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The map label for this gene is tmk [H]

Identifier: 170755522

GI number: 170755522

Start: 88157

End: 88852

Strand: Direct

Name: tmk [H]

Synonym: CLD_0731

Alternate gene names: 170755522

Gene position: 88157-88852 (Clockwise)

Preceding gene: 170757865

Following gene: 170754360

Centisome position: 2.23

GC content: 27.3

Gene sequence:

>696_bases
ATGGAAAGAGGTAGGTTAATAGTTATAGAGGGTAGTGATGGAAGTGGTAAAGCTACCCAAACTAAAAAACTTTATGATAA
ATTAGTAAGAGAAAATAAGAAAGTTAAAAAAGTAGAATTCCCTAATTATAAAAGTGAATCATCTGCTTTAATAAAGATGT
ACTTAAGTGGAGAATTTGGAAGGGATCCGGATAGTGTAAATCCTTATGCTTCATCTACATTTTATGCGGTAGATAGATTT
GCATCCTATAAAAAAGATTGGGAAGAGTTTTACCTAAAGGGTGGAATTGTTATTGCAGATAGATATACTACATCCAATAT
GATACATCAAGCAGCAAAAATAAAAGATGTACAAGCCAAAGATAACTTTTTAAATTGGCTATGGGATTTTGAATTTAAAA
AGTTTAATTTACCTGTACCAGATTGTGTTATATTTTTGGATATGCCTCCTAAATTCAGTAAAATTCTTATGAAAACCAGG
AATAATAAATTTACGGGAGAAAAAGAAAAGGATATACACGAAAATAATTATGAGTATTTATTAGAGTCATATAACAATTC
TAAATATATATCAGAAAAATATGATTGGAATAGAATTGAATGTACTAATAAGGATAAGATTAAAAGTATAGATCAAATAA
ATGATGATATAATTAAAATTATAACACAATATATAGATTTCAGTGAACAAAGGTAA

Upstream 100 bases:

>100_bases
ATGCTATATGTTATTATAAAAATAATGGAATAGATGTATTAGGTTTAAAGAATAATAAGATTCAAATAGTAAAATAATAA
GTATAAATGTGGAGGACAAA

Downstream 100 bases:

>100_bases
TTATAATTGTAAACTTGTATAAAAAAATATAAAATATAGGTAAGAAACTACAATGTAATATCCTTTAAGGAGGTAATAAT
ATGAAATTAGTTATTGCTAT

Product: putative thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVRENKKVKKVEFPNYKSESSALIKMYLSGEFGRDPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIVIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFKKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR

Sequences:

>Translated_231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVRENKKVKKVEFPNYKSESSALIKMYLSGEFGRDPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIVIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFKKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
>Mature_231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVRENKKVKKVEFPNYKSESSALIKMYLSGEFGRDPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIVIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFKKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 27273; Mature: 27273

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERGRLIVIEGSDGSGKATQTKKLYDKLVRENKKVKKVEFPNYKSESSALIKMYLSGEFG
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCC
RDPDSVNPYASSTFYAVDRFASYKKDWEEFYLKGGIVIADRYTTSNMIHQAAKIKDVQAK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCHHH
DNFLNWLWDFEFKKFNLPVPDCVIFLDMPPKFSKILMKTRNNKFTGEKEKDIHENNYEYL
HHHHHHHCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
HHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERGRLIVIEGSDGSGKATQTKKLYDKLVRENKKVKKVEFPNYKSESSALIKMYLSGEFG
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCC
RDPDSVNPYASSTFYAVDRFASYKKDWEEFYLKGGIVIADRYTTSNMIHQAAKIKDVQAK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCHHH
DNFLNWLWDFEFKKFNLPVPDCVIFLDMPPKFSKILMKTRNNKFTGEKEKDIHENNYEYL
HHHHHHHCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
HHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]