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The map label for this gene is pepD

Identifier: 170755558

GI number: 170755558

Start: 3098012

End: 3099448

Strand: Reverse

Name: pepD

Synonym: CLD_1675

Alternate gene names: 170755558

Gene position: 3099448-3098012 (Counterclockwise)

Preceding gene: 170757726

Following gene: 170756114

Centisome position: 78.3

GC content: 28.95

Gene sequence:

>1437_bases
ATGTTAGAAAATTTACAACCAAAATCAGTATTTCATTTTTTTGAGGAATTAACTAAAATACCACATGGATCAGGGGATGA
AAAAAGAATAAGTGATTACTTAGTTAATTTTGCAAAAGAAAGAAATTTAGAAGTTATTCAAGATAAATCTTTAAATGTAA
TAATAAGAAAACCAGCTACAAAAGGCTACGAAAATGCTCCAACTGTAATTATTCAAGGCCATATGGATATGGTTTGTGAA
AAAGTTAAGGAAAGTGATCATGATTTTGAAAAAGATCCTTTAAAATTAAGAATAGATGGAGATTATTTATATGCTACAGG
TACAACATTAGGGGGAGATGATGGGATCGCTGTTGCCTATGGACTAGCTGTCTTAAATTCAAAGGATATAGCGCATCCTA
GTATAGAATTTGTTGCTACAACTTCAGAAGAAACAGGCATGAATGGTGCTATAGGGCTAGATACTTCTAAATTAAATGGG
AAAATTTTGTTGAATATTGATTCAGAAGAGGAAGGAATATTTTTAGTTAGTTGTTCTGGTGGAGTAAATCCTATAGTTTA
TATACCAAAAGAGTATGAAAAAGCTACAGGTCAGTCTGTAAAAATAGAAATAAAAGGATTGAATGGTGGACATTCAGGTA
TGGAAATTATAAAACAAAGAGCAAATGCTAATAAGTTAATGGGAAGAGTTTTATATGACCTAAAGAAAGAAGTAGATTTC
AATCTTGTTGAAATAAATGGAGGATCAAAACATAATGCTATTGCTTTACATGCTGATTCAGTATTAACAATAGATGAAAA
TAAATTTAATGAAGTTAAATCTCTTTGTGATAAGCTAGAAGAAACTTTCCAAAATGAATTTAGAGTGGAAGATCCAAATA
TAAAAGTTGTAGTTGAAAAGATAGAAAACAGTGAAAAACAGTTAATTAAAAAAGTAACGGACAATATAATAAATTTCTTG
GTATTAGTTCCTTATGGAGTTCAAACTATGAGTAAAGATATAGATGGATTAGTTGAAAGTAGTTTAAATATTGGTATAGT
TGAAAATAAGGAAGAGGAAATTAAAGTTACAATAGCTGTTAGAAGTTCAGTAAGTAGTTTAAAATTAGAAGTTGTAAATA
GAATAGAGGCCTTATGTTCACTAATAGGTGCAAAATGTGTTAGAGAAGATGAGTATCCAGCATGGCAATTTGATCCAGAA
TCTAAAATAAAGGATTTATGTATTGATATATATACTAAATTATATGAAAAACCAGATGTATCAGCAATACATGCAGGATT
AGAATGTGGATTATTTAAAGGTACTATGAAAGATACTGATATGATAAGTTTTGGACCAAATTTATATGATGTTCATACAC
CAAATGAACACTTAAGTATATCTTCAGTAGAAAGAATATGGAGATTCTTAGTGGAACTATTAAAGAACATAAAATAA

Upstream 100 bases:

>100_bases
TAGTAGAATTAGGATAATGTCGTATTAATACTAAATTATATATAAATTTAAGTATTGGGGTAATTTTTAAATTTAATTTT
AAAAAGGGGGATATACTATC

Downstream 100 bases:

>100_bases
AAATTAATTATTGACATAGATAAGAAAAAGAGTTATATTAAAATTGTAAAATTTAATAAAATGAATCCTTCAGGGCGGGG
CGCAATTCCCCACCGGCGGT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MLENLQPKSVFHFFEELTKIPHGSGDEKRISDYLVNFAKERNLEVIQDKSLNVIIRKPATKGYENAPTVIIQGHMDMVCE
KVKESDHDFEKDPLKLRIDGDYLYATGTTLGGDDGIAVAYGLAVLNSKDIAHPSIEFVATTSEETGMNGAIGLDTSKLNG
KILLNIDSEEEGIFLVSCSGGVNPIVYIPKEYEKATGQSVKIEIKGLNGGHSGMEIIKQRANANKLMGRVLYDLKKEVDF
NLVEINGGSKHNAIALHADSVLTIDENKFNEVKSLCDKLEETFQNEFRVEDPNIKVVVEKIENSEKQLIKKVTDNIINFL
VLVPYGVQTMSKDIDGLVESSLNIGIVENKEEEIKVTIAVRSSVSSLKLEVVNRIEALCSLIGAKCVREDEYPAWQFDPE
SKIKDLCIDIYTKLYEKPDVSAIHAGLECGLFKGTMKDTDMISFGPNLYDVHTPNEHLSISSVERIWRFLVELLKNIK

Sequences:

>Translated_478_residues
MLENLQPKSVFHFFEELTKIPHGSGDEKRISDYLVNFAKERNLEVIQDKSLNVIIRKPATKGYENAPTVIIQGHMDMVCE
KVKESDHDFEKDPLKLRIDGDYLYATGTTLGGDDGIAVAYGLAVLNSKDIAHPSIEFVATTSEETGMNGAIGLDTSKLNG
KILLNIDSEEEGIFLVSCSGGVNPIVYIPKEYEKATGQSVKIEIKGLNGGHSGMEIIKQRANANKLMGRVLYDLKKEVDF
NLVEINGGSKHNAIALHADSVLTIDENKFNEVKSLCDKLEETFQNEFRVEDPNIKVVVEKIENSEKQLIKKVTDNIINFL
VLVPYGVQTMSKDIDGLVESSLNIGIVENKEEEIKVTIAVRSSVSSLKLEVVNRIEALCSLIGAKCVREDEYPAWQFDPE
SKIKDLCIDIYTKLYEKPDVSAIHAGLECGLFKGTMKDTDMISFGPNLYDVHTPNEHLSISSVERIWRFLVELLKNIK
>Mature_478_residues
MLENLQPKSVFHFFEELTKIPHGSGDEKRISDYLVNFAKERNLEVIQDKSLNVIIRKPATKGYENAPTVIIQGHMDMVCE
KVKESDHDFEKDPLKLRIDGDYLYATGTTLGGDDGIAVAYGLAVLNSKDIAHPSIEFVATTSEETGMNGAIGLDTSKLNG
KILLNIDSEEEGIFLVSCSGGVNPIVYIPKEYEKATGQSVKIEIKGLNGGHSGMEIIKQRANANKLMGRVLYDLKKEVDF
NLVEINGGSKHNAIALHADSVLTIDENKFNEVKSLCDKLEETFQNEFRVEDPNIKVVVEKIENSEKQLIKKVTDNIINFL
VLVPYGVQTMSKDIDGLVESSLNIGIVENKEEEIKVTIAVRSSVSSLKLEVVNRIEALCSLIGAKCVREDEYPAWQFDPE
SKIKDLCIDIYTKLYEKPDVSAIHAGLECGLFKGTMKDTDMISFGPNLYDVHTPNEHLSISSVERIWRFLVELLKNIK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=479, Percent_Identity=39.2484342379958, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53298; Mature: 53298

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENLQPKSVFHFFEELTKIPHGSGDEKRISDYLVNFAKERNLEVIQDKSLNVIIRKPAT
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCC
KGYENAPTVIIQGHMDMVCEKVKESDHDFEKDPLKLRIDGDYLYATGTTLGGDDGIAVAY
CCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHH
GLAVLNSKDIAHPSIEFVATTSEETGMNGAIGLDTSKLNGKILLNIDSEEEGIFLVSCSG
HHHHCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCCCEEEEECCC
GVNPIVYIPKEYEKATGQSVKIEIKGLNGGHSGMEIIKQRANANKLMGRVLYDLKKEVDF
CCCCEEECCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
NLVEINGGSKHNAIALHADSVLTIDENKFNEVKSLCDKLEETFQNEFRVEDPNIKVVVEK
EEEEECCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEEH
IENSEKQLIKKVTDNIINFLVLVPYGVQTMSKDIDGLVESSLNIGIVENKEEEIKVTIAV
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEE
RSSVSSLKLEVVNRIEALCSLIGAKCVREDEYPAWQFDPESKIKDLCIDIYTKLYEKPDV
ECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
SAIHAGLECGLFKGTMKDTDMISFGPNLYDVHTPNEHLSISSVERIWRFLVELLKNIK
HHHHCCCHHCEEECCCCCCCEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLENLQPKSVFHFFEELTKIPHGSGDEKRISDYLVNFAKERNLEVIQDKSLNVIIRKPAT
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCC
KGYENAPTVIIQGHMDMVCEKVKESDHDFEKDPLKLRIDGDYLYATGTTLGGDDGIAVAY
CCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHH
GLAVLNSKDIAHPSIEFVATTSEETGMNGAIGLDTSKLNGKILLNIDSEEEGIFLVSCSG
HHHHCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCCCEEEEECCC
GVNPIVYIPKEYEKATGQSVKIEIKGLNGGHSGMEIIKQRANANKLMGRVLYDLKKEVDF
CCCCEEECCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
NLVEINGGSKHNAIALHADSVLTIDENKFNEVKSLCDKLEETFQNEFRVEDPNIKVVVEK
EEEEECCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEEH
IENSEKQLIKKVTDNIINFLVLVPYGVQTMSKDIDGLVESSLNIGIVENKEEEIKVTIAV
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEE
RSSVSSLKLEVVNRIEALCSLIGAKCVREDEYPAWQFDPESKIKDLCIDIYTKLYEKPDV
ECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
SAIHAGLECGLFKGTMKDTDMISFGPNLYDVHTPNEHLSISSVERIWRFLVELLKNIK
HHHHCCCHHCEEECCCCCCCEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]