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The map label for this gene is hssS [H]

Identifier: 170756525

GI number: 170756525

Start: 1023791

End: 1024819

Strand: Direct

Name: hssS [H]

Synonym: CLD_3654

Alternate gene names: 170756525

Gene position: 1023791-1024819 (Clockwise)

Preceding gene: 170755580

Following gene: 170757572

Centisome position: 25.86

GC content: 29.15

Gene sequence:

>1029_bases
ATGAATAATAAAATATCCGTTAAAATGGTAGTTGCTTTTTCTTTAATAGTTTTTTTTATTGTTACTTCGGCTGTTGTTAT
TAGTGCCTTAGTAGTGGTATTTCTTTCGCGTTTTAATGTATTTACTCAACCTAATCCTTTAATTTTATTAGGCTGGTTAG
GTATTATCAGTATAATGGTAAGCACAGCGATTGCTCAAATTATAGGAAAAAAAGTACTATCCCCAATTTCTGATCTTAAC
AAAGCAACTAAAGAAGTTGCTAAGGGAAATTTTAATACTAGACTTTCAGAAAATAGCTGGACAGATGAAATAAGAGAAAT
GGCACATAGCTTTAATATAATGACTCATGAATTAGGTAATATTGAAACCTTAAGAGATGATTTTATTAGCAATGTTTCTC
ATGAATTTAAGACTCCTATTTCAGCTATTGAAGGCTATGCTACATTGCTACAAGATGATGAATTATCTGATGAAGAACGT
AAGGAATATATTCATAAAATACTTATAAGTACAAAAAGATTATCTTCTCTTTCGGGGAATATTTTGCAAATAACAGAACT
TGAAAATCAAAAGATTTTACCTTTAAAACAAAAATATTATTTAGATGAACAAATCAGACAAACTATTTTATTATTTGAAT
ATCAGTGGACAAAGAAAAATATAACTTTAGATATTAATCTAGACAATATTACTTACATTGGAAGTAAAGAGTTGTTAGCT
CAAGTATGGCAAAATATTTTAGGGAATGCCATTAAATTTTCCCACCAGAATGGAACAATACAGGTAACATTAACACAAAC
AAATGAGGAAATTTTAATTACAATAAAGGATAATGGTATAGGCATGTCTGAAGAGGTTAAGAACCGAGTGTTCGAAAAGT
TTTATCAGGGAGATAGTTCACATTATTCAGATGGTAATGGATTAGGTTTAGCACTTGTGAAAAGAATTATAGATATTTGT
GAAGGAACTATAAAAATCTCAAGCCATGAAGAAGTAGGTACAGAATTTACTGTTAAACTTCCTAAGTAG

Upstream 100 bases:

>100_bases
TTGATGTTCATATAAATAGATTACGAGATCGGTTTAAAGACAATAAAGACTTCAATATTATTACAATTAGAGGATTAGGT
TATAAGGTGGTTAAACAGTG

Downstream 100 bases:

>100_bases
GATATTTAATTGAAATAAAAATCATTAATATCATAAGTTCCATTTATAAAATCAGATGTTGCCAAAGCACTTTTGTATTT
GTAAAGTAGGAGGATTCTTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MNNKISVKMVVAFSLIVFFIVTSAVVISALVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNTRLSENSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
KEYIHKILISTKRLSSLSGNILQITELENQKILPLKQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEILITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDIC
EGTIKISSHEEVGTEFTVKLPK

Sequences:

>Translated_342_residues
MNNKISVKMVVAFSLIVFFIVTSAVVISALVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNTRLSENSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
KEYIHKILISTKRLSSLSGNILQITELENQKILPLKQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEILITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDIC
EGTIKISSHEEVGTEFTVKLPK
>Mature_342_residues
MNNKISVKMVVAFSLIVFFIVTSAVVISALVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNTRLSENSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
KEYIHKILISTKRLSSLSGNILQITELENQKILPLKQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEILITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDIC
EGTIKISSHEEVGTEFTVKLPK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=27.2401433691756, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=22.962962962963, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=28.8888888888889, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=26.7123287671233, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=30.4166666666667, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=26.9565217391304, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=25, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=25.2747252747253, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=21.0526315789474, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994928, Length=219, Percent_Identity=27.3972602739726, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=27.0386266094421, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=23.6301369863014, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=25.462962962963, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=21.1940298507463, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=24.0802675585284, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787374, Length=268, Percent_Identity=23.8805970149254, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38657; Mature: 38657

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKISVKMVVAFSLIVFFIVTSAVVISALVVVFLSRFNVFTQPNPLILLGWLGIISIMV
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHH
STAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSENSWTDEIREMAHSFNIMTHELGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
IETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERKEYIHKILISTKRLSSLSGN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ILQITELENQKILPLKQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCEEEECCHHHHH
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEILITIKDNGIGMSEEVKNRVFEKFYQGDSS
HHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
HYSDGNGLGLALVKRIIDICEGTIKISSHEEVGTEFTVKLPK
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCC
>Mature Secondary Structure
MNNKISVKMVVAFSLIVFFIVTSAVVISALVVVFLSRFNVFTQPNPLILLGWLGIISIMV
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHH
STAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSENSWTDEIREMAHSFNIMTHELGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
IETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERKEYIHKILISTKRLSSLSGN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ILQITELENQKILPLKQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCEEEECCHHHHH
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEILITIKDNGIGMSEEVKNRVFEKFYQGDSS
HHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
HYSDGNGLGLALVKRIIDICEGTIKISSHEEVGTEFTVKLPK
CCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA