Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 170756048

GI number: 170756048

Start: 2553449

End: 2554165

Strand: Reverse

Name: pyrH

Synonym: CLD_2207

Alternate gene names: 170756048

Gene position: 2554165-2553449 (Counterclockwise)

Preceding gene: 170757774

Following gene: 170756757

Centisome position: 64.53

GC content: 32.91

Gene sequence:

>717_bases
ATGAATGAACCAAAGTATAAGCGCGTTATGTTAAAGCTATCAGGAGAAGCTTTGTCAGGGGAGAAGGGTTTTGGATTTGA
TTTTGATTTTACCAAGGAAATATCAGAACAAATAAAAAAAATAGTTGACATGGGAATAGAAGTAGGCGCAGTAGTTGGTG
GAGGAAACATTTGGAGAGGCAGAAGTGGTTCAGAAATGGATAGAACTACCGCAGATTATATGGGAATGTTAGCTACTTGT
ATAAATGCTTTAGCCCTTCAAGATTCATTAGAACAACTTGGAGTTAATACTAGAGTTCAAACTGCTATAGAAATGAAGGA
AATTGCAGAACCATTTATAAGAAGAAGAGCTATGAGACACTTAGAAAAAGAAAGAGTGGTAATATTTGCATCTGGAACAG
GTAATCCATATTTTTCAACTGATACAGCAGCTGCATTAAGAGCTGCAGAAATAGAAGCAGATGTTATATTACTTGCTAAA
AAAGTAGATGGGGTTTATGATAAGGACCCTCATAAGTATGATGATGCTAAAAAATATAATAAATTATCTTATATAGAAGT
ATTAGAACAAGGATTACAAGTGATGGATTCTACAGCTACTTCTTTATGTATGGATAATGATATTCCTATATTAGTTTTTG
GATTAGATGAACCTTGTAATATAATAAAAGCTGTAACTGGAGAAGAAATAGGTACTCTAGTTTCAAATTCAAAATAA

Upstream 100 bases:

>100_bases
TCTATTGTGTTTTATAGAAATATTAGATTTCTTTTAATCTAGAATCGAAGTTATAATACATAATATATTTAATTTAAAAC
AATTTGGAGGTATAATATAG

Downstream 100 bases:

>100_bases
GGGGAGGTTATTTAAGTGATAAAAGAAATATTAAAAAAAGCAGATGAAAAAATGGGGAAAACTATTGTAGCTTTAAAAAG
AGAATTAGCTTCAATGAAAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNEPKYKRVMLKLSGEALSGEKGFGFDFDFTKEISEQIKKIVDMGIEVGAVVGGGNIWRGRSGSEMDRTTADYMGMLATC
INALALQDSLEQLGVNTRVQTAIEMKEIAEPFIRRRAMRHLEKERVVIFASGTGNPYFSTDTAAALRAAEIEADVILLAK
KVDGVYDKDPHKYDDAKKYNKLSYIEVLEQGLQVMDSTATSLCMDNDIPILVFGLDEPCNIIKAVTGEEIGTLVSNSK

Sequences:

>Translated_238_residues
MNEPKYKRVMLKLSGEALSGEKGFGFDFDFTKEISEQIKKIVDMGIEVGAVVGGGNIWRGRSGSEMDRTTADYMGMLATC
INALALQDSLEQLGVNTRVQTAIEMKEIAEPFIRRRAMRHLEKERVVIFASGTGNPYFSTDTAAALRAAEIEADVILLAK
KVDGVYDKDPHKYDDAKKYNKLSYIEVLEQGLQVMDSTATSLCMDNDIPILVFGLDEPCNIIKAVTGEEIGTLVSNSK
>Mature_238_residues
MNEPKYKRVMLKLSGEALSGEKGFGFDFDFTKEISEQIKKIVDMGIEVGAVVGGGNIWRGRSGSEMDRTTADYMGMLATC
INALALQDSLEQLGVNTRVQTAIEMKEIAEPFIRRRAMRHLEKERVVIFASGTGNPYFSTDTAAALRAAEIEADVILLAK
KVDGVYDKDPHKYDDAKKYNKLSYIEVLEQGLQVMDSTATSLCMDNDIPILVFGLDEPCNIIKAVTGEEIGTLVSNSK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=46.8085106382979, Blast_Score=226, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26243; Mature: 26243

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPKYKRVMLKLSGEALSGEKGFGFDFDFTKEISEQIKKIVDMGIEVGAVVGGGNIWRG
CCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECC
RSGSEMDRTTADYMGMLATCINALALQDSLEQLGVNTRVQTAIEMKEIAEPFIRRRAMRH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKERVVIFASGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYN
HHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCCCCCHHHHHH
KLSYIEVLEQGLQVMDSTATSLCMDNDIPILVFGLDEPCNIIKAVTGEEIGTLVSNSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure
MNEPKYKRVMLKLSGEALSGEKGFGFDFDFTKEISEQIKKIVDMGIEVGAVVGGGNIWRG
CCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECC
RSGSEMDRTTADYMGMLATCINALALQDSLEQLGVNTRVQTAIEMKEIAEPFIRRRAMRH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKERVVIFASGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYN
HHHCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCCCCCHHHHHH
KLSYIEVLEQGLQVMDSTATSLCMDNDIPILVFGLDEPCNIIKAVTGEEIGTLVSNSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA