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The map label for this gene is comEC [H]

Identifier: 170756362

GI number: 170756362

Start: 3218177

End: 3219460

Strand: Reverse

Name: comEC [H]

Synonym: CLD_1576

Alternate gene names: 170756362

Gene position: 3219460-3218177 (Counterclockwise)

Preceding gene: 170755293

Following gene: 170757391

Centisome position: 81.34

GC content: 22.12

Gene sequence:

>1284_bases
ATGATAATGTCTTTATGCTTTGGAGAAACTAAATATATATCTAATAGTGATAAAGATATATTAAAGAAATTAGGTGTTAT
ACATGCAGTTAGTGTATCTGGTTTTCATATGGCTATAATATATAAGCTCCTAGAGAGGGTGTTAGGTCTTACCTTAGCTA
TCCCAGTATCTTTTTTATATGTAATCTTAACAGGAATGAAATCATCCGCTATAAGAGCTTTTATAATGATTATAATATTA
AAGCTTTCTAAAAAGGTTTTTAGAAAGTATGATAGTTTATCTTCTATAAGTTTAGCAGCTATAATAATATTATTAAATAA
GCCATATTACATATTGGATATAGGATTTATGTTATCTTTTTTATCTACCCTAGGTATATTATTATATAATAAAAAAATAT
CTAGGACTCTTTATAAATTGCCACAGAGAATTAATTCTTGTGTAAGTCTTACGTTGAGTTCTCAGGTATATACATTCCCC
TATATGTGTTTTACCATTCAAAGCTTTGGTTTAGGTTTTATAATAGGAAATTTAGTGTTAGTACCTCTTTATGCTCCTAT
AGTATTATTAGGAAATTTAGCAATGCTTTTAATAAAAATACCTTTTGTATTTAAGATTATAAATAAAATTATATATATTT
TTTTAATAATGATAGAAGGAGCTCAGTATTTACTCTCTAATATAACTCCAGATTGTATTTATATAGGGGAGTTTGAGGGG
ATATGTTTTGTGATTATATATATGAGCTATGTATTATACAAACATGGTTATAAAAATGTAAAATATATACCCTTAAGTTG
TATAATGTTTTTGATTTTATTCAATTATACTTTTTTCCCAAGTATAGATTTTTATAGAGAAAAAGATTATAATATTACAG
TTGTAAAATATAAGTTTGATACTATAATGCTTTGTAATTATGAAAGTAATGCAGGTAAAAATATATTAAGGGTAAAACAG
CAGGTAAAACCAGATAAAGTAATTACAAATATAAAAAATAATACAAAGATAAATTTAGATAAAAATTTAAAAGTCTATAT
TTTAAGTTGTGAAAAAGAACCTAATTTTTATAATGAAAGGTCAATGGAAAATGAGAATAAATATAGTAAGATAAATATTT
TATTAAAAAATAAAAACAAAAATATAGTTTTTACAGAAAAACCTATTAGCTTAAAAATTCCTAAAAATAATTATGTTATA
ATAAATTTAAAAGAAAAAAATTATACAGATATTTTAAATAAAAGATATATAGTAGTTTTTAATAAAATTTTATGTTTAAA
ATAA

Upstream 100 bases:

>100_bases
TAGTATACAATATATATAATTTTAAATCTATAGCATATATAATTTTAAATCTATAGCCTATAATGAATTTAAGGAACAGT
TAGGAGAAAATAAGACTGCT

Downstream 100 bases:

>100_bases
AGGAAATGTTAAATAAGGAGTGAACATTTTGTTAGATATACTAGAGTTTGAACAAAACACAAAGAAATATATAAATAATA
ATTGTTATATTTTTTGTGGA

Product: ComE operon protein 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MIMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIRAFIMIIIL
KLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCVSLTLSSQVYTFP
YMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEG
ICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFDTIMLCNYESNAGKNILRVKQ
QVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNERSMENENKYSKINILLKNKNKNIVFTEKPISLKIPKNNYVI
INLKEKNYTDILNKRYIVVFNKILCLK

Sequences:

>Translated_427_residues
MIMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIRAFIMIIIL
KLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCVSLTLSSQVYTFP
YMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEG
ICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFDTIMLCNYESNAGKNILRVKQ
QVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNERSMENENKYSKINILLKNKNKNIVFTEKPISLKIPKNNYVI
INLKEKNYTDILNKRYIVVFNKILCLK
>Mature_427_residues
MIMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLYVILTGMKSSAIRAFIMIIIL
KLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSFLSTLGILLYNKKISRTLYKLPQRINSCVSLTLSSQVYTFP
YMCFTIQSFGLGFIIGNLVLVPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEG
ICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFDTIMLCNYESNAGKNILRVKQ
QVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNERSMENENKYSKINILLKNKNKNIVFTEKPISLKIPKNNYVI
INLKEKNYTDILNKRYIVVFNKILCLK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 49408; Mature: 49408

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLY
CEEEEECCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILTGMKSSAIRAFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCEEEEEHHHHHHH
LSTLGILLYNKKISRTLYKLPQRINSCVSLTLSSQVYTFPYMCFTIQSFGLGFIIGNLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHH
VPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFD
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCHHCCCCEEEECCCCEEEEEEEEEE
TIMLCNYESNAGKNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNER
EEEEEECCCCCCCHHHHHHHHCCCHHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCC
SMENENKYSKINILLKNKNKNIVFTEKPISLKIPKNNYVIINLKEKNYTDILNKRYIVVF
CCCCCCCEEEEEEEEEECCCCEEEECCCEEEEECCCCEEEEEECCCCHHHHHCCCEEEEE
NKILCLK
EEHHHCC
>Mature Secondary Structure
MIMSLCFGETKYISNSDKDILKKLGVIHAVSVSGFHMAIIYKLLERVLGLTLAIPVSFLY
CEEEEECCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILTGMKSSAIRAFIMIIILKLSKKVFRKYDSLSSISLAAIIILLNKPYYILDIGFMLSF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEECCCEEEEEHHHHHHH
LSTLGILLYNKKISRTLYKLPQRINSCVSLTLSSQVYTFPYMCFTIQSFGLGFIIGNLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHCCHHHHHHHHHH
VPLYAPIVLLGNLAMLLIKIPFVFKIINKIIYIFLIMIEGAQYLLSNITPDCIYIGEFEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ICFVIIYMSYVLYKHGYKNVKYIPLSCIMFLILFNYTFFPSIDFYREKDYNITVVKYKFD
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCHHCCCCEEEECCCCEEEEEEEEEE
TIMLCNYESNAGKNILRVKQQVKPDKVITNIKNNTKINLDKNLKVYILSCEKEPNFYNER
EEEEEECCCCCCCHHHHHHHHCCCHHHHHCCCCCCEEEECCCEEEEEEEECCCCCCCCCC
SMENENKYSKINILLKNKNKNIVFTEKPISLKIPKNNYVIINLKEKNYTDILNKRYIVVF
CCCCCCCEEEEEEEEEECCCCEEEECCCEEEEECCCCEEEEEECCCCHHHHHCCCEEEEE
NKILCLK
EEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]