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The map label for this gene is panE

Identifier: 170756187

GI number: 170756187

Start: 1296681

End: 1297592

Strand: Direct

Name: panE

Synonym: CLD_3399

Alternate gene names: 170756187

Gene position: 1296681-1297592 (Clockwise)

Preceding gene: 170755365

Following gene: 170756609

Centisome position: 32.76

GC content: 27.3

Gene sequence:

>912_bases
ATGAAAATTGCTATAGTGGGTTCTGGAGCTATGGGATCCTTATATGGGGCTTATTTACATAAAAGTGGAGAGGAAGTTTA
TTTAATTAATAAATGGAAAGAACATATAAACACTATAAATAAAGTGGGATTAGTAATAGAAGAAGGAGATAAAAAATTAA
AGTTTTATCCAAAGGCTGTTACAAATTCTAAGGATATAGGTATAGTAGATTTAGCAATAGTATTTGTAAAATCTACAAAA
ACAGAGGAAGCGATTTTAGAAAATAAAAATATAATAGAAGAAAATACCTATGTCTTAACCCTTCAAAATGGATATGGAAA
TGGAGAAAAAATAGAAAAACATATAAATAAGAATAGAATAATAGTAGGAACTACTGGTGAAGGATGTACTACCATAAAGC
CAGGATATATAAAACATGCAGGTTCAGGAGATACTTACATAGGTATGTTTTCTGGGAAAGAAGATAATATTTTAAAAAGG
TTAGAAAATATTTTAAATAATAGCGGTTTTAATGCACATATATGCAAAGATCCTAGAGAACTTATCTGGGATAAACTTAT
TATAAATATTGGAATTAATGCTATAACAGCTATTTTAGGTATAAAAAATGGTGAAATTTTAAAGGAAATAGCTACAAAAA
AAATCATGAAAGATGCGGTTATAGAGGCAGTAAAGGTAGCTAATGCTAAAGGTCTTAGTTTTAATGAGGAAGAAATGATA
AAAAAAGTAGAAAATGTAGCCTTAAAAACAGCAGAAAATAAATCCTCTATGTTGCAAGATGTTTTAAACAATAAAAAAAC
AGAAATAGAAGATATAAATGGAGCTATTGTAAAAGAAGGAAGTAAATTTAATATAAAGACACCTGTAAACGAAACTCTAA
CTAATTTAATAATTTCTCTAGAAAAGAAATAG

Upstream 100 bases:

>100_bases
TTAGCACAATTATTTTTATTCATTTGAGTATTATTAACCGGAGAATGGTATAAGAATATTAAAAATGGGATAAAAAATTA
ATAAATTTGGGGGAGAGAAT

Downstream 100 bases:

>100_bases
ACTTATAACACTGCAAAGATAAAAAATATACTCATAAATCAATTCATTTCCCTAATAAGTTTTAAATCTGATTTCATTAA
AATTATATTAAAGTTAAATT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIEENTYVLTLQNGYGNGEKIEKHINKNRIIVGTTGEGCTTIKPGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEIATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIEDINGAIVKEGSKFNIKTPVNETLTNLIISLEKK

Sequences:

>Translated_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIEENTYVLTLQNGYGNGEKIEKHINKNRIIVGTTGEGCTTIKPGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEIATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIEDINGAIVKEGSKFNIKTPVNETLTNLIISLEKK
>Mature_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIEENTYVLTLQNGYGNGEKIEKHINKNRIIVGTTGEGCTTIKPGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEIATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIEDINGAIVKEGSKFNIKTPVNETLTNLIISLEKK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=299, Percent_Identity=29.0969899665552, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33444; Mature: 33444

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEEEECCCCEEEEEEHHH
TNSKDIGIVDLAIVFVKSTKTEEAILENKNIIEENTYVLTLQNGYGNGEKIEKHINKNRI
CCCCCCCCEEEEEEEEECCCHHHHHHHCCCEEECCEEEEEEECCCCCHHHHHHHCCCCEE
IVGTTGEGCTTIKPGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCCEECCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEIATKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIEDINGAIVKEGSKFNIKTPVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCEEEECCCEEEEECCHHHHHHHHHHEE
EKK
CCC
>Mature Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEEEECCCCEEEEEEHHH
TNSKDIGIVDLAIVFVKSTKTEEAILENKNIIEENTYVLTLQNGYGNGEKIEKHINKNRI
CCCCCCCCEEEEEEEEECCCHHHHHHHCCCEEECCEEEEEEECCCCCHHHHHHHCCCCEE
IVGTTGEGCTTIKPGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCCEECCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEIATKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIEDINGAIVKEGSKFNIKTPVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCEEEECCCEEEEECCHHHHHHHHHHEE
EKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]