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The map label for this gene is dut

Identifier: 170756597

GI number: 170756597

Start: 1369276

End: 1369902

Strand: Direct

Name: dut

Synonym: CLD_3332

Alternate gene names: 170756597

Gene position: 1369276-1369902 (Clockwise)

Preceding gene: 170754332

Following gene: 170757101

Centisome position: 34.59

GC content: 28.39

Gene sequence:

>627_bases
ATGAACAATAAAGTTAATGTTTATATAAAGGTTTCAGAGGATGGTAAAATGCCAAGCTATGGATCTTTAAATGCTGCAGG
CTGTGATTTATATGCTACAAAGTATATGGAGATAAAGCCAGGGGAAATAAAAGTTATGCCATTAAATTTTGTTATGGCTA
TGGATGAAAACTTAGAAGCACAAATAAGACCAAGAAGTGGATTATCCTTAAAAACTAACTTAAGAGTTCCTAATAGTCCA
GGGACTATAGATAGTGATTATAGGGATACAGTAGGAGTTATACTGGAAAATACATATGATATAGCTAATTTGCCTTATGA
TATAGCAAAAGATCCTAATGTATTGAAAGTTTTAAAAGAAAAATATAAAGAAATATCTTTAGTTGATTATTTAAATAGTA
AAGAAGATATAAATTTAGATACTAATAATTTTTTAAGTATATTGGAGCAAAAGATATATTTAGATGAAAAGGGAAATCCT
TACGGAACTATATATATAAATAAAGGAGAGAGAATAGCCCAAATGGTATTTAAAGAATATAAAAGAGCTAATTTTATAGA
ATGCGAAAATCCTCAAAAAATAGGAGAAAATAGAGGCGGAGGATTTGGACATACAGGAGTAAAATAA

Upstream 100 bases:

>100_bases
TATAAAAAATTACTCATTAATATTATAATCATATATTTTTATAGTATAATATGTATAGTTAACAAAAGTATAAGACTATG
TCAAAAGAGGTGAAAGTAGT

Downstream 100 bases:

>100_bases
TATTAATAAAAGGTGCTGAAGGTTAACTTTCAGCACCTTTCATTGAATTATATATTATTTTAGTTATTTAGTTTGTTACA
TTCACTAAGAGTTTTTACAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLVDYLNSKEDINLDTNNFLSILEQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK

Sequences:

>Translated_208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLVDYLNSKEDINLDTNNFLSILEQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK
>Mature_208_residues
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLVDYLNSKEDINLDTNNFLSILEQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPQKIGENRGGGFGHTGVK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 23490; Mature: 23490

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLVDYLNSKEDINLDTNNFLSILEQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPQKIGENRGGGFGHTGVK
HCCCCEECCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNNKVNVYIKVSEDGKMPSYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLVDYLNSKEDINLDTNNFLSILEQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPQKIGENRGGGFGHTGVK
HCCCCEECCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA