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The map label for this gene is vanR [H]

Identifier: 170756456

GI number: 170756456

Start: 295896

End: 296597

Strand: Direct

Name: vanR [H]

Synonym: CLD_0529

Alternate gene names: 170756456

Gene position: 295896-296597 (Clockwise)

Preceding gene: 170757161

Following gene: 170755434

Centisome position: 7.48

GC content: 27.78

Gene sequence:

>702_bases
ATGGACAAAAGAGCTAAGATTTTAATAGTTGAAGATGACAATGATATTAATAAATTACTTTGTAGTATTTTAAAAAATAA
GGGGTATAAATCTAGAGCGGCTTTTTCAGGAACAGAAGCTTTAATGTGTGTAGAAAATGAAAAGTGGGATATGATTTTAT
TAGATTTAATGATTCCAGGTATTAGTGGAGAAGAAGCTATATTAAAAATAAGAAAAATTACAAAGGCTCCAATAATTATT
GTGAGTGCAAAAACATCTAAAAAAACTAAGTTAGAATTATTAGAAAAGGGAGCTGACGATTTTATTTGTAAGCCTTTTGA
TCCAGATGAAGTAGTTGCAAGGGTTAATTCTAACTTAAGAAGATATTTAGAATTTTCTACAGATGAAGAAAAGAAAAACA
ACATTTTGAGTTATAAGGATATTACTTTAAATAAAGAAAGTAAGGAAGTAAAAGTTGCACAAACCATTGTTATCTTAACG
GCAAGAGAATTTGCAGTATTAGAGTTGTTATTAAATAATCCTAATAAAGTGTACAGTAAAGCTAATATTTTTGAAAGTAT
ATGGGGAGAAGAATTTTTAGGTGATGATAATACTGTAAATGTGCATGTAAGTAGATTGAGGAGTAAATTATCTAAAGCTA
ATAATAATGGAGAAGATTACATAGAAACAGTTTGGGCAATGGGATATAGATTAAGAAAATAG

Upstream 100 bases:

>100_bases
CATAGTAGATAGGTTTTCTAGAAATAAGTTATGGTAAAATATACATATAGAAATTATAAAATAAAAAATAACTTTATGTA
GATTTAGAAGGGGAGAAATT

Downstream 100 bases:

>100_bases
TTAATTGAAATTTAATATAAAAGTATCTAGTAAAAAGATTTAATACTTTTGAAAGGTTTTGGTAAAGTTTTCTTATAAAA
CATTGTTTATTATGAAAGCA

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MDKRAKILIVEDDNDINKLLCSILKNKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDEEKKNNILSYKDITLNKESKEVKVAQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRLRSKLSKANNNGEDYIETVWAMGYRLRK

Sequences:

>Translated_233_residues
MDKRAKILIVEDDNDINKLLCSILKNKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDEEKKNNILSYKDITLNKESKEVKVAQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRLRSKLSKANNNGEDYIETVWAMGYRLRK
>Mature_233_residues
MDKRAKILIVEDDNDINKLLCSILKNKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPGISGEEAILKIRKITKAPIII
VSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLRRYLEFSTDEEKKNNILSYKDITLNKESKEVKVAQTIVILT
AREFAVLELLLNNPNKVYSKANIFESIWGEEFLGDDNTVNVHVSRLRSKLSKANNNGEDYIETVWAMGYRLRK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=32.1739130434783, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=33.0434782608696, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=31.1688311688312, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=32.4675324675325, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=29.3333333333333, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=29.9107142857143, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=32.3144104803493, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=30.3964757709251, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=30.5676855895196, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=27.7056277056277, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=27.1111111111111, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1787229, Length=220, Percent_Identity=27.7272727272727, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=244, Percent_Identity=23.3606557377049, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=29.2682926829268, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=32.4561403508772, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26562; Mature: 26562

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRAKILIVEDDNDINKLLCSILKNKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCEEEEEECCCCCEEEEEEECCC
ISGEEAILKIRKITKAPIIIVSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLR
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RYLEFSTDEEKKNNILSYKDITLNKESKEVKVAQTIVILTAREFAVLELLLNNPNKVYSK
HHHCCCCCCHHHCCCEEEEEEEECCCCCHHEEEEEEEEEEHHHHHHHHHHHCCCHHHHHH
ANIFESIWGEEFLGDDNTVNVHVSRLRSKLSKANNNGEDYIETVWAMGYRLRK
HHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKRAKILIVEDDNDINKLLCSILKNKGYKSRAAFSGTEALMCVENEKWDMILLDLMIPG
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCEEEEEECCCCCEEEEEEECCC
ISGEEAILKIRKITKAPIIIVSAKTSKKTKLELLEKGADDFICKPFDPDEVVARVNSNLR
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RYLEFSTDEEKKNNILSYKDITLNKESKEVKVAQTIVILTAREFAVLELLLNNPNKVYSK
HHHCCCCCCHHHCCCEEEEEEEECCCCCHHEEEEEEEEEEHHHHHHHHHHHCCCHHHHHH
ANIFESIWGEEFLGDDNTVNVHVSRLRSKLSKANNNGEDYIETVWAMGYRLRK
HHHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]