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The map label for this gene is mepA [H]

Identifier: 170755612

GI number: 170755612

Start: 2755917

End: 2757266

Strand: Reverse

Name: mepA [H]

Synonym: CLD_1984

Alternate gene names: 170755612

Gene position: 2757266-2755917 (Counterclockwise)

Preceding gene: 170756675

Following gene: 170754599

Centisome position: 69.66

GC content: 29.11

Gene sequence:

>1350_bases
ATGATAAAGAATATAGAAGATAAGCAGGGAAAATTTGAAGAACTTACTAAGACGCCAATTCCCAAATTAATATTGAAAAT
GGCTATACCGTCTACAATGGCAATGTTAATAGGAATTGCATACAGTTTGGCAGATACTTATTTTATATCAAAGATTGATA
CAATATCTACAGCATCAGTAGGATTGGCATTTTCATTTATGAGTGTTACCCAGGCCTTTGGACTTTTATATGGACATGGT
TCAGGAAATTATATGTCAAGAATGGAAAGTGAAAAAAATAGAACAGAGTCATCAAAAATGGCAATAGATGGTCTTGTTAT
ATCATTTCTTACAGGGACAATTATAATGATTTTTGGAGAACTATATTTAAATGAATTAGCACTTTTTTTAGGAGCTACTA
ATTCTCTTTTATCCTCAACGAAAGAATATCTCTTAATACTATTAATAGGTACCCCATTTATGATTTCAGCTTTGACGATG
AATAATCAATTTAGATTACAAGGGAATCCAAGTTTGGGGGCAGCCGCCATTACATCCGGAGCAGTAATTAACTGTATACT
TGATCCTATTTTTATTTTTTATTTTAATTTAGGAATTAAAGGAGCCGCATATGCCACGGTTATTGGAGAAATAATAAGTT
TTATCATTTTAATTGTAGTTAGTGGAATGAGAGAGAATATAAAGTTTAATCTAAAAAATTTTTCTATAAATAAAAAAATA
TTGTCTGAGCTTTATGGAGGAGGGATACCGAATTTTACAAGAGAAATTTTTATAGGAATATCTCTTATGCTTTTGAATAA
TGAATTAAAAATTTTTGGTGAAGAATATATAGCTTCCTTTACTATAGTTAATAGATTAGTGCTTGCAGGAACTTATCTTA
TGGTAGGGCTTGGACATGGATTTCAGCCTGTGTGTATATTTAATTATGGTGCTAAGTTATATGAACGAGTAGAGAAAGCT
TTAAAATTTACATTAAGATCAGCTATAATATTTATGGTTTTTATTTCTATAATATTTTTAATGTACAGCGAAAATATGGT
AATGTTGTTCAGAAATGATAATGAAATAATTAATATAGGTTCACAAGTTCTAAGTATACAATCAATCACTTTACCACTCA
TAGGATATATTACTATAACGGGTATGTTCTTACAAAGTACGCATAAATTTAAAGAAGCTACTTTAATTACTTCATCTAGG
CAGGGTTATATATATATACCTCTAATTTTAATAATGCCTAAGATGTTGGGGGTAAAGGGGATATTGTATGTTCAACCTTT
ATCAGATTTTATTACTTTTGTTATTTCAGTTGTTTTAGTAGCTAAGTATAAAAAAGAGTTAAAATGTTAG

Upstream 100 bases:

>100_bases
TATTGGGTGTTGGAAATGCCACAGTAAATTTATCAGATGGGGAATATATATTATTAGACGGAAATAATGGTATTGTAAAG
CGATTATCAGAGGAAATAAT

Downstream 100 bases:

>100_bases
AGTATAATTTAATATAAAATAATTATAAACTACTACCAAGGAAATATGAATGGGAGTAGTTTTTTTATATATAGTTCATA
AAATTATAGATTTTAAAGAT

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIKNIEDKQGKFEELTKTPIPKLILKMAIPSTMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHG
SGNYMSRMESEKNRTESSKMAIDGLVISFLTGTIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTM
NNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKA
LKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSR
QGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC

Sequences:

>Translated_449_residues
MIKNIEDKQGKFEELTKTPIPKLILKMAIPSTMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHG
SGNYMSRMESEKNRTESSKMAIDGLVISFLTGTIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTM
NNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKA
LKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSR
QGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC
>Mature_449_residues
MIKNIEDKQGKFEELTKTPIPKLILKMAIPSTMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHG
SGNYMSRMESEKNRTESSKMAIDGLVISFLTGTIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTM
NNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKA
LKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSR
QGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49857; Mature: 49857

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNIEDKQGKFEELTKTPIPKLILKMAIPSTMAMLIGIAYSLADTYFISKIDTISTASV
CCCCCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GLAFSFMSVTQAFGLLYGHGSGNYMSRMESEKNRTESSKMAIDGLVISFLTGTIIMIFGE
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMNNQFRLQGNPSLGAAAITSG
HHHHHHHHHHCCCHHHHHCHHHHEEEEEECCCHHHEEEEECCEEEEECCCCCCHHHHHCC
AVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHG
HHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FQPVCIFNYGAKLYERVEKALKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECC
SQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQGYIYIPLILIMPKMLGVKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHCCCC
ILYVQPLSDFITFVISVVLVAKYKKELKC
EEEECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKNIEDKQGKFEELTKTPIPKLILKMAIPSTMAMLIGIAYSLADTYFISKIDTISTASV
CCCCCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GLAFSFMSVTQAFGLLYGHGSGNYMSRMESEKNRTESSKMAIDGLVISFLTGTIIMIFGE
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMNNQFRLQGNPSLGAAAITSG
HHHHHHHHHHCCCHHHHHCHHHHEEEEEECCCHHHEEEEECCEEEEECCCCCCHHHHHCC
AVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHG
HHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FQPVCIFNYGAKLYERVEKALKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECC
SQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQGYIYIPLILIMPKMLGVKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHCCCC
ILYVQPLSDFITFVISVVLVAKYKKELKC
EEEECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA