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The map label for this gene is xdhA [H]

Identifier: 170755646

GI number: 170755646

Start: 1412351

End: 1414648

Strand: Direct

Name: xdhA [H]

Synonym: CLD_3283

Alternate gene names: 170755646

Gene position: 1412351-1414648 (Clockwise)

Preceding gene: 170756928

Following gene: 170754833

Centisome position: 35.68

GC content: 32.42

Gene sequence:

>2298_bases
ATGGAAGATTCTTATGATTTAATTGGAAAAAGCATAAATAGAGTAGATGCAGTAGCTAAAGTTACAGGTAGAGCTAAGTA
TTGCTCAGATCATTTTGAAGCTAATTCACTTGTAGCAATGGTTTTAAGAAGTCCCTATGCTCATGCAAAAGTAAAAAATA
TAGATACTAAAGAAGCTGAAAGCTTAGATGGTGTTGAAGCTGTATTAACGTATAAAAATGTACCAAATACGAAATTTCCT
ACGGCAGGACATCCATATTCATTAGATCCAAGTCATAGAGACATAGAAGATTATGTATTACTTACAGACAAAGCACGCTT
TGTAGGAGATGCAGTTGCAGCAGTTATTGCGACTGATGAACTTATAGCCAAAAAAGCCTTAAAATTAATAAAAGTAGAAT
ATGAAGTTTTGCCTTTTGTAATCGATCAAGAAGAAGCAATAAAAGAGGGAGCTCCTGTTATTCATGATGAAAGACCAAAT
AATATAGTTAGTGATTTTGGTATAACAGTAGGAGATCCAGATGAAGTATTTAAAAATGCAGATAAAATTTATAAGGGTCA
ATATGAAACTCAAATAGTGCAACATTGTCAAATGGAAACGCACAATGCTATGGCAAAGCTTGATGAGAAAGGTAGAATGC
TTATTATAACATCAACACAAATACCACATATTGTACGAAGAATAGTTTCAAAAGCTTGTAATTTACCTATTGGTAAAATA
AGAGTAATAAAGCCTTATGTTGGTGGAGGCTTTGGAGGAAAGCAAGATGTTATAATAGAACCACTTACAGCTATAATGTC
TCTTGCAGTTAATGGAAGATGTGTAAGGTTACAATTAAGTAGAGAAGAGGCAATTATTGCAACTAGAACAAGACATGCAA
TGAGAGTAAATATCAAAATAGCTTTATCAAAAGATAATAAAATAGAAGGGTATGATATAGAGAACTTTGTAAATAATGGA
GCTTATGCATCCCATGGACATTCAATTGCTATGAGTGCAGGAAGTAAAATTAGACCTCTTTATGATATAAAGGCAGAAAA
ATATCGCCCCAAAACTATATATACTAATCTTCCAGTTGCAGGTGCAATGAGAGCATATGGTATACCACAAATGTGTTTTG
TTATAGAATCTATGATTGATGATATATGTAATGATCTAAATATAGACCCTGTAGATTTTAGACTTAATAGTTTTATAAAG
AAAGGTCATATAGATAAGGCATCAGATCTTGTAGTTAGAACCTTTGGATTACCAGAATGTTTAAAAAGAGGTAGAAAATT
AATAGATTGGGACAGAAAAAGAGAATTATATAAAAATCAAAATGGTCCTATAAGAAAAGGTGTTGGAATGGCCTGTTTCA
GTTATTTTTCAGGAACTTGGCCAGTATCACTTGAGGCAGCGGGAACAAGAATAGTAATGAATCAAGATGGTTCAGTCCAA
GTTCAAGTAGGAGCTACAGAAATAGGACAGGGTAGTGATACAGTATTTAGTCAAATGGCAGCAGAAACTATTGGAATACC
ATTTGATATGGTAACAATAGTCTCCCAGCAAGATACAGATATTACTCCTTTTGATACAGGATCCTATGCATCAAGACAAT
CTTTTATAGCAGGCCAAGCTATAAAAAAAGCAGCAACAGAAGTAAAAAGAAAAGTTCTAAAAATTGCCAGTGATAAATGT
GGATTAGATGCAGAGCTTTTGGATATTGTAGATGCAAAGGTGATAGAGAAAGGATTAAGAAGAGAACTTTATACTTTAGA
AGAAATTGCGATGGAGGCATATTACAATAGAGAAAAATATGCACCTATAACAAGTGATTTAACCGTAAAGGTTAAAAATA
ATGCTATAGCCTATGGGGCAACCTTTGTAGAAGTAGAAGTTGATATAAGAACAGGAAAAATAAAAGTTTTAGATATTTAT
AACATACATGATTCAGGAAAAATTTTAAATAAAAAGTTAGCAGAAGGACAAGTACATGGTGGTGTTAGTATGGCTTTAGG
ATTTGCCTTATCAGAAAAATTCATAATAGATGAGAAAACAGGATCTATAATAAACAATAATCTTTTACATTATAAACTTC
CAACTATTATGGATACTCCAAATATAAAATGTGAATTTGTAAATACCTATGATCCAACATCTAGTTATGGACAAAAATCT
TTAGGTGAAAATACAACAATCTCTCCAGCTCCAGCTATACGCAATGCCGTATTGAATGCAACAGGAGTAGCATTTAATAA
ATTACCAATGGATGCTCAATCTGTTTTTGAGAAATTTAAAGAGGTTGGACTTATATAG

Upstream 100 bases:

>100_bases
CTAGTAAATATAAGAGAGAAGTAAAAGAAAAAAAAGAATCATAAAATAAATAATATATGTAGTTATTATAGAAGGCAAAA
TATTAAAGGGGGAACTATAC

Downstream 100 bases:

>100_bases
GAGGCGAAATAATATGTATGATATAAATGAAATTTTAGAACCTAAAACATTAGAAAAGGCATTAGAATTATTATCAGAAC
ACGATAATTTAACGGTAATA

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVAMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIIATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKASDLVVRTFGLPECLKRGRKLIDWDRKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Sequences:

>Translated_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVAMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIIATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKASDLVVRTFGLPECLKRGRKLIDWDRKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
>Mature_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVAMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIIATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKASDLVVRTFGLPECLKRGRKLIDWDRKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=712, Percent_Identity=26.685393258427, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI71773480, Length=737, Percent_Identity=26.3229308005427, Blast_Score=183, Evalue=6e-46,
Organism=Escherichia coli, GI1789230, Length=753, Percent_Identity=46.6135458167331, Blast_Score=726, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=809, Percent_Identity=30.778739184178, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1786478, Length=778, Percent_Identity=26.9922879177378, Blast_Score=207, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17540638, Length=750, Percent_Identity=26, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539860, Length=735, Percent_Identity=23.8095238095238, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32566215, Length=730, Percent_Identity=23.5616438356164, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=27.1870794078062, Blast_Score=213, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24647193, Length=729, Percent_Identity=24.0054869684499, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24647199, Length=724, Percent_Identity=21.9613259668508, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24647201, Length=739, Percent_Identity=23.2746955345061, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24647195, Length=729, Percent_Identity=22.6337448559671, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647197, Length=717, Percent_Identity=23.0125523012552, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84510; Mature: 84510

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVAMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIIATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKASDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LKRGRKLIDWDRKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCHHCCCHHHHHHHHCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKVLKIASDKCGLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCCEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVAMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKLDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAIIATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKASDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LKRGRKLIDWDRKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCHHCCCHHHHHHHHCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKVLKIASDKCGLDAELLDIVDAKVIEKGLRRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCCEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]