAAAAAGGAAACTACTACTTAA

Upstream 100 bases:

>100_bases
TAAAACCTGGTGCAATTGCATCAGGTTTTAAGTTATAATATAATGAAAAATATTATATATAAAATATTTATTAAATAAAC
ATATTTAAGAGGAGGGCATT

Downstream 100 bases:

>100_bases
CAGCTTTTAAAGATTGAGAATTAAAACAAGAAATACTTTTGTTCAATAGATAGCTATAAAAATATTTCTTGTTTTAATTC
CTTTAAAAGCTGTTATAATA

Product: sodium:solute symporter family protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKGAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFWVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGINKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIVMIIFLALKKETTT

Sequences:

>Translated_471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKGAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFWVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGINKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIVMIIFLALKKETTT
>Mature_471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKGAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFWVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGINKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIVMIIFLALKKETTT

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI14140236, Length=402, Percent_Identity=23.3830845771144, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI109659836, Length=352, Percent_Identity=23.0113636363636, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87082237, Length=425, Percent_Identity=26.1176470588235, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790113, Length=368, Percent_Identity=23.9130434782609, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1787251, Length=393, Percent_Identity=23.1552162849873, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648033, Length=307, Percent_Identity=24.4299674267101, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356865, Length=307, Percent_Identity=24.4299674267101, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50909; Mature: 50909

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGYLIFIIIYAIILILAGFFVKKYVKGAADFFVAGRKLNSKLLCTTLIAANIGAGSTVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHCCCCCCCCC
ITGIAYKYGVSSYWWIFMSAIGTAVLAFWVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AISIMMTIGTLALFAGQLMGIAWILDVTSGINKNIGILIGAVVVVLYFSSGGLLSSAIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
VLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQ
HHCHHHHCCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELALPMVMKNLMPFSVSALALAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVSLTVPLLFGLFSEKPNTKIAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIVMIIFLALKKETTT
HHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGYLIFIIIYAIILILAGFFVKKYVKGAADFFVAGRKLNSKLLCTTLIAANIGAGSTVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHCCCCCCCCC
ITGIAYKYGVSSYWWIFMSAIGTAVLAFWVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AISIMMTIGTLALFAGQLMGIAWILDVTSGINKNIGILIGAVVVVLYFSSGGLLSSAIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
VLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQ
HHCHHHHCCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELALPMVMKNLMPFSVSALALAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVSLTVPLLFGLFSEKPNTKIAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIVMIIFLALKKETTT
HHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]